Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly

Mechanisms of Ageing and Development

Volumn 102, Issue 2-3, 1998, Pages 211-219

  Lio, Domenico ^a   D'Anna, Claudia ^a   Gervasi, Francesco ^b   Scola, Letizia ^a   Potestio, Marcella ^a   Di Lorenzo, Gabriele ^c   Listì, Florinda ^d   Colombo, Alfredo ^a   Candore, Giuseppina ^d   Caruso, Calogero ^d  

^a UNIVERSITY OF PALERMO   (Italy)

^b Servizio di Patologia Clinica ARNAS   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d Servizio di Tipizzazione Tissutale   (Italy)

Author keywords

Elderly; Interleukin 12; Mitogen stimulated mononuclear cells

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD40 ANTIGEN; GLYCOPROTEIN GP 39; INTERLEUKIN 12; MITOGENIC AGENT; MONOCLONAL ANTIBODY CD3; PHYTOHEMAGGLUTININ;

ADULT; AGED; CELL CULTURE; CELL STIMULATION; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE RELEASE; HELPER CELL; HUMAN; HUMAN CELL; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD40; CD40 LIGAND; CELLS, CULTURED; FEMALE; HUMANS; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MITOGENS; PHYTOHEMAGGLUTININS;

BACTERIA (MICROORGANISMS);

EID: 0032525013     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(98)00016-5     Document Type: Conference Paper

References (38)

