Phosphorylation and coupling of ζ-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans

Mechanisms of Ageing and Development

Volumn 105, Issue 1-2, 1998, Pages 115-135

  Whisler, Ronald L ^a   Karanfilov, Chris I ^a   Newhouse, Yvonne G ^a   Fox, Charity C ^a   Lakshmanan, Romola R ^a   Liu, Beiqing ^a  

^a William H Davis Med Res C   (United States)

Author keywords

Aging; Human T cells; Protein tyrosine kinases; Protein tyrosine phosphatases; T cell receptor signaling; Zeta chains

Indexed keywords

CD3 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

AGED; AGING; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD3; ANTIGENS, CD4; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; PHOSPHORYLATION; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0032531124     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(98)00084-0     Document Type: Article

References (67)

1. - T lymphocytes. Antigenic and functional properties. J. Immunol. 150:1993;1147-1159.
2. lck) that phosphorylates the CD3 complex. Proc. Natl. Acad. Sci. USA. 86:1989;3277-3281.
3. Ben-Yehuda A., Weksler M.E. Immune senescence: mechanisms and clinical implications. Cancer Invest. 10:1992;525-531.
4. Beyers A.D., Spruyt L.L., Williams A.F. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA. 89:1992;2945-2949.
5. lck tyrosine kinases in human T-cells. EMBO J. 13:1994;1920-1929.
6. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Invest. 21:1968;77-86.
7. Chan A.C., Irving B.A., Fraser J.D., Weiss A. The ζ-chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA. 88:1991;9166-9170.
8. Chan A.C., Desai D.M., Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T-cell antigen receptor signal transduction. Annu. Rev. Immunol. 12:1994;555-592.
9. Cooke M.P., Abraham K.M., Forbush K.A., Perlmutter R.M. Regulation of T-cell receptor signaling by an src family protein-tyrosine kinase (p59fyn). Cell. 65:1991;281-291.
10. Effros R.B. Loss of CD28 expression on T lymphocytes: a marker of replicative senescence. Dev. Comp. Immunol. 21:1997;471-478.
11. + T-cells in centenarians and in long-term T-cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol. 29:1994;601-609.
12. Elder M.E., Lin D., Clever J., Chan A.C., Hope T.J., Weiss A., Parslow T.G. Human severe combined immunodeficiency due to a defect in ZAP-70, a T-cell tyrosine kinase. Science. 264:1994;1596-1599.
13. Engwerda C.R., Handwerger B.S., Fox B.S. Aged T-cells are hyporesponsive to costimulation mediated by CD28. J. Immunol. 152:1994;3740-3747.
14. Fantl W.J., Johnson D.E., Williams L.T. Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62:1993;453-481.
15. lck in T-cells infiltrating human renal cell carcinoma. Cancer Res. 53:1993;5613-5616.
16. Flurkey K., Stadecker M., Miller R.A. Memory T lymphocyte hyporesponsiveness to non-cognate stimuli: a key factor in age-related immunodeficiency. Eur. J. Immunol. 22:1992;931-935.
17. Garcia G.G., Miller R.A. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age. Cell. Immunol. 175:1997;51-57.
18. Gelfand E.W., Weinberg K., Mazer B.D., Kadlecek T.A., Weiss A. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T-cells but not on thymocytes. J. Exp. Med. 182:1995;1057-1065.
19. Ghosh J., Miller R.A. Rapid tyrosine phosphorylation of Grb2 and Shc in T-cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: differential effects of aging. Mech. Ageing Dev. 80:1995;171-187.
20. Gillis S., Kozak R., Durante M., Weksler M.E. Immunologic studies of aging. Decreased production and response to T-cell growth factor by lymphocytes from aged humans. J. Clin. Invest. 67:1981;937-942.
21. Glantz, S.A., 1987. Alternatives to analysis of variance and the t-test based on ranks. In: Primer of Biostatistics. McGraw-Hill, New York, pp. 287-330.
22. Granelli-Piperno A., Keane M., Steinman R.M. Growth factor production and requirements during the proliferative response of human T lymphocytes to anti-CD3 monoclonal antibody. J. Immunol. 142:1989;4138-4143.
23. Hodes R.J. Molecular alterations in the aging immune system. J. Exp. Med. 182:1995;1-3.
24. Iwashima M., Irving B.A., Van Oers N.S.C., Chan A.C., Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 263:1994;1136-1139.
25. Jackola D.R., Ruger J.K., Miller R.A. Age-associated changes in human T-cell phenotype and function. Aging Clin. Exp. Res. 6:1994;25-34.
26. lck dissociation. J. Immunol. 154:1995;2996-3005.
27. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
28. hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur. J. Immunol. 19:1989;977-982.
29. Lewis L.A., Chung C.D., Chen J.Y., Parnes J.R., Moran M., Patel V.P., Miceli M.C. The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the ζ-chain and IL-2 production. J. Immunol. 159:1997;2292-2300.
30. Ley S.C., Marsh M., Bebbington C.R., Proudfoot K., Jordan P. Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes. J. Cell Biol. 125:1994;639-649.
31. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28:1984;47-55.
32. Linton P.J., Haynes L., Klinman N.R., Swain S.L. Antigen-independent changes in naive CD4 T-cells with aging. J. Exp. Med. 184:1996;1891-1900.
33. Madrenas J., Wange R.L., Wang J.L., Isakov N., Samelson L.E., Germain R.N. ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science. 267:1995;515-518.
