메뉴 건너뛰기




Volumn 462, Issue 2-3, 2000, Pages 71-82

Unmasking a killer: DNA O6-methylguanine and the cytotoxicity of methylating agents

Author keywords

Cytotoxicity; Mismatch repair; Mutation induction; O6 methylguanine

Indexed keywords

2 AMINOPURINE; 6 O METHYLGUANINE; ALKYLATING AGENT; DACARBAZINE; DIMETHYLHYDRAZINE; DIMETHYLNITROSAMINE; ETHYLNITROSOUREA; MESYLIC ACID METHYL ESTER; METHYLNITRONITROSOGUANIDINE; METHYLNITROSOUREA; TEMOZOLOMIDE;

EID: 0034027358     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(00)00016-8     Document Type: Article
Times cited : (180)

References (63)
  • 1
    • 0014355386 scopus 로고
    • Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate
    • Swann P.F., Magee P.M. Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate. Biochem. J. 110:1968;39-47.
    • (1968) Biochem. J. , vol.110 , pp. 39-47
    • Swann, P.F.1    Magee, P.M.2
  • 2
    • 0014672640 scopus 로고
    • 6 alkylation of deoxyguanosine to mutagenicity of nitrosamines and nitrosamides
    • 6 alkylation of deoxyguanosine to mutagenicity of nitrosamines and nitrosamides. Nature. 223:1969;206-208.
    • (1969) Nature , vol.223 , pp. 206-208
    • Loveless, A.1
  • 3
    • 0016042235 scopus 로고
    • 6-ethylguanine in rat brain DNA: Correlation with nervous system specific carcinogenesis by ethylnitrosourea
    • 6-ethylguanine in rat brain DNA: correlation with nervous system specific carcinogenesis by ethylnitrosourea. Proc. Natl. Acad. Sci. U. S. A. 71:1974;639-643.
    • (1974) Proc. Natl. Acad. Sci. U. S. A. , vol.71 , pp. 639-643
    • Goth, R.1    Rajewsky, M.F.2
  • 6
    • 0026750738 scopus 로고
    • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
    • Karran P., Bignami M. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res. 20:1992;2933-2940.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2933-2940
    • Karran, P.1    Bignami, M.2
  • 7
    • 0017395439 scopus 로고
    • A new pathway for DNA repair in Escherichia coli
    • Samson L., Cairns J. A new pathway for DNA repair in Escherichia coli. Nature. 267:1977;281-283.
    • (1977) Nature , vol.267 , pp. 281-283
    • Samson, L.1    Cairns, J.2
  • 8
    • 0020565479 scopus 로고
    • Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli
    • Sedgwick B. Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli. Mol. Gen. Genet. 191:1983;466-472.
    • (1983) Mol. Gen. Genet. , vol.191 , pp. 466-472
    • Sedgwick, B.1
  • 9
    • 0023919219 scopus 로고
    • Regulation and expression of the adaptive response to alkylating agents
    • Lindahl T., Sedgwick B., Sekiguchi M. Regulation and expression of the adaptive response to alkylating agents. Annu. Rev. Biochem. 57:1988;133-157.
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 133-157
    • Lindahl, T.1    Sedgwick, B.2    Sekiguchi, M.3
  • 12
    • 0020644818 scopus 로고
    • 6-methylguanine-DNA methyltransferase of human lymphoid cells:structural and kinetic properties and absence in repair-deficient cells
    • 6-methylguanine-DNA methyltransferase of human lymphoid cells:structural and kinetic properties and absence in repair-deficient cells. Cancer Res. 43:1983;3247-3252.
    • (1983) Cancer Res. , vol.43 , pp. 3247-3252
    • Harris, A.L.1    Karran, P.2    Lindahl, T.3
  • 14
    • 0020412740 scopus 로고
    • Effect of acute doses of 2-acetylaminofluorene on the capacity of rat liver to repair methylated purines in DNA in vivo and in vitro
    • Cooper D.P., O'Connor P.J., Margison G.P. Effect of acute doses of 2-acetylaminofluorene on the capacity of rat liver to repair methylated purines in DNA in vivo and in vitro. Cancer Res. 42:1982;4203-4209.
    • (1982) Cancer Res. , vol.42 , pp. 4203-4209
    • Cooper, D.P.1    O'Connor, P.J.2    Margison, G.P.3
  • 18
    • 0026438385 scopus 로고
    • Alkylating agents relating to carcinogenesis in man
    • In: Relevance of animal studies to the evaluation of human risk
    • R. Montesano, J. Hall, C.P. Wild, Alkylating agents relating to carcinogenesis in man. In: Relevance of animal studies to the evaluation of human risk, Prog. Clin. Biol. Res. 374 (1992) 175-196.
