Role of MED1 (MBD4) gene in DNA repair and human cancer

Journal of Cellular Physiology

Volumn 187, Issue 2, 2001, Pages 137-144

  Bellacosa, Alfonso ^a,b  

^a FOX CHASE CANCER CENTER   (United States)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; DNA GLYCOSYLTRANSFERASE; FLUOROURACIL; GENE PRODUCT; GUANINE; PROTEIN MBD4; PROTEIN MED1; THYMINE; UNCLASSIFIED DRUG; URACIL;

AMINO TERMINAL SEQUENCE; CANCER CELL; CANCER GENETICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEAMINATION; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; ENZYME ACTIVITY; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE; TWO HYBRID SYSTEM; YEAST;

DNA REPAIR; ENDODEOXYRIBONUCLEASES; HUMANS; NEOPLASMS;

BACTERIA (MICROORGANISMS);

EID: 0035064989     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.1064     Document Type: Review

References (67)

1. Clues to the pathogenesis of familial colorectal cancer
2. Antimetabolites
3. Mismatch repair in correction of replication errors and processing of DNA damage
4. Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene
5. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency
6. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
7. MED1, a novel human methyl-CpG-binding endonuclease, interacts with the DNA mismatch repair protein MLH1
8. A mammalian protein with specific demethylase activity for mCpG DNA
9. The relationship of DNA methylation to cancer
10. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
11. Roles of etheno-DNA adducts in tumorigenicity of olefins
12. Cancer of the colon
13. A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins
14. Chemistry of glycosylases and endonucleases involved in base-excision repair
15. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
16. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA
17. Cdil, a human G1 and S phase protein phosphatase that associates with Cdk2
18. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays
19. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
20. 4-ethenocytosine and the G/T mismatch
21. Identification and characterization of a family of mammalian methyl-CpG binding proteins
22. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
23. General introduction to DNA base excision repair
24. Counteracting the mutagenic effect of hydrolytic deamination of DNA 5-methylcytosine residues at high temperature: DNA mismatch N-glycosylase Mig.Mth of the thermophilic archaeon Methanobacterium thermoautotrophicum THF
25. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
26. Replication errors: Cha(lle)nging the genome
27. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
28. Tumors associated with p53 germline mutations: A synopsis of 91 families
29. Eukaryotic DNA mismatch repair
30. DNA glycosylases in the base excision repair of DNA
31. Base excision repair of DNA in mammalian cells
32. The role of DNA methylation in cancer genetic and epigenetics
33. Very short patch repair: Reducing the cost of cytosine methylation
34. Quality control by DNA repair
35. Significance of multiple mutations in cancer
36. 4-ethenocytosine from DNA
37. MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III
38. Mismatch repair, genetic stability, and cancer
39. Mismatch repair in replication fidelity, genetic recombination, and cancer biology
40. DNA repair mechanisms for the recognition and removal of damaged DNA bases
41. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
42. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
43. The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells
44. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
45. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
46. Active repression of methylated genes by the chromosomal protein MBD1
47. Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1
48. Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): Fundamental role of the catalytic domain
49. Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
50. Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/a basic lyase that proceeds via an imino enzyme-DNA intermediate
51. Single-turnover and presteady-state kinetics of the reaction of the adenine glycosylase MutY with mismatch-containing DNA substrates
52. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
53. 4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
54. Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli
55. Chromosomal localizations and molecular analysis of TDG gene-related sequences
56. Involvement of DNA methylation in human carcinogenesis
57. Human thymine-DNA glycosylase maps at chromosome 12q22q24.1: A region of high loss of heterozygosity in gastric cancer
58. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure
59. Microsatellite instability in cancer of the proximal colon
60. PC3TIS21/BTG2 prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?
61. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis
62. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
63. The solution structure of the domain from MeCP2 that binds to methylated DNA
64. DNA damages processed by base excision repair: Biological consequences
65. Kinetics of the action of thymine DNA glycosylase
66. 3-Methyladenine DNA glycosylases: Structure, function, and biological importance
67. 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence