메뉴 건너뛰기




Volumn 5, Issue REVIEW, 1996, Pages 1489-1494

Mismatch repair defects in human carcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM; COLON CARCINOGENESIS; COLORECTAL CANCER; DNA REPAIR; FAMILIAL CANCER; GENETIC COMPLEMENTATION; GENOME; HUMAN; PHENOTYPE; PRIORITY JOURNAL; SHORT SURVEY; TUMOR SUPPRESSOR GENE;

EID: 0029837248     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/5.supplement_1.1489     Document Type: Short Survey
Times cited : (197)

References (81)
  • 1
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
    • Fishel, R., Lescoe, M.K., Rao, M.R.S., Copeland, N.G., Jenkins, N.A., Garber, J., Kane, M., Kolodner, R. (1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038.
    • (1993) Cell , vol.75 , pp. 1027-1038
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.S.3    Copeland, N.G.4    Jenkins, N.A.5    Garber, J.6    Kane, M.7    Kolodner, R.8
  • 6
    • 0029070143 scopus 로고
    • Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
    • Drummond, J.T., Li, G.M., Longley, M.J., Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science 268: 1909-1912.
    • (1995) Science , vol.268 , pp. 1909-1912
    • Drummond, J.T.1    Li, G.M.2    Longley, M.J.3    Modrich, P.4
  • 9
    • 0014421995 scopus 로고
    • Defective repair replication of DNA in xeroderma pigmentosum
    • Cleaver, J.E. (1968) Defective repair replication of DNA in xeroderma pigmentosum. Nature 218: 652-656.
    • (1968) Nature , vol.218 , pp. 652-656
    • Cleaver, J.E.1
  • 11
    • 0028606403 scopus 로고
    • Mechanisms of DNA excision repair
    • Sancar, A. (1994) Mechanisms of DNA excision repair. Science 266: 1954-1956.
    • (1994) Science , vol.266 , pp. 1954-1956
    • Sancar, A.1
  • 12
    • 0028596398 scopus 로고
    • Transcription-coupled repair and human disease
    • Hanawalt, P.C. (1994) Transcription-coupled repair and human disease. Science 266: 1957-1958.
    • (1994) Science , vol.266 , pp. 1957-1958
    • Hanawalt, P.C.1
  • 14
    • 0016753815 scopus 로고
    • Genetic consequences of transfection with heteroduplex bacteriophage λ DNA
    • White, R.L., Fox, M.S. (1975) Genetic consequences of transfection with heteroduplex bacteriophage λ DNA. Mol. Gen. Genet. 141: 163-171.
    • (1975) Mol. Gen. Genet. , vol.141 , pp. 163-171
    • White, R.L.1    Fox, M.S.2
  • 15
    • 0026355962 scopus 로고
    • Mechanisms and biological effects of mismatch repair
    • Modrich, P. (1991) Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet. 25: 229-253.
    • (1991) Annu. Rev. Genet. , vol.25 , pp. 229-253
    • Modrich, P.1
  • 16
    • 0029654337 scopus 로고
    • Mismatch repair, genetic stability, and tumor avoidance
    • Modrich, P. (1995) Mismatch repair, genetic stability, and tumor avoidance. Phil. Trans. R. Soc. London B 347: 89-95.
    • (1995) Phil. Trans. R. Soc. London B , vol.347 , pp. 89-95
    • Modrich, P.1
  • 18
    • 0028301255 scopus 로고
    • Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability
    • Umar, A., Boyer, J., Thomas, D., Nguyen, D., Risinger, J., Boyd, J., Ionov, Y., Perucho, M., Kunkel, T. (1994) Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem. 269: 14367-14370.