    • (1992) Prog. Clin. Biol. Res. , vol.374 , pp. 175-196
    • Montesano, R.1    Hall, J.2    Wild, C.P.3
  • 20
    • 0019395086 scopus 로고
    • 6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines
    • 6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature. 289:1981;417-420.
    • (1981) Nature , vol.289 , pp. 417-420
    • Sklar, R.1    Strauss, B.2
  • 21
    • 0018803369 scopus 로고
    • Human brain tumour cell strains with deficient host- cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5
    • Day R.S., Ziolkowski C.H.J. Human brain tumour cell strains with deficient host- cell reactivation of N-methyl-N′-nitro-N-nitrosoguanidine-damaged adenovirus 5. Nature. 279:1979;797-799.
    • (1979) Nature , vol.279 , pp. 797-799
    • Day, R.S.1    Ziolkowski, C.H.J.2
  • 22
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50:1990;6119-6129.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 23
    • 0022271991 scopus 로고
    • 6-methylguanine-DNA methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N′-nitro-N-nitrosoguanidine
    • 6-methylguanine-DNA methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N′-nitro-N-nitrosoguanidine. Carcinogenesis. 6:1985;1823-1826.
    • (1985) Carcinogenesis , vol.6 , pp. 1823-1826
    • Domoradzki, J.1    Pegg, A.E.2    Dolan, M.E.3    Maher, V.M.4    McCormick, J.J.5
  • 24
    • 0028533694 scopus 로고
    • DNA damage tolerance, mismatch repair and genome instability
    • Karran P., Bignami M. DNA damage tolerance, mismatch repair and genome instability. BioEssays. 16:1994;833-839.
    • (1994) BioEssays , vol.16 , pp. 833-839
    • Karran, P.1    Bignami, M.2
  • 25
    • 0343328947 scopus 로고
    • Suppression of human DNA alkylation-repair defects by Escherichia coli DNA repair genes
    • Samson L., Derfler B., Waldstein E. Suppression of human DNA alkylation-repair defects by Escherichia coli DNA repair genes. Proc. Natl. Acad. Sci. U. S. A. 83:1986;5607-5610.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 5607-5610
    • Samson, L.1    Derfler, B.2    Waldstein, E.3
  • 26
    • 0023001905 scopus 로고
    • Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harbouring the Escherichia coli alkyltransferase gene
    • Brennand J., Margison G.P. Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harbouring the Escherichia coli alkyltransferase gene. Proc. Natl. Acad. Sci. U. S. A. 83:1986;6292-6296.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 6292-6296
    • Brennand, J.1    Margison, G.P.2
  • 27
    • 0022989218 scopus 로고
    • 6-alkylguanine alkyltransferase reduces the toxic effect of alkylating agents
    • 6-alkylguanine alkyltransferase reduces the toxic effect of alkylating agents. Carcinogenesis. 7:1986;2081-2084.
    • (1986) Carcinogenesis , vol.7 , pp. 2081-2084
    • Brennand, J.1    Margison, G.P.2
  • 28
    • 0022962212 scopus 로고
    • Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene
    • Kataoka H., Hall J., Karran P. Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene. EMBO J. 5:1986;3195-3200.
    • (1986) EMBO J. , vol.5 , pp. 3195-3200
    • Kataoka, H.1    Hall, J.2    Karran, P.3
  • 30
    • 0030294633 scopus 로고    scopus 로고
    • Drug-related killings: A case of mistaken identity
    • Karran P., Bignami M. Drug-related killings: a case of mistaken identity. Chem. Biol. 3:1996;875-879.
    • (1996) Chem. Biol. , vol.3 , pp. 875-879
    • Karran, P.1    Bignami, M.2
  • 31
    • 0027502938 scopus 로고
    • Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
    • Branch P., Aquilina G., Bignami M., Karran P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature. 362:1993;652-654.
    • (1993) Nature , vol.362 , pp. 652-654
    • Branch, P.1    Aquilina, G.2    Bignami, M.3    Karran, P.4
  • 33
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi M., Umar A., Chauhan D.P., Cherian S.P., Carethers J.M., Kunkel T.A., Boland C.R. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:1994;4308-4312.
