Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine

Journal of Clinical Investigation

Volumn 98, Issue 1, 1996, Pages 199-206

  Carethers, John M ^a   Hawn, Mary T ^b   Chauhan, Dharam P ^a   Luce, Michael C ^c   Marra, Giancarlo ^a   Koi, Minoru ^d   Boland, C Richard ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Roche Biomedical Laboratories   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

alkylation damage; cell cycle; cell death; DNA repair; hMLH1

Indexed keywords

DNA; METHYLNITRONITROSOGUANIDINE;

ALKYLATION; ARTICLE; BASE MISPAIRING; CANCER INHIBITION; CELL CLONING; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL;

EID: 0030015770     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118767     Document Type: Article

References (43)

1. 6-methylguanine-DNA-methyltransferase-proficient CHO cells. Carcinogenesis. 9:1217-1222.
2. Karran, P., and M. Bignami. 1992. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res. 20:2933-2940.
3. 6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents. Carcinogenesis. 14:1671-1675.
4. 6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese Hamster Ovary cell line and its response to certain alkylating agents. Cancer Res. 52:32-35.
5. 6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest. 2:223-231.
6. 6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine. Mutat. Res. 166:135-141.
7. Branch, P., R. Hampson, and P. Karran. 1995. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res. 55:2304-2309.
8. 6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosurea-resistant Chinese hamster ovary cells. Cancer Res. 50:4248-4253.
9. Branch, P., G. Aquilina, M. Bignami, and P. Karran. 1993. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature (Lond.). 362:652-654.
10. Kat, A., W.G. Thilly, W.-H. Fang, M.J. Longley, G.-M. Li, and P. Modrich. 1993. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl. Acad. Sci. USA. 90:6424-6428.
11. Leach, F.S., N.C. Nicolaides, N. Papadopoulos, B. Liu, J. Jen, R. Parsons, P. Peltomaki, P. Sistonen, L.A. Aaltonen, M. Nystrom-Lahti, et al. 1993. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 75:1215-1225.
12. Fishel, R., M.K. Lescoe, M.R.S. Rao, N.G. Copeland, N.A. Jenkins, J. Garber, M. Kane, and R. Kolodner. 1993. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 75: 1027-1038.
13. Papadopoulos, N., N.C. Nicolaides, Y.-F. Wei, S.M. Ruben, K.C. Carter, C.A. Rosen, W.A. Haseltine, R.D. Fleischmann, C.M. Fraser, M.D. Adams, J.C. Venter, S.R. Hamilton, G.M. Petersen, P. Watson, H.T. Lynch, P. Peltomaki, J.-P. Mecklin, A. de la Chapelle, K.W. Kinzler, and B. Volgelstein. 1994. Mutation of a mutL homolog in hereditary colon cancer. Science (Wash. DC). 263:1625-1629.
14. Bronner, C.E., S.M. Baker, P.T. Morrison, G. Warren, L.G. Smith, M.K. Lescoe, M. Kane, C. Earabino, J. Lipford, A. Lindblom, P. Tannergard, R.J. Bollag, A.R. Godwin, D. Ward, M. Nordenskjold, R. Fishel, R. Kolodner, and R.M. Liskay. 1994. Mutation in the DNA mismatch repair homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (Lond.). 368: 258-261.
15. Nicolaides, N.C., N. Papadopoulos, B. Liu, Y.-F. Wei, K.C. Carter, S.M. Ruben, C.A. Rosen, W.A. Haseltine, R.D. Fleischmann, C.M. Fraser, M.D. Adams, J.C. Venter, M.G. Dunlop, S.R. Hamilton, G.M. Peteresen, A. de la Chapelle, B. Vogelstein, and K.W. Kinzler. 1994. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond.). 371:75-80.
16. Palombo, F., P. Gallinari, I. Iaccarino, T. Lettieri, M. Hughes, A. D'Arrigo, O. Truong, J.J. Hsuan, and J. Jiricny. 1995. GTBP, a 60-kilodalton protein essential for mismatch-binding activity in human cells. Science (Wash. DC). 268: 1912-1914.
17. Drummond, J.T., G.-M. Li, M.J. Longley, and P. Modrich. 1995. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (Wash. DC). 268:1909-1912.
18. Papadopoulos, N., N.C. Nicolaides, B. Liu, R. Parsons, C. Lengauer, F. Palombo, A. D'Arrigo, S. Markowitz, J.K.V. Willson, K.W. Kinzler, J. Jiricny, and B. Vogelstein. 1995. Mutations of GTBP in genetically unstable cells. Science (Wash. DC). 268:1915-1917.
