메뉴 건너뛰기




Volumn 15, Issue 8, 1996, Pages 1810-1817

A 41 amino acid motif in importin-α confers binding to importin-β and hence transit into the nucleus

Author keywords

IBB domain; Importin; Nuclear pore; Nuclear transport; Ran

Indexed keywords

KARYOPHERIN;

EID: 0029921174     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00530.x     Document Type: Article
Times cited : (370)

References (34)
  • 1
    • 0028217405 scopus 로고
    • Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
    • Adam, E J. and Adam, S.A. (1994) Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. J. Cell Biol., 125, 547-555.
    • (1994) J. Cell Biol. , vol.125 , pp. 547-555
    • Adam, E.J.1    Adam, S.A.2
  • 2
    • 0026042170 scopus 로고
    • Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
    • Adam, S.A. and Gerace, L (1991) Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell, 66, 837-847.
    • (1991) Cell , vol.66 , pp. 837-847
    • Adam, S.A.1    Gerace, L.2
  • 3
    • 0025083331 scopus 로고
    • Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
    • Adam, S.A., Sterne-Marr, R. and Gerace, L. (1990) Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J. Cell Biol., 111, 807-816.
    • (1990) J. Cell Biol. , vol.111 , pp. 807-816
    • Adam, S.A.1    Sterne-Marr, R.2    Gerace, L.3
  • 5
    • 0029392854 scopus 로고
    • HEAT repeats in Huntington's disease protein
    • Bork, P. and Andrade, M.A. (1995) HEAT repeats in Huntington's disease protein. Nature Genet., 11, 115-116.
    • (1995) Nature Genet. , vol.11 , pp. 115-116
    • Bork, P.1    Andrade, M.A.2
  • 6
    • 0029115837 scopus 로고
    • Sequence and characterization of cytoplasmic nuclear protein import factor P97
    • Chi, N.C., Adam, E.J.H and Adam, S.A. (1995) Sequence and characterization of cytoplasmic nuclear protein import factor P97. J. Cell Biol., 130, 265-274.
    • (1995) J. Cell Biol. , vol.130 , pp. 265-274
    • Chi, N.C.1    Adam, E.J.H.2    Adam, S.A.3
  • 7
    • 0027994484 scopus 로고
    • RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1
    • Cortes, P., Ye, Z.S. and Baltimore, D. (1994) RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc. Natl Acad. Sci. USA, 91, 7633-7637
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 7633-7637
    • Cortes, P.1    Ye, Z.S.2    Baltimore, D.3
  • 8
    • 0028239241 scopus 로고
    • Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein
    • Cuomo, C.A. Kirch, S.A., Gyuris, J , Brent, R. and Oettinger, M.A. (1994) Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc. Natl Acad. Sci USA, 91, 6156-6160.
    • (1994) Proc. Natl Acad. Sci USA , vol.91 , pp. 6156-6160
    • Cuomo, C.A.1    Kirch, S.A.2    Gyuris, J.3    Brent, R.4    Oettinger, M.A.5
  • 9
    • 0020188311 scopus 로고
    • A polypeptide domain that specifies migration of nucleoplasmin into the nucleus
    • Dingwall, C, Sharnick, S.V. and Laskey, R.A. (1982) A polypeptide domain that specifies migration of nucleoplasmin into the nucleus. Cell, 30, 449-458.
    • (1982) Cell , vol.30 , pp. 449-458
    • Dingwall, C.1    Sharnick, S.V.2    Laskey, R.A.3
  • 10
    • 0021717131 scopus 로고
    • Movement of karyophilic protein through the nuclear pores of oocytes
    • Feldherr, C M., Kallenbach, E and Schultz, N. (1984) Movement of karyophilic protein through the nuclear pores of oocytes. J. Cell Biol., 99, 2216-2222.
    • (1984) J. Cell Biol. , vol.99 , pp. 2216-2222
    • Feldherr, C.M.1    Kallenbach, E.2    Schultz, N.3
  • 11
    • 0027937653 scopus 로고
    • Isolation of a protein that is essential for the first step of nuclear protein import
    • Göilich, D., Prehn, S., Laskey, R.A and Hartmann, E. (1994) Isolation of a protein that is essential for the first step of nuclear protein import. Cell, 79, 767-778.
    • (1994) Cell , vol.79 , pp. 767-778
    • Göilich, D.1    Prehn, S.2    Laskey, R.A.3    Hartmann, E.4
  • 12
    • 0029278621 scopus 로고
    • Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
    • Görlich, D., Kostka, S., Kraft, R., Dingwall, C., Laskey, R.A , Hartmann, E. and Prehn, S. (1995a) Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr. Biol., 5, 383-392.
    • (1995) Curr. Biol. , vol.5 , pp. 383-392
    • Görlich, D.1    Kostka, S.2    Kraft, R.3    Dingwall, C.4    Laskey, R.A.5    Hartmann, E.6    Prehn, S.7
  • 13
    • 0029059548 scopus 로고
