Mismatch repair, G2/M cell cycle arrest and lethality after DNA damage

Carcinogenesis

Volumn 20, Issue 12, 1999, Pages 2317-2325

  Aquilina, Gabriele ^a   Crescenzi, Marco ^b   Bignami, Margherita ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LOMUSTINE; METHYLNITROSOUREA;

ARTICLE; BASE MISPAIRING; CELL CYCLE G2 PHASE; CELL KILLING; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; DNA REPLICATION; GAMMA RADIATION; HELA CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; LETHALITY; MITOSIS; PRIORITY JOURNAL; RAJI CELL;

EID: 0033402721     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.12.2317     Document Type: Article

References (57)

1. Bhattacharyya, N.P., Skandalis, A., Ganesh, A., Groden, J. and Meuth, M. (1994) Mutator phenotypes in human colorectal carcinoma cell lines. Proc. Natl Acad. Sci. USA, 91, 6319-6323.
2. Eshleman, J.R., Lang, E.Z., Bowenin, G.K., Parsons, R., Vogelstein, B., Wilson, J.K.V., Veigl, M.L., Sedwick, W.D. and Markowitz, S.D. (1995) Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogens, 10, 33-37.
3. Branch, P., Hampson, R. and Karran, P. (1995) DNA mismatch binding defects, DNA damage tolerance and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55, 2304-2309.
4. Narayanan, L., Fritzell, J.A., Baker, S.M., Liskay, R.M. and Glazer, P.M. (1997) Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2. Proc. Natl Acad. Sci. USA, 94, 3122-3127.
5. Andrew, S.E., Reitmair, A.H., Fox, J., Hsiao, L., Francis, A., McKinnon, M., Mak, T.W. and Jirik, F.R. (1997) Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. Oncogene, 15, 123-129.
6. Reitmar, A.H., Risley, R., Bristow, R.G., Wilson, T., Ganesh, A., Jang, A., Peacock, J., Benchimol, S., Hill, R.P., Mak, T.W., Fishel, R. and Meuth, M. (1997) Mutator phenotype in Msh2-deficient murine embryonic fibroblasts. Cancer Res., 57, 3765-3771.
7. Drummond, J.T., Li, G.-M., Longley, M.J. and Modrich, P. (1995) Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science, 268, 1909-1912.
8. Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A. and Jiricny, J. (1995) GTBP, a 160 kD protein essential for mismatch-binding activity in human cells. Science, 268, 1912-1914.
9. Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T. and Jiricny, J. (1996) Binding of insertion/deletion loops in DNA by hMutsβ. a heterodimer of hMSH2 and hMSH3. Curr. Biol., 6, 1181-1184.
10. Drummond, J.T., Genschel, J., Wolf, E. and Modrich, P. (1997) DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base-base mismatch repair. Proc. Natl Acad. Sci. USA, 94, 10144-10149.
11. Modrich, P. and Lahue, R. (1996) Mismatch repair in replication fidelity, genetic recombination and cancer biology. Annu. Rev. Biochem., 65, 101-133.
12. Branch, P., Aquilina, G., Bignami, M. and Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature, 362, 652-654.
13. Kat, A., Thilly, W.G., Fang, W.-H., Longley, M.J., Li, G.-M. and Modrich, P. (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. Natl Acad. Sci. USA, 90, 6424-6428.
14. Koi, M., Umar, A., Chauhan, D., Cherian, S.P., Carethers, J.M., Kunkel, T.A. and Boland, C.R. (1994) Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrososguanidine tolerance in colon tumor cells with homozygous hMLHI mutation. Cancer Res., 54, 4308-4312.
15. Risinger, J.I., Umar, A., Barrett, J.C. and Kunkel, T.A. (1995) A hPMS2 mutant cell line is defective in strand-specific mismatch repair. J. Biol. Chem., 270, 18183-18186.
16. Aquilina, G., Hess, P., Fiumicino, S., Ceccotti, S. and Bignami, M. (1995) A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage. Cancer Res., 55, 2569-2575.
