A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

Cell

Volumn 88, Issue 1, 1997, Pages 97-107

  Mahajan, Rohit ^a   Delphin, Christian ^a   Guan, Tinglu ^a   Gerace, Larry ^a   Melchior, Frauke ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL NUCLEUS MEMBRANE; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER HOMOGENATE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT;

EID: 0030932134     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81862-0     Document Type: Article

References (45)

1. Bastos, R., Pante, N., and Burke, B. (1995). Nuclear pore complex proteins. Int. Rev. Cytol. 162B, 257-302.
2. Becker, J., Melchior, F., Gerke, V., Bischoff, F.R., Ponstingl, H., and Wittinghofer, A. (1995). RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J. Biol. Chem. 270, 11860-11865.
3. Bischoff, F.R., and Ponstingl, H. (1991). Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354, 80-82.
4. Bischoff, F.R., Klebe, C., Kretschmer, J., Wittinghofer, A., and Ponstingl, H. (1994). RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Natl. Acad. Sci. USA 91, 2587-2591.
5. Bischoff, F.R., Krebber, H., Kempf, T., Hermes, I., and Ponstingl, H. (1995a). Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc. Natl. Acad. Sci. USA 92, 1749-1753.
6. Bischoff, F.R., Krebber, H., Smirnova, E., Dong, W., and Ponstingl, H. (1995b). Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. EMBO J. 14, 705-715.
7. Bourne, H.R., Sanders, D.A., and McCormick, F. (1990). The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348, 125-132.
8. Ciechanover, A. (1994). The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21.
9. Corbett, A.H., Koepp, D.M., Schlenstedt, G., Lee, M.S., Hopper, A.K., and Silver, P.A. (1995). Rna1 p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J. Cell Biol. 130, 1017-1026.
10. Dasso, M., Seki, T., Ohba, T., and Nishimoto, T. (1994). A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation. EMBO J. 13, 5732-5744.
11. DeGregori, J., RUSS, A., von Melchner, H., Rayburn, H., Priyaranjan, P., Jenkins, N.A., Copeland, N.G., and Ruley, H.E. (1994). A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 8, 265-276.
12. Floer, M., and Blobel, G. (1996). The nuclear transport factor kary-opherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. J. Biol. Chem. 271, 5313-5316.
13. Görlich, D., and Mattaj, I.W. (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.
14. Görlich, D., Vogel, F., Mille, A.D., Hartmann, E., and Laskey, R.A. (1995). Distinct functions for the two importin subunits in nuclear protein import. Nature 377, 246-248.
15. Hochstrasser, M. (1995). Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol. 7, 215-223.
16. Hochstrasser, M. (1996). Protein degradation or regulation: Ub the judge. Cell 84, 813-815.
17. Hopper, A.K., Traglia, H.M., and Dunst, R.W. (1990). The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus. J. Cell Biol. 111, 309-321.
18. Hu, T., Guan, T., and Gerace, L. (1996). Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. J. Cell Biol. 134, 589-601.
19. Kumar, S., Yoshida, Y., and Noda, M. (1993). Cloning of a cDNA which encodes a novel ubiquitin-like protein. Biochem. Biophys. Res. Commun. 195, 393-399.
20. Lennon, G.G., Auffray, C., Polymeropoulos, M., and Soares, M.B. (1996). The I. M. A. G. E. consortium: an integrated molecular analysis of genomes and their expression. Genomics 33, 151-152.
21. Mannen, H., Tseng, H.M., Cho, C.L., and Li, S.S. (1996). Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. Biochem. Biophys. Res. Commun. 222, 178-180.
