Human T-cell clones in long-term culture as a model of immunosenescence

Immunological Reviews

Volumn 160, Issue , 1997, Pages 31-42

  Pawelec, Graham ^a,b   Rehbein, Arnika ^a   Haehnel, Karin ^a   Merl, Andrea ^a   Adibzadeh, Medi ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; CELL SURVIVAL; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE CLONE; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; ORGAN TRANSPLANTATION; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SENESCENCE; T LYMPHOCYTE;

EID: 0031434175     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1997.tb01025.x     Document Type: Review

References (87)

1. Horiuchi S, Wilmoth JR. Age patterns of the life table aging rate for major causes of death in Japan, 1951-1990. J Gerontol A Biol Sci Med Sci 1997;52: B67-B77.
2. Roberts-Thomson IC, Whittingham S, Young-Chaiyud U, Mackay IR. Ageing, immune response and mortality. Lancet 1974;2:368-370.
3. Murasko DM, Weiner P, Kaye D. Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly. Aging Immunol Infect Dis 1988;1:1-23.
4. Wayne SJ, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J Gerontol 1990;45:45-48.
5. Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 1995;50: B378-B382.
6. Pawelec G, Solana R. Immunosenescence. Immunol Today 1997;18:514-516.
7. Ligthart GJ, Corberand JX, Goertzen HGM, Minders AE, Knook DL, Hijmans W. Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech Ageing Dev 1990;55:89-98.
8. Remarque E, Pawelec G. T cell immunosenescence and its clinical relevance in man. Reviews in Clinical Gerontology 1997 (In press).
9. Franceschi C, Monti D, Sansoni P, Cossatizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995;16:12-16.
10. Chandra RK. Nutritional regulation of immunity and risk of infection in old age. Immunology 1989;67:141-147.
11. Meydani SN, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial. JAMA 1997;277:1380-1386.
12. Roecker EB, Kemnitz JW, Ershler WB, Weindruch R. Reduced immune responses in rhesus monkeys subjected to dietary restriction. J Gerontol A Biol Sci Med Sci 1996;51: B276-B279.
13. Evans TG, Judd ME, Dowell T, Poe S, Daynes RA, Araneo BA. The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly. Vaccine 1996;14:1531-1537.
14. Pawelec G, Adibzadeh M, Pohla H, Schaudt K. Immunosenescence: ageing of the immune system. Immunol Today 1995;16:420-422.
15. Pawelec G. Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech Ageing Dev 1995;79:1-32.
16. Effros RB, Pawelec G. Replicative senescence of T lymphocytes: does the Hayflick Limit lead to immune exhaustion? Immunol Today 1997;18:450-454.
17. Bach FH, Inouye H, Hank JA, Alter BJ. Human T-lymphocyte clones reactive in primed lymphocyte typing and cytotoxicity. Nature 1979;281:307-309.
18. Pawelec G, Wernet P. Restimulation properties of human alloreactive cloned T cell lines. Dissection of HLA-D-region alleles in population studies and in family segregation analysis. Immunogenetics 1980;11:507-519.
19. Pawelec G, Kahle P, Müller C, Wernet P. HLA-Dw5 dissected by cloned PLT reagents. Immunogenetics 1981;14:549-552.
20. Kahle P, Wernet P, Rehbein A, Kumbier I, Pawelec G. Cloning of functional human T lymphocytes by limiting dilution: impact of filler cells and interleukin 2 sources on cloning efficiencies. Scand J Immunol 1981;14:493-502.
21. Effros RB, Walford RL. T cell cultures and the Hayflick limit. Hum Immunol 1984;9:49-65.
22. Pawelec G. Cloning and propagation of human T lymphocytes. In: Gallagher G, Rees RC, Reynolds CW, eds. Tumour immunobiology. A practical approach. Oxford: IRL Press; 1993. p. 131-141.
23. Pawelec GP, Rehbein A, Schaudt K, Busch FW. IL-4-responsive human helper T cell clones are resistant to growth inhibition by tumor necrosis factor-α. J Immunol 1989;143:902-906.
24. Pawelec G, Schaudt K, Rehbein A, Busch FW. Differential secretion of tumor necrosis factor-α and granulocyte/macrophage colony stimulating factors but not interferon-gamma from CD4+ compared to CD8+ human T cell clones. Eur J Immunol 1989;19:197-200.
25. Bruserud O, Hamann W, Patel S, Ehninger G, Pawelec G. IL 2 and IL 4-dependent proliferation of T lymphocyte clones derived very shortly after allogeneic bone marrow transplantation. Eur J Haematol 1992;48:221-227.
26. + human T cells. Transplantation 1996;62:1095-1101.
27. Adibzadeh M, Pohla H, Rehbein A, Pawelec G. Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech Ageing Dev 1995;83:171-183.
28. Mariani E, et al. Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis. Clin Exp Immunol 1990;81:479-484.
