Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice

Mechanisms of Ageing and Development

Volumn 94, Issue 1-3, 1997, Pages 71-83

  Gorgas, Gayle ^a   Butch, Elizabeth R ^a   Guan, Kun Liang ^a,b   Miller, Richard A ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

ERK; Immune senescence; MAP kinase; MEK; Signal transduction; T lymphocytes

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

AGING; ANIMAL CELL; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE ACTIVATION; LYMPHOCYTE ACTIVATION; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

AGING; ANIMALS; ANTIBODIES; ANTIGENS, CD3; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CROSS-LINKING REAGENTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGENS; PHYTOHEMAGGLUTININS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; T-LYMPHOCYTES;

EID: 0030927563     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01857-X     Document Type: Conference Paper

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