-
1
-
-
0029985445
-
Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells
-
Anthoney DA, Macllwrath AJ, Gallagher WM, Edlin ARM, and Brown R (1996) Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells. Cancer Res 56:1374-1381.
-
(1996)
Cancer Res
, vol.56
, pp. 1374-1381
-
-
Anthoney, D.A.1
Macllwrath, A.J.2
Gallagher, W.M.3
Edlin, A.R.M.4
Brown, R.5
-
2
-
-
0024394466
-
Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells
-
Aquilina G, Zijno A, Moscufo N, Dogliotti E, and Bignami M (1989) Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells. Carcinogenesis (Lond) 10:1219-1223.
-
(1989)
Carcinogenesis (Lond)
, vol.10
, pp. 1219-1223
-
-
Aquilina, G.1
Zijno, A.2
Moscufo, N.3
Dogliotti, E.4
Bignami, M.5
-
3
-
-
0001044228
-
The plant alkaloids
-
(Chabner BA and Collins JM, eds) JB Lippincott, Philadelphia
-
Bender RA, Hamel E, and Handle KR (1990) The plant alkaloids, in Cancer Chemotherapy: Principles and Practice (Chabner BA and Collins JM, eds) pp 253-275, JB Lippincott, Philadelphia.
-
(1990)
Cancer Chemotherapy: Principles and Practice
, pp. 253-275
-
-
Bender, R.A.1
Hamel, E.2
Handle, K.R.3
-
4
-
-
0024532949
-
Cell cycle perturbation and cell death after exposure of a human lymphoblastoid cell strain to N-methyl-N'-nitro-N-nitrosoguanidine
-
Black KA, McFarland RD, Grisham JW, and Smith GJ (1989) Cell cycle perturbation and cell death after exposure of a human lymphoblastoid cell strain to N-methyl-N'-nitro-N-nitrosoguanidine. Am J Pathol 134:53-61.
-
(1989)
Am J Pathol
, vol.134
, pp. 53-61
-
-
Black, K.A.1
McFarland, R.D.2
Grisham, J.W.3
Smith, G.J.4
-
5
-
-
0028944359
-
Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma
-
Bleehen NM, Newlands ES, Lee SM, Thatcher N, Selby P, Calvert AH, Rustin GJ, Brampton M, and Stevens MF (1995) Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma. J Clin Oncol 13:910-913.
-
(1995)
J Clin Oncol
, vol.13
, pp. 910-913
-
-
Bleehen, N.M.1
Newlands, E.S.2
Lee, S.M.3
Thatcher, N.4
Selby, P.5
Calvert, A.H.6
Rustin, G.J.7
Brampton, M.8
Stevens, M.F.9
-
6
-
-
0030015770
-
Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanide
-
Carethers JM, Hawn MT, Chauhan DP, Luce MC, Marra G, Koi M, and Boland CR (1996) Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanide. J Clin Invest 98:199-206.
-
(1996)
J Clin Invest
, vol.98
, pp. 199-206
-
-
Carethers, J.M.1
Hawn, M.T.2
Chauhan, D.P.3
Luce, M.C.4
Marra, G.5
Koi, M.6
Boland, C.R.7
-
7
-
-
3543026063
-
Role of mismatch repair system in apoptosis induced by methyltriazenes
-
Cadmus Journal Services, Linthicum, MD
-
D'Atri S, Graziani G, Lacal PM, Tentori L, Pagani E, and Jiricny J (1997) Role of mismatch repair system in apoptosis induced by methyltriazenes, in Proceedings of the 88th Annual Meeting of the American Association for Cancer Research, p1, Cadmus Journal Services, Linthicum, MD.
-
(1997)
Proceedings of the 88th Annual Meeting of the American Association for Cancer Research
, pp. 1
-
-
D'Atri, S.1
Graziani, G.2
Lacal, P.M.3
Tentori, L.4
Pagani, E.5
Jiricny, J.6
-
8
-
-
0025196019
-
6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
-
6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci USA 87:5368-5372.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 5368-5372
-
-
Dolan, E.M.1
Moshel, R.C.2
Pegg, A.E.3
-
9
-
-
0029812676
-
Cisplatin and Adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line
-
Drummond JT, Anthoney A, Brown R, and Modrich P (1996) Cisplatin and Adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem 271:19645-19648.
-
(1996)
J Biol Chem
, vol.271
, pp. 19645-19648
-
-
Drummond, J.T.1
Anthoney, A.2
Brown, R.3
Modrich, P.4
-
10
-
-
0028294605
-
1 arrest and apoptosis
-
1 arrest and apoptosis. Cancer Res 54:1169-1174.
-
(1994)
Cancer Res
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrel, M.8
Hill, D.E.9
Wang, Y.10
Wiman, K.G.11
Mercer, W.E.12
Kastan, M.B.13
Kohn, K.W.14
Elledge, S.J.15
Kinzler, K.W.16
Vogelstein, B.17
-
12
-
-
0022971473
-
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine
-
Goldmacher VS, Cuzick RA, and Thilly WG (1986) Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. J Biol Chem 261: 12462-12471.