22. Melchior, F., and Gerace, L. (1995). Mechanisms of nuclear protein import. Curr. Opin. Cell Biol. 7, 310-318.
23. Melchior, F., Paschal, B., Evans, J., and Gerace, L. (1993a). Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123, 1649-1659.
24. Melchior, F., Weber, K., and Gerke, V. (1993b). A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif. Mol. Biol. Cell 4, 569-581.
25. Melchior, F., Guan, T., Yokoyama, N., Nishimoto, T., and Gerace, L. (1995a). GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. J. Cell Biol. 131, 571-581.
26. Melchior, F., Sweet, D.J., and Gerace, L. (1995b). Analysis of Ran/TC4 function in nuclear protein import. Methods Enzymol. 257, 279-291.
27. Meluh, P.B., and Koshland, D. (1995). Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol. Biol. Cell 6, 793-807.
28. Moore, M.S., and Blobel, G. (1993). The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365, 661-663.
29. Nehrbass, U., and Blobel, G. (1996). Role of the nuclear transport factor p10 in nuclear import. Science 272, 120-122.
30. Ohtsubo, M., Kai, R., Furuno, N., Sekiguchi, T., Sekiguchi, M., Hayashida, M., Kuma, K., Miyata, T., Fukushige, S., Murotsu., T., Matsubara, K., and Nishimoto, T. (1987). Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Genes Dev. 1, 585-593.
31. Panté, N., and Aebi, U. (1996a). Toward the molecular dissection of protein import into nuclei. Curr. Opin. Cell Biol. 8, 397-406.
32. Panté, N., and Aebi, U. (1996b). Sequential binding of import ligands to distinct nucleopore regions during their nuclear import. Science 273, 1729-1732.
33. Paschal, B.M., and Gerace, L. (1995). Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. J. Cell Biol. 129, 925-937.
34. Paschal, B.M., Delphin, C., and Gerace, L. (1996). Nucleotide specific interaction of Ran/TC4 with nuclear transport factor NTF2 and p97. Proc. Natl. Acad. Sci. USA 93, 7679-7683.
35. Rexach, M., and Blobel, G. (1995). Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83, 683-692.
36. Rout, M.P., and Wente, S.R. (1994). Pores for thought: nuclear pore complex proteins. Trends Cell Biol. 4, 357-365.
37. Saitoh, H., and Dasso, M. (1995). The RCC1 protein interacts with Ran, RanBP1, hsc70, and a 340-kDa protein in Xenopus extracts. J. Biol. Chem. 270, 10658-10663.
38. Saitoh, H., Cooke, C.A., Burgess, W.H., Earnshaw, W.C., and Dasso, M. (1996). Direct and indirect association of the small GTPase Ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts. Mol. Biol. Cell 7, 1319-1334.
39. Sazer, S. (1996). The search for the primary function of the Ran GTPase continues. Trends Cell Biol. 6, 81-85.
40. Snow, C.M., Senior, A., and Gerace, L. (1987). Monoclonal antibodies identify a group of nuclear pore complex glycoproteins. J. Cell Biol. 704, 1143-1156.
41. Sweet, D.J., and Gerace, L. (1995). Taking from the cytoplasm and giving to the pore: soluble transport factors in nuclear protein import. Trends Cell Biol. 5, 444-447.
42. Sweet, D.J., and Gerace, L. (1996). A GTPase distinct from Ran is involved in nuclear protein import. J. Cell Biol. 133, 971-983.
43. Traglia, H.M., Atkinson, N.S., and Hopper, A.K. (1989). Structural and functional analyses of Saccharomyces cerevisiae wild-type and mutant RNA1 genes. Mol. Cell. Biol. 9, 2989-2999.
44. Wu, J., Matunis, M.J., Kraemer, D., Blobel, G., and Coutavas, E. (1995). Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J. Biol. Chem. 270, 14209-14213.
45. Yokoyama, N., Hayashi, N., Seki, T., Panté, N., Ohba, T., Nishii, K., Kuma, K., Hayashida, T., Miyata, T., Aebi, U., Fukui, M., and Nishimoto, T. (1995). A giant nucleopore protein that binds Ran/TC4. Nature 376,184-188.