    • (1994) J. Biol. Chem. , vol.269 , pp. 14367-14370
    • Umar, A.1    Boyer, J.2    Thomas, D.3    Nguyen, D.4    Risinger, J.5    Boyd, J.6    Ionov, Y.7    Perucho, M.8    Kunkel, T.9
  • 19
    • 0027988576 scopus 로고
    • DNA loop repair by human cell extracts
    • Umar, A., Boyer, J.C., Kunkel, T.A. (1994) DNA loop repair by human cell extracts. Science 266: 814-816.
    • (1994) Science , vol.266 , pp. 814-816
    • Umar, A.1    Boyer, J.C.2    Kunkel, T.A.3
  • 20
    • 0027482444 scopus 로고
    • Base selection, proofreading and mismatch repair during DNA replication in Escherichia coli
    • Schaaper, R. (1993) Base selection, proofreading and mismatch repair during DNA replication in Escherichia coli. J. Biol. Chem. 268: 23762-23765.
    • (1993) J. Biol. Chem. , vol.268 , pp. 23762-23765
    • Schaaper, R.1
  • 23
    • 8244246804 scopus 로고    scopus 로고
    • Mutation hMRP/DUG1, the human homologue of yMSH3 in human endometrial cancers with microsatellite instability
    • Risinger, J.I., Umar, A., Berchuck, A., Kunkel, T.A., Barrett, J.C. (1996) Mutation hMRP/DUG1, the human homologue of yMSH3 in human endometrial cancers with microsatellite instability. Proc. Am. Assoc. Cancer Res. 37: 554.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 554
    • Risinger, J.I.1    Umar, A.2    Berchuck, A.3    Kunkel, T.A.4    Barrett, J.C.5
  • 24
    • 0028941627 scopus 로고
    • Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs
    • Li, G.M., Modrich, P. (1995) Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl Acad. Sci. USA 92: 1950-1954.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1950-1954
    • Li, G.M.1    Modrich, P.2
  • 26
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau, S., Bren, G., Schaid, D. (1993) Microsatellite instability in cancer of the proximal colon. Science 260: 816-819.
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.1    Bren, G.2    Schaid, D.3
  • 27
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov, Y., Peinado, M., Malkhosyan, S., Shibata, D., Perucho, M. (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 28
    • 0024514081 scopus 로고
    • A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene
    • Litt, M., Luty, J.A. (1989) A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. Am. J. Hum. Genet. 44: 397-401.
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 397-401
    • Litt, M.1    Luty, J.A.2
  • 29
    • 0024582686 scopus 로고
    • Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
    • Weber, J.L., May, P.E. (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet. 44: 388-396.
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 388-396
    • Weber, J.L.1    May, P.E.2
  • 30
    • 0021988148 scopus 로고
    • Mechanisms of spontaneous and induced frameshift mutation in bacteriophage T4
    • Streisinger, G., Owen, J.E. (1985) Mechanisms of spontaneous and induced frameshift mutation in bacteriophage T4. Genetics 109: 633-659.
    • (1985) Genetics , vol.109 , pp. 633-659
    • Streisinger, G.1    Owen, J.E.2
  • 31
    • 0025109103 scopus 로고
    • Misalignment-mediated DNA synthesis errors
    • Kunkel, T.A. (1990) Misalignment-mediated DNA synthesis errors. Biochemistry 29: 8003-8011.
    • (1990) Biochemistry , vol.29 , pp. 8003-8011
    • Kunkel, T.A.1
  • 32
    • 0027215019 scopus 로고
    • Frameshift fidelity during replication of double-stranded DNA in HeLa cell extracts
    • Roberts, J.D., Nguyen, D., Kunkel, T.A. (1993) Frameshift fidelity during replication of double-stranded DNA in HeLa cell extracts. Biochemistry 32: 4083-4089.
    • (1993) Biochemistry , vol.32 , pp. 4083-4089
    • Roberts, J.D.1    Nguyen, D.2    Kunkel, T.A.3
  • 33
    • 0028813895 scopus 로고
    • Microsatellite instability in inherited and sporadic neoplasms
    • Eshleman, J.R., Markowitz, S.D. (1995) Microsatellite instability in inherited and sporadic neoplasms. Curr. Opin. Oncol. 7: 83-89.
