Up-regulation of c-FLIP(short) and reduction of activation-induced cell death in CD28-co-stimulated human T cells

European Journal of Immunology

Volumn 30, Issue 10, 2000, Pages 2765-2774

  Kirchhoff, Sabine ^a   Müller, Wolfgang W ^a   Li Weber, Min ^a   Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Activation induced cell death; CD95 (APO 1 Fas); Co stimulation; FLICE inhibitory protein; T cell

Indexed keywords

CASPASE 8; CD28 ANTIGEN; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL X; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIGENS, CD95; APOPTOSIS; CARRIER PROTEINS; CASPASES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, IMMUNOLOGICAL; MUROMONAB-CD3; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; RNA, NEOPLASM; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TRANSFECTION;

EID: 0033790128     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<2765::AID-IMMU2765>3.0.CO;2-W     Document Type: Article

References (49)

1. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
2. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death
3. Tumor necrosis factor receptor and Fas signaling mechanisms
4. Activation interferes with the APO-1 pathway in mature human T cells
5. The Role of c-FLIP in modulation of CD95-induced apoptosis
6. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
7. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
8. Fas ligand mediates activation-induced cell death in human T lymphocytes
9. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
10. A novel protein that interacts with the death domain of Fas/APO-1 contains a sequence motif related to the death domain
11. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
12. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
13. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
14. The Ced-3/interleukin 1beta converting enzyme-like homologue Mch6 and lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
15. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
16. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
17. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
18. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
19. Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product
20. The role of caspases in development, immunity, and apoptotic signal transduction: Lessons from knockout mice
21. Involvement of an ICE-like protease in Fas-mediated apoptosis
22. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
23. Two CD95 (APO-1/Fas) signaling pathways
24. Viral Flice-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
25. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD95-induced apoptosis
26. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
27. Inhibition of death receptor signals by cellular FLIP
28. CASH, a novel caspase homologue with death effector domains
29. Casper is a FADD-and caspase-related inducer of apoptosis
30. Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
31. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
32. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BClX(L) and initiates cell death
33. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD95 (Fas, APO-1) receptor complex
34. Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
35. The B7 and CD28 receptor families
36. A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation
37. CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation
38. Distinct regulation of T-cell death by CD28 depending on both its aggregation and T-cell receptor triggering: A role for Fas-FasL
39. Receptors that regulate T-cell susceptibility to apoptotic cell death
40. CD28 and apoptosis
41. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death
42. Differential regulation of bcl-2 and bcl-x by CD3, CD28, and the IL-2 receptor in cloned CD4+ helper T cells. A model for the long-term survival of memory cells
43. CD28 can promote T cell survival through a phosphatidylinositol 3-kinase-independent mechanism
44. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
45. The regulation of CD95 ligand expression and function in CTL
46. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
47. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells
48. Firefly luciferase gene: Structure and expression in mammalian cells
49. Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens