-
1
-
-
0022556211
-
Antigen-driven selection of virgin and memory B cells
-
MacLennan IC, Gray D: Antigen-driven selection of virgin and memory B cells. Immunol Rev 1986, 91:61-85.
-
(1986)
Immunol Rev
, vol.91
, pp. 61-85
-
-
MacLennan, I.C.1
Gray, D.2
-
2
-
-
0031861905
-
Long-lived plasma cells: A mechanism for maintaining persistent antibody production
-
Slifka MK, Ahmed R: Long-lived plasma cells: A mechanism for maintaining persistent antibody production. Curr Opin Immunol 1998, 10:252-258.
-
(1998)
Curr Opin Immunol
, vol.10
, pp. 252-258
-
-
Slifka, M.K.1
Ahmed, R.2
-
3
-
-
0030001674
-
Immunological memory and protective immunity: Understanding their relation
-
Ahmed R, Gray D: Immunological memory and protective immunity: Understanding their relation. Science 1996, 272:54-60.
-
(1996)
Science
, vol.272
, pp. 54-60
-
-
Ahmed, R.1
Gray, D.2
-
5
-
-
0031213648
-
Immune response decisions at the single cell level
-
McHeyzer-Williams MG: Immune response decisions at the single cell level. Semin Immunol 1997, 9:219-227.
-
(1997)
Semin Immunol
, vol.9
, pp. 219-227
-
-
McHeyzer-Williams, M.G.1
-
6
-
-
0342711256
-
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
-
Lam KP, Kuhn R, Rajewsky K: In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997, 90:1073-1083. This study highlights the role of surface immunoglobulin expression in the survival of mature, naïve B cells. Inducible ablation of surface immunoglobulin through deletion of variable-region genes in peripheral B cells leads to rapid cell death which is preceded by a decrease in MHC class II expression and an increase in Fas.
-
(1997)
Cell
, vol.90
, pp. 1073-1083
-
-
Lam, K.P.1
Kuhn, R.2
Rajewsky, K.3
-
7
-
-
0032479526
-
Visualization of specific B and T lymphocyte interactions in the lymph node
-
Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK: Visualization of specific B and T lymphocyte interactions in the lymph node. Science 1998, 281:96-99. These workers adoptively transferred antigen-specific B cells and antigen- specific helper T cells to visualize the earliest cognate T-B interactions in the outer T-cell-rich regions of peripheral lymph nodes.
-
(1998)
Science
, vol.281
, pp. 96-99
-
-
Garside, P.1
Ingulli, E.2
Merica, R.R.3
Johnson, J.G.4
Noelle, R.J.5
Jenkins, M.K.6
-
8
-
-
0030936275
-
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
-
Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharps AH: B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 1997, 6:303-313.
-
(1997)
Immunity
, vol.6
, pp. 303-313
-
-
Borriello, F.1
Sethna, M.P.2
Boyd, S.D.3
Schweitzer, A.N.4
Tivol, E.A.5
Jacoby, D.6
Strom, T.B.7
Simpson, E.M.8
Freeman, G.J.9
Sharps, A.H.10
-
9
-
-
0032142893
-
CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells
-
Cerutti A, Schaffer A, Shah S, Zan H, Liou HC, Goodwin RG, Casali P: CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells. Immunity 1998, 9:247-256.
-
(1998)
Immunity
, vol.9
, pp. 247-256
-
-
Cerutti, A.1
Schaffer, A.2
Shah, S.3
Zan, H.4
Liou, H.C.5
Goodwin, R.G.6
Casali, P.7
-
10
-
-
0032167549
-
Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes
-
Dubois B, Massacrier C, Vanbervliet B, Fayette J, Briere F, Banchereau J, Caux C: Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J Immunol 1998, 161:2223-2231.
-
(1998)
J Immunol
, vol.161
, pp. 2223-2231
-
-
Dubois, B.1
Massacrier, C.2
Vanbervliet, B.3
Fayette, J.4
Briere, F.5
Banchereau, J.6
Caux, C.7
-
11
-
-
0030917141
-
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
-
Hanissian SH, Geha RS: Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 1997, 6:379-387.
-
(1997)
Immunity
, vol.6
, pp. 379-387
-
-
Hanissian, S.H.1
Geha, R.S.2
-
12
-
-
0031041644
-
Germinal center founder cells display propensity for apoptosis before onset of somatic mutation
-
Lebecque S, de Bouteiller O, Arpin C, Banchereau J, Liu YJ: Germinal center founder cells display propensity for apoptosis before onset of somatic mutation. J Exp Med 1997, 185:563-571. This study analyzes the physiology of GC founder cells (expressing IgM, IgD, CD10 and CD38) and places the susceptibility to apoptosis in GC B cells before the onset of somatic hypermutation, thereby allowing for the selection of germline variable-region genes that has been seen in many systems.
-
(1997)
J Exp Med
, vol.185
, pp. 563-571
-
-
Lebecque, S.1
De Bouteiller, O.2
Arpin, C.3
Banchereau, J.4
Liu, Y.J.5
-
13
-
-
0031984671
-
A periarteriolar lymphoid sheath-associated B cell focus response is not observed during the development of the anti-arsonate germinal center reaction
-
Vora KA, Tumas-Brundage KM, Manser T: A periarteriolar lymphoid sheath-associated B cell focus response is not observed during the development of the anti-arsonate germinal center reaction. J Immunol 1998, 160:728-733.
-
(1998)
J Immunol
, vol.160
, pp. 728-733
-
-
Vora, K.A.1
Tumas-Brundage, K.M.2
Manser, T.3
-
14
-
-
0030582773
-
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
-
Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M: A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996, 87:1037-1047.