    • (1995) Curr. Opin. Oncol. , vol.7 , pp. 83-89
    • Eshleman, J.R.1    Markowitz, S.D.2
  • 35
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim, H., Jen, J., Vogelstein, B., Hamilton, S.R. (1994) Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am. J. Pathol. 145: 148-156.
    • (1994) Am. J. Pathol. , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3    Hamilton, S.R.4
  • 40
    • 0028785603 scopus 로고
    • Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer
    • Parsons, R., Myeroff, L.L., Liu, B., Willson, J.K.V., Markowitz, S.D., Kinzler, K.W., Vogelstein, B. (1995) Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res. 55: 5548-5550.
    • (1995) Cancer Res. , vol.55 , pp. 5548-5550
    • Parsons, R.1    Myeroff, L.L.2    Liu, B.3    Willson, J.K.V.4    Markowitz, S.D.5    Kinzler, K.W.6    Vogelstein, B.7
  • 41
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitro-soguanidine tolerance in colon tumor cells with homozygous hMLHI mutation
    • Koi, M., Umar, A., Chauhan, D., Cherian, S., Carethers, J., Kunkel, T., Boland, C. (1994) Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitro-soguanidine tolerance in colon tumor cells with homozygous hMLHI mutation. Cancer Res. 54: 4308-4312.
    • (1994) Cancer Res. , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.3    Cherian, S.4    Carethers, J.5    Kunkel, T.6    Boland, C.7
  • 42
    • 2642691756 scopus 로고    scopus 로고
    • Correction of mismatch repair defective lines via chromosome transfer
    • Umar, A., Koi, M., Risinger, J.I., Barrett, J.C., Kunkel, T.A. (1996) Correction of mismatch repair defective lines via chromosome transfer. FASEB J. 10: A961.
    • (1996) FASEB J. , vol.10
    • Umar, A.1    Koi, M.2    Risinger, J.I.3    Barrett, J.C.4    Kunkel, T.A.5
  • 43
    • 9544231589 scopus 로고    scopus 로고
    • Mismatch repair and cancer susceptibility
    • Kolodner, R. (1996) Mismatch repair and cancer susceptibility. FASEB J. 10: A961.
    • (1996) FASEB J. , vol.10
    • Kolodner, R.1
  • 44
    • 0028167882 scopus 로고
    • Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2, and MSH2 genes
    • Jeyaprakash, A., Welch, J.W., Fogel, S. (1994) Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2, and MSH2 genes. Mutat. Res. 325: 21-29.
    • (1994) Mutat. Res. , vol.325 , pp. 21-29
    • Jeyaprakash, A.1    Welch, J.W.2    Fogel, S.3
  • 46
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
    • Lynch, H.T., Smyrk, T.C., Watson, P., Lanspa, S.J., Lynch, J.F., Lynch, P.M., Cavalieri, R.J., Boland, C.R. (1993) Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104: 1535-1549.
    • (1993) Gastroenterology , vol.104 , pp. 1535-1549
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3    Lanspa, S.J.4    Lynch, J.F.5    Lynch, P.M.6    Cavalieri, R.J.7    Boland, C.R.8
  • 47
    • 74549208765 scopus 로고
    • Heredity with reference to carcinoma
    • Warthin, A.S. (1913) Heredity with reference to carcinoma. Arch. Intern. Med. 12: 546-555.
    • (1913) Arch. Intern. Med. , vol.12 , pp. 546-555
    • Warthin, A.S.1
  • 48
    • 0015043748 scopus 로고
    • Mutation and Cancer: Statistical study of retinoblastoma
    • Knudson, A.G. (1971) Mutation and Cancer: Statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA 68: 820-823.
