The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

Genes and Development

Volumn 13, Issue 9, 1999, Pages 1126-1139

  Kang, Yibin ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Constitutive transport element; mRNA; Nuclear export; Nuclear import; Retroviral

Indexed keywords

ANIMAL CELL; ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEIN TRANSPORT; QUAIL; RETROVIRUS; RNA SEQUENCE; VIRUS REPLICATION;

EID: 0033135976     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.9.1126     Document Type: Article

References (50)

1. Blair, W.S., T.B. Parsley, H.P. Bogerd, J.S. Towner, B.L. Semler, and B.R. Cullen. 1998. Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. RNA 4: 215-225.
2. Bogerd, H.P., A. Echarri, T.M. Ross, and B.R. Cullen. 1998. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not mason-pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J. Virol. 72: 8627-8635.
3. Bogerd, H.P., R.E. Benson, R. Truant, A. Herold, M. Phingbodhipakkiya, and B.R. Cullen. 1999. Definition of a consensus transportin-specific nucleocytoplasmic transport signal. J. Biol. Chem. 274: 9771-9777.
4. Bray, M., S. Prasad, J.W. Dubay, E. Hunter, K.-T. Jeang, D. Rekosh, and M.-L. Hammarskjöld. 1994. A small element from the mason-pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Revindependent. Proc. Natl. Acad. Sci. 91: 1256-1260.
5. Chang, D.D. and P.A. Sharp. 1989. Regulation of HIV Rev depends upon recognition of splice sites. Cell 59: 789-795.
6. Cullen, B.R. 1998. Retroviruses as model systems for the study of nuclear RNA export pathways. Virology 249: 203-210.
7. Cullen, B.R., A.M. Skalka, and G. Ju. 1983. Endogenous avian retroviruses contain deficient promoter and leader sequences. Proc. Natl. Acad. Sci. 80: 2946-2950.
8. Ernst, R.K., M. Bray, D. Rekosh, and M-L. Hammarskjöld. 1997. Secondary structure and mutational analysis of the mason-pfizer monkey virus RNA constitutive transport element. RNA 3: 210-222.
9. Fan, H.C. and J.A. Steitz. 1998. HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc. Natl. Acad. Sci. 95: 15293-15298.
10. Fischer, U., J. Huber, W.C. Boelens, I.W. Mattaj, and R. Lührmann. 1995. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82: 475-483.
11. Fornerod, M., M. Ohno, M. Yoshida, and I.W. Mattaj. 1997a. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
12. Fornerod, M., J. van Deursen, S. van Baal, A. Reynolds, D. Davis, K.G. Murti, J. Fransen, and G. Grosveld. 1997b. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 16: 807-816.
13. Fridell, R.A., R.E. Benson, J. Hua, H.P. Bogerd, and B.R. Cullen. 1996. A nuclear role for the fragile X mental retardation protein. EMBO J. 15: 5408-5414.
14. Gröne, M., E. Hoffmann, S. Berchtold, B.R. Cullen, and R. Grassmann. 1994. A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo. Virology 204: 144-152.
15. Grüter, P., C. Tabernero, C. von Kobbe, C. Schmitt, C., Saavedra, A. Bachi, M. Wilm, B.K. Felber, and E. Izaurralde. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1: 649-659.
16. Hammarskjöld, M.-L. 1997. Regulation of retroviral RNA export. Cell Dev. Biol. 8: 83-90.
17. Herold, A., R. Truant, H. Wiegand, and B.R. Cullen. 1998. Determination of the functional domain organization of the importin α nuclear import factor. J. Cell Biol. 143: 309-318.
18. Hope, T.J., X. Huang, D. McDonald, and T.G. Parslow. 1990. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: Mapping cryptic functions of the arginine-rich motif. Proc. Natl. Acad. Sci. 87: 7787-7791.
19. Hua, J., W. Blair, R. Truant, and B.R. Cullen. 1997. Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4. Virology 231: 231-238.
20. Huang, X., T.J. Hope, B.L. Bond, D. McDonald, K. Grahl, and T.G. Parslow. 1991. Minimal Rev-response element for type 1 human immunodeficiency virus. J. Virol 65: 2131-2134.
21. Izaurralde, E. and S. Adam. 1998. Transport of macromolecules between the nucleus and the cytoplasm. RNA 4: 351-364.
22. Izaurralde, E., A. Jarmolowski, C. Beisel, I.W. Mattaj, G. Dreyfuss, and U. Fischer. 1997. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137: 27-35.
