Cse1p is involved in export of yeast importin α from the nucleus

Molecular and Cellular Biology

Volumn 18, Issue 11, 1998, Pages 6805-6815

  Solsbacher, Jens ^a   Maurer, Patrick ^a   Bischoff, F Ralf ^b   Schlenstedt, Gabriel ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

KARYOPHERIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CYTOPLASM; GENE TRANSLOCATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; YEAST;

EID: 0031774336     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.11.6805     Document Type: Article

References (78)

1. Aitchison, J. D., G. Blobel, and M. P. Rout. 1996. Kap104p; a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274:624-627.
2. Aitchison, J. D., G. Blobel, and M. P. Root. 1995. Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport. J. Cell Biol. 131:1659-1675.
3. Azuma, Y., K. Takio, M. M. Tabb, L. Vu, and M. Nomura. 1997. Phosphorylation of Srp1p, the yeast nuclear localization signal receptor, in vitro and in vivo. Biochimie 79:247-259.
4. Bischoff, F. R., and P. Görlich. 1997. RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors. FEBS Lett. 419:249-254.
5. Bischoff, F. R., C. Klebe, J. Kretschmer, A. Wittinghofer, and H. Ponstingl. 1994. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Natl. Acad. Sci. USA 91:2587-2591.
6. Bischoff, F. R., H. Krebber, T. Kempt, I. Hermes, and H. Ponstingl. 1995. Human RanGTPase activating protein RanGap1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc. Natl. Acad. Sci. USA 92:1749-1753.
7. Bischoff, F. R., H. Krebber, E. Smirnova, W. Dong, and H. Ponstingl. 1995. Co-activation of RanGTPase and inhibition of GTP dissociation by RanGTP binding protein RanBP1. EMBO J. 14:705-715.
8. Boche, I., and E. Fanning. 1997. Nucleocytoplasmic recycling of the nuclear localization signal receptor α subunit in vivo is dependent on a nuclear export signal, energy, and RCC1. J. Cell Biol. 139:313-325.
9. Bonifaci, N., J. Moroianu, A. Radu, and G. Blobel. 1997. Karyopherin β2 mediates nuclear import of a mRNA binding protein. Proc. Natl. Acad. Sci. USA 94:5055-5060.
10. Bossie, M. A., C. DeHoratius, G. Barcelo, and P. Silver. 1992. A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast. Mol. Biol. Cell 3:875-893.
11. Brinkmann, U., E. Brinkmann, M. Gallo, and I. Pastan. 1995. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. Proc. Natl. Acad. Sci. USA 92:10427-10431.
12. Chi, N. C., E. J. Adam, G. D. Visser, and S. A. Adam. 1996. RanBP1 stabilizes the interaction of Ran with p97 in nuclear protein import. J. Cell Biol. 135:559-569.
13. Chi, N. C., E. J. H. Adam, and S. A. Adam. 1997. Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97. J. Biol. Chem. 272:6818-6822.
14. Chi, N. C., J. H. E. Adam, and S. A. Adam. 1995. Sequence and characterization of cytoplasmic nuclear protein import factor p97. J. Cell Biol. 130: 265-274.
15. Corbett, A. H., D. M. Koepp, G. Schlenstedt, M. S. Lee, A. K. Hopper, and P. A. Silver. 1995. Rna1p, a Ran/TC4 GTPase activating protein is required for nuclear import. J. Cell Biol. 130:1017-1026.
16. Corbett, A. H., and P. A. Silver. 1997. Nucleocytoplasmic transport of macromolecules. Microbiol. Mol. Biol. Rev. 61:193-211.
17. Davis, L. I., and G. R. Fink. 1990. The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61:965-978.
18. Deane, R., W. Schäfer, H. P. Zimmermann, L. Müller, D. Görlich, S. Prehn, H. Ponstingl, and F. R. Bischoff. 1997. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-β but interacts differently with RanBP1. Mol. Cell. Biol. 17:5087-5096.
19. DeHoratius, C., and P. A. Silver. 1996. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene. Mol. Biol. Cell 7:1835-1855.
20. Dingwall, C., and R. A. Laskey. 1991. Nuclear targeting sequences - a consensus? Trends Biochem. Sci. 16:178-181.
21. Floer, M., and G. Blobel. 1996. The nuclear transport factor karyopherin β binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J. Biol. Chem. 271:5313-5316.