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 51
    • 0029078288 scopus 로고
    • Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer
    • Jacoby, R.F., Marshall, D.J., Kailas, S., Schlack, S., Harms, B., Love, R. (1995) Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 109: 73-82.
    • (1995) Gastroenterology , vol.109 , pp. 73-82
    • Jacoby, R.F.1    Marshall, D.J.2    Kailas, S.3    Schlack, S.4    Harms, B.5    Love, R.6
  • 53
    • 0028362325 scopus 로고
    • Genomic instability in repeated sequences is an early somatic event in colonectal tumorigenesis that persists after transformation
    • Shibata, D., Peinado, M.A., Ionov, Y., Malkhosyan, S., Perucho, M. (1994) Genomic instability in repeated sequences is an early somatic event in colonectal tumorigenesis that persists after transformation. Nature Genet. 6: 273-281.
    • (1994) Nature Genet. , vol.6 , pp. 273-281
    • Shibata, D.1    Peinado, M.A.2    Ionov, Y.3    Malkhosyan, S.4    Perucho, M.5
  • 54
    • 0029917009 scopus 로고    scopus 로고
    • Evidence for genomic instability in human colonic aberrant crypt foci
    • Augenlicht, L.H., Richards, C., Corner, G., Pretlow, T.P. (1996) Evidence for genomic instability in human colonic aberrant crypt foci. Oncogene 12: 1767-1772.
    • (1996) Oncogene , vol.12 , pp. 1767-1772
    • Augenlicht, L.H.1    Richards, C.2    Corner, G.3    Pretlow, T.P.4
  • 58
    • 0028883556 scopus 로고
    • Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas
    • Katabuchi, H., van Rees, B., Lambers, A.R., Ronnett, B.M., Blazes, M.S., Leach, F.S., Cho, K.R., Hedrick, L. (1995) Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res. 55: 5556-5560.
    • (1995) Cancer Res. , vol.55 , pp. 5556-5560
    • Katabuchi, H.1    Van Rees, B.2    Lambers, A.R.3    Ronnett, B.M.4    Blazes, M.S.5    Leach, F.S.6    Cho, K.R.7    Hedrick, L.8
  • 61
    • 0028877162 scopus 로고
    • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity
    • Risinger, J.I., Umar, A., Boyer, J.C., Evans, A.C., Berchuck, A., Kunkel, T.A., Barrett, J.C. (1995) Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. Cancer Res. 55: 5664-5669.
    • (1995) Cancer Res. , vol.55 , pp. 5664-5669
    • Risinger, J.I.1    Umar, A.2    Boyer, J.C.3    Evans, A.C.4    Berchuck, A.5    Kunkel, T.A.6    Barrett, J.C.7
  • 63
    • 0028845919 scopus 로고
    • DNA mismatch repair and cancer
    • Chung, D.C., Rustgi, A.K. (1995) DNA mismatch repair and cancer. Gastroenterology 109: 1685-1699.
    • (1995) Gastroenterology , vol.109 , pp. 1685-1699
    • Chung, D.C.1    Rustgi, A.K.2
  • 65
    • 0030061148 scopus 로고    scopus 로고
    • Better survival rates in patients with MLH1-associated hereditary colorectal cancer
    • Sankila, R., Aaltonen, L.A., Jarvinen, H.J., Mecklin, J.P. (1996) Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology 110: 682-687.
    • (1996) Gastroenterology , vol.110 , pp. 682-687
    • Sankila, R.1    Aaltonen, L.A.2    Jarvinen, H.J.3    Mecklin, J.P.4
  • 66
    • 0022971473 scopus 로고
    • Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitroso-N-nitrosoguanidine
    • Goldmacher, V.S., Cuzick, R.A., Thilly, W.G. (1986) Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitroso-N-nitrosoguanidine. J. Biol. Chem. 261: 12462-12471.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12462-12471
    • Goldmacher, V.S.1    Cuzick, R.A.2    Thilly, W.G.3
  • 67
    • 0027292234 scopus 로고
    • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
    • Kat, A., Thilly, W., Fang, W., Longley, M., Li, G., Modrich, P. (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl Acad. Sci. USA 90: 6424-6428.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6424-6428
    • Kat, A.1    Thilly, W.2    Fang, W.3    Longley, M.4    Li, G.5    Modrich, P.6
  • 68
    • 0027502938 scopus 로고
    • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
    • Branch, P., Aquilina, G., Bignami, M., Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 362: 652-654.
