메뉴 건너뛰기




Volumn 17, Issue 9, 1998, Pages 2677-2686

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα

Author keywords

ATPase activity; hMutS ; Mismatch repair; Mismatch binding proteins

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ARGININE; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSINE; OLIGONUCLEOTIDE; RECOMBINANT PROTEIN;

EID: 0032079736     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.9.2677     Document Type: Article
Times cited : (146)

References (36)
  • 2
    • 0030962031 scopus 로고    scopus 로고
    • Genetic and biochemical analysis of msh2p-msh6p: Role of ATP hydrolysis and msh2p-msh6p subunit interactions in mismatch base pair recognition
    • Alani, E., Sokolsky, T., Studamire, B., Miret, J. and Lahue, R. (1997) Genetic and biochemical analysis of msh2p-msh6p: role of ATP hydrolysis and msh2p-msh6p subunit interactions in mismatch base pair recognition. Mol. Cell. Biol., 17, 2436-2447.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2436-2447
    • Alani, E.1    Sokolsky, T.2    Studamire, B.3    Miret, J.4    Lahue, R.5
  • 3
    • 0030856429 scopus 로고    scopus 로고
    • MutS mediates heteroduplex loop formation by a translocation mechanism
    • Allen, D.J., Makhov, A., Grilley, M., Taylor, J., Thresher, R. and Griffith, J.D. (1997) MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J., 16, 4467-4476.
    • (1997) EMBO J. , vol.16 , pp. 4467-4476
    • Allen, D.J.1    Makhov, A.2    Grilley, M.3    Taylor, J.4    Thresher, R.5    Griffith, J.D.6
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 10144248959 scopus 로고    scopus 로고
    • A partially functional DNA helicase II mutant defective in forming stable binary complexes with ATP and DNA. A role for helicase motif III
    • Brosh, R.M., Jr and Matson, S.W. (1996) A partially functional DNA helicase II mutant defective in forming stable binary complexes with ATP and DNA. A role for helicase motif III. J. Biol. Chem., 271, 25360-25368.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25360-25368
    • Brosh Jr., R.M.1    Matson, S.W.2
  • 6
    • 0026598237 scopus 로고
    • Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells
    • Chen, M., Pan, Z.Q. and Hurwitz, J. (1992) Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. Proc. Natl Acad. Sci. USA, 89, 2516-2520.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 2516-2520
    • Chen, M.1    Pan, Z.Q.2    Hurwitz, J.3
  • 7
    • 0029070143 scopus 로고
    • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
    • Drummond, J.T., Li, G.M., Longley, M.J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science, 268, 1909-1912.
    • (1995) Science , vol.268 , pp. 1909-1912
    • Drummond, J.T.1    Li, G.M.2    Longley, M.J.3    Modrich, P.4
  • 8
    • 0029042130 scopus 로고
    • Identification of mismatch repair genes and their role in the development of cancer
    • Fishel, R. and Kolodner, R.D. (1995) Identification of mismatch repair genes and their role in the development of cancer. Curr. Opin. Genet. Dev., 5, 382-395.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 382-395
    • Fishel, R.1    Kolodner, R.D.2
  • 9
    • 0028595722 scopus 로고
    • Binding of mismatched microsatellite DNA sequences by the human MSH2 protein
    • Fishel, R., Ewel, A., Lee, S., Lescoe, M.K. and Griffith, J. (1994a) Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science, 266, 1403-1405.
    • (1994) Science , vol.266 , pp. 1403-1405
    • Fishel, R.1    Ewel, A.2    Lee, S.3    Lescoe, M.K.4    Griffith, J.5
  • 10
    • 0028053411 scopus 로고
    • Purified human MSH2 protein binds to DNA containing mismatched nucleotides
    • Fishel, R., Ewel, A. and Lescoe, M.K. (1994b) Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res., 54, 5539-5542.
    • (1994) Cancer Res. , vol.54 , pp. 5539-5542
    • Fishel, R.1    Ewel, A.2    Lescoe, M.K.3
  • 11
    • 0025363116 scopus 로고
    • Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems
    • Gorbalenya, A.E. and Koonin, E.V. (1990) Superfamily of UvrA-related NTP-binding proteins. Implications for rational classification of recombination/repair systems. J. Mol. Biol., 213, 583-591.
    • (1990) J. Mol. Biol. , vol.213 , pp. 583-591
    • Gorbalenya, A.E.1    Koonin, E.V.2
  • 12
    • 0031456973 scopus 로고    scopus 로고
    • The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
    • Gradia, S., Acharya, S. and Fishel, R. (1997) The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell, 91, 995-1005.
    • (1997) Cell , vol.91 , pp. 995-1005
    • Gradia, S.1    Acharya, S.2    Fishel, R.3
  • 13
    • 0024494766 scopus 로고
    • Isolation and characterization of the Escherichia coli mutL gene product
    • Grilley, M., Welsh, K.M., Su, S.S. and Modrich, P. (1989) Isolation and characterization of the Escherichia coli mutL gene product. J. Biol. Chem., 264, 1000-1004.
    • (1989) J. Biol. Chem. , vol.264 , pp. 1000-1004
    • Grilley, M.1    Welsh, K.M.2    Su, S.S.3    Modrich, P.4
  • 14
    • 0025734115 scopus 로고
    • Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities
    • Haber, L.T. and Walker, G.C. (1991) Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. EMBO J., 10, 2707-2715.
    • (1991) EMBO J. , vol.10 , pp. 2707-2715