-
(1986)
J Biol Chem
, vol.261
, pp. 12462-12471
-
-
Goldmacher, V.S.1
Cuzick, R.A.2
Thilly, W.G.3
-
13
-
-
0027423911
-
Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines
-
Hamaguchi K, Godwin AK, Yakushiji M, O'Dwyer PJ, Ozols RF, and Hamilton TC (1993) Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines. Cancer Res 53:5225-5232.
-
(1993)
Cancer Res
, vol.53
, pp. 5225-5232
-
-
Hamaguchi, K.1
Godwin, A.K.2
Yakushiji, M.3
O'Dwyer, P.J.4
Ozols, R.F.5
Hamilton, T.C.6
-
14
-
-
0031034762
-
p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in Rat-1 fibroblasts constitutively expressing c-Myc
-
Han J, Dionne CA, Kedersha NL, and Goldmacher VS (1997) p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in Rat-1 fibroblasts constitutively expressing c-Myc. Cancer Res 57:176-182.
-
(1997)
Cancer Res
, vol.57
, pp. 176-182
-
-
Han, J.1
Dionne, C.A.2
Kedersha, N.L.3
Goldmacher, V.S.4
-
15
-
-
0029845760
-
Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
-
Harris CC (1996) Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 88:1442-1455.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1442-1455
-
-
Harris, C.C.1
-
17
-
-
0030472346
-
Mismatch repair and cancer
-
(Lindahl T, ed) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Jiricny J (1996) Mismatch repair and cancer, in Genetic Instability in Cancer (Lindahl T, ed) pp 47-68, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
-
(1996)
Genetic Instability in Cancer
, pp. 47-68
-
-
Jiricny, J.1
-
18
-
-
0026750738
-
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
-
Karran P and Bignami M (1992) Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res 20:2933-2940.
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 2933-2940
-
-
Karran, P.1
Bignami, M.2
-
19
-
-
0027292234
-
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
-
Kat A, Thilly WG, Fang WH, Longley MJ, Li GM, and Modrich P (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci USA 90:6424-6428.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 6424-6428
-
-
Kat, A.1
Thilly, W.G.2
Fang, W.H.3
Longley, M.J.4
Li, G.M.5
Modrich, P.6
-
20
-
-
0027936057
-
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
-
Koi M, Umar A, Chauhan DP, Cherian SP, Carethers JM, Kunkel TA, and Boland CR (1994) Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 54:4308-4312.
-
(1994)
Cancer Res
, vol.54
, pp. 4308-4312
-
-
Koi, M.1
Umar, A.2
Chauhan, D.P.3
Cherian, S.P.4
Carethers, J.M.5
Kunkel, T.A.6
Boland, C.R.7
-
21
-
-
0029200766
-
The role of p53 in cell-cycle control and apoptosis: Implications for cancer
-
(De Vita VT, Hellman S, and Rosenberg SA, eds) J. B. Lippincott, Philadelphia, PA
-
Leonard CJ, Canman CE, and Kastan MB (1995) The role of p53 in cell-cycle control and apoptosis: implications for cancer, in Important Advances in Oncology (De Vita VT, Hellman S, and Rosenberg SA, eds) pp 33-42, J. B. Lippincott, Philadelphia, PA.
-
(1995)
Important Advances in Oncology
, pp. 33-42
-
-
Leonard, C.J.1
Canman, C.E.2
Kastan, M.B.3
-
22
-
-
0030479125
-
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea
-
Liu L, Markowitz S, and Gerson SL (1996) Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res 56:5375-5379.
-
(1996)
Cancer Res
, vol.56
, pp. 5375-5379
-
-
Liu, L.1
Markowitz, S.2
Gerson, S.L.3
-
23
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
Ludwig RL, Bates S, and Vousden KH (1996) Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 16: 4952-4960.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4952-4960
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
24
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, and Reed JC (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewska, M.3
Wang, H.G.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
25
-
-
0030803659
-
Strand-specific mismatch repair in mammalian cells
-
Modrich P (1997) Strand-specific mismatch repair in mammalian cells. J Biol Chem 272:24727-24730.
-
(1997)
J Biol Chem
, vol.272
, pp. 24727-24730
-
-
Modrich, P.1
-
26
-
-
0026513077
-
Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
-
Newlands ES, Blackledge GRP, Slack JA, Rustin GJS, Smith DB, Stuart NSA, Quarterman CP, Hoffman R, Stevens MFG, Brampton MH, and Gibson AC (1992) Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br J Cancer 65:287-291.
-
(1992)
Br J Cancer
, vol.65
, pp. 287-291
-
-
Newlands, E.S.1
Blackledge, G.R.P.2
Slack, J.A.3
Rustin, G.J.S.4
Smith, D.B.5
Stuart, N.S.A.6
Quarterman, C.P.7
Hoffman, R.8
Stevens, M.F.G.9
Brampton, M.H.10
Gibson, A.C.11
-
27
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, and Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271-279.
-
(1991)
J Immunol Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
28
-
-
0027217084
-
Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
-
Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR, and Sikorska M (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO (Eur Mol Biol Organ) J 12:3679-3684.
