Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

Carcinogenesis

Volumn 18, Issue 6, 1997, Pages 1127-1133

  Ohzeki, Shuji ^a,b   Tachibana, Akira ^c   Tatsumi, Kouichi ^d   Kato, Takesi ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

AGAR GEL ELECTROPHORESIS; ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA REPAIR; EXON; FRAMESHIFT MUTATION; GENE AMPLIFICATION; GENE DELETION; GENE INSERTION; GENE LOCUS; HUMAN; HUMAN CELL; KARYOTYPE; MICROSATELLITE INSTABILITY; MUTATION RATE; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SPONTANEOUS MUTATION; T LYMPHOCYTE; TANDEM REPEAT;

COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA, NEOPLASM; DNA, SATELLITE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; POINT MUTATION; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031407606     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.6.1127     Document Type: Article

References (40)

1. Cairns, J. (1975) Mutation, selection and the natural history of cancer Nature, 255, 197-200.
2. Nowell, P.C. (1976) The clonal evolution of tumor cell populations. Science, 194, 23-28.
3. Loeb, L.A. (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res., 51, 3075-3079.
4. Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
5. Vogelstein, B. and Kinzler, K.W. (1994) Colorectal cancer and the intersection between basic and clinical research. Cold Spring Harbor Symp. Quant. Biol., 59, 517-521.
6. Modrich, P. (1994) Mismatch repair, genetic stability, and cancer. Science, 266, 1959-1960.
7. Modrich, P. and Lahue, R. (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Ann. Rev. Biochem., 65, 101-133.
8. Fischel, R. and Kolodner, R.D. (1995) Identification of mismatch repair genes and their role in the development of cancer. Curr. Opin. Genet., 5, 382-395.
9. + tumor cells Cell, 75, 1227-1236.
10. Umar, A., Boyer, J.C., Thomas, D.C., Nguyen, D.C., Risinger, J.I., Boyd, J., Ionov, Y., Perucho, M. and Kunkel, T.A. (1994) Defective heteroduplex repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem., 269, 14 367-14 370.
11. Risinger, J.I., Umer, A., Barrett, J.C. and Kunkel, T.A. (1995) A hPMS2 mutant cell line is defective in strand-specific mismatch repair. J. Biol. Chem., 270, 18 183-18 186.
12. Risinger, J.I., Umar, A., Boyd, J., Berchuck, A., Kunkel, T.A. and Barrett, J.C. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nature Genet., 14, 102-105.
13. Papadopolous, N., Nicolaides, N.C., Liu, B., et al. (1995) Mutations of GTBP in genetically unstable cells. Science, 268, 1915-1917.
14. Bhattacharyya, N.P., Skandalis, A., Ganesh, A., Groden, J. and Meuth, M. (1994) Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl Acad. Sci. USA, 91, 6319-6323.
15. Eshleman, J.E., Lang, E.Z., Bowerfind, G.K., Parsons, R., Vogelstein, B., Willson, J.K.V., Viegl, M.L., Sedwick, W.D. and Markowitz, S.D. (1995) Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene, 10, 33-37.
16. Branch, P., Hampson, R. and Karran, P. (1995) DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55, 2304-2309.
17. Strand, M., Prolla, T.A., Liskay, R.M. and Petes, T.D. (1993) Destabilization of tracts of single repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature, 365, 274-276.
18. Marsischky, G.T., Filosi, N., Kane, M.F. and Kolodner, R. (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Gene Dev., 10, 407-420.
19. Boyer, J., Umar, C., Risinger, A.J.I., Lipford, J.R., Kane, M., Yin, S., Barrett, J.C., Kolodner, R.D. and Kunkle, T.A. (1995) Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res., 55, 6063-6070.
20. Drummond, J.T., Li, G.-M., Longley, M.J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science, 268, 1909-1912.
21. Li, G.-M. and Modrich, P. (1995) Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl Acad. Sci. USA, 92, 1950-1954.
22. Aquilina, G., Hess, P., Branch, P., MacGeoch, C., Casciano, I., Karran, P. and Bignami, M. (1994) Mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and mutator phenotype. Proc. Natl Acad. Sci. USA, 91, 8905-8909.
23. Bhattacharyya, N.P., Ganesh, A., Phear, G., Richards, B., Skandalis, A. and Meuth, M. (1995) Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet., 4, 2057-2064.
24. Malkhosyan, S., McCarty, A., Sawai, H. and Perucho, M. (1995) Differences in the spectrum of spontaneous mutations in the hprt gene between cells of the microsatellite mutator phenotype. Mutat. Res., 316, 249-259.
25. Hess, P., Aquilina, G., Dogliotti, E. and Bignami, M. (1994) Spontaneous mutations at aprt locus in a mammalian cell line defective in mismatch recognition. Somat. Cell Mol. Genet., 20, 409-421.
26. Shimahara, H., Kato, T., Hirai, Y. and Akiyama, M. (1995) Spectra of in vivo hprt mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA. Carcinogenesis, 16, 583-591.
27. Steingrimsdottir, H., Rowley, G., Dorado, G., Cole, J. and Lehmann, A.R. (1992) Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene. Nucleic Acids Res., 20, 1201-1208.
28. Rigaud, O., Laquerbe, A. and Moustacchi, E. (1995) DNA sequence analysis of HPRT mutations induced in human lymphoblastoid cells adapted to ionizing radiation. Radiat. Res., 144, 181-189.
29. Fang, W.-H. and Modrich, P. (1993) Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J. Biol. Chem., 268, 11 838-11 844.
30. Umar, A., Boyer, J.C. and Kunkel, T.A. (1994) DNA loop repair by human cell extracts. Science, 266, 814-816.
31. Shibata, D., Peinado, M.A., Inovo, Y., Malkhosyan, S. and Perucho, M. (1994) Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nature Genet., 6, 273-281.
32. Schaaper, R.M. and Dunn, R.L. (1987) Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors. Proc. Natl Acad. Sci. USA, 84, 6220-6224.
33. Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tugita, A., Terzaghi, E. and Inouye, M. (1966) Frameshift mutations and the genetic code. Cold Spring Harbor Symp. Quant. Biol., 31, 77-84.
34. Kunkel, T.A. and Soni, A. (1988) Mutagenesis by transient misalignment. J. Biol. Chem., 263, 14784-14789.
35. Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Justin, J. and Jiricry, M. (1995) GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science, 268, 1912-1914.
36. Prolla, T.A., Alani, P.E., Kolodner, R.D. and Liskay, R.M. (1994) Interaction between the MSH2, MLH1 and PMS1 proteins during the initiation of DNA mismatch repair. Science, 265, 1091-1093.
37. Coulondre, C., Miller, J.H., Farabaugh, P.J. and Gilbert, W. (1978) Molecular basis of base substitution hot spots in Escherichia coli. Nature, 274, 775-780.
38. Cariello, N.F. and Skopek, T.R. (1993) Analysis of mutations occurring at the human hprt locus. J. Mol. Biol., 231, 41-57.
39. Cost, LT., Liu, B., El-Deiry, W.S., et al. (1996) Polymerase δ variants in RER colorectal tumours. Nature Genet., 9, 10-11.
40. Simon, M., Giot, L. and Faye, G. (1991) The 3′ to 5′ exonuclease activity located in the DNA polymerase δ subunit of Saccharomyces cerevisiae is required for accurate replication. EMBO J., 10, 2165-2170.