19. 6-methylguanine residues in E. coli DNA. Nature (Lond.). 296:868-869.
20. Fishel, R., A. Ewel, and M.K. Lescoe. 1994. Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54:5539-5542.
21. + derivatives if an SV40-immortalized human fibroblast cell line. Carcinogenesis. 10: 893-898.
22. Hayward, I.P., and P.G. Parsons. 1984. Comparison of virus reactivation, DNA base damage, and cell cycle effects in autologous human melanoma cells resistant to methylating agents. Cancer Res. 44:55-58.
23. Goldmacher, V.S., R.A. Cuzick Jr., and W.G. Thilly. 1986. Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosurea and N-methyl-N′-nitro-N-nitrosoguanidine. J. Biol. Chem. 261:12462-12471.
24. Plant, J.E., and J.J. Roberts. 1971. A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells. Chem. Biol. Interact. 3:337-342.
25. Black, K.A., R.D. McFarland, J.W. Grisham, and G.J. Smith. 1989. Cell cycle perturbation and cell death after exposure of a human lymphoblastoid cell strain to N-methyl-N′-nitro-N-nitrosoguanidine. Am. J. Pathol. 134:53-61.
26. Holmes, J. Jr., S. Clark, P. Modrich. 1990. Strand specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl. Acad. Sci. USA. 87:5837-5841.
27. Thomas, D.C., J.D. Roberts, T.A. Kunkel. 1990. Heteroduplex repair in extracts of human HeLa cells. J. Biol. Chem. 266:3744-3751.
28. + tumor cells. Cell. 75:1227-1236.
29. Koi, M., A. Umar, D.P. Chauhan, S.J. Cherian, J.M. Carethers, T.A. Kunkel, and C.R. Boland. 1994. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:4308-4312.
30. Umar, A., J.C. Boyer, D.C. Thomas, D.C. Nguyen, J.I. Risinger, J. Boyd, Y. Ionov, M. Perucho, and T.A. Kunkel. 1994. Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J. Biol. Chem. 269:14367-14370.
31. Liu, B., N.C. Nicolaides, S. Markowitz, J.K.V. Willson, R.E. Parsons, J. Jen, N. Papadopolous, P. Peltomaki, A. de la Chapelle, S.R. Hamilton, K.W. Kinzler, and B. Vogelstein. 1995. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genet. 9:48-55.
32. Orth, K., J. Hung, A. Gazdar, A. Bowcock, J.M. Mathis, and J. Sambrook. 1994. Genetic instability in human ovarian cancer cell lines. Proc. Natl. Acad. Sci. USA. 91:9495-9499.
33. Hawn, M.T., A. Umar, J.M. Carethers, G. Marra, T.A. Kunkel, C.R. Boland, and M. Koi. 1995. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res. 55:3721-3725.
34. Luce, M.C., G. Marra, D.P. Chauhan, L. Laghi, J.M. Carethers, S.P. Cherian, M. Hawn, C.G. Binnie, L.N.W. Kam-Morgan, M.C. Cayouette, M. Koi, and C.R. Boland. 1995. In vitro transcription/translation assay for the screening of hMLH1 and HMSH2 mutations in familial colon cancer. Gastroenterology. 109:1368-1374.
35. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
36. Ormerod, M.G., and M. Kubbies. 1992. Cell cycle analysis of asynchronous cell populations by flow cytometry using bromodeoxyuridine label and Hoechst-propidium iodide stain. Cytometry. 13:678-805.
37. Umar, A., J.C. Boyer, and T.A. Kunkel. 1994. DNA loop repair by human cell extracts. Science (Wash. DC). 266:814-816.
38. Li, G.-M., P. Modrich. 1995. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl. Acad. Sci. USA. 92:1950-1954.
39. Prolla, T.A., Q. Pang, E. Alani, R.D. Kolodner, R.M. Liskay. MLH1, PMS2 and MSH2 interactions during the initiation of DNA mismatch repair in yeast. 1994. Science (Wash. DC). 265:1091-1093.
40. Fishel, R., A. Ewel, S. Lee, M.K. Lescoe, J. Griffith. 1994. Binding of mismatched microsatellite DNA sequences by human MSH2 protein. Science (Wash. DC). 266:1403-1405.
41. King, R.W., P.K. Jackson, and M.W. Kirschner. 1994. Mitosis in transition. Cell. 79:563-571.
42. cdc2/cyclin B complex formation. Proc. Natl. Acad. Sci. USA. 88:6843-6847.
43. O'Connor, P.M., D.K. Ferris, I. Hoffmann, J. Jackman, G. Draetta, and K.W. Kohn. 1994. Role of cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc. Natl. Acad. Sci. USA. 91:9480-9484.