34. Migita K., Eguchi K., Kawabe Y., Tsukada T., Ichinose Y., Nagataki S. Defective TCR-mediated signaling in anergic T-cells. J. Immunol. 155:1995;5083-5087.
35. Miller R.A. Aging and immune function. Int. Rev. Cytol. 124:1991;187-215.
36. Murasko D.M., Nelson B.J., Silver R., Matour D., Kaye D. Immunologic response in an elderly population with a mean age of 85. Am. J. Med. 81:1986;612-618.
37. Murasko D.M., Gold M.J., Hessen M.T., Kaye D. Immune reactivity, morbidity, and mortality of elderly humans. Aging Immunol. Infect. Dis. 2:1990;171-179.
38. Nagel J.E., Chopra R.K., Chrest F.J., McCoy M.T., Schneider E.L., Holbrook N.J., Adler W.H. Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81:1988;1096-1102.
39. Nakagomi H., Petersson M., Magnusson I., Juhlin C., Matsuda M., Mellstedt H., Taupin J.-L., Vivier E., Anderson P., Kiessling R. Decreased expression of the signal-transducing ζ-chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res. 53:1993;5610-5612.
40. Patel H.R., Miller R.A. Age-associated changes in mitogen-induced protein phosphorylation in murine T lymphocytes. Eur. J. Immunol. 22:1992;253-260.
41. Posnett D.N., Sinha R., Kabak S., Russo C. Clonal populations of T-cells in normal elderly humans: the T-cell equivalent to 'benign monoclonal gammapathy'. J. Exp. Med. 179:1994;609-618.
42. Qian D., Griswold-Prenner I., Rosner M.R., Fitch F.W. Multiple components of the T-cell antigen receptor complex become tyrosine-phosphorylated upon activation. J. Biol. Chem. 268:1993;4488-4493.
43. Quadri R.A., Plastre O., Phelouzat M.A., Arbogast A., Proust J.J. Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor. Mech. Ageing Dev. 88:1996;125-138.
44. 2 hydrolysis in Jurkat T-cells. J. Immunol. 154:1995;1136-1145.
45. Saltzman R.L., Peterson P.K. Immunodeficiency of the elderly. Rev. Infect. Dis. 9:1987;1127-1139.
46. Samelson L.E., Klausner R.D. Tyrosine kinases and tyrosine-based activation motifs. J. Biol. Chem. 267:1992;24913-24916.
47. Samelson L.E., Phillips A.F., Luong E.T., Klausner R.D. Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor. Proc. Natl. Acad. Sci. USA. 87:1990;4358-4362.
48. Sarosi G.P., Thomas P.M., Egerton M., Phillips A.F., Kim K.W., Bonvini E., Samelson L.E. Characterization of the T-cell antigen receptor-p60fyn protein tyrosine kinase association by chemical cross-linking. Int. Immunol. 4:1992;1211-1217.
49. Schwab R., Staiano-Coico L., Weksler M.E. Immunological studies of aging. IX. Quantitative differences in T lymphocyte subsets in young and old individuals. Diagn. Immunol. 1:1983;195-198.
50. Shi J., Miller R.A. Tyrosine-specific protein phosphorylation in response to anti-CD3 antibody is diminished in old mice. J. Gerontol. Biol. Sci. 47:1992;B147-153.
51. Shi J., Miller R.A. Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets: effect of age. J. Immunol. 151:1993;730-739.
52. Sloan-Lancaster J., Shaw A.S., Rothbard J.B., Allen P.M. Partial T-cell signaling: altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T-cell anergy. Cell. 79:1994;913-922.
53. Song L., Kim Y.H., Chopra R.K., Proust J.J., Nagel J.E., Nordin A.A., Adler W.H. Age-related effects in T-cell activation and proliferation. Exp. Gerontol. 28:1993;313-321.
54. Straus D.B., Chan A.C., Patai B., Weiss A. SH2 domain function is essential for the role of the Lck tyrosine kinase in T-cell receptor signal transduction. J. Biol. Chem. 271:1996;9976-9981.
55. lck. EMBO J. 14:1995;3403-3414.
56. Thoman M.L., Weigle W.O. The cellular and subcellular bases of immunosenescence. Adv. Immunol. 46:1989;221-261.
57. fyn following T-cell antigen receptor cross-linking. J. Biol. Chem. 267:1992;18259-18262.
58. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60:1990;755-765.
59. Van Oers N.S.C., Killeen N., Weiss A. Lck regulates the tyrosine phosphorylation of the T-cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1996;1053-1062.
60. Van Oers N.S.C., Love P.E., Shores E.W., Weiss A. Regulation of TCR signal transduction in murine thymocytes by multiple TCR ζ-chain signaling motifs. J. Immunol. 160:1998;163-170.
61. Wayne S.J., Rhyne R.L., Garry P.J., Goodwin J.S. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol. Med. Sci. 45:1990;M45-48.
62. Whisler R.L., Liu B.Q., Chen M. Age-related decreases in IL-2 production by human T-cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell. Immunol. 169:1996;185-195.
63. mapk/ERK2 in human T-cells stimulated via ligation of the T-cell receptor complex. Cell. Immunol. 168:1996;201-210.
64. Whisler R.L., Bagenstose S.E., Newhouse Y.G., Carle K.W. Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T-cells from elderly humans stimulated through the T-cell receptor (TCR)/CD3 complex. Mech. Ageing Dev. 98:1997;57-73.
65. Whisler R.L., Chen M., Liu B.Q., Carle K.W. Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T-cells during aging. Cell. Immunol. 175:1997;41-50.
66. Wysocki L.J., Sato V.L. 'Panning' for lymphocytes: a method for cell selection. Proc. Natl. Acad. Sci. USA. 75:1978;2844-2848.
67. Yamasaki S., Takamatsu M., Iwashima M. The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization. Mol. Cell. Biol. 16:1996;7151-7160.