Exportin 1 (Crm1p) is an essential nuclear export factor

Cell

Volumn 90, Issue 6, 1997, Pages 1041-1050

  Stade, Katrin ^a   Ford, Charleen S ^a   Guthrie, Christine ^a   Weis, Karsten ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN;

ARTICLE; CELL NUCLEUS; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0030985459     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80370-0     Document Type: Article

References (60)

1. Adachi, Y., and Yanagida, M. (1989). Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+, which encodes a 115-kD protein preferentially localized in the nucleus and its periphery. J. Cell Biol. 108, 1195-1207.
2. Adam, S.A., Marr, R.S., and Gerace, L. (1990). Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol. 111, 807-816.
3. Aitchison, J.D., Blobel, G., and Rout, M.P. (1996). Kap 104p: a karyopherin involved in the nuclear transport of messenger RNA-binding proteins. Science 274, 624-627.
4. Amberg, D.C., Goldstein, A.L., and Cole, C.N. (1992). Isolation and characterization of RAT1: an essential gene of S. cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes Dev. 6, 1173-1189.
5. Bataille, N., Helser, T., and Fried, H.M. (1990). Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: a generalized, facilitated process. J. Cell Biol. 111, 1571-1582.
6. Bogerd, H.P., Fridell, R.A., Madore, S., and Cullen, B.R. (1995). Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82, 485-494.
7. Bonifaci, N., Moroianu, J., Radu, A., and Blobel, G. (1997). Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Proc. Natl. Acad. Sci. USA 94, 5055-5060.
8. Cole, C.N., and Saavedra, C. (1997). Regulation of the export of RNA from the nucleus. Semin. Cell Dev. Biol. 8, 71-78.
9. Dasso, M. (1993). RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. Trends Biochem. Sci. 18, 96-101.
10. Dieffenbach, C.W., and Dveksler, G.S. (1995). PCR Primer: A Laboratory Manual, 1st Ed. (New York: Cold Spring Harbor Laboratory Press).
11. Dingwall, C., and Laskey, R.A. (1991). Nuclear targeting sequences - a consensus? Trends. Biochem. Sci. 16, 478-481.
12. Doye, V., and Hurt, E. (1997). From nucleoporins to nuclear pore complexes. Curr. Opin. Cell Biol. 9, 401-411.
13. Doye, V.R., Wepf, R., and Hurt, E.C. (1994). A novel nuclear pore protein Nup 133p with distinct roles in poly(A)+RNA transport and nuclear pore distribution. EMBO J. 13, 6062-6075.
14. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W., and Lührmann, R. (1995). The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483.
15. Fornerod, M., van Deursen, J., van Baal, S., Reynolds, A., Davis, D., Murti, K.G., Fransen, J., and Grosveld, G. (1997). The human homolog of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 16, 807-816.
16. Fritz, C.C., and Green, M.R. (1996). HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr. Biol. 6, 848-854.
17. Fritz, C.C., Zapp, M.L., and Green, M.R. (1995). A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature 367, 530-533.
18. Goldberg, M.W., and Allen, T.D. (1995). Structural and functional organization of the nuclear envelope. Curr. Biol. 7, 301-309.
19. Görlich, D., and Mattaj, I.W. (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.
20. Guthrie, C., and Fink, G.R. (1991). Guide to Yeast Genetics and Molecular Biology, Volume 194 (San Diego, CA: Academic Press).
21. Gyuris, J., Golemis, E., Chertkov, H., and Brent, R. (1993). Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75, 791-803.
22. Iovine, M.K., and Wente, S.R. (1997). A nuclear export signal in kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of nup 116p and nup 100p. J. Cell Biol. 137, 797-811.
23. Izaurralde, E., and Mattaj, I.W. (1995). RNA export. Cell 81, 153-159.
24. Izaurralde, E., Jarmolowski, A., Beisel, C., Mattaj, I.W., Dreyfuss, G., and Fischer, U. (1997). A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J. Cell Biol. 137, 27-35.
25. Jarmolowski, A., Boelens, W.C., Izaurralde, E., and Mattaj, I.W. (1994). Nuclear export of different classes of RNA is mediated by specific factors. J. Cell Biol. 124, 627-635.
26. Kadowaki, T., Chen, S., Hitomi, M., Jacobs, E., Kumagai, C., Liang, S., Schneiter, R., Singleton, D., Wisniewska, J., and Tartakoff, A.M. (1994). Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants. J. Cell Biol. 126, 649-659.
27. Kandels-Lewis, S., and Seraphin, B. (1993). Involvement of U6 snRNA in 5′ splice site selection. Science 262, 2035-2039.
28. Kumada, K., Yanagida, M., and Toda, T. (1996). Caffeine resistance in fission yeast is caused by mutations in a single essential gene, crm1+. Mol. Gen. Genet. 250, 59-68.