22. Floer, M., G. Blobel, and M. Rexach. 1997. Disassembly of RanGTP-karyopherin β complex, an intermediate in nuclear protein import. J. Biol. Chem. 272:19538-19546.
23. Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90:1051-1060.
24. Fornerod, M., J. van Deursen, S. van Baal, A. Reynolds, D. Davis, K. G. Murti, J. Fransen, and G. Grosveld. 1997. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 16:807-816.
25. Fridell, R. A., R. Truant, L. Thorne, R. E. Benson, and B. R. Cullen. 1997. Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β. J. Cell Sci. 110:1325-1331.
26. Fukuda, M., S. Asano, T. Nakamura, M. Adachi, M. Yoshida, M. Yanagida, and E. Nishida. 1997. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390:308-311.
27. Goldfarb, D. S., J. Gariépy, G. Schoolnik, and R. D. Kornberg. 1986. Synthetic peptides as nuclear localization signals. Nature 322:641-644.
28. Görlich, D., M. Dabrowski, F. R. Bischoff, U. Kutay, P. Bork, E. Hartmann, S. Prehn, and E. Izaurralde. 1997. A novel class of RanGTP binding proteins. J. Cell Biol. 138:65-80.
29. Görlich, D., P. Henklein, R. A. Laskey, and E. Hartmann. 1996. A 41 aa motif in importin-α confers binding to importin-β and hence transit into the nucleus. EMBO J. 15:1810-1817.
30. Görlich, D., S. Kostka, R. Kraft, C. Dingwall, R. A. Laskey, E. Hartmann, and S. Prehn. 1995. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr. Biol. 5:383-392.
31. Görlich, D., R. Kraft, S. Kostka, F. Vogel, E. Hartmann, R. A. Laskey, I. W. Mattaj, and E. Izaurralde. 1996. Importin provides a link between nuclear protein import and U snRNA export. Cell 87:21-32.
32. Görlich, D., and I. W. Mattaj. 1996. Nucleocytoplasmic transport. Science 271:1513-1518.
33. Görlich, D., N. Panté, U. Kutay, U. Aebi, and F. R. Bischoff. 1996. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J. 15:5584-5594.
34. Guthrie, C., and G. R. Fink (ed.). 1991. Guide to yeast genetics and molecular biology. Methods Enzymol. 194:1-21.
35. +RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. J. Cell Biol. 131:1677-1697.
36. Hopper, A. K., L. D. Schultz, and R. A. Shapiro. 1980. Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs. Cell 19:741-751.
37. Hurt, D. J., S. S. Wang, Y. H. Lin, and A. K. Hopper. 1987. Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing. Mol. Cell. Biol. 7:1208-1216.
38. Iovine, M. K., and S. R. Wente. 1997. A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p. J. Cell Biol. 137:797-811.
39. Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81:269-278.
40. Izaurralde, E., U. Kutay, C. v. Kobbe, I. W. Mattaj, and D. Görlich. 1997. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J. 16:6535-6547.
41. Izaurralde, E., J. Lewis, C. Gamberi, A. Jarmolowski, C. McGuigan, and I. W. Mattaj. 1995. A cap-binding protein complex mediating U snRNA export. Nature 376:709-712.
42. Koepp, D. M., D. H. Wong, A. H. Corbett, and P. A. Silver. 1996. Dynamic localization of the nuclear import receptor and its interactions with transport factors. J. Cell Biol. 133:1163-1176.
43. Küssel, P., and M. Frasch. 1995. Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis. Mol. Gen. Genet. 248:351-363.
44. Kutay, U., F. R. Bischoff, S. Kostka, R. Kraft, and D. Görlich. 1997. Export of importin a from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061-1071.
45. Kutay, U., E. Izaurralde, F. R. Bischoff, I. W. Mattaj, and D. Görlich. 1997. Dominant-negative mutants of importin-β block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16:1153-1163.
46. Kutay, U., G. Lipowsky, E. Izaurralde, F. R. Bischoff, P. Schwarzmaier, E. Hartmann, and D. Görlich. 1998. Identification of a tRNA-specific nuclear export receptor. Mol. Cell 1:359-369.
47. Loeb, J. D. L., G. Schlenstedt, D. Pellman, D. Kornitzer, P. A. Silver, and G. R. Fink. 1995. The yeast nuclear import receptor is required for mitosis. Proc. Natl. Acad. Sci. USA 92:7647-7651.
48. Lounsbury, K. M., and I. G. Macara. 1997. Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin β and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin β. J. Biol. Chem. 272:551-555.
