Cytotoxic mechanism of 6-thioguanine: hMutSα, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine

Biochemistry

Volumn 36, Issue 9, 1997, Pages 2501-2506

  Waters, Timothy R ^a   Swann, Peter F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 METHYLTHIOGUANINE; DNA; TIOGUANINE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; DIMERIZATION; DNA BINDING; DNA METHYLATION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

BASE COMPOSITION; BASE SEQUENCE; CELL EXTRACTS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGUANINE; TUMOR CELLS, CULTURED;

EID: 0031037835     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9621573     Document Type: Article

References (31)

1. Aquilina, G., Zijno, A., Moscufo, N., Dogliotti, E., & Bignami, M. (1989) Carcinogenesis 10, 1219-1223.
2. Aquilina, G., Hess, P., Fiumicino, S., Ceccotti, S., & Bignami, M. (1995) Cancer Res. 55, 2569-2575.
3. Bodell, W. J. (1991) Mutagenesis 6, 175-177.
4. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
5. Branch, P., Aquilina, G., Bignami, M., & Karran, P. (1993) Nature 362, 652-654.
6. Branch, P., Hampson, R., & Karran, P. (1995) Cancer Res. 55, 2304-2309.
7. Cross, S. H., & Bird, A. P. (1995) Curr. Opin. Genet. Dev. 5, 309-314.
8. de Wind, N., Dekker, M., Berns, A., Radman, M., & te Riele, H. (1995) Cell 82, 321-330.
9. Drummond, J. T., Li, G. M., Longley, M. J., & Modrich, P. (1995) Science 268, 1909-1912.
10. Duckett, D. R., Drummond, J. T., Murchie, A. I. H., Reardon, J. T., Sancar, A., Lilley, D. M., & Modrich, P. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 6443-6447.
11. Elion, G. B. (1989) Science 244, 41-47.
12. Fishel, R., Lescoe, M. K., Rao, M. R., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., & Kolodner, R. (1993) Cell 75, 1027-1038.
13. Green, M. H., Lowe, J. E., Petit-Frere, C., Karran, P., Hall, J., & Kataoka, H. (1989) Carcinogenesis 10, 893-898.
14. Griffin, S., & Karran, P. (1993) Biochemistry 32, 13032-13039.
15. Griffin, S., Branch, P., Xu, Y.-Z., & Karran, P. (1994) Biochemistry 33, 4787-4793.
16. Hawn, M. T., Umar, A., Carethers, J. M., Marra, G., Kunkel, T. A., Boland, C. R., & Koi, M. (1995) Cancer Res. 55, 3721-3725.
17. Jiricny, J., Hughes, M., Corman, N., & Rudkin, B. B. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 8860-8864.
18. Karran, P., & Bignami, M. (1994) BioEssays 16, 833-839.
19. Kolodner, R. D. (1995) Trends Biochem. Sci. 20, 397-401.
20. Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., Peltomaki, P., Sistonen, P., Aaltonen, L. A., Nystrom-Lahti, M., Guan, X.-Y., Zhang, J., Meltzer, P. S., Yu, J.-W., Kao, F.-T., Chen, D. J., Cerosaletti, K. M., Fournier, R. E. K., Todd, S., Lewis, T., Leach, R. J., Naylor, S. L., Weissenbach, J., Mecklin, J. P., Jarvinen, H., Petersen, G. M., Hamilton, S. R., Green, J., Jass, J., Watson, P., Lynch, H. T., Trent, J. M., de la Chapelle, A., Kinzler, K. W., & Vogelstein, B. (1993) Cell 75, 1215-1225.
21. LePage, G. A. (1963) Cancer Res. 23, 1202-1206.
22. Modrich, P. (1991) Annu. Rev. Genet. 25, 229-253.
23. Modrich, P. (1994) Science 266, 1959-1960.
24. Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J. J., & Jiricny, J. (1995) Science 268, 1912-1914.
25. Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K., Kinzler, K. W., Jiricny, J., & Vogelstein, B. (1995) Science 268, 1915-1917.
26. Plant, J. E., & Roberts, J. J. (1971) Chem. Biol. Interact. 3, 337-342.
27. Rasouli-Nia, A., Sibghat-Ullah, Mirzayans, R., Paterson, M. C., & Day. R. S., III (1994) Mutation Res. 314, 99-113.
28. Swann, P. F., Waters, T. R., Moulton, D. C., Xu, Y.-Z., Zheng, Q., Edwards, M., & Mace, R. (1996) Science 273, 1109-1111.
29. Umar, A., Boyer, J. C., Thomas, D. C., Nguyen, D. C., Risinger, J. I., Boyd, J., Ionov, Y., Perucho, M., & Kunkel, T. A. (1994) J. Biol. Chem. 269, 14367-14370.
30. Xu, Y.-Z., & Swann, P. F. (1992) Anal. Biochem. 204, 185-189.
31. Xu, Y.-Z., Zheng, Q., & Swann, P. F. (1995) Nucleosides Nucleotides 14, 929-933.