A novel nuclear import pathway for the transcription factor TFIIS

Journal of Cell Biology

Volumn 143, Issue 6, 1998, Pages 1447-1455

  Albertini, Markus ^a   Pemberton, Lucy F ^a   Rosenblum, Jonathan S ^a   Blobel, Günter ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Import; Karyopherin; Nucleus; Transcription factor; Yeast

Indexed keywords

ELONGATION FACTOR; FUNGAL PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; YEAST;

CELL NUCLEUS; CYTOPLASM; FUNGAL PROTEINS; GENE DELETION; GENES, FUNGAL; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; KINETICS; NUCLEAR PROTEINS; RAN GTP-BINDING PROTEIN; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS, GENERAL; TRANSCRIPTIONAL ELONGATION FACTORS;

EID: 0032517779     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.6.1447     Document Type: Article

References (11)

1. Aebi, M., M.W. Clark, U. Vijayraghavan, and J. Abelson. 1990. A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation. Mol. Gen. Genet. 224: 72-80.
2. Agarwal, K., K.H. Back, C.J. Jeon, K. Miyamoto, A. Ueno, and H. Yoon. 1991. Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS. Biochemistry. 30:7842-7851.
3. Aitchison, J.D., M.P. Rout, M. Marelli, G. Blobel, and R.W. Wozniak. 1995. Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J. Cell Biol. 131: 1133-1148.
4. Aitchison, J.D., G. Blobel, and M.P. Rout. 1996. Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science. 274:624-627.
5. Kohler, M., S. Ansieau, S. Prehn, A. Leutz, H. Haller, and E. Hartmann. 1997. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. FEBS (Fed. Eur. Biochem. Soc.) Lett. 417:104-108.
6. Kraemer, D.M., C. Strambio-de-Castillia, G. Blobel, and M.P. Rout. 1995. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate. J. Biol. Chem. 270:19017-19021.
7. Kutay, U., F.R. Bischoff, S. Kostka, R. Kraft, and D. Görlich. 1997. Export of importin α from the nucleus is mediated by a specific nuclear transport factor. Cell. 90:1061-1071.
8. Kutay, U., G. Lipowsky, E. Izaurralde, R. Bischoff, P. Schwarzmaier, E. Hartmann, and D. Görlich. 1998. Identification of a tRNA-specific nuclear export receptor. Cell. 1:359-369.
9. Malik, H.S., T.H. Eickbush, and D.S. Goldfarb. 1997. Evolutionary specialization of the nuclear targeting apparatus. Proc. Natl. Acad. Sci. USA. 94: 13738-13742.
10. Melchior, F., B. Paschal, J. Evans, and L. Gerace. 1993. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123: 1649-1659.
11. Melchior, F., T. Guan, N. Yokoyama, T. Nishimoto, and L. Gerace. 1995. GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. J. Cell Biol. 131:571-581.