29. Paganelli R, et al. A shift to Th0 cytokine production by CD4+ cells in human longevity: studies on two healthy centenarians. Eur J Immunol 1996;26:2030-2034.
30. Weng NP, Levine BL, June CH, Hodes RJ. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci USA 1995;92:11091-11094.
31. Bell EB, Sparshott SM. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 1990;348:163-166.
32. Bodnar AG, Kim NW, Effros RB, Chiu CP. Mechanism of telomerase induction during T cell activation. Exp Cell Res 1996;228:58-64.
33. Pohla H, et al. Evolution of a CD3+CD4+ alpha/beta T-cell receptor plus mature T-cell clone from CD3-CD7+ sorted human bone marrow cells. Dev Immunol 1993;3:197-210.
34. Adibzadeh M, et al. Extrathymic development and function of human T-lymphocytes from bone marrow cells in vitro. Cell Immunol 1994;154:25-42.
35. McLean AR, Michie CA. In vivo estimates of division and death rates of human T lymphocytes. Proc Natl Acad Sci USA 1995;92:3707-3711.
36. Pawelec G, Sansom D, Rehbein A, Adibzadeh M, Beckman I. Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones. Exp Gerontol 1996;31:655-668.
37. Pawelec G, Adibzadeh M, Solana R, Beckman I. The T cell in the ageing individual. Mech Ageing Dev 1997;93:35-45.
38. Wu Y, Guo Y, Huang A, Zheng P, Liu Y. CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion. J Exp Med 1997;185:1327-1335.
39. Paterson DJ, et al. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4-positive T blasts. Mol Immunol 1987;24:1281-1290.
40. Godfrey WR, Fagnoni FF, Harara MA, Buck D, Engleman EG. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J Exp Med 1994;180:757-762.
41. Merl A, Pohla H, Adibzadeh M, Pawelec G. Expression of cytokine receptors on anergic CD4+ TCR2+ TH0 cell clones. In: Kishimoto T, ed. Leukocyte typing VI. London: Garland Publishing; 1997 (In press).
42. Schwab R, Pfeffer LM, Szabo P, Gamble D, Shnurr CM, Weksler ME. Defective expression of high affinity IL 2 receptors on activated T cells from aged humans. Int Immunol 1990;2:239-246.
43. Miller RA. The aging immune system: primer and prospectus. Science 1996;273:70-74.
44. Pawelec G, Schneider EM, Wernet P. Acquisition of suppressive activity and natural killer-like cytotoxicity by human alloproliferative "helper" T cell clones. J Immunol 1986;136:402-411.
45. Pawelec G. Modulation of IL-2- and IL-4-induced cytotoxicities in human T helper lymphocyte clones by tumor necrosis factor-α. J Immunol 1991;146:572-576.
46. Pawelec G, Schneider EM, Wernet P. Human T-cell clones with multiple and changing functions: indications of unexpected flexibility in immune response networks. Immunol Today 1983;4:275-278.
47. Falcioni F, Pawelec G, Brattig N, Schneider E, Berg P, Wernet P. Functionally distinct human T-lymphocyte clones sharing potent suppressive activity on immunoglobulin secretion. Immunology 1985;54:685-692.
48. Rosen-Bronson S, Eckels DD. Longevity of human allospecific TLCs: mycoplasma infection as the cause of in vitro "suppression" of MLC Hum Immunol 1985;14:365-377.
49. Wernet P, Schneider EM, Kalthoff F, Pawelec G. Constitutive functional heterogeneity without detectable somatic mutation of antigen receptor genes in helper T cell clones: possible regulation by novel HLA class II "DY" determinants. Immunol Rev 1987;96:109-140.
50. Pawelec G, Fernandez N, Brocker T, Schneider EM, Festenstein H, Wernet P. DY determinants, possibly associated with novel class II molecules, stimulate autoreactive CD4+ T cells with suppressive activity. J Exp Med 1988;167:243-261.
51. Del Prete G, Decarli M, Almerigogna F, Giudizi MG, Biagiotti R, Romagnani S. Human IL-10 is produced by both Type-1 helper (Th1) and Type-2 helper (Th2) T-cell clones and inhibits their antigen-specific proliferation and cytokine production. J Immunol 1993;150:353-360.
52. Moore KW, O'Garra A, Malefyt RD, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993;11:165-190.
53. Taga K, Cherney B, Tosato G. IL-10 Inhibits apoptotic cell death in human T-cells starved of IL-2. Int Immunol 1993;5:1599-1608.
54. Pawelec G, et al. Interleukin 10 is a human T cell growth factor in vitro. Cytokine 1995;7:355-363.
55. Becker JC, Czerny C, Brocker EB. Maintenance of clonal energy by endogenously produced IL-10. Int Immunol 1994;6:1605-1612.
56. Lamb JR, Skidmore BJ, Green N, Chiller JM, Feldmann M. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med 1983;157:1434-1447.
57. Lombardi G, Sidhu S, Batchelor R, Lechler R. Anergic T cells as suppressor cells in vitro. Science 1994;264:1587-1589.
