Nuclear import of the TATA-binding protein: Mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting

Journal of Cell Biology

Volumn 145, Issue 7, 1999, Pages 1407-1417

  Pemberton, Lucy F ^a   Rosenblum, Jonathan S ^a   Blobel, Günter ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Biological transport; Nuclear localization signal; Saccharomyces cerevisiae; Transcription factors

Indexed keywords

DNA; KARYOPHERIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL TRANSPORT; COMPLEX FORMATION; CYTOPLASM; CYTOSOL; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL PROCESSING; TRANSCRIPTION REGULATION;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL NUCLEUS; CYTOPLASM; DNA; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE DELETION; GENES, ESSENTIAL; GENES, FUNGAL; GUANOSINE TRIPHOSPHATE; KARYOPHERINS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PROTEIN BINDING; RAN GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; TATA BOX; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTOR TFIIA; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 0033612576     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.7.1407     Document Type: Article

References (61)

1. Aitchison, J.D., M.P. Rout, M. Marelli, G. Blobel, and R.W. Wozniak. 1995. Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J. Cell Biol. 131: 1133-1148.
2. Aitchison, J.D., G. Blobel, and M.P. Rout. 1996. Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science. 274:624-627.
3. Akada, R., L. Kallal, D.I. Johnson, and J. Kurjan. 1996. Genetic relationships between the G protein beta gamma complex, Ste5p. Ste20p, and Cdc42p: investigation of effector roles in the yeast pheromone response pathway. Genetics. 143:103-117.
4. Albertini, M., L.F. Pemberton, J.S. Rosenblum, and G. Blobel. 1998. A novel nuclear import pathway for the transcription factor TFIIS. J. Cell Biol. 143: 1447-1455.
5. Bischoff, F.R., and H. Ponstingl. 1991. Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc. Natl. Acad. Sci. USA. 88:10830-10834.
6. Burley, S.K., and R.G. Roeder. 1996. Biochemistry and structural biology of transcription factor IID (TFIID). Annu. Rev. Biochem. 65:769-799.
7. Chen, W., and K. Struhl. 1988. Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein. Proc. Natl. Acad. Sci. USA. 85:2691-2695.
8. Chook, Y., and G. Blobel. 1999. Structure of the nuclear transport complex karyopherin-β2-Ran-GppNHp. Nature. 399:230-237.
9. Chow, T.Y., J.J. Ash, D. Dignard, and D.Y. Thomas. 1992. Screening and identification of a gene, PSE-1, that affects protein secretion in Saccharomyces cerevisiae. J. Cell Sci. 101:709-719.
10. Coleman, R.A., and B.F. Pugh. 1995. Evidence for functional binding and stable sliding of the TATA binding protein on nonspecific DNA. J. Biol. Chem. 270:13850-13859.
11. Coleman, R.A., A.K. Taggart, L.R. Benjamin, and B.F. Pugh. 1995. Dimerization of the TATA binding protein. J. Biol. Chem. 270:13842-13849.
12. Eisenmann, D.M., C. Dollard, and F. Winston. 1989. SPT15, the gene encoding the yeast TATA binding factor TFIID, is required for normal transcription initiation in vivo. Cell. 58:1183-1191.
13. Enenkel, C., G. Blobel, and M. Rexach. 1995. Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J. Biol. Chem. 270:16499-16502.
14. Fernandez, J., L. Andrews, and S.M. Mische. 1994. An improved procedure for enzymatic digestion of polyvinylidene difluoride-bound proteins for internal sequence analysis. Anal. Biochem. 218:112-117.
15. Ferrigno, P., F. Posas, D. Koepp, H. Saito, and P.A. Silver. 1998. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO (Eur. Mol. Biol. Organ.) J. 17:5606-5614.
