Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLα

Molecular and Cellular Biology

Volumn 20, Issue 17, 2000, Pages 6390-6398

  Tran, P T ^a   Liskay, R M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BASE MISPAIRING; ENZYME ACTIVITY; ENZYME CONFORMATION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

ADENINE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BETA-GALACTOSIDASE; CARRIER PROTEINS; DNA MUTATIONAL ANALYSIS; DNA REPAIR; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FUNGAL PROTEINS; HYDROLYSIS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES CEREVISIAE;

EID: 0033838152     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.17.6390-6398.2000     Document Type: Article

References (71)

1. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
2. The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions
3. Genetic and biochemical analysis of Msh2p-Msh6p: Role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition
4. The 43-kilodalton N-terminal fragment of the DNA gyrase b protein hydrolyzes ATP and binds coumarin drugs
5. Dominant negative mutator mutations in the mutL gene of Escherichia coli
6. Topoisomerase II drives DNA transport by hydrolyzing one ATP
7. Involvement of Mlh1 in DNA mismatch repair and meiotic crossing over
8. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
9. Transformation of MutL by ATP binding and hydrolysis: A switch in DNA mismatch repair
10. Crystal structure and ATPase activity of MutL: Implications for DNA repair and mutagenesis
11. An atypical topoisomerase II from Archaea with implications for meiotic recombination
12. A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition
13. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer
14. Mammalian DNA mismatch repair
15. Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
16. The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast
17. Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast
18. Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line
19. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
20. GHKL, an emergent ATPase/kinase superfamily
21. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
22. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations
23. Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha
24. Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier
25. The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes
26. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
27. Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex
28. Pre-steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. 2. Kinetic mechanism for the sequential hydrolysis of two ATP
29. Division of labor - Sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA
30. Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis
31. The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid
32. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha
33. MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2
34. Identifying the catalytic residue of the ATPase reaction of DNA gyrase
35. Assessment of the ATP binding properties of Hsp90
36. Eukaryotic mismatch repair: An update
37. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
38. Eukaryotic DNA mismatch repair
39. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
40. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
41. Biochemical characterization of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 complex and mispaired bases in DNA
42. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
43. Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
44. The yeast gene MSH3 defines a new class of eukaryotic MutS homologues
45. A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype
46. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
47. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
48. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
49. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
50. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to hereditary nonpolyposis colorectal cancer-associated mutations
51. Mutation of a mutL homolog in hereditary colon cancer
52. Recombination in yeast
53. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade
54. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
55. A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone
56. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
57. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene
58. Interactions between the Msh2, Mlh1 and Pms1 proteins during the initiation of DNA mismatch repair
59. Molecular matchmakers
60. ATP-binding properties of human Hsp90
61. Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae
62. Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations
63. Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair
64. The intrinsic ATPase of DNA gyrase
65. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
66. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
67. Single-strand DNA-specific exonucleases in Escherichia coli. Roles in repair and mutation avoidance
68. Mammalian ras interacts directly with the serine/threonine kinase raf
69. Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
70. Crystal structure of an N-terminal fragment of the DNA gyrase B protein