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Volumn 21, Issue 4, 1998, Pages 137-151

Effect of age on cytokine production in humans

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032462502     PISSN: 01619152     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11357-998-0024-6     Document Type: Article
Times cited : (34)

References (62)
  • 3
    • 0029091594 scopus 로고
    • Transcriptional control of IL-2 and IL-4 in T cells of young and old mice
    • Albright JW, Zuiga-Pflcker JC, Albright JF: Transcriptional control of IL-2 and IL-4 in T cells of young and old mice. Cell. Immunol., 164:170-175, 1995.
    • (1995) Cell. Immunol. , vol.164 , pp. 170-175
    • Albright, J.W.1    Zuiga-Pflcker, J.C.2    Albright, J.F.3
  • 5
    • 0028806679 scopus 로고
    • Long-term culture of monoclonal human T lymphocytes: Models for immunosenescence?
    • Adibzadeh M, Pohla H, Rehbein A, Pawelec G: Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech. Ageing Develop., 83:171-183, 1995.
    • (1995) Mech. Ageing Develop. , vol.83 , pp. 171-183
    • Adibzadeh, M.1    Pohla, H.2    Rehbein, A.3    Pawelec, G.4
  • 7
    • 0027180547 scopus 로고
    • Vitamin/mineral supplementation, the aging immune response, and risk of infection
    • Meydani S: Vitamin/mineral supplementation, the aging immune response, and risk of infection. Nutr. Rev., 51:106-109, 1993.
    • (1993) Nutr. Rev. , vol.51 , pp. 106-109
    • Meydani, S.1
  • 11
    • 0026658397 scopus 로고
    • Preliminary report on cytokine determination in human synovial fluids: A consensus study of the European Workshop for Rheumatology Research
    • Lombard PR, Steiner G: Preliminary report on cytokine determination in human synovial fluids: a consensus study of the European Workshop for Rheumatology Research. Clin. Exp. Rheumat., 10:515-520, 1992.
    • (1992) Clin. Exp. Rheumat. , vol.10 , pp. 515-520
    • Lombard, P.R.1    Steiner, G.2
  • 13
    • 0003536924 scopus 로고
    • New York: W.H. Freeman and Company
    • Kuby J: Immunology. New York: W.H. Freeman and Company; 1994.
    • (1994) Immunology
    • Kuby, J.1
  • 14
    • 0019434273 scopus 로고
    • Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans
    • Gillis S, Kozak R, Durante M, Weksler ME: Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Investig., 67:937-942, 1981.
    • (1981) J. Clin. Investig. , vol.67 , pp. 937-942
    • Gillis, S.1    Kozak, R.2    Durante, M.3    Weksler, M.E.4
  • 15
    • 0027056547 scopus 로고
    • Comparison of CD3 and CD2 activation pathways in T cells from young and elderly adults
    • Song LJ, Nagel JE, Chrest FJ, Collins GD, Adler WH: Comparison of CD3 and CD2 activation pathways in T cells from young and elderly adults. Aging, 4:307-315, 1992.
    • (1992) Aging , vol.4 , pp. 307-315
    • Song, L.J.1    Nagel, J.E.2    Chrest, F.J.3    Collins, G.D.4    Adler, W.H.5
  • 17
    • 0024435582 scopus 로고
    • Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans
    • Chopra RK, Holbrook NJ, Powers DC, McCoy MT, Adler WH, Nagel J:. Interleukin 2, interleukin 2 receptor, and interferon-γ synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans. Clin. Immunol. Immunopath., 53:297-308, 1989.
    • (1989) Clin. Immunol. Immunopath. , vol.53 , pp. 297-308
    • Chopra, R.K.1    Holbrook, N.J.2    Powers, D.C.3    McCoy, M.T.4    Adler, W.H.5    Nagel, J.6
  • 18
    • 0029558551 scopus 로고
    • Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep
    • Born J, Uthgenannt D, Dodt C, Nunninghoff D, Ringvolt E, WagnerT et al: Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep. Mech. Ageing Develop., 84:113-126, 1995.
    • (1995) Mech. Ageing Develop. , vol.84 , pp. 113-126
    • Born, J.1    Uthgenannt, D.2    Dodt, C.3    Nunninghoff, D.4    Ringvolt, E.5    Wagner, T.6
  • 20
    • 0027501913 scopus 로고
    • Age-related changes in the expression of IL-2 and high-affinity IL-2-binding sites
    • Xu X, Beckman I, Bradley J: Age-related changes in the expression of IL-2 and high-affinity IL-2-binding sites. Intern. Arch. Allergy & Immunol., 102:224-231, 1993.