    • (1993) Nature , vol.362 , pp. 652-654
    • Branch, P.1    Aquilina, G.2    Bignami, M.3    Karran, P.4
  • 70
    • 0000666175 scopus 로고    scopus 로고
    • Increased sensitivity to camptothecin in human colon carcinoma cell lines with mismatch repair deficiency
    • Gariboldi, M., Gupta, M., Boland, C.R., Pommier, Y. (1996) Increased sensitivity to camptothecin in human colon carcinoma cell lines with mismatch repair deficiency. Proc. Am. Assoc. Cancer Res. 37: 431.
    • (1996) Proc. Am. Assoc. Cancer Res. , vol.37 , pp. 431
    • Gariboldi, M.1    Gupta, M.2    Boland, C.R.3    Pommier, Y.4
  • 71
    • 0029101616 scopus 로고
    • Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
    • de Wind, N., Dekker, M., Berns, A., Radman, M., te Riele, H. (1995) Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82: 321-330.
    • (1995) Cell , vol.82 , pp. 321-330
    • De Wind, N.1    Dekker, M.2    Berns, A.3    Radman, M.4    Te Riele, H.5
  • 73
    • 0029654349 scopus 로고
    • Editing DNA replication and recombination by mismatch repair: From bacterial genetics to mechanisms of predisposition to cancer in humans
    • Radman, M., Matic, L., Halliday, J.A., Taddei, F. (1995) Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans. Phil. Trans. R. Soc. London B 347: 97-103.
    • (1995) Phil. Trans. R. Soc. London B , vol.347 , pp. 97-103
    • Radman, M.1    Matic, L.2    Halliday, J.A.3    Taddei, F.4
  • 74
    • 0023653330 scopus 로고
    • Mismatch repair and recombination in E.coli
    • Jones, M., Wagner, R., Radman, M. (1987) Mismatch repair and recombination in E.coli. Cell 50: 621-626.
    • (1987) Cell , vol.50 , pp. 621-626
    • Jones, M.1    Wagner, R.2    Radman, M.3
  • 75
    • 0028204781 scopus 로고
    • Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs
    • Worth, L., Clark, S., Radman, M., Modrich, P. (1994) Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs. Proc. Natl Acad. Sci. USA 91: 3238-3241.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 3238-3241
    • Worth, L.1    Clark, S.2    Radman, M.3    Modrich, P.4
  • 77
    • 0029887819 scopus 로고    scopus 로고
    • Transcription-coupled repair deficiency and mutations in human mismatch repair genes
    • Mellon, I., Rajpal, D.K., Koi, M., Boland, C.R., Champe, G.N. (1996) Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 272: 557-560.
    • (1996) Science , vol.272 , pp. 557-560
    • Mellon, I.1    Rajpal, D.K.2    Koi, M.3    Boland, C.R.4    Champe, G.N.5
  • 78
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb, L.A. (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51: 3075-3079.
    • (1991) Cancer Res. , vol.51 , pp. 3075-3079
    • Loeb, L.A.1
  • 79
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon, E.R., Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 80
    • 0028019398 scopus 로고
    • Microsatellite instability: Marker of a mutator phenotype in cancer
    • Loeb, L.A. (1994) Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res. 54: 5059-5063.
    • (1994) Cancer Res. , vol.54 , pp. 5059-5063
    • Loeb, L.A.1
  • 81
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell, P.C. (1976) The clonal evolution of tumor cell populations. Science 194: 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.