The CD28-related molecule ICOS is required for effective T cell-dependent immune responses

Immunity

Volumn 13, Issue 1, 2000, Pages 95-105

  Coyle, Anthony J ^a   Lehar, Sophie ^a   Lloyd, Clare ^a   Tian, Jane ^a   Delaney, Tracy ^a   Manning, Stephen ^a   Nguyen, Trang ^a   Burwell, Tim ^a   Schneider, Helga ^b   Gonzalo, Jose Angel ^a   Gosselin, Michael ^a   Owen, Laura Rudolph ^a   Rudd, Christopher E ^b   Gutierrez Ramos, Jose Carlos ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDUCIBLE COSTIMULATORY PROTEIN; INTERLEUKIN 2; INTERLEUKIN 4; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

EID: 0033696961     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00011-X     Document Type: Article

References (49)

1. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation
2. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
3. A two-step, two-signal model for the primary activation of precursor helper T cells
4. Limited role of CD28-mediated signals in T helper subset differentiation
5. OX40 ligand has a critical costimulatory role in dendritic cell:T cell interactions
6. Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
7. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
8. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis
9. T1/ST2 plays a critical role in Th2 cell function and regulates allergen induced lung pathology and airway hyperresponsiveness
10. Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation
11. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
12. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
13. H. polygyrus: B7-independence of the secondary type 2 response
14. CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response
15. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
16. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
17. CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis
18. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
19. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
20. B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens
21. OX-40 deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
22. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
23. Enhancement of antitumor immunity by CTLA-4 blockade
24. Systemic administration of endotoxin induces bronchopulmonary hyperreactivity dissociated from TNF-alpha formation and neutrophil sequestration into the murine lungs
25. Immunosuppression in vivo by a soluble form of the CTLA-4T cell activation molecule
26. CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo
27. + T cells
28. Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response
29. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
30. + T lymphocytes from TCR transgenic mice
31. CTLA4Ig inhibits airway eosinophila and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma
32. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
33. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
34. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
35. CD28 costimulation promotes the production of Th2 cytokines
36. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
37. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras
38. A cell culture model for T lymphocyte clonal anergy
39. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
40. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
41. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha
42. Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand
43. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
44. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
45. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness
46. CTLA-4 can function as a negative regulator of T cell activation
47. Interleukin-13: Central mediator of allergic asthma
48. CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen
49. T-cell co-stimulation through B7RP-1 and ICOS