    • (1993) Intern. Arch. Allergy & Immunol. , vol.102 , pp. 224-231
    • Xu, X.1    Beckman, I.2    Bradley, J.3
  • 21
    • 0024354614 scopus 로고
    • Interleukin 2 receptor expression by T cells in human aging
    • Orson FM, Saadeh CK, Lewis DE, Nelson DL: Interleukin 2 receptor expression by T cells in human aging. Cell, Immunol., 124:278-291, 1989.
    • (1989) Cell, Immunol. , vol.124 , pp. 278-291
    • Orson, F.M.1    Saadeh, C.K.2    Lewis, D.E.3    Nelson, D.L.4
  • 22
    • 0023950743 scopus 로고
    • Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors
    • Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ et al.: Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Investig., 81:1096-1102, 1988.
    • (1988) J. Clin. Investig. , vol.81 , pp. 1096-1102
    • Nagel, J.E.1    Chopra, R.K.2    Chrest, F.J.3    McCoy, M.T.4    Schneider, E.L.5    Holbrook, N.J.6
  • 25
    • 0026599173 scopus 로고
    • The effect of influenza vaccination on IL2 production in healthy elderly: Implications for current vaccination practices
    • McElhaney JE, Meneilly GS, Beattie BL, Helgason CD, Lee SF, Devine RD et al.: The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices. J. Gerontol., 47:M3-M8, 1992.
    • (1992) J. Gerontol. , vol.47
    • McElhaney, J.E.1    Meneilly, G.S.2    Beattie, B.L.3    Helgason, C.D.4    Lee, S.F.5    Devine, R.D.6
  • 26
    • 0028798452 scopus 로고
    • Vaccine-related determinants of the interleukin-2 response to influenza vaccination in healthy young and elderly adults
    • McElhaney JE, Meneilly GS, Pinkoski MJ, Lechelt KE, Bleackley RC: Vaccine-related determinants of the interleukin-2 response to influenza vaccination in healthy young and elderly adults. Vaccine. 13:6-10, 1995.
    • (1995) Vaccine , vol.13 , pp. 6-10
    • McElhaney, J.E.1    Meneilly, G.S.2    Pinkoski, M.J.3    Lechelt, K.E.4    Bleackley, R.C.5
  • 31
    • 0025924836 scopus 로고
    • Heterogeneous effects of exogenous lymphokines on lymphoproliferation of elderly subjects
    • Hessen MT, Kaye D, Murasko DM: Heterogeneous effects of exogenous lymphokines on lymphoproliferation of elderly subjects. Mech.Aging Develop.58:61-73, 1991.
    • (1991) Mech.Aging Develop. , vol.58 , pp. 61-73
    • Hessen, M.T.1    Kaye, D.2    Murasko, D.M.3
  • 32
    • 0026388979 scopus 로고
    • Determination of interleukin 2 receptor number of Con A stimulated human lymphocytes with aging
    • Fulop Jr. T, Utsuyama M, Hirokawa K: Determination of interleukin 2 receptor number of Con A stimulated human lymphocytes with aging. J. Clin. & Laborat. Immunol., 34:31-36, 1991.
    • (1991) J. Clin. & Laborat. Immunol. , vol.34 , pp. 31-36
    • Fulop Jr., T.1    Utsuyama, M.2    Hirokawa, K.3
  • 33
    • 0022981386 scopus 로고
    • Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified TAC-positive T cells
    • Negoro, S, Hara, H, Miyata, S, Saiki, O, Tanaka ,T, Yoshizaki, K et al: Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified TAC-positive T cells. Mech. Ageing Develop., 36:223-241, 1986.
    • (1986) Mech. Ageing Develop. , vol.36 , pp. 223-241
    • Negoro, S.1    Hara, H.2    Miyata, S.3    Saiki, O.4    Tanaka, T.5    Yoshizaki, K.6
  • 34
    • 0024504613 scopus 로고
    • The role of T cell phenotypes in decreased lymphoproliferation of the elderly
    • Matour D, Melnicoff M, Kaye D, Murasko DM: The role of T cell phenotypes in decreased lymphoproliferation of the elderly. Clin. Immunol. Immunopath., 50:82-99, 1988.
