TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus

EMBO Journal

Volumn 18, Issue 7, 1999, Pages 1953-1965

  Braun, Isabelle C ^a   Rohrbach, Emmanuelle ^a   Schmitt, Christel ^a   Izaurralde, Elisa ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

CTE; Leucine rich repeats; mRNA export; Nuclear export; RNA protein interactions

Indexed keywords

LEUCINE; RNA BINDING PROTEIN; VIRUS MESSENGER RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA TRANSPORT; STRUCTURE ACTIVITY RELATION;

ANIMALIA; SIMIAE; TYPE D RETROVIRUSES;

EID: 0033119628     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.7.1953     Document Type: Article

References (41)

1. Bogerd, H.P., Fridell, R.A., Benson, R.E., Hua, J. and Cullen, B.R. (1996) Protein sequence requirements for function of the human T-cell leukemia virus type I Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol. Cell. Biol., 16, 4207-4214.
2. Bogerd, H.P., Echarri, A., Ross, T.M. and Cullen, B.R. (1998) Inhibition of HIV-1 Rev and HTLV-I Rex function, but not MPMV CTE activity, by a mutant human nucleoporin targeted to Crml. J. Virol., 72, 8627-8635.
3. Bray, M., Prasad, S., Dubay, J.W., Hunter, E., Jeang, K-T., Rekosh, D. and Hammarskjold, M.-L. (1994) A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type I expression and replication Rev-independent. Proc. Natl Acad. Sci. USA, 91, 1256-1260.
4. Burd, C.G. and Dreyfuss, G. (1994) Conserved structures and diversity of functions of RNA-binding proteins. Science, 265, 615-621.
5. Cullen, B.R. (1998) Retroviruses as model system for the study of nuclear RNA export pathways. Virology, 249, 203-210.
6. Daneholt, B. (1997) A look at messenger RNP moving through the nuclear pore. Cell, 88, 585-588.
7. Ernst, R.K., Bray, M., Rekosh, D. and Hammarskjold, M.-L. (1997a) A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Mol. Cell. Biol., 17, 135-144.
8. Ernst, R.K., Bray, M., Rekosh, D. and Hammarskjold, M.-L. (1997b) Secondary structure and mutational analysis of the Mason-Pfizer monkey virus RNA constitutive transport element. RNA, 3, 210-222.
9. Felber, B.K. (1997) Regulation of mRNA expression in HIV-1 and other retroviruses. In Morris, D. and Harford, J.B. (eds), mRNA Metabolism and Post-Transcriptional Gene Regulation. Wiley-Liss Inc., New York, NY, pp. 323-340.
10. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. and Luhrmann, R. (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell, 82, 475-483.
11. Fornerod, M., Ohno, M., Yoshida, M. and Mattaj, I.W. (1997a) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell, 90, 1051-1060.
12. Fornerod, M., van Deursen, J., van Baal, S., Reynolds, A., Davis, D., Murti, K.G., Fransen, J. and Grosveld, G. (1997b) The human homologue of yeast Crm1 is in a dynamic subcomplex with Can/ Nup214 and a novel nuclear pore component Nup 88. EMBO J., 16, 807-816.
13. Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M. and Nishida, E. (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature, 390, 308-311.
14. Görlich, D., Dabrowski, M., Bischoff, F.R., Kutay, U., Bork, P., Hartmann, E., Prehn, S. and Izaurralde, E. (1997) A novel class of Ran-GTP binding proteins. J. Cell Biol., 138, 65-80.
15. Grüter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B.K. and Izaurralde, E. (1998) TAP, the human homologue of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell, 1, 649-659.
16. Hamm, J. and Mattaj, I.W. (1990) Monomethylated cap structures facilitate RNA export from the nucleus. Cell, 63, 109-118.
17. Hope, T.J. (1997) Viral RNA export. Chem. Biol., 4, 335-344.
18. Izaurralde, E. and Adam, S. (1998) Transport of macromolecules between the nucleus and the cytoplasm. RNA, 4, 1-14.
19. Jarmolowski, A., Boelens, W., Izaurralde, E. and Mattaj, I.W. (1994) Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol., 124, 627-635.
20. Kambach, C. and Mattaj, I.W. (1992) Intracellular distribution of the U1A protein depends on active transport and nuclear binding to U1 snRNA. J. Cell Biol., 118, 11-21.
21. Kobe, B. and Deisenhofer, J. (1994) The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci., 19, 415-421.
22. Kobe, B. and Deisenhofer, J. (1995) Proteins with leucine-rich repeats. Curr. Opin. Struct. Biol., 5, 409-416.
23. Legrain, P. and Rosbash, M. (1989) Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Cell, 57, 573-583.
24. Mattaj, I.W. and Englmeier, L. (1998) Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem., 67, 256-306.
25. Nakielny, S. and Dreyfuss, G. (1996) The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J. Cell Biol., 134, 1365-1373.
26. Otero, G.C., Harris, M.E., Donello, J.E. and Hope, T.J. (1998) Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus Rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol., 72, 7593-7597.
27. Parks, T.D., Leuther, K.K., Howard, E.D., Johnston, S.A. and Dougherty, W.G. (1994) Release of proteins and peptides from fusion proteins with a recombinant plant virus proteinase. Anal. Biochem., 216, 413-117.
28. Pasquinelli, A.E., Ernst, R.K., Lund, E., Grimm, C., Zapp, M.L., Rekosh, D., Hammarskjold, M.-L. and Dahlberg, J.E. (1997) The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses an RNA export pathway utilized by cellular messenger RNAs. EMBO J., 16, 7500-7510.
29. Saavedra, C., Felber, B.K. and Izaurralde, E. (1997) The simian retrovirus-1 constitutive transport element (CTE), unlike HIV-1 RRE, utilises factors required for cellular RNA export. Curr. Biol., 7, 619-628.
30. Santos-Rosa, H., Moreno, H., Simos, G., Segref, A., Fahrenkrog, B., Panté, N. and Hurt, E. (1998) Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol. Cell. Biol., 18, 6826-6838.
31. + RNA and nuclear pores. EMBO J., 16, 3256-3271.
32. Stade, K., Ford, C.S., Guthrie, C. and Weis, K. (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell, 90, 1041-1050.
33. Stutz, F. and Rosbash, M. (1998) Nuclear RNA export. Genes Dev., 12, 3303-3319.
34. Tabernero, C., Zolotukhin, A.S., Valentin, A., Pavlakis, G.N. and Felber, B.K. (1996) The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J. Virol., 70, 5998-6011.
35. Tabernero, C., Zolotukhin, A.S., Bear, J., Schneider, R., Karsenty, G. and Felber, B.K. (1997) Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. J. Virol., 71, 95-101.
36. Ullman, K.S., Powers, M.A. and Forbes, D.J. (1997) Nuclear export receptors: from importin to exportin. Cell, 90, 967-970.
37. Vankan, P., McGuigan, C. and Mattaj, I.W. (1992) Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J., 11, 335-342.
38. Wen, W., Meinkoth, J.L., Tsien, R.Y. and Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell, 82, 463-473.
39. Yoon, D.W., Lee, H., Seol, W., DeMaria, M., Rosezweig, M. and Jung, J.U. (1997) Tap: a novel cellular protein that interacts with tip of herpes virus saimiri and induces lymphocyte aggregation. Immunity, 6, 571-582.
40. Zolotukhin, A.S. and Felher, B.K. (1997) Mutations in the nuclear export signal of human Ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. J. Biol. Chem., 272, 11356-11360.
41. - human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. J. Virol., 68, 7944-7952.