    • Distinct functions for the 2 importin subunits in nuclear protein import
    • Görlich, D., Vogel, F., Mills, A D , Hartmann, E. and Laskey, R.A (1995b) Distinct functions for the 2 importin subunits in nuclear protein import. Nature, 377, 246-248
    • (1995) Nature , vol.377 , pp. 246-248
    • Görlich, D.1    Vogel, F.2    Mills, A.D.3    Hartmann, E.4    Laskey, R.A.5
  • 14
    • 0021167363 scopus 로고
    • Targeting of E.coli beta galactosidase to the nucleus in yeast
    • Hall, M.N., Hereford, L. and Herskowitz, I. (1984) Targeting of E.coli beta galactosidase to the nucleus in yeast Cell, 36, 1057-1065.
    • (1984) Cell , vol.36 , pp. 1057-1065
    • Hall, M.N.1    Hereford, L.2    Herskowitz, I.3
  • 16
    • 0029093824 scopus 로고
    • In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import
    • Imamoto, N., Shimamoto, T, Takao, T., Tachibana, T., Kose, S., Matsubae, M., Sekimoto, T., Shimonishi, Y. and Yoneda, Y. (1995b) In vivo evidence for involvement of a 58 kDa component of nuclear pore targeting complex in nuclear protein import. EMBO J., 14, 3617-3626.
    • (1995) EMBO J. , vol.14 , pp. 3617-3626
    • Imamoto, N.1    Shimamoto, T.2    Takao, T.3    Tachibana, T.4    Kose, S.5    Matsubae, M.6    Sekimoto, T.7    Shimonishi, Y.8    Yoneda, Y.9
  • 17
    • 0028970112 scopus 로고
    • A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding J
    • Imamoto, N., Tachibana, T., Matsubae, M. and Yoneda Y (1995c) A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore binding J. Biol. Chem., 270, 8559-8565.
    • (1995) Biol. Chem. , vol.270 , pp. 8559-8565
    • Imamoto, N.1    Tachibana, T.2    Matsubae, M.3    Yoneda, Y.4
  • 18
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon, D., Roberts, B.L., Richardson, W.D. and Smith, A E. (1984) A short amino acid sequence able to specify nuclear location. Cell, 39, 499-509.
    • (1984) Cell , vol.39 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 19
    • 0021670868 scopus 로고
    • Construction and characterisation of an SV40 mutant defective in nuclear transport of T antigen
    • Lanford, R.E. and Butel, J S (1984) Construction and characterisation of an SV40 mutant defective in nuclear transport of T antigen. Cell, 37, 801-813
    • (1984) Cell , vol.37 , pp. 801-813
    • Lanford, R.E.1    Butel, J.S.2
  • 20
    • 0027714921 scopus 로고
    • Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
    • Melchior, F., Paschal, B., Evans, J. and Gerace, L. (1993) Inhibition of nuclear protein import by nonhydrolyzable analogs of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol , 123, 1649-1659.
    • (1993) J. Cell Biol , vol.123 , pp. 1649-1659
    • Melchior, F.1    Paschal, B.2    Evans, J.3    Gerace, L.4
  • 21
    • 0019332580 scopus 로고
    • An acid protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei
    • Mills, A.D., Laskey, R.A., Black, B. and De Robertis, E M. (1980) An acid protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei. J. Mol. Biol., 139, 561-568.
    • (1980) J. Mol. Biol. , vol.139 , pp. 561-568
    • Mills, A.D.1    Laskey, R.A.2    Black, B.3    De Robertis, E.M.4
  • 22
    • 0026723508 scopus 로고
    • The 2 steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore-require different cytosolic factors
    • Moore, M.S and Blobel, G (1992) The 2 steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore-require different cytosolic factors. Cell, 69, 939-950.
    • (1992) Cell , vol.69 , pp. 939-950
    • Moore, M.S.1    Blobel, G.2
  • 23
    • 0027376308 scopus 로고
    • The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
    • Moore, M.S. and Blobel, G. (1993) The GTP-binding protein Ran/TC4 is required for protein import into the nucleus Nature, 365, 661-663.
    • (1993) Nature , vol.365 , pp. 661-663
    • Moore, M.S.1    Blobel, G.2
  • 24
    • 0028170744 scopus 로고
    • Purification of a Ran-interacting protein that is required for protein import into the nucleus
    • Moore, M.S. and Blobel, G (1994) Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc. Natl Acad. Sci. USA, 91, 10212-10216.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10212-10216
    • Moore, M.S.1    Blobel, G.2
  • 25
    • 0028962511 scopus 로고
    • Previously identified protein of uncertain function is karyopherin α and together with karyopherin β docks import substrate at nuclear pore complexes