    • (1988) Clin. Immunol. Immunopath. , vol.50 , pp. 82-99
    • Matour, D.1    Melnicoff, M.2    Kaye, D.3    Murasko, D.M.4
  • 39
    • 0022839691 scopus 로고
    • The capacity of lymphocyte production by peripheral blood lymphocytes from aged humans
    • Weifeng C, Schulin L. Xinomei G, Xuewen F: The capacity of lymphocyte production by peripheral blood lymphocytes from aged humans. Immunolog. Invest., 15:575-583, 1986.
    • (1986) Immunolog. Invest. , vol.15 , pp. 575-583
    • Weifeng, C.1    Schulin, L.2    Xinomei, G.3    Xuewen, F.4
  • 40
    • 0030991126 scopus 로고    scopus 로고
    • Cytokine production in response to stimulation with tetanus toxoid, mycobacterium tuberculosis and influenza antigens in peripheral blood mononuclear cells and T cell lines from healthy elderlies
    • Bodnar Z, Steger MM, Saurwein-Teissl M, Maczek C, Grubeck-Loebenstein, B: Cytokine production in response to stimulation with tetanus toxoid, mycobacterium tuberculosis and influenza antigens in peripheral blood mononuclear cells and T cell lines from healthy elderlies. Intern. Arch. Allergy &Immunol., 112:323-330, 1997.
    • (1997) Intern. Arch. Allergy &Immunol. , vol.112 , pp. 323-330
    • Bodnar, Z.1    Steger, M.M.2    Saurwein-Teissl, M.3    Maczek, C.4    Grubeck-Loebenstein, B.5
  • 41
    • 0032212474 scopus 로고    scopus 로고
    • Cytokine production after influenza vaccination in a healthy elderly population
    • Bernstein ED, Gardner EM, Abrutyn E, Gross P, Murasko DM: Cytokine production after influenza vaccination in a healthy elderly population. Vaccine, 16:1722-1731, 1998.
    • (1998) Vaccine , vol.16 , pp. 1722-1731
    • Bernstein, E.D.1    Gardner, E.M.2    Abrutyn, E.3    Gross, P.4    Murasko, D.M.5
  • 42
    • 0028593934 scopus 로고
    • Influence of age on the production of Fos and Jun by influenza virus-exposed T cells
    • Salkind AR: Influence of age on the production of Fos and Jun by influenza virus-exposed T cells. J. Leuk. Biol., 56:817-820, 1994.
    • (1994) J. Leuk. Biol. , vol.56 , pp. 817-820
    • Salkind, A.R.1
  • 43
    • 0030913726 scopus 로고    scopus 로고
    • Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents
    • Castle S, Uyemura K, Wong W, Modlin R, Effros R: Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech. Ageing Develop., 94:7-16, 1997.
    • (1997) Mech. Ageing Develop. , vol.94 , pp. 7-16
    • Castle, S.1    Uyemura, K.2    Wong, W.3    Modlin, R.4    Effros, R.5
  • 44
    • 0025290641 scopus 로고
    • Polymorphism of age-related changes in interleukin (IL) production: Differential changes of T helper subpopulations, synthesizing IL2, IL3 and IL4
    • Kubo M, Cinader B: Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL2, IL3 and IL4. Eur. J. Immunol., 20:1289-1296, 1990.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1289-1296
    • Kubo, M.1    Cinader, B.2
  • 45
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: Primer and prospectus
    • Miller RA. The aging immune system: primer and prospectus. Science, 273:70-74, 1996.
    • (1996) Science , vol.273 , pp. 70-74
    • Miller, R.A.1
  • 47
    • 0027503291 scopus 로고
    • Interleukin-6: A cytokine for gerontologists
    • Ershler WB. Interleukin-6: A cytokine for gerontologists. J. Amer. Ger. Soc., 41:176-181, 1993.
    • (1993) J. Amer. Ger. Soc. , vol.41 , pp. 176-181
    • Ershler, W.B.1
  • 48
    • 0026497223 scopus 로고
    • Increase of plasma IL-6 concentration with age in healthy subjects
    • Wei J, Xu H, Davies JL, Hemmings GP: Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci., 51:1953-1956, 1992.
    • (1992) Life Sci. , vol.51 , pp. 1953-1956
    • Wei, J.1    Xu, H.2    Davies, J.L.3    Hemmings, G.P.4
  • 50
    • 0027161033 scopus 로고
    • Interleukin-6 and aging: Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction
    • Ershler WB, Sun WH, Binkley N, Gravenstein S, Volk MJ, Kamoske G et al.: Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymph. Cytokine Res.. 12:225-230, 1993.
