Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: Age-associated differences in cell surface molecule expression and cytokine secretion

Biogerontology

Volumn 1, Issue 3, 2000, Pages 247-254

  Pawelec, Graham ^a   Mariani, Erminia ^b   Bradley, Ben ^c   Solana, Rafael ^d  

^a Section for Transplantation Immunology and Immunohaematology   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Immunosenescence; Replicative senescence; T cells; T cell clones; T cell longevity

Indexed keywords

CYTOKINE; MEMBRANE ANTIGEN;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL CLONE; CELL MEMBRANE; COMPARATIVE STUDY; CYTOLOGY; DONOR; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; PHYSIOLOGY; SECRETION;

ADULT; AGED; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CLONE CELLS; CYTOKINES; HEMATOPOIETIC STEM CELLS; HUMANS; TISSUE DONORS;

EID: 0034571009     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010086229931     Document Type: Article

References (32)

1. Adibzadeh M, Pohla H, Rehbein A and Pawelec G (1995) Long-term culture of monoclonal human T lymphocytes: models for immunosenescence? Mech Ageing Dev 83: 171-183
2. Bach FH, Inouye H, Hank JA and Alter BJ (1979) Human T-lymphocyte clones reactive in primed lymphocyte typing and cytotoxicity. Nature 281: 307-309
3. Broker BM, Tsygankov AY, Muller-Fleckenstein I, Guse AH, Chitaev NA, Biesinger B, Fleckenstein B and Emmrich F (1993) Immortalization of human T-cell clones by herpesvirus-saimiri - signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors. J Immunol 151: 1184-1192
4. Cakman I, Rohwer J, Schutz RM, Kirchner H and Rink L (1996) Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev 87: 197-209
5. Candore G, Di Lorenzo G, Melluso M, Cigna D, Colucci AT, Modica MA and Caruso C (1993) Gamma-interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmumty 16: 275-280
6. Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG and Beck JC (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci USA 95: 10614-10619
7. Duquesnoy R and Zeevi A (1983) Immunogenetic analysis of the HLA complex with alloreactive T-cell clones. Human Immunol 8: 17-23
8. Effros RB and Pawelec G (1997) Replicative senescence of T lymphocytes: does the Hayflick Limit lead to immune exhaustion? Immunol Today 18: 450-454
9. Effros RB and Walford RL (1984) T-cell cultures and the Hayflick limit. Human Immunol 9: 49-65
10. Effros RB and Walford RL (1987) Neonatal T cells as a model system to study the possible in vitro senescence of lymphocytes. Exp Gerontol 22: 307-316
11. Effros RB, Penllo NL, Bhuta S and Walford R (1990): In vitro studies of human T lymphocyte senescence. In: Finch C and Johnson T (eds) UCLA Symposium. Molecular Biology of Aging, pp 265-279. Alan R. Liss, New York
12. Effros RB, Boucher N, Porter V, Zhu XM, Spaulding C, Walford RL, Kronenberg M, Cohen D and Schachter F (1994) Decline in CD28(+) T cells in centenarians and in long-term T-cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29: 601-609
13. Ferrucci L, Harris TB, Guralnik JM, Tracy RP, Corti M-C, Cohen HJ, Penninx B, Pahor M, Wallace R and Havlik RJ (1999) Serum IL-6 level and the developmemt of disability in older persons. J Am Geriatr Soc 47: 639-646
14. Grubeck-Loebenstein B, Lechner H and Trieb K (1994) Long-term in vitro growth of human T-cell clones: can postmitotic 'senescent' cell populations be defined? Int Arch Allergy Immunol 104: 232-239
15. Hempel L, Korholz D, Bonig H, Schneider M, Kleinvehne A, Packeisen J, Mauzkorholz C and Burdach S (1995) Interleukin-10 directly inhibits the interleukin-6 production in T-cells. Scand J Immunol 41: 462-466
16. Hutloff A, Dittrich AM, Beier KC, Eljaschewitsch B, Kraft R, Anagnostopoulos I and Kroczek RA (1999) ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397: 263-266
17. Kaltoft K, Pedersen CB, Hansen BH, Lemonidis AS, Frydenberg J and Thestrup-Pedersen K (1994) In vitro genetically aberrant T-cell clones with continuous growth are associated with atopic dermatitis. Arch Dermatol Res 287: 42-47
18. Kaltoft K, Pedersen CB, Hansen BH and Thestrup-Pedersen K (1995) Appearance of isochromosome 18q can be associated with in vitro immortalization of human T lymphocytes. Cancer Genet Cytogenet 81: 13-16
19. Leal IS, Smedegard B, Andersen P and Appelberg R (1999) Interleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine. Infec Immunity 67: 5747-5754
20. Maini MK, Soares MVD, Zilch CF, Akbar AN and Beverley PCL (1999) Virus-induced CD8(+) T-cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence. J Immunol 162: 4521-4526
21. Mariani E, Roda P, Mariani AR, Vitale M, Degrassi A, Papa S and Faccini A (1990) Age-associated changes in CD8+ and CD16+ cell reactivity: clonal analysis. Clin Exp Immunol 81: 479-484
22. McCarron M, Osborne Y, Story C, Dempsey JL, Turner R and Morley A (1987) Effect of age on lymphocyte proliferation. Mech Ageing Dev 41: 211-218
23. Paganelli R, Scala E, Rosso R, Cossarizza A, Bertollo L, Barbieri D, Fabrizi A, Lusi EA, Fagiolo U and Franceschi C (1996) A shift to ThO cytokine production by CD4(+) cells in human longevity: studies on two healthy centenarians. Eur J Immunol 26: 2030-2034
24. Pawelec G and Wernet P (1980) Restimulation properties of human alloreactive cloned T-cell lines dissection of HLA-D-region alleles in population studies and in family segregation analysis. Immunogenetics 11: 507-519
25. Pawelec G, Obata F, Sansom D, Friccius H, Daikeler T, Adibzadeh M, Schaudt K and Pohla H (1997a) Analysis of MHC class II-specific T-cell clones. In: Fernandez N and Butcher G (eds) MHC: A Practical Approach, pp 71-89. IRL Press (Oxford University Press), Oxford
26. Pawelec G, Rehbein A, Haehnel K, Merl A and Adibzadeh M (1997b) Human T-cell clones as a model for immunosenescence. Immunol Rev 160: 31-43
27. Pawelec G, Muller R, Rehbein A, Hahnel K and Ziegler BL (1998) Extrathymic T-cell differentiation in vitro from human CD34(+) stem cells. J Leukocyte Biol 64: 733-739
28. Pawelec G, Wagner W, Adibzadeh M and Engel A (1999) T cell immunosenescence in vitro and in vivo. Exp Gerontol 34: 419-429
29. Penllo NL, Walford RL, Newman MA and Effros RB (1989) Human T lymphocytes possess a limited in vitro life span. Exp Gerontol 24: 177-187
30. Perillo NL, Naeim F, Walford RL and Effros RB (1993) The in vitro senescence of human T-Lymphocytes - failure to divide is not associated with a loss of cytolytic activity or memory T-cell phenotype. Mech Ageing Dev 67: 173-185
31. Peterson PK, Chao CC, Carson P, Hu SX, Nichol K and Janoff EN (1994) Levels of tumor necrosis factor alpha, interleukin 6, interleukin 10, and transforming growth factor beta are normal in the serum of the healthy elderly. Clin Infect Dis 19: 1158-1159
32. Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boulet S and Proust JJ (1997) Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mech Ageing Dev 96: 35-46