-
(1993)
EMBO (Eur Mol Biol Organ) J
, vol.12
, pp. 3679-3684
-
-
Oberhammer, F.1
Wilson, J.W.2
Dive, C.3
Morris, I.D.4
Hickman, J.A.5
Wakeling, A.E.6
Walker, P.R.7
Sikorska, M.8
-
29
-
-
0029003501
-
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
-
Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara I, Roth JA, Deisseroth AB, Zhang WW, Kruzel E, and Radinsky R (1995) Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 15:3032-3040.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3032-3040
-
-
Owen-Schaub, L.B.1
Zhang, W.2
Cusack, J.C.3
Angelo, L.S.4
Santee, S.M.5
Fujiwara, I.6
Roth, J.A.7
Deisseroth, A.B.8
Zhang, W.W.9
Kruzel, E.10
Radinsky, R.11
-
30
-
-
0029069972
-
Mutation of GTBP in genetically unstable cells
-
Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JKV, Kinzler KV, Jiricny J, and Vogelstein B (1995) Mutation of GTBP in genetically unstable cells. Science (Washington DC) 268:1915-1917.
-
(1995)
Science (Washington DC)
, vol.268
, pp. 1915-1917
-
-
Papadopoulos, N.1
Nicolaides, N.C.2
Liu, B.3
Parsons, R.4
Lengauer, C.5
Palombo, F.6
D'Arrigo, A.7
Markowitz, S.8
Willson, J.K.V.9
Kinzler, K.V.10
Jiricny, J.11
Vogelstein, B.12
-
31
-
-
0025195404
-
6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
-
6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res 50:6119-6129.
-
(1990)
Cancer Res
, vol.50
, pp. 6119-6129
-
-
Pegg, A.E.1
-
32
-
-
0029935573
-
Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells
-
Peled A, Zipori D, and Rotter V (1996) Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells. Cancer Res 56:2148-2156.
-
(1996)
Cancer Res
, vol.56
, pp. 2148-2156
-
-
Peled, A.1
Zipori, D.2
Rotter, V.3
-
33
-
-
0015132710
-
A novel mechanism for the inhibition of DNA synthesis following methylation: The effect of N-methyl-N-nitrosourea on HeLa cells
-
Plant JE and Roberts JJ (1971) A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells. Chem Biol Interact 3:337-342.
-
(1971)
Chem Biol Interact
, vol.3
, pp. 337-342
-
-
Plant, J.E.1
Roberts, J.J.2
-
34
-
-
0018118326
-
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay
-
Skopek TR, Liber HL, Penman BW, and Thilly WG (1978) Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem Biophys Res Commun 84:411-416.
-
(1978)
Biochem Biophys Res Commun
, vol.84
, pp. 411-416
-
-
Skopek, T.R.1
Liber, H.L.2
Penman, B.W.3
Thilly, W.G.4
-
35
-
-
0023605735
-
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M&B 39831), a novel drug with potential as an alternative to dacarbazine
-
Stevens MF, Hickman JA, Langdon SP, Chubb D, Vickers L, Stone R, Baig G, Goddard C, Gibson NW, and Slack JA (1987) Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M&B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res 47:5846-5852.
-
(1987)
Cancer Res
, vol.47
, pp. 5846-5852
-
-
Stevens, M.F.1
Hickman, J.A.2
Langdon, S.P.3
Chubb, D.4
Vickers, L.5
Stone, R.6
Baig, G.7
Goddard, C.8
Gibson, N.W.9
Slack, J.A.10
-
36
-
-
0029822592
-
Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
-
Swann PF, Waters TR, Moulton DC, Xu YZ, Zheng Q, Edwards M, and Mace R (1996) Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science (Washington DC) 273:1109-1111.
-
(1996)
Science (Washington DC)
, vol.273
, pp. 1109-1111
-
-
Swann, P.F.1
Waters, T.R.2
Moulton, D.C.3
Xu, Y.Z.4
Zheng, Q.5
Edwards, M.6
Mace, R.7
-
38
-
-
0030611436
-
6-alkylguanine DNA-alkyltransferase or poly-(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide
-
6-alkylguanine DNA-alkyltransferase or poly-(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Mol Pharmacol 52:249-258.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 249-258
-
-
Tentori, L.1
Orlando, L.2
Lacal, P.M.3
Benincasa, E.4
Faraoni, I.5
Bonmassar, E.6
D'Atri, S.7
Graziani, G.8
-
39
-
-
0027138785
-
Detection of the initial stages of DNA fragmentation in apoptosis
-
Walker PR, Kokileva L, LeBlanc J, and Sikorska M (1993) Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15:1032-1040.
-
(1993)
Biotechniques
, vol.15
, pp. 1032-1040
-
-
Walker, P.R.1
Kokileva, L.2
LeBlanc, J.3
Sikorska, M.4
-
41
-
-
0027717617
-
p21 is a universal inhibitor of cyclin kinases
-
Xiong Y, Hannon GJ, Zhang H, Casso D, and Kobayashi R (1993) p21 is a universal inhibitor of cyclin kinases. Nature (Lond) 366:701-704.
-
(1993)
Nature (Lond)
, vol.366
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
|