    • (1993) Lymph. Cytokine Res. , vol.12 , pp. 225-230
    • Ershler, W.B.1    Sun, W.H.2    Binkley, N.3    Gravenstein, S.4    Volk, M.J.5    Kamoske, G.6
  • 52
    • 0028081456 scopus 로고
    • Levels of tumor necrosis factor α, interleukin 6, interleukin 10, and transforming growth factor β are normal in the serum of the healthy elderly
    • Peterson PK, Chao CC, Carson P, Hu S, Nichol K, Janoff EN: Levels of tumor necrosis factor α, interleukin 6, interleukin 10, and transforming growth factor β are normal in the serum of the healthy elderly. Clin. Infect. Dis., 19:1158-1159, 1994.
    • (1994) Clin. Infect. Dis. , vol.19 , pp. 1158-1159
    • Peterson, P.K.1    Chao, C.C.2    Carson, P.3    Hu, S.4    Nichol, K.5    Janoff, E.N.6
  • 54
    • 0028363328 scopus 로고
    • In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects
    • Wu D, Meydani SN, Sastre J, Hayek M, Meydani M: In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects. J. Nutr., 124:655-663, 1994.
    • (1994) J. Nutr. , vol.124 , pp. 655-663
    • Wu, D.1    Meydani, S.N.2    Sastre, J.3    Hayek, M.4    Meydani, M.5
  • 55
    • 0029737506 scopus 로고    scopus 로고
    • Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly
    • Gon Y, Hashimoto S, Hayashi S, Koura T, Matsumoto K, Horie T. Lower serum concentrations of cytokines in elderly patients with pneumonia and the impaired production of cytokines by peripheral blood monocytes in the elderly. Clin. Exper. Immunol., 106:120-126, 1996.
    • (1996) Clin. Exper. Immunol. , vol.106 , pp. 120-126
    • Gon, Y.1    Hashimoto, S.2    Hayashi, S.3    Koura, T.4    Matsumoto, K.5    Horie, T.6
  • 57
    • 0028597408 scopus 로고
    • Cytokine production and aging: Overproduction of IL-8 in elderly males in response to lipopolysaccharide
    • Clark JA, Peterson TC: Cytokine production and aging: overproduction of IL-8 in elderly males in response to lipopolysaccharide. Mech. Ageing Develop., 77:127-139, 1994.
    • (1994) Mech. Ageing Develop. , vol.77 , pp. 127-139
    • Clark, J.A.1    Peterson, T.C.2
  • 59
    • 0024554593 scopus 로고
    • Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes
    • Nagel JE, Chopra RK, Powers DC, Adler W.H.: Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes. Clin. & Exper. Immunol., 75:286-291, 1989.
    • (1989) Clin. & Exper. Immunol. , vol.75 , pp. 286-291
    • Nagel, J.E.1    Chopra, R.K.2    Powers, D.C.3    Adler, W.H.4
  • 60
    • 0023790982 scopus 로고
    • Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic Stimulation
    • Hara H, Tanaka T, Negoro S, Deguchi Y, Nishio S, Saiki O et al: Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic Stimulation. Mech. Ageing Develop., 45:167-175, 1988.
    • (1988) Mech. Ageing Develop. , vol.45 , pp. 167-175
    • Hara, H.1    Tanaka, T.2    Negoro, S.3    Deguchi, Y.4    Nishio, S.5    Saiki, O.6
  • 61
    • 0029585876 scopus 로고
    • Evaluation of lymphokine-activated killer cell development in young and old healthy humans
    • Provinciali M, DiStefano G, Fabris N: Evaluation of lymphokine-activated killer cell development in young and old healthy humans. Nat. Immun., 14:134-144, 1995.
    • (1995) Nat. Immun. , vol.14 , pp. 134-144
    • Provinciali, M.1    DiStefano, G.2    Fabris, N.3
  • 62
    • 0029925555 scopus 로고    scopus 로고
    • Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age
    • Rea LM, Stewart M, Campbell P, Alexander HD, Crockard AD, Morris TC: Changes in lymphocyte subsets, interleukin 2, and soluble interleukin 2 receptor in old and very old age. Gerontology, 42:69-78, 1996.
    • (1996) Gerontology , vol.42 , pp. 69-78
    • Rea, L.M.1    Stewart, M.2    Campbell, P.3    Alexander, H.D.4    Crockard, A.D.5    Morris, T.C.6


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