Functional analysis of Tpr: Identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export

Journal of Cell Biology

Volumn 143, Issue 7, 1998, Pages 1801-1812

  Bangs, Peter ^a   Burke, Brian ^b   Powers, Christine ^a   Craig, Roger ^a   Purohit, Aruna ^a   Doxsey, Stephen ^a,c  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

MRNA; Nuclear export; Nuclear localization sequence; Nuclear pore; Tpr

Indexed keywords

MESSENGER RNA; POLYADENYLATED RNA; PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL STRAIN BHK; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; MONKEY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CELL NUCLEUS; COS CELLS; CRICETINAE; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MACROMOLECULAR SUBSTANCES; MESOCRICETUS; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; MODELS, BIOLOGICAL; NUCLEAR ENVELOPE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0032576612     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.7.1801     Document Type: Article

References (11)

1. Akey, C.W., and M. Radermacher. 1993. Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy. J. Cell Biol. 122:1-19.
2. Aitchison, J.D., M.P. Rout, M. Marelli, G. Blobel, and R.W. Wozniak. 1995. Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J. Cell Biol. 131:1133-1148.
3. Bangs, P.L., C.A. Sparks, P.R. Odgren, and E.G. Fey. 1996. Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex. J. Cell. Biochem. 61:48-60.
4. Bastos, R., N. Panté, and B. Burke. 1995. Nuclear pore complex proteins. Int. Rev. Cytol. 162:257-302.
5. Bastos, R., A. Lin, M. Enarson, and B. Burke. 1996. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J. Cell Biol. 134:1141-1156.
6. Bastos, R., L. Ribas de Pouplana, M. Enarson, K. Bodoor, and B. Burke. 1997. Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex. J. Cell Biol. 137:989-1000.
7. 2 terminus is involved in the activation of oncogenic kinases, is localized to the cytoplasmic face of the nuclear pore complex. J. Cell Biol. 127:1515-1526.
8. Cordes, V.C., S. Reidenbach, A. Kohler, N. Stuurman, R. van Driel, and WAV. Franke. 1993. Intranuclear filaments containing a nuclear pore complex protein. J. Cell Biol. 123:1333-1344.
9. Cordes, V.C., S. Reidenbach, H.R. Rackwitz, and W.W. Franke. 1997. Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J. Cell Biol. 136:515-529.
10. Davis, L.I., and G. Blobel. 1986. Identification and characterization of a nuclear pore complex protein. Cell. 45:699-709.
11. Dingwall, C. 1991. Transport across the nuclear envelope: enigmas and explanations. Bioessays. 13:213-218.