58. Fernandez N, Kurpisz M, Labeta M, Sachs J, Pawelec G. A ligand-epitope invitro analysis of major histocompatibility determinants expressed on lymphocyte-B and lymphocyte-T. Immunology 1992;77:116-122.
59. Fernandez N, Labeta MO, Festenstein H. A novel HLA class II molecule. Immunogenetics 1988;27:363-369.
60. Santoli D, Radka SF, Igarashi M, Kreider BL, Ferrone S. Autologous B-lymphoblastoid cell lines and long-term cultured T cells as stimulators in the mixed lymphocyte reaction: analysis of the role of HLA class II antigens as stimulatory molecules. J Immunol 1986;137:400-407.
61. Carra G. et al. Selective association of a 22-38 kDa glycoprotein with MHC class II DP antigen on activated human lymphocytes at the plasma membrane. Mol Immunol 1996;33:269-278.
62. Wilson KM, Morrison IEG, Smith PR, Fernandez N, Cherry RJ. Single particle tracking of cell-surface HLA-DR molecules using R-phycoerythrin labeled monoclonal antibodies and fluorescence digital imaging. J Cell Sci 1996;109:2101-2109.
63. Pawelec G, et al. "Tolerisation" of human T-helper cell clones by chronic exposure to alloantigen: culture conditions dictate autocrine proliferative status but not acquisition of cytotoxic potential and suppressor-induction capacity. J Mol Cell Immunol 1988;4:21-34.
64. Dhein J, Walczak H, Baumler C, Debatin KM, Krammer PH. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 1995;373:438-441.
65. Salmon M, et al. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur J Immunol 1994;24:892-899.
66. Nagata S. Fas and fas ligand: a death factor and its receptor. Adv Immunol 1994;57:129-144.
67. Grubeck-Loebenstein B, Lechner H, Trieb K. Long-term in vitro growth of human T cell clones: can postmitotic 'senescent' cell populations be defined? Int Arch Allergy Immunol 1994;104:232-239.
68. Shinohara S, et al. Differential expression of Fas antigen and bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. Cell Immunol 1995;163:303-308.
69. Miyawaki T, et al. Differential expression of apoptosis-related fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 1992;149:3753-3758.
70. Seishima M, et al. Highly sensitive ELISA for soluble fas in serum: increased soluble fas in the elderly. Clin Chem 1996;42:1911-1914.
71. Phelouzat MA, Arbogast A, Laforge TS, Quadri RA, Proust JJ. Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 1996;88:25-38.
72. Noel PJ, Boise LH, Green JM, Thompson CB. CD28 costimulation prevents cell death during primary T cell activation. J Immunol 1996;157:636-642.
73. Engwerda CR, Handwerger BS, Fox BS. An age-related decrease in rescue from T cell death following costimulation mediated by CD28. Cell Immunol 1996;170:141-148.
74. Effros RB, Zhu XM, Walford RL. Stress response of senescent T lymphocytes - reduced Hsp70 is independent of the proliferative block. J Gerontol 1994;49:B65-B70.
75. He LS, Fox MH. Variation of heat shock protein 70 through the cell cycle in HL-60 cells and its relationship to apoptosis. Exp Cell Res 1997;232:64-71.
76. Zhou T, Edwards CK, Mountz JD. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med 1995;182:129-137.
77. Spaulding CC, Walford RL, Effros RB. The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev 1997;93:25-33.
78. Catania J, Fairweather DS. DNA methylation and cellular ageing. Mutat Res 1991;256:283-293.
79. Wadhwa R, Ikawa Y, Sugimoto Y. Natural and conditional ageing of mouse fibroblasts - genetic vs epigenetic control. Biochem Biophys Res Commun 1991;178:269-275.
80. Holliday R. Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts. Exp Cell Res 1986;166:543-552.
81. Fairweather DS, Fox M, Margison GP. The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation. Exp Cell Res 1987;168:153-159.
82. Golbus J, Palella TD, Richardson BC. Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol 1990;20:1869-1872.
83. Mazin AL. Life span prediction from the rate of age-related DNA demethylation in normal and cancer cell lines. Exp Gerontol 1995;30:475-484.
84. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994;211:90-98.
85. Smith JR, Pereira-Smith OM. Replicative senescence: implications for in vivo aging and tumor suppression. Science 1996;273:63-67.
86. Adibzadeh M, Pohla H, Schenk A, Pawelec G. Lymphocyte-T immunosenescence in vitro: identification of gene sequences preferentially expressed in aged human cells. Immunobiology 1992;186:101.
87. Adibzadeh M, et al. Lifespans of T lymphocytes. Mech Ageing Dev 1996;91:145-154.