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Volumn 21, Issue 11, 2000, Pages 567-573

Protein kinase Cθ: A new essential superstar on the T-cell stage

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; PROTEIN KINASE C; PROTEIN KINASE C THETA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PRKCQ PROTEIN, HUMAN; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 0033625869     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01749-7     Document Type: Review
Times cited : (139)

References (55)
  • 3
    • 0029060391 scopus 로고
    • Protein kinase C and lipid signaling for sustained cellular responses
    • (1995) FASEB J. , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 4
    • 0027418818 scopus 로고
    • Molecular cloning and characterization of PKCθ, a human novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells
    • (1993) J. Biol. Chem. , vol.268 , pp. 4997-5004
    • Baier, G.1
  • 5
    • 0026665459 scopus 로고
    • A new member of the protein kinase C family, n PKCθ, predominantly expressed in skeletal muscle
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3930-3938
    • Osada, S.1
  • 6
    • 0027153592 scopus 로고
    • Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC)
    • (1993) J. Biol. Chem. , vol.268 , pp. 14208-14214
    • Chang, J.D.1
  • 7
    • 0028960579 scopus 로고
    • Mapping of the human protein kinase Cν gene locus to the short arm of chromosome 10 (10p15) by FISH
    • (1995) Genomics , vol.25 , pp. 595-597
    • Erdel, M.1
  • 9
    • 0031595974 scopus 로고    scopus 로고
    • New perspectives on PKCθ, a member of the novel subfamily of protein kinase C
    • (1998) Stem Cells , vol.16 , pp. 178-192
    • Meller, N.1
  • 15
    • 18844473151 scopus 로고    scopus 로고
    • PKCθ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
    • (2000) Nature , vol.404 , pp. 402-407
    • Sun, Z.1
  • 16
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1
  • 17
  • 18
    • 0032101707 scopus 로고    scopus 로고
    • Calcineurin preferentially synergizes with PKCθ to activate JNK and IL-2 promoter in T lymphocytes
    • (1998) EMBO J. , vol.17 , pp. 3101-3111
    • Werlen, G.1
  • 19
    • 0032587013 scopus 로고    scopus 로고
    • Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T-cells
    • (1999) Eur. J. Immunol. , vol.29 , pp. 132-142
    • Ghaffari-Tabrizi, N.1
  • 20
    • 0034604093 scopus 로고    scopus 로고
    • JNK is required for effector T-cell function but not for T-cell activation
    • (2000) Nature , vol.405 , pp. 91-94
    • Dong, C.1
  • 21
    • 0034598346 scopus 로고    scopus 로고
    • 2-terminal Kinase (Jnk) gene expression during T cell activation
    • (2000) J. Exp. Med. , vol.191 , pp. 139-146
    • Weiss, L.1
  • 22
  • 23
    • 0034176032 scopus 로고    scopus 로고
    • Vav synergizes with protein kinase C-θ to mediate IL-4 gene expression in response to CD28 costimulation in T cells
    • (2000) J. Immunol. , vol.164 , pp. 2829-2836
    • Hehner, S.P.1
  • 24
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular clusters in T cells
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1
  • 25
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: A molecular machine controlling T cell activation
    • (1999) Science , vol.285 , pp. 221-227
    • Grakoui, A.1
  • 26
    • 0032545218 scopus 로고    scopus 로고
    • A receptor/cytoskeletal movement triggered by costimulation during T cell activation
    • (1998) Science , vol.282 , pp. 2266-2269
    • Wulfing, C.1    Davis, M.M.2
  • 29
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-θ during T-cell activation
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.F.1
  • 30
    • 0028169441 scopus 로고
    • The role of p21(ras) in CD28 signal transduction: Triggering of CD28 with antibodies, but not the ligand B7-1, activates p21(ras)
    • (1994) J. Exp. Med. , vol.180 , pp. 1067-1076
    • Nunes, J.A.1
  • 31
    • 13144259727 scopus 로고    scopus 로고
    • Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
    • (1998) Curr. Biol. , vol.8 , pp. 554-562
    • Fischer, K.D.1
  • 32
    • 0032493028 scopus 로고    scopus 로고
    • Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
    • (1998) Curr. Biol. , vol.8 , pp. 563-572
    • Holsinger, L.J.1
  • 33
    • 0034288906 scopus 로고    scopus 로고
    • Functional interactions between Vav and PKCθ are required for TCR-induced T cell activation
    • (2000) Immunity , vol.12 , pp. 151-160
    • Villalba, M.1
  • 34
    • 0033516468 scopus 로고    scopus 로고
    • Direct interaction in T-cells between θ-PKC and the tyrosine kinase p59(fyn)
    • (1999) J. Biol. Chem. , vol.274 , pp. 19003-19010
    • Ron, D.1
  • 36
    • 0029000938 scopus 로고
    • RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4260-4271
    • Lai, J.H.1
  • 37
    • 0026061865 scopus 로고
    • Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28
    • (1991) Science , vol.251 , pp. 313-316
    • Fraser, J.D.1
  • 38
    • 0026332710 scopus 로고
    • Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-κB-like response element
    • (1991) J. Biol. Chem. , vol.266 , pp. 14179-14182
    • Verweij, C.L.1
  • 39
    • 0031001510 scopus 로고    scopus 로고
    • CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4051-4058
    • Shapiro, V.S.1
  • 40
    • 0031204429 scopus 로고    scopus 로고
    • Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
    • (1997) J. Immunol. , vol.159 , pp. 1319-1327
    • McGuire, K.L.1    Iacobelli, M.2
  • 42
    • 0034031401 scopus 로고    scopus 로고
    • Protein kinase C θ participates in NF-κB/Rel activation induced by CD3/CD28 costimulation through selective activation of IκB β (IKKβ)
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2933-2940
    • Lin, X.1
  • 44
    • 0034658333 scopus 로고    scopus 로고
    • RasGRP links T-cell receptor signaling to Ras
    • (2000) Blood , vol.95 , pp. 3199-3203
    • Ebinu, J.O.1
  • 48
    • 0031570119 scopus 로고    scopus 로고
    • Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events
    • (1997) J. Immunol. , vol.158 , pp. 4602-4611
    • Latinis, K.M.1
  • 49
    • 0029807140 scopus 로고    scopus 로고
    • Apoptosis but not other activation events is inhibited by a mutation in the transmembrane domain of T cell receptor β chain that impairs CD3ζ association
    • (1996) J. Biol. Chem. , vol.271 , pp. 30417-30425
    • Rodriguez-Tarduchy, G.1
  • 50
    • 0033248120 scopus 로고    scopus 로고
    • PKCθ is a necessary component, and cooperates with calcineurin, to induce FasL expression during activation-induced T cell death
    • (1999) J. Immunol. , vol.163 , pp. 5813-5819
    • Villalba, M.1
  • 51
    • 0032703372 scopus 로고    scopus 로고
    • Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a CrmA-sensitive apoptosis pathway in Jurkat T cells
    • (1999) Eur. J. Immunol. , vol.29 , pp. 3549-3561
    • Villunger, A.1
  • 54
  • 55
    • 0028987950 scopus 로고
    • Absolute dependence on κB responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes
    • (1995) EMBO J. , vol.14 , pp. 1552-1560
    • Alcami, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.