16. Finley, D., E. Ozkaynak, and A. Varshavsky. 1987. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell. 48:1035-1046.
17. Floer, M., and G. Blobel. 1996. The nuclear transport factor karyopherin β binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J. Biol. Chem. 271:5313-5316.
18. Floer, M., and G. Blobel. 1999. Putative reaction intermediates in Crm1-mediated nuclear protein export. J. Biol. Chem. 274:16279-16286.
19. Fornerod, M., M. Ohno, M. Yoshida, and I.W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 90:1051-1060.
20. Geiger, J.H., S. Hahn, S. Lee, and P.B. Sigler. 1996. Crystal structure of the yeast TFIIA/TBP/DNA complex. Science. 272:830-836.
21. Gharahdaghi, F., M. Kirchner, J. Fernandez, and S.M. Mische. 1996. Peptide-mass profiles of polyvinylidene difluoride-bound proteins by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the presence of nonionic detergents. Anal. Biochem. 233:94-99.
22. Görlich, D., M. Dabrowski, F.R. Bischoff, U. Kutay, P. Bork, E. Hartmann, S. Prehn, and E. Izaurralde. 1997. A novel class of RanGTP binding proteins. J. Cell Biol. 138:65-80.
23. Gygi, S.P., Y. Rochon, B.R. Franza, and R. Aebersold. 1999. Correlation between protein and mRNA abundance in yeast. Mol. Cell Biol. 19:1720-1730.
24. Hellmuth, K., D.M. Lau, F.R. Bischoff, M. Kunzler, E. Hurt, and G. Simos. 1998. Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA. Mol. Cell Biol. 18:6374-6386.
25. Hood, J.K., and P.A. Silver. 1998. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J. Biol. Chem. 273: 35142-35146.
26. Imbalzano, A.N., K.S. Zaret, and R.E. Kingston. 1994. Transcription factor (TF) IIB and TFIIA can independently increase the affinity of the TATA-binding protein for DNA. J. Biol. Chem. 269:8280-8286.
27. Izaurralde, E., U. Kutay, C. von Kobbe, I.W. Mattaj, and D. Gorlich. 1997. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO (Eur. Mol. Biol. Organ.) J. 16: 6535-6547.
28. Jakel, S., and D. Görlich. 1998. Importin beta, transportin, RanBP5, and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO (Eur. Mol. Biol. Organ.) J. 17:4491-4502.
29. Kaffman, A., N.M. Rank, E.M. O'Neill, L.S. Huang, and E.K. O'Shea. 1998a. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature. 396:482-486.
30. Kaffman, A., N.M. Rank, and E.K. O'Shea. 1998b. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Genes Dev. 12:2673-2683.
31. Kim, J.L., D.B. Nikolov, and S.K. Burley. 1993. Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature. 365:520-527.
32. Kim, Y., J.H. Geiger, S. Hahn, and P.B. Sigler. 1993. Crystal structure of a yeast TBP/TATA-box complex. Nature. 365:512-520.
33. Kunzler, M., and E.C. Hurt. 1998. Cse1p functions as the nuclear export receptor for importin alpha in yeast. FEBS (Fed. Eur. Biochem Soc.) Lett. 433: 185-190.
34. Kutay, U., F.R. Bischoff, S. Kostka, R. Kraft, and D. Görlich. 1997. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell. 90:1061-1071.
35. Lee, T.I., and R.A. Young. 1998. Regulation of gene expression by TBP-associated proteins. Genes Dev. 12:1398-1408.
36. Marelli, M., J.D. Aitchison, and R.W. Wozniak. 1998. Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p. J. Cell Biol. 143:1813-1830.
37. Moore, M.S. 1998. Ran and nuclear transport. J. Biol. Chem. 273:22857-22860.
38. Nikolov, D.B., S.H. Hu, J. Lin, A. Gasch, A. Hoffmann, M. Horikoshi, N.H. Chua, R.G. Roeder, and S.K. Burley. 1992. Crystal structure of TFIID TATA-box binding protein. Nature. 360:40-46.
