Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic Lymphoma and are partially protected by transgenfe expression of human MGMT

Oncogene

Volumn 18, Issue 30, 1999, Pages 4394-4400

  Qin, Xiusheng ^a   Liu, Lili ^a   Gerson, Stanton ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

hMGMT; Lymphoma; MNU; PMS2 deficiency

Indexed keywords

ADENOSINE; CARCINOGEN; DNA METHYLTRANSFERASE; ENVIRONMENTAL CHEMICAL; GUANINE; NITROSOUREA; THYMINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASE MISPAIRING; BASE PAIRING; CANCER INCIDENCE; CARCINOGENESIS; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CODON; CONTROLLED STUDY; DNA REPAIR; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; KNOCKOUT MOUSE; LATENT PERIOD; METHYLATION; MOUSE; NONHUMAN; ONCOGENE RAS; POINT MUTATION; PRIORITY JOURNAL; PROGENY; STATISTICAL ANALYSIS; THYMUS LYMPHOMA; TRANSGENE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CARCINOGENS; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERSENSITIVITY; LYMPHOMA; METHYLNITROSOUREA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POLYMERASE CHAIN REACTION; PROTEINS; THYMUS NEOPLASMS; TIME FACTORS;

EID: 0033615013     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202798     Document Type: Article

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