49. Michael, W. M., M. Choi, and G. Dreyfuss. 1995. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83:415-422.
50. Nigg, E. A. 1997. Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386:779-787.
51. Nonet, M., C. Scafe, J. Sexton, and R. Young. 1987. Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol. Cell. Biol. 7:1602-1611.
52. Ohno, M., M. Fornerod, and I. W. Mattaj. 1998. Nucleocytoplasmic transport: the last 200 nanometers. Cell 92:327-336.
53. Ossareh-Nazari, B., F. Bachelerie, and C. Dargemont. 1997. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278:141-144.
54. Pemberton, L. F., S. R. Rosenblum, and G. Blobel. 1997. A distinct parallel pathway for the nuclear import of an mRNA-binding protein. J. Cell Biol. 139:1645-1653.
55. Pollard, V. W., W. M. Michael, S. Nakielny, M. C. Siomi, F. Wang, and G. Dreyfuss. 1996. A novel receptor-mediated nuclear protein import pathway. Cell 86:985-994.
56. Rexach, M., and G. Blobel. 1995. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83:683-692.
57. Rosenblum, S. R., L. F. Pemberton, and G. Blobel. 1997. A nuclear import pathway for a protein involved in tRNA maturation. J. Cell Biol. 139:1655-1661.
58. Rout, M. P., G. Blobel, and J. D. Aitchison. 1997. A distinct nuclear import pathway used by ribosomal proteins. Cell 89:715-725.
59. Scherer, S., and R. W. Davis. 1979. Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc. Natl. Acad. Sci. USA 76:4951-4955.
60. Scherf, U., I. Pastan, M. C. Willingham, and U. Brinkmann. 1995. The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle. Proc. Natl. Acad. Sci. USA 93:2670-2674.
61. Schlenstedt, G. 1996. Protein import into the nucleus. FEBS Lett. 389:75-79.
62. +RNA in the cytoplasm. Proc. Natl. Acad. Sci. USA 92:225-229.
63. Schlenstedt, G., E. Smirnova, R. Deane, J. Solsbacher, U. Kutay, D. Görlich, H. Ponstingl, and F. R. Bischoff. 1997. Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. EMBO J. 16:6237-6249.
64. Schlenstedt, G., D. H. Wong, D. M. Koepp, and P. A. Silver. 1995. Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J. 14:5367-5378.
65. Seedorf, M., and P. A. Silver. 1997. Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc. Natl. Acad. Sci. USA 94:8590-8595.
66. Shulga, N., P. Roberts, Z. Gu, L. Spitz, M. M. Tabb, M. Nomura, and D. S. Goldfarb. 1997. In vivo nuclear transport kinetics in Saccharomyces cerevisiae: a role for heat shock protein 70 during targeting and translocation. J. Cell Biol. 135:329-339.
67. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
68. Siomi, M. C., P. S. Eder, N. Kataoka, L. Wan, Q. Liu, and G. Dreyfuss. 1997. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J. Cell Biol. 138:1181-1192.
69. Solsbacher, J., and G. Schlenstedt. Unpublished data.
70. Stade, K., C. S. Ford, C. Guthrie, and K. Weis. 1997. Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90:1041-1050.
71. Taura, T., G. Schlenstedt, and P. A. Silver. 1997. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. J. Biol. Chem. 272: 31877-31884.
72. Tollervey, D., H. Lehtonen, R. Jansen, H. Kern, and E. C. Hurt. 1993. Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. Cell 72:443-457.
73. Ullman, K. S., M. A. Powers, and D. J. Forbes. 1997. Nuclear export receptors: from importin to exportin. Cell 90:967-970.
74. Weis, K., C. Dingwall, and A. I. Lamond. 1996. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J. 15:7120-7128.
75. Weis, K., U. Ryder, and A. I. Lamond. 1996. The conserved amino-terminal domain of hSRP1α is essential for nuclear import. EMBO J. 15:1818-1825.
76. Wong, D. H., A. H. Corbett, H. M. Kent, M. Stewart, and P. A. Silver. 1997. Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport. Mol. Cell. Biol. 17:3755-3767.
77. Xiao, Z., J. T. McGrew, A. J. Schroeder, and M. Fitzgerald-Hayes. 1993. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:4691-4702.
78. Yano, R., M. Oakes, M. M. Tabb, and M. Nomura. 1992. Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations in Saccharomyces cerevisiae. Mol. Cell. Biol. 12:5640-5651.