17. 6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells. J. Biol. Chem., 272, 28596-28606.
18. Umar, A., Koi, M., Risinger, J.I., Glaab, W.E., Tindall, K.R., Kolodner, R.D., Boland, C.R., Barrett, J.C. and Kunkel, T.A. (1997) Correction of hypermutability, MNNG resistance and defective DNA mismatch repair by introducing chromosome 2 into tumor cells with mutations in MSH2 and MSH6. Cancer Res., 57, 3949-3955.
19. Griffin, S., Branch, P., Xu, Y.-Z. and Karran, P. (1994) DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage. Biochemistry, 33, 4787-4793.
20. 4-methylthymine, or the cisplatin d (GpG) adduct. Proc. Natl Acad. Sci. USA, 93, 6443-6447.
21. Swann, P.F., Waters, T.R., Moulton, D.C., Xu, Y.-Z., Zheng, Q., Edwards, M. and Mace, R. (1996) Role of post-replicative DNA mismatch repair in the cytotoxic action of thioguanine. Science, 273, 1109-1111.
22. 6-methylthioguanine. Biochemistry, 36, 2501-2506.
23. Karran, P. and Bignami, M. (1996) Drug-related killings: a case of mistaken identity. Chem. Biol., 3, 875-879.
24. Anthoney, D.A., McIlwrath, A.J., Gallagher, W.M., Edlin, A.R.M. and Brown, R. (1996) Microsatellite instability, apoptosis and loss of p53 function in drug-resistant tumor cells. Cancer Res., 56, 1374-1381.
25. Drummond, J.T., Anthoney, A., Brown, R. and Modrich, P. (1996) Cisplatin and adriamycin resistance are associated with MutLa and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem., 271, 19645-19648.
26. Fink, D., Nebel, S., Aebi, S., Zheng, H., Cenni, B., Nehmé, A., Christen, R.D. and Howell, S.B. (1996) The role of DNA mismatch repair in platinum drug resistance. Cancer Res., 56, 4881-4886.
27. Aebi, S., Kurdi, B.-H., Gordon, R., Cenni, B., Zheng, H., Fink, D., Christen, R.D., Boland, C.R., Koi, M., Fishel, R. and Howell, S.B. (1996) Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res., 56, 3087-3090.
28. Fink, D., Zheng, H., Nebel, S., Norris, P.S., Aebi, S., Lin, T.P., Nehmé, A., Christen, R.D., Haas, M., MacLeod, C.L. and Howell, S.B. (1997) In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res., 57, 1841-1845.
29. Yamada, M., O'Regan, E., Brown, R. and Karran, P. (1997) Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins. Nucleic Acids Res., 25, 491-496.
30. Nasmyth, K. (1996) Viewpoint: putting the cell cycle in order. Science, 274, 1643-1645.
31. Hawn, M.T., Umar, A., Carethers, J.M., Marra, G., Kunkel, T.A., Boland, C.R. and Koi, M. (1995) Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res., 55, 3721-3725.
32. Carethers, J.M., Hawn, M.T., Chauhan, D.P., Luce, M.C., Marra, G., Koi, M. and Boland, C.R. (1996) Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Clin. Invest., 98, 199-206.
33. Goldmacher, V.S., Cuzick, R.A. and Thilly, W.G. (1986) Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine. J. Biol. Chem., 261, 12462-12471.
34. D'Atri, S., Tentori, L., Lacal, P.M., Graziani, G., Pagani, E., Benincasa, E., Zambruno, G., Bonmassar, E. and Jiricny, J. (1998) Involvement of the mismatch repair system in temozolomide-induced apoptosis. Mol. Pharmacol., 54, 334-341.
35. Aquilina, A., Ceccotti, S., Martinelli, S., Hampson, R. and Bignami, M. (1998) CCNU sensitivity in mismatch repair defective human cells. Cancer Res., 58, 135-141.
36. Leadon, S.A. and Avrutskaya, A.V. (1997) Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2 in transcription-coupled repair. Cancer Res., 57, 3784-3791.
37. Fritzell, J.A., Narayanan, L., Baker, S.M., Bronner, C.E., Andrew, S.E., Prolla, T.A., Bradley, A., Jirik, F.R., Liskay, R.M. and Glazer, P.M. (1997) Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res., 57, 5143-5147.
