Mismatch repair in correction of replication errors and processing of DNA damage

Journal of Cellular Physiology

Volumn 187, Issue 2, 2001, Pages 145-154

  Aquilina, Gabriele ^a   Bignami, Margherita ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; MICROSATELLITE DNA;

ANIMAL CELL; BASE MISPAIRING; CARCINOGENESIS; COLORECTAL CANCER; CORRELATION FUNCTION; DNA DAMAGE; DNA REPLICATION; FRAMESHIFT MUTATION; GENETIC STABILITY; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SEQUENCE ANALYSIS;

ANIMALS; BASE PAIR MISMATCH; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; HUMANS;

EID: 0035060081     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.1067     Document Type: Review

References (125)

1. Loss of DNA mismatch repair in acquired resistance to Cisplatin
2. Sister chromatid exchanges in cells defective in mismatch, post-replication and excision repair
3. Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice
4. Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells
5. CCNU sensitivity in mismatch repair defective human cells
6. Genetic consequences of tolerance to methylation DNA damage in mammalian cells
7. Mismatch repair, G2/M cell cycle arrest and lethality after DNA damage
8. A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage
9. Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
10. Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability
11. The role of the MED1 (MBD4) gene in DNA repair and human cancer
12. The effect of O6-methylguanine DNA adducts on the adenosine nucleotide switch functions of hMSH2-hMSH6 and hMSH2-hMSH3
13. The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity. DNA incorporation, and radiosensitization in human colon cancer cells
14. Molecular analysis of mutations in mutator colorectal carcinoma cell lines
15. Mutator phenotypes in human colorectal carcinoma cell lines
16. 6-methylguanine and the cytotoxicity of methylating agents
17. Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
18. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
19. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines
20. Spontaneous development of drug resistance: Mismatch repair and p53 defects in resistance to cisplatin in human tumor cells
21. Mammalian DNA mismatch repair
22. The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts
23. Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N-nitro-N-nitroso-guanidine
24. Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells
25. Cytotoxicity and mutagenicity of frameshift-inducing agent ICR191 in mismatch repair-deficient colon cancer cells
26. Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents
27. Functional interaction of PCNA with MSH2-MSH6 and MSH2-MSH3 complexes
28. Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents
29. Correction of large mispaired DNA loops by extracts of Saccharomyces cerevisiae
30. Involvement of the mismatch repair system in temozolomide-induced apoptosis
31. Defective expression of the mismatch repair protein, hMLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation
32. Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation
33. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination and predisposition to cancer
34. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
35. Mouse models for Hereditary nonpolyposis colorectal cancer
36. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA
37. Cisplatin and adriamycin resistance are associated with MutLa and mismatch repair deficiency in an ovarian rumor cell line
38. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
39. hMutSalpha-and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
40. 4-methylthymine, or the cisplatin d(GpG) adduct
41. Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes
42. The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae
43. Mismatch repair defects in human carcinogenesis
44. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
45. The role of DNA mismatch repair in platinum drug resistance
46. Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cells in vitro and in xenografts
47. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
48. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells
49. Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage
50. The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
51. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
52. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation
53. A role for mismatch repair in the production of chromosome aberrations by methylating agents in human cells
54. Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα
55. Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumor
56. Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate
57. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
58. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
59. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
60. Properties of N-methyl-N-nitrosourea-resistant mex- derivatives of an SV40-immortalized human fibroblast cell line
61. DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: Implications for tolerance to DNA methylation damage
62. ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
63. Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3
64. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex
65. Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta
66. Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
67. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint
68. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
69. Mismatch repair and differential sensitivity of mouse and human cells to DNA methylating agents
70. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα
71. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2
72. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
73. DNA damage tolerance, mismatch repair and genome instability
74. Genomic instability and tolerance to alkylating agents
75. 6-methylguanine residues in E. coli DNA
76. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
77. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrososguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
78. Eukaryotic DNA mismatch repair
79. DNA replication fidelity
80. Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2 in transcription-coupled repair
81. Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae
82. Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15
83. Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells
84. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
85. Human MutSα specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts
86. MLH3: A DNA mismatch repair gene associated with mammalian microsatellite instability
87. Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5′ single-strand break and is independent of the mismatch repair system
88. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
89. DNA polymerase δ is required for human mismatch repair in vitro
90. Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype
91. Frameshift mutator mutations
92. Mismatch repair deficiency is associated with overexpression of the MSH3 gene
93. Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotideexcision repair of the lactose operon in Escherichia coli
94. Transcription-coupled repair deficiency and mutations in human mismatch repair genes
95. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems
96. Differential induction of c-jun NH2-terminal kinase and c-abl kinase in DNA mismatch repair-proficient and deficient cells exposed to cisplatin
97. MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxoguanine in S. cerevisiae
98. Combined mismatch and nucleotide excision repair defects in a human cell line: Mismatch repair processes methylation but not UV- or ionizing radiation -induced DNA damage
99. Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair
100. GTBP, a 160 kD protein essential for mismatch-binding activity in human cells
101. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
102. MLH1, PMS1, and MSH2 interactions during the initiation of a DNA mismatch repair in yeast
103. Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT
104. Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1
105. Mutator phenotype in Msh2-deficient murine embryonic fibroblasts
106. Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type I
107. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair
108. Human exonuclease I interacts with the mismatch repair protein hMSH2
109. Role of post-replicative DNA mismatch repair in the cytotoxic action of thioguanine
110. Mismatch repair mutants in yeast are not defective in transcription- coupled DNA repair of UV-induced DNA damage
111. Msh2 status modulates both apoptosis and mutation frequency in the small intestine
112. Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLα
113. Functional overlap in mismatch repair by human MSH3 and MSH6
114. Requirement for PCNA in DNA mismatch repair at a step preceding DNA synthesis
115. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
116. Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases
117. Neurofibromatosis and early onset of cancers in hMLH1-deficient children
118. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
119. 6-methylthioguanine
120. Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis
121. Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins
122. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
123. Ionizing radiation-induced apoptosis via separate Pms2- and p53- dependent pathways
124. Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts
125. DNA replication arrest and tolerance to DNA methylation damage