39. Nikolov, D.B., H. Chen, E.D. Halay, A.A. Usheva, K. Hisatake, D.K. Lee, R.G. Roeder, and S.K. Burley. 1995. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature. 377:119-128.
40. Nikolov, D.B., H. Chen, E.D. Halay, A. Hoffman, R.G. Roeder, and S.K. Burley. 1996. Crystal structure of a human TATA box-binding protein/TATA element complex. Proc. Natl. Acad. Sci. USA. 93:4862-4867.
41. Orphanides, G., T. Lagrange, and D. Reinberg. 1996. The general transcription factors of RNA polymerase II. Genes Dev. 10:2657-2683.
42. Pemberton, L.F., J.S. Rosenblum, and G. Blobel. 1997. A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J. Cell Biol. 139:1645-1653.
43. Pemberton, L.F., G. Blobel, and J.S. Rosenblum. 1998. Transport routes through the nuclear pore complex. Curr. Opin. Cell. Biol. 10:392-399.
44. Ranish, J.A., W.S. Lane, and S. Hahn. 1992. Isolation of two genes that encode subunits of the yeast transcription factor IIA. Science. 255:1127-1129.
45. Rexach, M., and G. Blobel. 1995. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell. 83:683-692.
46. Roeder, R.G. 1996. The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem. Sci. 21:327-335.
47. Rosenblum, J.S., L.F. Pemberton, and G. Blobel. 1997. A nuclear import pathway for a protein involved in tRNA maturation. J. Cell Biol. 139:1655-1661.
48. Rosenblum, J.S., L.F. Pemberton, N. Bonifaci, and G. Blobel. 1998. Nuclear import and the evolution of a multifunctional RNA-binding protein. J. Cell Biol. 143:887-899.
49. Rout, M.P., G. Blobel, and J.D. Aitchison. 1997. A distinct nuclear import pathway used by ribosomal proteins. Cell. 89:715-725.
50. Schlenstedt, G., E. Smirnova, R. Deane, J. Solsbacher, U. Kutay, D. Görlich, H. Ponstingl, and F.R. Bischoff. 1997. Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO (Eur. Mol. Biol. Organ.) J. 16:6237-6249.
51. Seedorf, M., and P.A. Silver. 1997. Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc. Natl. Acad. Sci. USA. 94:8590-8595.
52. Senger, B., G. Simos, F.R. Bischoff, A. Podtelejnikov, M. Mann, and E. Hurt. 1998. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p. EMBO (Eur. Mol. Biol. Organ.) J. 17:2196-2207.
53. Shen, W.C., D. Selvakumar, D.R. Stanford, and A.K. Hopper. 1993. The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix. J. Biol. Chem. 268:19436-19444.
54. Sogo, J.M., H. Stahl, T. Koller, and R. Knippers. 1986. Structure of replicating simian virus 40 minichromosomes. The replication fork, core histone segregation and terminal structures. J. Mol Biol. 189:189-204.
55. Solsbacher, J., P. Maurer, F.R. Bischoff, and G. Schlenstedt. 1998. Cse1p is involved in export of yeast importin alpha from the nucleus. Mol. Cell Biol. 18: 6805-6815.
56. Stade, K., C.S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1) is an essential nuclear export factor. Cell. 90:1041-1050.
57. Tan, S., Y. Hunziker, D.F. Sargent, and T.J. Richmond. 1996. Crystal structure of a yeast TFIIA/TBP/DNA complex. Nature. 381:127-151.
58. Toda, T., M. Shimanuki, Y. Saka, H. Yamano, Y. Adachi, M. Shirakawa, Y. Kyogoku, and M. Yanagida. 1992. Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol. Cell Biol. 12:5474-5484.
59. Wozniak, R.W., M.P. Rout, and J.D. Aitchison. 1998. Karyopherins and kissing cousins. Trends Cell Biol. 8:184-188.
60. Xiao, Z., J.T. McGrew, A.J. Schroeder, and M. Fitzgerald-Hayes. 1993. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol. Cell Biol. 13:4691-4702.
61. Yan, C., L.H. Lee, and L.I. Davis. 1998. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO (Eur. Mol. Biol. Organ.) J. 17:7416-7429.