    • Haber, L.T.1    Walker, G.C.2
  • 15
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Harlow, E. and Lane, D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 16
    • 0023684064 scopus 로고
    • A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
    • Higuchi, R., Krummel, B. and Saiki, R.K. (1988) A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Adds Res., 16, 7351-7367.
    • (1988) Nucleic Adds Res. , vol.16 , pp. 7351-7367
    • Higuchi, R.1    Krummel, B.2    Saiki, R.K.3
  • 17
    • 0027095976 scopus 로고
    • The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities
    • Hughes, M.J. and Jiricny, J. (1992) The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities. J. Biol. Chem., 267, 23876-23882.
    • (1992) J. Biol. Chem. , vol.267 , pp. 23876-23882
    • Hughes, M.J.1    Jiricny, J.2
  • 18
  • 19
    • 0030472346 scopus 로고    scopus 로고
    • Mismatch repair and cancer
    • Jiricny, J. (1996) Mismatch repair and cancer. Cancer Surv., 28, 47-68.
    • (1996) Cancer Surv. , vol.28 , pp. 47-68
    • Jiricny, J.1
  • 20
    • 0024209144 scopus 로고
    • A human 200-kDa protein binds selectively to DNA fragments containing G·T mismatches
    • Jiricny, J., Hughes, M., Corman, N. and Rudkin, B.B. (1988) A human 200-kDa protein binds selectively to DNA fragments containing G·T mismatches. Proc. Natl Acad. Sci. USA, 85, 8860-8864.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 8860-8864
    • Jiricny, J.1    Hughes, M.2    Corman, N.3    Rudkin, B.B.4
  • 21
    • 0024396565 scopus 로고
    • DNA mismatch correction in a defined system
    • Lahue, R.S., Au, K.G. and Modrich, P. (1989) DNA mismatch correction in a defined system. Science, 245, 160-164.
    • (1989) Science , vol.245 , pp. 160-164
    • Lahue, R.S.1    Au, K.G.2    Modrich, P.3
  • 22
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach, F.S. et al. (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75, 1215-1225.
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1
  • 23
    • 2942569549 scopus 로고    scopus 로고
    • Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
    • Liu, B. et al. (1996) Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nature Med., 2, 169-174.
    • (1996) Nature Med. , vol.2 , pp. 169-174
    • Liu, B.1
  • 24
    • 0029089259 scopus 로고
    • Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
    • Marra, G. and Boland, C.R. (1995) Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J. Natl Cancer Inst., 87, 1114-1125.
    • (1995) J. Natl Cancer Inst. , vol.87 , pp. 1114-1125
    • Marra, G.1    Boland, C.R.2
  • 26
    • 0024596295 scopus 로고
    • Methyl-directed DNA mismatch correction
    • Modrich, P. (1991) Methyl-directed DNA mismatch correction. J. Biol. Chem., 264, 6597-6600.
    • (1991) J. Biol. Chem. , vol.264 , pp. 6597-6600
    • Modrich, P.1
  • 27
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich, P. and Lahue, R.S. (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem., 65, 101-133.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.S.2
  • 31
    • 0029659046 scopus 로고    scopus 로고
    • HMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
    • Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T. and Jiricny, J. (1996) hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr. Biol., 6, 1181-1184.
    • (1996) Curr. Biol. , vol.6 , pp. 1181-1184
    • Palombo, F.1    Iaccarino, I.2    Nakajima, E.3    Ikejima, M.4    Shimada, T.5    Jiricny, J.6
  • 32
    • 0029069972 scopus 로고
    • Mutations of GTBP in genetically unstable cells
    • Papadopoulos, N. et al. (1995) Mutations of GTBP in genetically unstable cells. Science, 268, 1915-1917.
    • (1995) Science , vol.268 , pp. 1915-1917
    • Papadopoulos, N.1
  • 33
    • 0024095589 scopus 로고
    • Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP
    • Sung, P., Higgins, D., Prakash, L. and Prakash, S. (1988) Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP. EMBO J., 7, 3263-3269.
    • (1988) EMBO J. , vol.7 , pp. 3263-3269
    • Sung, P.1    Higgins, D.2    Prakash, L.3    Prakash, S.4
  • 34
    • 0025777777 scopus 로고
    • Heteroduplex repair in extracts of human HeLa cells
    • Thomas, D.C., Roberts, J.D. and Kunkel, T.A. (1991) Heteroduplex repair in extracts of human HeLa cells. J. Biol. Chem., 266, 3744-3751.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3744-3751
    • Thomas, D.C.1    Roberts, J.D.2    Kunkel, T.A.3
  • 35
    • 0001607723 scopus 로고
    • Distantly related sequences in the alpha- And beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    • Walker, J.E., Saraste, M., Runswick, M.J. and Gay, N.J. (1982) Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J., 1, 945-951.
    • (1982) EMBO J. , vol.1 , pp. 945-951
    • Walker, J.E.1    Saraste, M.2    Runswick, M.J.3    Gay, N.J.4
  • 36
    • 0027980253 scopus 로고
    • Dominant negative mutator mutations in the mutS gene of Escherichia coli
    • Wu, T.H. and Marinus, M.G. (1994) Dominant negative mutator mutations in the mutS gene of Escherichia coli. J. Bacteriol., 176, 5393-5400.
    • (1994) J. Bacteriol. , vol.176 , pp. 5393-5400
    • Wu, T.H.1    Marinus, M.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.