    • Moroianu, J., Blobel, G. and Radu, A. (1995a) Previously identified protein of uncertain function is karyopherin α and together with karyopherin β docks import substrate at nuclear pore complexes. Proc. Natl Acad. Sci. USA, 92, 2008-2011
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 2008-2011
    • Moroianu, J.1    Blobel, G.2    Radu, A.3
  • 26
    • 0028983494 scopus 로고
    • Mammalian karyopherin αlb and α2b heterodimers: α1 or α2 subunit binds nuclear localization sequence and β subunit interacts with peptide repeat containing nucleoporins
    • Moroianu, J., Hijikata, M , Blobel, G and Radu, A (1995b) Mammalian karyopherin αlb and α2b heterodimers: α1 or α2 subunit binds nuclear localization sequence and β subunit interacts with peptide repeat containing nucleoporins. Proc. Natl Acad Sci. USA, 92, 6532-6536.
    • (1995) Proc. Natl Acad Sci. USA , vol.92 , pp. 6532-6536
    • Moroianu, J.1    Hijikata, M.2    Blobel, G.3    Radu, A.4
  • 27
    • 0024284086 scopus 로고
    • Nuclear import can be separated into distinct steps in vitro nuclear pore binding and translocation
    • Newmeyer, D.D. and Forbes, D.J. (1988) Nuclear import can be separated into distinct steps in vitro nuclear pore binding and translocation. Cell, 52, 641-653.
    • (1988) Cell , vol.52 , pp. 641-653
    • Newmeyer, D.D.1    Forbes, D.J.2
  • 28
    • 0029027836 scopus 로고
    • Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62
    • Paschal,B.M. and Gerace, L. (1995) Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore protein p62. J. Cell Biol., 129, 925-937.
    • (1995) J. Cell Biol. , vol.129 , pp. 925-937
    • Paschal, B.M.1    Gerace, L.2
  • 29
    • 0028266975 scopus 로고
    • A repeating amino acid motif shared by proteins with diverse cellular roles
    • Peifer, M., Berg, S. and Reynolds, A.B (1994) A repeating amino acid motif shared by proteins with diverse cellular roles. Cell, 76, 789-791.
    • (1994) Cell , vol.76 , pp. 789-791
    • Peifer, M.1    Berg, S.2    Reynolds, A.B.3
  • 30
    • 0028950991 scopus 로고
    • Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
    • Radu, A., Blobel, G. and Moore, M.S. (1995) Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc. Natl Acad. Sci. USA, 92, 1769-1773.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1769-1773
    • Radu, A.1    Blobel, G.2    Moore, M.S.3
  • 31
    • 0023852444 scopus 로고
    • Nuclear protein migration involves 2 steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
    • Richardson, W.D., Mills, A D., Dilworth, S.M., Laskey, R.A. and Dingwall, C. (1988) Nuclear protein migration involves 2 steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell, 52, 655-664.
    • (1988) Cell , vol.52 , pp. 655-664
    • Richardson, W.D.1    Mills, A.D.2    Dilworth, S.M.3    Laskey, R.A.4    Dingwall, C.5
  • 32
    • 0029064439 scopus 로고
    • The overgrown hematopoietic organs-31 tumour suppressor gene of Drosophila encodes an importin-like protein accumulating in the nucleus at the onset of mitosis
    • Török, I., Strand, D., Schmitt, R., Tick, G., Török, T., Kiss, I. and Mechler, B.M. (1995) The overgrown hematopoietic organs-31 tumour suppressor gene of Drosophila encodes an importin-like protein accumulating in the nucleus at the onset of mitosis. J. Cell Biol., 129, 1473-1489.
    • (1995) J. Cell Biol. , vol.129 , pp. 1473-1489
    • Török, I.1    Strand, D.2    Schmitt, R.3    Tick, G.4    Török, T.5    Kiss, I.6    Mechler, B.M.7
  • 33
    • 0028988731 scopus 로고
    • Identification of hSRP1a as a functional receptor for nuclear localisation sequences
    • Weis, K., Mattaj, I.W. and Lamond, A.I. (1995) Identification of hSRP1a as a functional receptor for nuclear localisation sequences. Science, 268, 1049-1051.
    • (1995) Science , vol.268 , pp. 1049-1051
    • Weis, K.1    Mattaj, I.W.2    Lamond, A.I.3
  • 34
    • 0026490039 scopus 로고
    • Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae
    • Yano, R., Oakes, M., Yamaghishi, M., Dodd, J.A. and Nomura, M. (1992) Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae. Mol. Cell. Biol., 12, 5640-5651.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5640-5651
    • Yano, R.1    Oakes, M.2    Yamaghishi, M.3    Dodd, J.A.4    Nomura, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.