29. Lee, M.S., Henry, M., and Silver, P.A. (1996). A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA export. Genes Dev. 10, 1233-1246.
30. Melchior, F., and Gerace, L. (1995). Mechanisms of nuclear protein import. Curr. Biol. 7, 310-318.
31. Melchior, F., Paschal, B., Evans, J., and Gerace, L. (1993). Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123, 1649-1659. Erratum, 124(1-2): 217.
32. Michael, W.M., Choi, M., and Dreyfuss, G. (1995). A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83, 415-422.
33. Moore, M.S., and Blobel, G. (1993). The GTP-binding protein Ran/ TC4 is required for protein import into the nucleus. Nature 365, 661-663.
34. Moore, M.S., and Blobel, G. (1994). Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc. Natl. Acad. Sci. USA 91, 10212-10216.
35. Murphy, R., and Wente, S.R. (1996). An RNA-export mediator with an essential nuclear export signal. Nature 383, 357-360.
36. Nehrbass, U., Rout, M.P., Maguire, S., Blobel, G., and Wozniak, R.W. (1996). The yeast nucleoporin Nup 188p interacts genetically and physically with the core structures of the nuclear pore complex. J. Cell Biol. 133, 1153-1162.
37. Newmeyer, D.D., Finlay, D.R., and Forbes, D.J.(1986). In vitro transport of a fluorescent nuclear protein and exclusion of nonnuclear proteins. J. Cell Biol. 103, 2091-2102.
38. Nigg, E.A. (1997). Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386, 779-787.
39. Nishi, K., Yoshida, M., Fujiwara, D., Nishikawa, M., Horinouchi, S., and Beppu, T. (1994). Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J. Biol. Chem. 269, 6320-6324.
40. Palacios, I., Weis, K., Klebe, C., Mattaj, I.W., and Dingwall, C. (1996). Ran/TC4 mutants identify common requirement for snRNP and protein import into the nucleus. J. Cell Biol. 133, 485-494.
41. Paschal, B.M., and Gerace, L. (1995). Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. J. Cell Biol. 129, 925-937.
42. Pokrywka, N.J., and Goldfarb, D.S. (1995). Nuclear export pathways of tRNA and 40 S ribosomes include both common and specific intermediates. J. Biol. Chem. 270, 3619-3624.
43. Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F., and Dreyfuss, G. (1996). A novel receptor-mediated nuclear protein import pathway. Cell 86, 985-993.
44. Rout, M.P., and Wente, S.R. (1994). Pores for thought: nuclear pore complex proteins. Trends Cell Biol. 4, 357-365.
45. Rout, M.P., Blobel, G., and Aitchison, J.D. (1997). A distinct nuclear protein import pathway used by ribosomal proteins. Cell 89, 715-725.
46. Rush, M.G., Drivas, G., and D'Eustachio, P. (1996).The small nuclear GTPase Ran: how much does it run? BioEssays 18, 103-112.
47. Schlenstedt, G., Saavedra, C., Loeb, J.D., Cole, C.N., and Silver, P.A. (1995). The GTP-bound form of the yeast Ran/TC4 homolog blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Proc. Natl. Acad. Sci. USA 92, 225-229.
48. Shulga, N., Roberts, P., Gu, Z., Spitz, L., Tabb, M.M., Nomura, M., and Goldfarb, D.S. (1996). In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation. J. Cell Biol. 135, 329-339.
49. Siomi, H., and Dreyfuss, G. (1995). A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol. 129, 551-560.
50. Stutz, F., Neville, M., and Rosbash, M. (1995). Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast. Cell 82, 495-506.
51. Stutz, F., Izaurralde, E., Mattaj, I.W., and Rosbash, M. (1996). A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol. Cell Biol. 16, 7144-7150.
52. Toda, T., Shimanuki, M., Saka, Y., Yamano, H., Adachi, Y., Shirakawa, M., Kyogoku, Y., and Yanagida, M. (1992). Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol. Cell Biol. 12, 5474-5484.
53. Turi, T.G., Webster, P., and Rose, J.K. (1994). Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance. J. Biol. Chem. 269, 24229-24236.
54. Weighard, F., Biamonti, G., and Riva, S. (1995). Nucleo-cytoplasmic distribution of hnRNP proteins: a search for the targeting domains in hnRNP A1. J. Cell Sci. 108, 545-555.
55. Weis, K., Dingwall, C., and Lamond, A.I. (1996a). Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J. 15, 7120-7128.
56. Wen, W., Meinkoth, J.L., Tsien, R.Y., and Taylor, S.S. (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473.
57. Wolff, B., Sanglier, J.J., and Wang, Y. (1997). Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4, 139-147.
58. Yaseen, N.R., and Blobel, G. (1997). Cloning and characterization of human karyopherin beta3. Proc. Natl. Acad. Sci. USA 94, 4451-4456.
59. Zabel, U., Doye, V., Tekotte, H., Wepf, R., Grandi, P., and Hurt, E.C. (1996). Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p. J. Cell Biol. 133, 1141-1152.
60. Zasloff, M. (1983). tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process. Proc. Natl. Acad. Sci 80, 6436-6440.