Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15

Carcinogenesis

Volumn 20, Issue 3, 1999, Pages 373-382

  Lettieri, Teresa ^a   Marra, Giancarlo ^a   Aquilina, Gabriele ^b   Bignami, Margherita ^b   Crompton, Nigel E A ^c   Palombo, Fabio ^d   Jiricny, Josef ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; METHYLNITRONITROSOGUANIDINE;

ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; COLON CANCER; DNA REPAIR; DNA TRANSFECTION; HUMAN; HUMAN CELL; MISSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033065150     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.3.373     Document Type: Article

References (44)

1. Marra, G. and Boland, C.R. (1996) DNA repair and colorectal cancer. Gastroenterol. Clin. North Am., 25, 755-772.
2. Jiricny, J. (1996) Mismatch repair and cancer. Cancer Surv., 28, 47-68.
3. Kolodner, R.D. (1995) Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci., 20, 397-401.
4. Modrich, P. and Lahue, R. (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem., 65, 101-133.
5. Modrich, P. (1991) Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet., 25, 229-253.
6. Ciotta, C., Ceccotti, S., Aquilina, G., Humbert, O., Palombo, F., Jiricny, J. and Bignami, M. (1998) Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair. J. Mol. Biol., 276, 705-719.
7. Perucho, M. (1996) Cancer of the microsatellite mutator phenotype. Biol. Chem., 377, 675-684.
8. Fink, D., Aebi, S. and Howell, S.B. (1998) The role of DNA mismatch repair in drug resistance. Clin. Cancer Res., 4, 1-6.
9. Drummond, J.T., Li, G.M., Longley, M.J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science, 268, 1909-1912.
10. Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J.J. and Jiricny, J. (1995) GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science, 268, 1912-1914.
11. Acharya, S., Wilson, T., Gradia, S., Kane, M.F., Guerrette, S., Marsischky, G.T. and Fishel, R. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl Acad. Sci. USA, 93, 13629-13634.
12. Li, G.M. and Modrich, P. (1995) Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs. Proc. Natl Acad. Sci. USA, 92, 1950-1954.
13. Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T. and Jiricny, J. (1996) hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr. Biol., 6, 1181-1184.
14. Risinger, J.I., Umar, A., Boyd, J., Berchuck, A., Kunkel, T.A. and Barrett, J.C. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nature Genet., 14, 102-105.
15. Marra, G., Iaccarino, I., Lettieri, T., Roscilli, G., Delmastro, P. and Jiricny, J. (1998) Mismatch repair deficiency associated with overexpression of the MSH3 gene. Proc. Natl Acad. Sci. USA, 95, 8568-8573.
16. Genschel, J., Littman, S.J., Drummond, J.T. and Modrich, P. (1998) Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. J. Biol. Chem., 273, 19895-19901.
17. Ionov, Y., Peinado, M.A., Malkhosyan, S., Shibata, D. and Perucho, M. (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature, 363, 558-561.
18. Karran, P. and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. BioEssays, 16, 833-839.
19. Papadopoulos, N., Nicolaides, N.C., Liu, B. et al. (1995) Mutations of GTBP in genetically unstable cells. Science, 268, 1915-1917.
20. Bhattacharyya, N.P., Skandalis, A., Ganesh, A., Groden, J. and Meuth, M. (1994) Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl Acad. Sci. USA, 91, 6319-6323.
21. Bhattacharyya, N.P. and Meuth, M. (1995) Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum. Mol. Genet., 4, 2057-2064.
22. Branch, P., Hampson, R. and Karran, P. (1995) DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55, 2304-2309.
23. da Costa, L.T., Liu, B., el Deiry, W. et al. (1995) Polymerase delta variants in RER colorectal tumours. Nature Genet., 9, 10-11.
24. Schaaper, R.M. (1988) Mechanisms of mutagenesis in the Escherichia coli mutator mutD5: role of DNA mismatch repair. Proc. Natl Acad. Sci. USA, 85, 8126-8130.
25. Hawn, M.T., Umar, A., Carethers, J.M., Marra, G., Kunkel, T.A., Boland, C.R. and Koi, M. (1995) Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res., 55, 3721-3725.
26. Sambrook, J., Fritsch, E. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Nicolaides, N.C., Palombo, F., Kinzler, K.W., Vogelstein, B. and Jiricny, J. (1996) Molecular cloning of the N-terminus of GTBP. Genomics, 31, 395-397.
28. Dignam, J.D., Martin, P.L., Shastry, B.S. and Roeder, R.G. (1983) Eukaryotic gene transcription with purified components. Methods Enzymol., 101, 582-598.
29. Iaccarino, I., Marra, G., Palombo, F. and Jiricny, J. (1998) hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutS-alpha. EMBO J., 17, 2677-2686.
30. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
31. Aquilina, G., Ceccotti, S., Martinelli, S., Hampson, R. and Bignami, M. (1998) N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells. Cancer Res., 58, 135-141.
32. Maquat, L.E. (1995) When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA, 1, 453-465.
33. Umar, A., Koi, M., Risinger, J.I., Glaab, W.E., Tindall, K.R., Kolodner, R.D., Boland, C.R., Barrett, J.C. and Kunkel, T.A. (1997) Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res., 57, 3949-3955.
34. Holmes, J. Jr, Clark, S. and Modrich, P. (1990) Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines. Proc. Natl Acad. Sci. USA, 87, 5837-5841.
35. Brown, T.C. and Jiricny, J. (1988) Different base/base mispairs are corrected with different efficiencies and specificities in monkey kidney cells. Cell, 54, 705-711.
36. Branch, P., Aquilina, G., Bignami, M. and Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature, 362, 652-654.
37. Parsons, R., Li, G.M., Longley, M., Modrich, P., Liu, B., Berk, T., Hamilton, S.R., Kinzler, K.W. and Vogelstein, B. (1995) Mismatch repair deficiency in phenotypically normal human cells. Science, 268, 738-740.
38. Hughes, M.J. and Jiricny, J. (1992) The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities. J. Biol. Chem., 267, 23876-23882.
39. Macpherson, P., Humbert, O. and Karran, P. (1998) Frameshift mismatch recognition by the human MutS alpha complex. Mutat. Res., 408, 55-66.
40. Gradia, S., Acharya, S. and Fishel, R. (1997) The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell, 91, 995-1005.
41. Duckett, D.R., Drummond, J.T., Murchie, A.I., Reardon, J.T., Sancar, A., Lilley, D.M. and Modrich, P. (1996) Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl Acad. Sci. USA, 93, 6443-6447.
42. D'Atri, S., Tentori, L., Lacal, P.M., Graziani, G., Pagani, E., Benincasa, E., Zambruno, G., Bonmassar, E. and Jiricny, J. (1998) Involvement of the mismatch repair system in temozolomide-induced apoptosis. Mol. Pharmacol., 54, 334-341.
43. Koi, M., Umar, A., Chauhan, D.P., Cherian, S.P., Carethers, J.M., Kunkel, T.A. and Boland, C.R. (1994) Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res., 54, 4308-4312.
44. Risinger, J.I., Umar, A., Glaab, W.E., Tindall, K.R., Kunkel, T.A. and Barrett, J.C. (1998) Single gene complementation of the hPMS2 defect in HEC-1-A endometrial carcinoma cells. Cancer Res., 58, 2978-2981.