38. Davis, T.W., Wilson-Patten, C., Meyers, M., Kunugi, K.A., Cuthill, S., Reznikoff, C., Garces, C., Boland, C.R., Kinsella, T.J., Fishel, R. and Boothman, D.A. (1998) Defective expression of the mismatch repair protein, hMLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res., 58, 767-778.
39. 6-methylguanine by mismatch correction in human cell extracts. Curr. Biol., 6, 1528-1531.
40. Branch, P., Aquilina, G., Bignami, M. and Karran, P. (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature, 362, 652-654.
41. Duthu, A., Debuire, B., Romano, J., Ehrhart, J.C., Fiscella, M., May, E., Appella, E. and May, P. (1992) p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas. Oncogene, 7, 2161-2167.
42. Karran, P. and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays, 16, 833-839.
43. Zhukovskaya, N., Branch, P., Aquilina, G. and Karran, P. (1994) DNA replication arrest and tolerance to DNA methylation damage. Carcinogenesis, 15, 2189-2194.
44. Brown, R., Hirst, G.L., Gallagher, W.M., McIlwrath, A.J., Margison, G.P., van der Zee, A.G.J. and Anthoney, D.A. (1997) hMLH1 expression and cellular responses of ovarian tumor cells to treatment with cytotoxic anticancer agents. Oncogene, 15, 45-52.
45. Galloway, S.M., Greenwood, S.K., Hill, R.B., Bradt, C.I. and Bean, C.L. (1995) A role for mismatch repair in the production of chromosome aberrations by methylating agents in human cells. Mutat. Res, 346, 231-245.
46. Armstrong, M.J. and Galloway, S.M. (1997) Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. Mutat. Res., 373, 167-178.
47. Plant, J.E. and Roberts, J.J. (1971) A novel mechanism for the inhibition of DNA synthesis following methylation: the effect of N-methyl-N-nitrosourea on HeLa cells. Chem. Biol. Interact., 3, 337-342.
48. Tan, K.B., Dorman, T.E., Falls, K.M., Chung, T.D.Y., Mirabelli, C.K., Crooke, S.T. and Mao, J.-I. (1992) Topoisomerase IIα and topoisomerase IIβ genes: characterization and mapping to human chromosomes 17 and 3, respectively. Cancer Res., 52, 231-234.
49. Kung, A.L., Sherwood, S.W. and Schimke, R.T. (1990) Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc. Natl Acad. Sci. USA, 87, 9553-9557.
50. Campisi, J. (1996) Replicative senescence: an old lives' tale? Cell, 84, 497-500.
51. Cleaver, J.E. (1998) Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease. Cell. 93, 1099-1102.
52. Humbert, O., Fiumicino, S., Aquilina, G., Branch, P., Oda, S., Zijno, A., Karran, P. and Bignami, M. (1999) Mismatch repair and differential sensitivity of mouse and human cells to DNA methylating agents. Carcinogenesis, 20, 205-214.
53. Ludlum, D.B. (1990) DNA alkylation by haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat. Res., 233, 117-126.
54. Matijasevic, Z., Boosalis, M., Mackay, W., Samson, L. and Ludlum, D.B. (1993) Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Proc. Natl Acad. Sci. USA, 90, 11855-11859.
55. O'Connor, P.M., Ferrsi, D.K., Hoffmann, I., Jackman, J., Draetta, G. and Kohn, K.W. (1994) Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc. Natl Acad. Sci. USA, 91, 9480-9484.
56. Wang, D., Kreutzer, D.A. and Essigmann, J.M. (1998) Mutagenicity and repair of oxidative damage: insights from studies using defined lesions. Mutat. Res., 400, 99-115.
57. DeWeese, T.L., Shipman, J.M., Larrier, N.A., Buckley, N.M., Kidd, L.R., Groopman, J.D., Cutler, R.G., te Riele, H. and Nelson, W.G. (1998) Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. Proc. Natl Acad. Sci. USA, 95, 11915-11920.