1. Afonso L.C.C., Scharton T.M., Vieira L.Q., Wysocka M., Trinchieri G., Scott P. The adiuvant effect of interleukin-12 in a vaccine against Leishmania Major. Science. 263:1994;235-238.
2. Banchereau J., Bazan F., Blanchard D., Biere F., Galizzi J.P., van Kooten C., Liu Y.J., Rousset F., saeland S. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:1994;881-896.
3. Candore G., Di Lorenzo G., Melluso M., Cigna D., Colucci A.T., Modica M.A., Caruso C. γ-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmunity. 16:1993;275-280.
4. Candore G., Di Lorenzo G., Caruso C., Modica M.A., Colucci A.T., Crescimanno G., Ingrassia A., Barbagallo Sangiorgi G., Salerno A. The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2. Mech. Ageing Develop. 63:1992;297-307.
5. Caruso C., Candore G., Cigna D., Di Lorenzo G., Sireci G., Dieli F., Salerno A. Cytokine production pathway in elderly. Immunol. Res. 15:1996;84-90.
6. Caruso C., Di Lorenzo G., Modica M.A., Candore G., Portelli M.R., Crescimanno G., Ingrassia A., Barbagallo Sangiorgi G., Salerno A. Soluble interleukin-2 receptor secretion defect in vitro in elderly subjects. Mech. Ageing Develop. 59:1991;27-35.
7. Castle S., Uyemura K., Wong W., Modlin R., Effros R. Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home resident. Mech. Ageing Develop. 94:1997;7-16.
8. Chan S.H., Kobayashi M., Santoli D., Perussia B., Trinchieri G. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of trascription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148:1992;92-98.
9. D'Andrea A., Rengaraju M., Valiante N.M., Cheimi J., Kubin M., Aste M., Chan S.H., Kobayashi M., Young D., Nickbarg E., Chizzonite R., Wolf S.F., Trinchieri G. Production of natural killer cell stimulatory factor (interleukin-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1992;1387-1398.
10. + lymphocytes in physically active adults. Eur. J. Immunol. 23:1993;2704-2706.
11. Gately M.K., Wolitzky A.G., Quinn P.M., Chizzonite R. Regulation of human cytolytic lymphocyte response by IL-12. Cell. Immunol. 143:1992;127-142.
12. Germann T., Rude E. Interleukin-12. Int. Arch. Allergy Immunol. 108:1995;103-112.
13. Germann T., Mattner F., Partenheimer A., Schmitt E., Reske Kunz A.B., Fisher H.G., Rude E. Different accessory function for Th1 cells of bone marrow derived macrophages cultured in granulocyte macrophage colony stimulating factor. Int. Immunol. 4:1992;755-764.
14. Graf D., Muller S., Korthauer U., van Kooten C., Weise C., Kroczek R.A. A soluble form of trap (CD40 Ligand) is rapidly released after T-cell activation. Eur. J. Immunol. 25:1995;1749-1754.
15. Gregersen, P.K., Batlivalla, F., Monteiro, J., Serrano, D., MacPhail, S., Chiorazzi, N., 1997. Lymphocyte oligoclonality in aging - a reflection of chronic immunestimlation? Abstracts book, 5th EUCAMBIS Congress on the molecular biology of immunesenescence. Cordoba, May 14-18, p. 19.
16. Grewal I.S., Xu J., Flavell R.A. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature. 378:1995;617-618.
17. Hobbs M.V., Ernst D.N., Torbett B.E., Glasebrook A.L., Rehse M.A., McQuitty D.N., Thoman M.L., Bottomly K., Rothermel A.L., Noonan D.J., Weigle W.O. Cell proliferation and cytokine production by CD4 cells from old mice. J. Cell. Biochem. 46:1991;312.
18. + T-cells through IL-12 produced by listeria-induced macrophages. Science. 260:1993;547-549.
19. Kennedy M.K., Picha K.S., Fanslow W.C., Grabstein K.H., Alderson M.R., Clifford K.N., Chin W.A., Mohler K.M. CD40/CD40 ligand interactions are required for T-cell-dependent production of Il-12 by mouse macrophages. Eur. J. Immunol. 26:1996;370-378.
20. Kubin M., Kamoun M., Trinchieri G. Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T-cells. J. Epidemiol. Med. 180:1994;223-231.
21. Lerner K., Yamada T., Miller R.A. Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin-A. Eur. J. Immunol. 19:1989;977-982.
22. Lio D., Candore G., Cigna D., DÆAnna C., Di Lorenzo G., Giordano C., Lucania G., Mansueto P., Melluso M., Modica M.A., Caruso C. In vitro T-cell activation in elderly individuals: failure in CD69 and CD71 expression. Mech. Ageing Develop. 89:1996;51-58.
23. McLellan A.D., Sorg R.V., Wlliams L.A., Hart D.N.J. Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur. J. Immunol. 26:1996;1204-1210.
24. Orange J.S., Salazar-Mather T.P., Opal S.M., Spencer R.L., Miller A.H., McEwen B.S., Biron C.A. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:1995;901-914.
25. Pawelec G., Adibzadeh M., Solana R., Beckman I. The T-cell in the ageing individual. Mech. Ageing Develop. 93:1997;35-45.
26. Pawelec G. Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech. Ageing Develop. 79:1995;1-32.
27. Peng X., Kasran A., Warmerdam P.A.M., de Boer M., Ceuppens J.L. Accessory signaling by CD40 for T-cell activation: induction of Th1 and Th2 cytokines ad synergy with Interleukin-12 for interferon-γ production. Eur. J. Immunol. 26:1996;1621-1627.
28. Romagnani S. Biology of human Th1 and Th2 cells. J. Clin. Immunol. 15:1995;1-15.
29. Seder R.A., Kelsall B.L., Jankovic D. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease. J. Immunol. 157:1996;2745-2748.
30. Shu U., Kiniwa M., Wu C.Y., Maliszewski C., Vezzio N., Hakimi H., Gately M., Delespesse G. Activated T-cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1995;1125-1128.
31. Song F., Matsuzaki G., Mitsuyama M., Nomoto K. Differential effects of viable ad killed bacteria on IL-12 expression of macrophages. J. Immunol. 156:1996;2979-2986.
32. Song L., Kim Y.H., Rajesh K. Age related effects in T-cell activation and proliferation. Exp. Gerontol. 28:1993;313-321.
33. Stuber E., Strober W., Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevent the priming of T helper 1 cells through the inhibition of interleukin-12 secretion. J. Exp. Med. 183:1996;693-699.
34. Thoman M.L., Weigle W.O. The cellular and subcellular bases of immunosenescence. Adv. Immunol. 46:1989;221-261.
35. Trebilcock G.U., Ponnappan U. Induction and regulation of NFkB during aging: role of protein kinases. Clin. Immunol. Immunopathol. 79:1996;87-91.
36. Utsuyama M., Wakikawa A., Tamura T., Nariuchi H., Hirokawa K. Impairment of signal transduction in T-cells from old mice. Mech. Ageing Develop. 93:1997;131-144.
37. - T-cells. Abstracts book, 5th EUCAMBIS Congress on the molecular biology of immunesenescence. Cordoba, May 14-18, p. 20.
38. Whisler R.L., Beiqing L., Chen M. Age related decreases in IL-2 production by human T-cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT. Cell. Immunol. 169:1996;185-195.