The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells

Cancer Research

Volumn 59, Issue 8, 1999, Pages 1840-1845

  Berry, Suzanne E ^a   Garces, Christopher ^b   Hwang, Hwa Shin ^a   Kunugi, Keith ^b   Meyers, Mark ^a   Davis, Thomas W ^a   Boothman, David A ^a   Kinsella, Timothy J ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDINE DERIVATIVE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; COLON CANCER; CYTOTOXICITY; DNA REPAIR; DRUG DNA BINDING; FAMILIAL CANCER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIZATION;

CARRIER PROTEINS; CELL SURVIVAL; COLONIC NEOPLASMS; DEOXYRIBONUCLEOTIDES; DNA REPAIR; DNA, NEOPLASM; HUMANS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; RADIATION, IONIZING; THIOGUANINE; THYMIDINE; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED; URIDINE;

EID: 0033561529     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Kinsella, T. An approach to the radiosensitization of human tumors. Cancer J. Sci. Am., 2: 184-193, 1996.
2. Urtasun, R., Kinsella, T., Farnan, N., Del Rowe, J., Lester, S., and Fulton, D. Survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: final report of RTOG 86-12, Phase I-II Study. Int. J. Radiat. Oncol. Biol. Phys., 36: 1163-1167, 1996.
3. Prados, M., Scott, C., Rotman, M., Rubin, P., Murray, K., Sause, W., Asbell, S., Comis, R., Curran, W., Nelson, J., Davis, R., Levin, V., Lamborn, K., and Phillips, T. Influence of bromodeoxyuridine radiosensitization on malignant glioma patient survival: a retrospective comparison of survival data from the Northern California Oncology Group (NCOG) and Radiation Therapy Oncology Group Trials (RTOG) for glioblastoma multiforme and anaplastic astrocytoma. Int. J. Radiat. Oncol. Biol. Phys., 40: 653-659, 1998.
4. Tochner, Z., Kinsella, T., Rowland, J., and Glatstein, E. Treatment of unresectable sarcomas of adults with hyperfractionated irradiation and iododeoxyuridine. Br. J. Radiol., 19: 107-111, 1989.
5. Knol, J., Walker, S., Robertson, J., Yang, Z., De Remer, S., Stetson, P., Ensminger, W., and Lawrence, T. Incorporation of 5-bromo-2′-deoxyuridine into colorectal liver metastases and liver in patients receiving a 7-day hepatic arterial infusion. Cancer Res., 55: 3687-3691, 1995.
6. Miller, E., Fowler, J., and Kinsella, T. Linear-quadratic analysis of radiosensitization by halogenaled pyrimidines. I. Radiosensitization of human colon cancer cells by iododeoxyuridine. Radiat. Res., 131: 81-89, 1992.
7. Christie, N., Drake, S., and Meyn, R. 6-Thiopurine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells. Cancer Res., 44: 3665-3671, 1984.
8. Koi, M., Umar, A., Chauhan, D., Cherian, S., Carethers, J., Kunkel, T., and Boland, C. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res., 54: 4308-4312, 1994.
9. 2 cell cycle checkpoint. Cancer Res., 55: 3721-3725, 1995.
10. Liu, L., Markowitz, S., and Gerson, S. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not 1,3-bis(2-chloroethyl) nitrosourea. Cancer Res., 56: 5375-5379, 1996.
11. Aebi, S., Fink, D., Gordon, R., Kim, H., Zheng, H., Fink, J., and Howell, S. Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells. Clin. Cancer Res., 3: 1763-1767, 1997.
12. Swann, P., Waters, T., Mouton, D., Xu, Y., Zheng, Q., Edwards, M., and Mace, R. Role of post-replicative DNA mismatch repair in the cytotoxic action of thioguanine. Science (Washington DC), 273: 1109-1111, 1996.
13. 2/M cell cycle checkpoint arrest following ionizing radiation. Cancer Res., 58: 767-778, 1998.
14. Drummond, J., Anthoney, A., Brown, R., and Modrich, P. Cisplatin and Adriamycin resistance are associated with MutL and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem., 271: 19645-19648, 1996.
15. Friedman, H., Johnson, S., Dong, Q., Schold, C., Rasheed, B., Bigner, S., Ali-Osman, F., Dolan, E., Colvin, O., Houghton, P., German, G., Drummond, J., Keir, S., Marcelli, S., Bigner, D., and Modrich, P. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res., 57: 2933-2936, 1997.
16. Lindstrom, M., Kunugi, K., and Kinsella, T. Global comparison of radiation and chemotherapy dose response curves with a test for interaction. Radiat. Res., 135: 269-277, 1993.
17. Belanger, K., Collins, J., and Klecker, R. Techniques for detection of DNA nucleo-bases by reversed-phase high-performance liquid chromatography optimized for quantitative determination of thymidine substitution by iododeoxyuridine. J. Chrom. 417: 51-63, 1987.
18. Lee, L., and Cheng, Y. Human thymidine kinase I. Purification and general properties of the cytoplasmic and mitochrondrial isozymes derived from blast cells of acute myelocytic leukemia. J. Biol. Chem., 251: 2600-2604, 1976.
19. Fisher, P., Vasquez-Padua, M., Reznikoff, C., and Ratschan, W. Preferential stimulation of iododeoxyuridine phosphorylation in human bladder cancer cells in vitro. Cancer Res., 46: 4522-4526, 1986.
20. Miller, E, and Kinsella, T. Radiosensitization by fluorodeoxyuridine: effects on thymidine synthase inhibition and cell synchronization. Cancer Res., 52: 1687-1694, 1992.
21. Freese, E. The specific mutagenic effect of base analogues on phage T4. J. Mol. Biol., 1: 87-105, 1959.
22. Branch, P., Aquilina, G., Bignami, M., and Karran, P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature (Lond.), 362: 652-654, 1993.
23. Fazakerly, G., Quignard, E., Woisard, A., Guschlbauer, W., van der Marel, G., van Boom, J., Jones, M., and Radman, M. Structures of mismatched base pairs in DNA and their recognition by the Escherichia coli mismatch repair system. EMBO J., 5: 3697-3703, 1986.
24. Acharya, S., Wilson, T., Gradia, S., Kane, M., Guerrette, S., Marsischky, G., Kolodner, R., and Fishel, R. hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. USA, 93: 13629-13634, 1996.
25. Kane, M., Loda, M., Gaida, G., Lipman, J., Mishra, R., Goldman, H., Jessup, J., and Kolodner, R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res., 57: 808-811, 1997.
26. Veigl, M., Kasturi, L., Olechnowicz, J., Ma, A., Lutterbaugh, J., Periyasamy, S., Li, G., Drummond, J., and Modrich, P. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc. Natl. Acad. Sci. USA, 95: 8698-8702, 1998.