23. Kadowaki, T., M. Hitomi, S. Chen, and A.M. Tartakoff. 1994. Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. Mol. Biol. Cell 5: 1253-1263.
24. Lee, M.S., M. Henry, and P.A. Silver. 1996. A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes & Dev. 10: 1233-1246.
25. Legrain, P. and M. Rosbash. 1989. Some cis-and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Cell 57: 573-583.
26. Malim, M.H., and B.R. Cullen. 1991. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency. Cell 65: 241-248.
27. Malim, M.H., J. Hauber, S.-Y. Le, J.V. Maizel, and B.R. Cullen. 1989. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338: 254-257.
28. Malim, M.H., L.S. Tiley, D.F. McCarn, J.R. Rusche, J. Hauber, and B.R. Cullen. 1990. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. Cell 60: 675-683.
29. Malim, M.H., D.F. McCarn, L.S. Tiley, and B.R. Cullen. 1991. Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. J. Virol. 65: 4248-4254.
30. Meyer, B.E. and M.H. Malim. 1994. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes & Dev. 8: 1538-1547.
31. Michael, W.M., M. Choi, and G. Dreyfuss. 1995. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83: 415-422.
32. Michael, W.M., P.S. Eder, and G. Dreyfuss. 1997. The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J. 16: 3587-3598.
33. Neville, M., F. Stutz, L. Lee, L.I. Davis, and M. Rosbash. 1997. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr. Biol. 7: 767-775.
34. Otero, G.C., M.E. Harris, J.E. Donello, and T.J. Hope. 1998. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus Rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol. 72: 7593-7597.
35. Pasquinelli, A.E., R.K. Ernst, E. Lund, C. Grimm, M.L. Zapp, D. Rekosh, M.-L. Hammarskjöld, and J.E. Dahlberg. 1997. The constitutive transport element (CTE) of mason-pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 16: 7500-7510.
36. Piñol-Roma, S. and G. Dreyfuss. 1992. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355: 730-732.
37. Saavedra, C., B. Felber, and E. Izaurralde. 1997. The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, utilises factors required for the export of cellular mRNAs. Curr. Biol. 7: 619-628.
38. Santos-Rosa, H., H. Moreno, G. Simos, A. Segref, B. Fahrenkrog, N. Panté, and E. Hurt. 1998. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Mol. Cell. Biol. 18: 6826-6838.
39. + RNA and nuclear pores. EMBO J. 16: 3256-3271.
40. Selby, M.J. and B.M. Peterlin. 1990. Trans-activation by HIV-1 Tat via a heterologous RNA binding protein. Cell 62: 769-776.
41. Stade, K., C.S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90: 1041-1050.
42. Stutz, F. and M. Rosbash. 1998. Nuclear RNA export. Genes & Dev. 12: 3303-3319.
43. Tabernero, C., A.S. Zolotukhin, Z. Valentin, G.N. Pavlakis, and B.K. Felber. 1996. The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J. Virol. 70: 5998-6011.
44. Tang, H., G.M. Gaietta, W.H. Fischer, M.H. Ellisman, and F. Wong-Staal. 1997. A cellular cofactor for the constitutive transport element of type D retrovirus. Science 276: 1412-1415.
45. Tiley, L.S., S.J. Madore, M.H. Malim, and B.R. Cullen. 1992. The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence. Genes & Dev. 6: 2077-2087.
46. Truant, R., R.A. Fridell, E.R. Benson, A. Herold, and B.R. Cullen. 1998. Nucleocytoplasmic shuttling by protein nuclear import factors. Eur. J. Cell Biol. 77: 269-275.
47. Wen, W., J.L. Meinkoth, R.Y. Tsien, and S.S. Taylor. 1995. Identification of a signal for rapid export of proteins from the nucleus. Cell 82: 463-473.
48. Yoon, D., H. Lee, W. Seol, M. Demaria, M. Rosenzweig, and J.U. Jung. 1997. Tap: A novel cellular protein that interacts with Tip of Herpes virus Saimiri and induces lymphocytes aggregation. Immunity 6: 571-582.
49. Zolotukhin, A.S. and B.K. Felber. 1999. Nucleoporins Nup98 and Nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J. Virol. 73: 120-127.
50. Zolotukhin, A.S., A. Valentin, G.N. Pavlakis, and B.K. Felber. 1994. Continuous Propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. J. Virol. 68: 7944-7952.