Age-related impairment of T cell proliferative responses related to the decline of CD28+ T cell subsets

Archives of Gerontology and Geriatrics

Volumn 26, Issue 1, 1997, Pages 55-70

  Tortorella, Cosimo ^a   Loria, Maria P ^a   Piazzolla, Giuseppina ^a   Schulze Koops, Hendrik ^b   Lipsky, Peter E ^b   Jirillo, Emilio ^a   Antonaci, Salvatore ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aging; B7.2; CD28; Costimulatory molecules; T cell proliferation

Indexed keywords

B7 ANTIGEN; CD14 ANTIGEN; CD28 ANTIGEN; INTERLEUKIN 2;

AGED; AGING; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0030772884     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(97)00033-2     Document Type: Article

References (36)

1. Antonaci S., Tortorella C., Polignano A., Ottolenghi A., Jirillo E., Bonomo L. Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderly. Immunopharmacol. Immunotoxicol. 13:1991;87-100.
2. Azuma M., Ito D., Yagita H., Okumura K., Phillips J.H., Lanier L.L., Somoza C. B70 is a second ligand for CTLA-4 and CD28. Nature. 366:1993;76-79.
3. Beckman I., Shepherd K., Firgaira F., Ahern M. Age-related defects in CD2 receptor-induced activation in human T-cell subsets. Immunology. 86:1995;533-536.
4. - T cells. AIDS. 8:1994;431-441.
5. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21(Suppl):1968;77-89.
6. Canonica G.W., Caria M., Venuti D., Cipro G., Ciprandi G., Bagnasco M. T cell activation through different membrane structures (T3/Ti, T11, T44) and frequency analysis of proliferating and interleukin-2 producer T lymphocyte precursor in aged individuals. Mech. Ageing Dev. 42:1988;27-35.
7. Davis S.J., Van der Merwe P.A. The structure and ligand interaction of CD2: implications for T-cell function. Immunol. Today. 17:1996;177-187.
8. De Paoli P., Battistin S., Santini G.F. Age related changes in human lymphocyte subsets; progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin. Immunol. Immunopathol. 48:1988;290-296.
9. Effros R.B. Immunosenescence-related diseases in the elderly. Immunol. Allergy Clin. N. Amer. 13:1993;695-712.
10. Effros R.B. Insights on immunological aging derived from the T lymphocyte cellular senescence model. Exp. Gerontol. 31:1996;21-27.
11. + T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29:1994;601-609.
12. Gerlier D., Thomasset N. Use of MTT colorimetric assay to measure cell activation. J. Immunol. Methods. 94:1986;57-63.
13. + subset. Exp. Cell. Res. 180:1989;367-382.
14. - T4 cell subsets. J. Immunol. 142:1989;2597-2607.
15. Hirohata S., Jelinek D.F., Lipsky P.E. T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3. J. Immunol. 140:1988;3736-3744.
16. Johnson J.G., Jenkins M.K. Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J. Immunol. 152:1994;429-437.
17. June C.H., Bluestone J.A., Nadler L.M., Thompson C.B. The B7 and CD28 receptor families. Immunol. Today. 15:1994;321-331.
18. + T cells by receptor activation. J. Immunol. 155:1995;3815-3822.
19. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28:1990;47-55.
20. Linsley P.S., Ledbetter J.A. The role of CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:1993;191-212.
21. Mondino A., Jenkins M.K. Surface proteins involved in T cell costimulation. J. Leukoc. Biol. 55:1994;805-815.
22. Murasko D.M., Weiner P., Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol. 70:1987;440-448.
23. Nagel J.E., Chopra R.K., Chrest F.J., McCoy M.T., Schneider E.L., Holbrook N.J., Adler W.H. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81:1988;1096-1102.
24. + T cells. Eur. J. Immunol. 21:1991;273-281.
25. + T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo. Clin. Exp. Immunol. 96:1994;528-534.
26. Olive D., Pages F., Klasen S., Battifora M., Costello R., Nunes J., Truneh A., Ragueneau M., Martin Y., Imbert J., Birg F., Mawas C., Bagnasco M., Cerdan C. Stimulation via the CD28 molecule: regulation of signalling, cytokine production and cytokine receptor expression. Fundam. Clin. Immunol. 2:1994;185-197.
27. Rosenberg S.A., Lipsky P.E. Monocyte dependence of pokeweed mitogen-induced differentiation of immunoglobulin-secreting cells from human peripheral blood mononuclear cells. J. Immunol. 122:1979;926-931.
28. Sefton B.M., Campbell M.A. The role of tyrosine protein phosphorylation in lymphocyte activation. Annu. Rev. Cell. Biol. 7:1991;257-274.
29. Shahinian A., Pfeffer K., Lee K.P., Kundig T.M., Kishihara K., Wakeham A., Kawai K., Ohashi P.S., Thompson C., Mak T.W. Differential costimulatory requirements in CD28-deficient mice. Science. 261:1993;609-612.
30. Thoman M.L., Weigle W.O. The cellular and subcellular basis of immunosenescence. Adv. Immunol. 46:1989;221-261.
31. Tortorella C., Jirillo E., Antonaci S. Polymorphonuclear cell-mediated oxidative responsiveness in the elderly. Arch. Gerontol. Geriatr. Suppl. 4:1994;247-256.
32. + memory T cells with different capacities to induce B cell differentiation. J. Immunol. 155:1995;149-162.
33. Tortorella C., Testa A., Jirillo E., Antonaci S. Phytohaemagglutinin- and OKT3-induced proliferative responsiveness in the elderly. Med. Sci. Res. 23:1995;245-247.
34. Whisler R.L., Newhouse Y.G. Function of T cells from elderly humans: Reduction of membrane events and proliferative responses mediated via T3 determinants and diminished elaboration of soluble T cell factors for B cell growth. Cell. Immunol. 99:1986;422-433.
35. Xu X., Beckman I., Dimopoulos K., Ahern M., Bradley J. Age-related changes in the expression of T cell activation antigens following phytohaemagglutinin stimulation. Exp. Clin. Immunogenet. 9:1992;203-211.
36. Zielen S., Dengler T.J., Bauscher P., Meuer S.C. Defective CD2 T cell pathway activation in common variable immunodeficiency (CVID). Clin. Exp. Immunol. 96:1994;253-259.