    • (1994) Cancer Res. , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3    Cherian, S.P.4    Carethers, J.M.5    Kunkel, T.A.6    Boland, C.R.7
  • 34
    • 0029007870 scopus 로고
    • DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines
    • Branch P., Hampson R., Karran P. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res. 55:1995;2304-2309.
    • (1995) Cancer Res. , vol.55 , pp. 2304-2309
    • Branch, P.1    Hampson, R.2    Karran, P.3
  • 35
    • 0030776227 scopus 로고    scopus 로고
    • Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
    • Umar A., Koi M., Risinger J.I., Glaab W.E., Tindall K.R., Kolodner R.D., Boland S.C.R., Barett J.C., Kunkel T.A. Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res. 57:1997;3949-3955.
    • (1997) Cancer Res. , vol.57 , pp. 3949-3955
    • Umar, A.1    Koi, M.2    Risinger, J.I.3    Glaab, W.E.4    Tindall, K.R.5    Kolodner, R.D.6    Boland, S.C.R.7    Barett, J.C.8    Kunkel, T.A.9
  • 36
    • 0022961641 scopus 로고
    • Mismatch repair in E. coli
    • Radman M., Wagner R. Mismatch repair in E. coli. Annu. Rev. Genet. 20:1986;523-538.
    • (1986) Annu. Rev. Genet. , vol.20 , pp. 523-538
    • Radman, M.1    Wagner, R.2
  • 37
    • 0017825071 scopus 로고
    • - mutants of Escherichia coli: A role for 6-methyladenine in mutation avoidance
    • - mutants of Escherichia coli: a role for 6-methyladenine in mutation avoidance. Mol. Gen. Genet. 163:1978;307-312.
    • (1978) Mol. Gen. Genet. , vol.163 , pp. 307-312
    • Glickman, B.1    Van Den Elsen, P.2    Radman, M.3
  • 38
    • 0020332947 scopus 로고
    • 6-methylguanine residues in E. coli DNA
    • 6-methylguanine residues in E. coli DNA. Nature. 296:1982;868-869.
    • (1982) Nature , vol.296 , pp. 868-869
    • Karran, P.1    Marinus, M.G.2
  • 39
    • 0028174274 scopus 로고
    • 1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase)
    • Dosanjh M.K., Roy R., Mitra S., Singer B. 1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase). Biochemistry. 33:1994;1624-1628.
    • (1994) Biochemistry , vol.33 , pp. 1624-1628
    • Dosanjh, M.K.1    Roy, R.2    Mitra, S.3    Singer, B.4
  • 40
    • 0028239225 scopus 로고
    • Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases
    • Saparbaev M., Laval J. Excision of hypoxanthine from DNA containing dIMP residues by the Escherichia coli, yeast, rat, and human alkylpurine DNA glycosylases. Proc. Natl. Acad. Sci. U. S. A. 91:1994;5873-5877.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 5873-5877
    • Saparbaev, M.1    Laval, J.2
  • 41
    • 0019173806 scopus 로고
    • Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase
    • Karran P., Lindahl T., Ofsteng I., Evensen G.B., Seeberg E. Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase. J. Mol. Biol. 140:1980;101-127.
    • (1980) J. Mol. Biol. , vol.140 , pp. 101-127
    • Karran, P.1    Lindahl, T.2    Ofsteng, I.3    Evensen, G.B.4    Seeberg, E.5
  • 42
    • 0020056580 scopus 로고
    • Adaptation to alkylation resistance involves the induction of a DNA glycosylase
    • Evensen G., Seeberg E. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature. 296:1982;773-775.
    • (1982) Nature , vol.296 , pp. 773-775
    • Evensen, G.1    Seeberg, E.2
  • 43
    • 0026474380 scopus 로고
    • Expression of the E. coli 3-methyladenine-DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents
    • Kungland A., Fairbairn L., Watson A.J., Margison G.P., Seeberg E. Expression of the E. coli 3-methyladenine-DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents. EMBO J. 11:1992;4439-4444.
    • (1992) EMBO J. , vol.11 , pp. 4439-4444
    • Kungland, A.1    Fairbairn, L.2    Watson, A.J.3    Margison, G.P.4    Seeberg, E.5
  • 44
    • 0028801762 scopus 로고
    • Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - A case in imbalanced DNA repair
    • Coquerelle T., Dosch J., Kaina B. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - a case in imbalanced DNA repair. Mutat. Res. 336:1995;9-17.
    • (1995) Mutat. Res. , vol.336 , pp. 9-17
    • Coquerelle, T.1    Dosch, J.2    Kaina, B.3
  • 45
    • 0030041960 scopus 로고    scopus 로고
    • Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
    • Engelward B.P., Dreslin A., Christensen J., Huszar D., Kurahara C., Samson L. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J. 15:1996;945-952.
    • (1996) EMBO J. , vol.15 , pp. 945-952
    • Engelward, B.P.1    Dreslin, A.2    Christensen, J.3    Huszar, D.4    Kurahara, C.5    Samson, L.6
  • 49
    • 0033118432 scopus 로고    scopus 로고
    • Cells deficient in DNA polymerase β are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage
    • Ochs K., Sobol R.W., Wilson S.H., Kaina B. Cells deficient in DNA polymerase β are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res. 59:1999;1544-1551.
    • (1999) Cancer Res. , vol.59 , pp. 1544-1551
    • Ochs, K.1    Sobol, R.W.2    Wilson, S.H.3    Kaina, B.4
  • 51
    • 0031783825 scopus 로고    scopus 로고
    • Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus
    • Glaab W.E., Risinger J.I., Umar A., Barrett J.C., Kunkel T.A., Tindall K.R. Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus. Carcinogenesis. 19:1998;1931-1937.
    • (1998) Carcinogenesis , vol.19 , pp. 1931-1937
    • Glaab, W.E.1    Risinger, J.I.2    Umar, A.3    Barrett, J.C.4    Kunkel, T.A.5    Tindall, K.R.6
  • 52
    • 0033060682 scopus 로고    scopus 로고
    • Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine
    • Glaab W.E., Skopek T.R. Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine. Carcinogenesis. 20:1999;391-394.
    • (1999) Carcinogenesis , vol.20 , pp. 391-394
    • Glaab, W.E.1    Skopek, T.R.2
  • 53
    • 0032574305 scopus 로고    scopus 로고
    • Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate
    • Glaab W.E., Risinger J.I., Umar A., Barrett J.C., Kunkel T.A., Tindall K.R. Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate. Mutat. Res. 398:1998;197-207.
    • (1998) Mutat. Res. , vol.398 , pp. 197-207
    • Glaab, W.E.1    Risinger, J.I.2    Umar, A.3    Barrett, J.C.4    Kunkel, T.A.5    Tindall, K.R.6
  • 57
    • 0025801019 scopus 로고
    • Carcinogenic N-nitrosamines in the diet: Occurrence, formation, mechanisms and carcinogenic potential
    • Tricker A.R., Preussmann R. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat. Res. 259:1991;277-289.
    • (1991) Mutat. Res. , vol.259 , pp. 277-289
    • Tricker, A.R.1    Preussmann, R.2
  • 58
    • 0031408198 scopus 로고    scopus 로고
    • N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastro-intestinal tract, including Helicobacter pylori
    • Ziebarth D., Spiegelhalder B., Bartsch H. N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastro-intestinal tract, including Helicobacter pylori. Carcinogenesis. 18:1997;383-389.
    • (1997) Carcinogenesis , vol.18 , pp. 383-389
    • Ziebarth, D.1    Spiegelhalder, B.2    Bartsch, H.3
  • 59
    • 0028218474 scopus 로고
    • Chronic infections and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
    • Ohshima H., Bartsch H. Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat. Res. 305:1994;253-264.
    • (1994) Mutat. Res. , vol.305 , pp. 253-264
    • Ohshima, H.1    Bartsch, H.2
  • 60
    • 0025885066 scopus 로고
    • L-Arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma
    • Ohshima H., Tsuda M., Adachi H., Ogura T., Sugimura T., Esumi H. L-Arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma. Carcinogenesis. 12:1991;1217-1220.
    • (1991) Carcinogenesis , vol.12 , pp. 1217-1220
    • Ohshima, H.1    Tsuda, M.2    Adachi, H.3    Ogura, T.4    Sugimura, T.5    Esumi, H.6
  • 61
    • 0029114193 scopus 로고
    • Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease
    • Sartor R.B. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol. Clin. North Am. 24:1995;475-507.
    • (1995) Gastroenterol. Clin. North Am. , vol.24 , pp. 475-507
    • Sartor, R.B.1
  • 63
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane M.F., Loda M., Gaida G.M., Lipman J., Mishra R., Goldman H., Jessup J.M., Kolodner R. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57:1997;808-811.
    • (1997) Cancer Res. , vol.57 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.