-
(1996)
Cell
, vol.87
, pp. 1037-1047
-
-
Forster, R.1
Mattis, A.E.2
Kremmer, E.3
Wolf, E.4
Brem, G.5
Lipp, M.6
-
15
-
-
1842333856
-
Abnormal expression of the B-cell homing chemokine receptor BLR1 during the progression of acquired immunodeficiency syndrome
-
Forster R, Schweigard G, Johann S, Emrich T, Kremmer E, Nerl C, Lipp M: Abnormal expression of the B-cell homing chemokine receptor BLR1 during the progression of acquired immunodeficiency syndrome. Blood 1997, 90:520-525.
-
(1997)
Blood
, vol.90
, pp. 520-525
-
-
Forster, R.1
Schweigard, G.2
Johann, S.3
Emrich, T.4
Kremmer, E.5
Nerl, C.6
Lipp, M.7
-
16
-
-
0032545987
-
A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
-
Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT: A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 1998, 391:799-803. This study describes a novel chemokine (BLC) that can stimulate cells transfected with BLR-1 (an orphan chemokine receptor described in [14]), suggesting that BLC may be the chemokine that guides B cells to follicles in secondary lymphoid organs.
-
(1998)
Nature
, vol.391
, pp. 799-803
-
-
Gunn, M.D.1
Ngo, V.N.2
Ansel, K.M.3
Ekland, E.H.4
Cyster, J.G.5
Williams, L.T.6
-
17
-
-
0032536373
-
B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
-
Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 1998, 187:655-660.
-
(1998)
J Exp Med
, vol.187
, pp. 655-660
-
-
Legler, D.F.1
Loetscher, M.2
Roos, R.S.3
Clark-Lewis, I.4
Baggiolini, M.5
Moser, B.6
-
18
-
-
0032490628
-
Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells
-
Ngo VN, Tang HL, Cyster JG: Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 1998, 188:181-191. These workers isolated the murine equivalent of the chemokine ELC (i.e. acting through CCR7) and characterized its constitutive expression in dendritic cells of the T-cell-rich regions. This chemokine is strongly chemotactic for resting T cells and activated B cells, implying an important role at the earliest stages of a immune response.
-
(1998)
J Exp Med
, vol.188
, pp. 181-191
-
-
Ngo, V.N.1
Tang, H.L.2
Cyster, J.G.3
-
19
-
-
0031841686
-
EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: Activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC
-
Yoshida R, Nagira M, Imai T, Baba M, Takagi S, Tabira Y, Akagi J, Nomiyama H, Yoshie O: EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: Activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC. Int Immunol 1998, 10:901-910.
-
(1998)
Int Immunol
, vol.10
, pp. 901-910
-
-
Yoshida, R.1
Nagira, M.2
Imai, T.3
Baba, M.4
Takagi, S.5
Tabira, Y.6
Akagi, J.7
Nomiyama, H.8
Yoshie, O.9
-
20
-
-
0031892090
-
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
-
Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT: A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci USA 1998, 95:258-263.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 258-263
-
-
Gunn, M.D.1
Tangemann, K.2
Tam, C.3
Cyster, J.G.4
Rosen, S.D.5
Williams, L.T.6
-
21
-
-
0031867534
-
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7
-
Willimann K, Legler DF, Loetscher M, Roos RS, Delgado MB, Clark-Lewis I, Baggiolini M, Moser B: The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur J Immunol 1998, 28:2025-2034.
-
(1998)
Eur J Immunol
, vol.28
, pp. 2025-2034
-
-
Willimann, K.1
Legler, D.F.2
Loetscher, M.3
Roos, R.S.4
Delgado, M.B.5
Clark-Lewis, I.6
Baggiolini, M.7
Moser, B.8
-
22
-
-
0032479869
-
Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells
-
Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, Seidl T, Andersson J, Melchers F, Rolink AG, Sideras P: Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med 1998, 188:451-463. This provides the description of a novel CC chemokine (ABCD-1), which is produced in large amounts by activated B cells and appears to act selectively on activated T cells. It is another key component in the development of a primary immune response and the formation of the GC reaction.
-
(1998)
J Exp Med
, vol.188
, pp. 451-463
-
-
Schaniel, C.1
Pardali, E.2
Sallusto, F.3
Speletas, M.4
Ruedl, C.5
Shimizu, T.6
Seidl, T.7
Andersson, J.8
Melchers, F.9
Rolink, A.G.10
Sideras, P.11
-
23
-
-
0029991923
-
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
-
Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD: Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 1996, 271:1289-1291.
-
(1996)
Science
, vol.271
, pp. 1289-1291
-
-
Matsumoto, M.1
Mariathasan, S.2
Nahm, M.H.3
Baranyay, F.4
Peschon, J.J.5
Chaplin, D.D.6
-
24
-
-
0006379753
-
Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
-
Matsumoto M, Lo SF, Carruthers CJL, Min J, Mariathasan S, Huang G, Plas DR, Martin SM, Geha RS, Nahm MH, Chaplin DD: Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature 1996, 382:462-466.
-
(1996)
Nature
, vol.382
, pp. 462-466
-
-
Matsumoto, M.1
Lo, S.F.2
Carruthers, C.J.L.3
Min, J.4
Mariathasan, S.5
Huang, G.6
Plas, D.R.7
Martin, S.M.8
Geha, R.S.9
Nahm, M.H.10
Chaplin, D.D.11
-
25
-
-
0030902491
-
Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
-
-/- animals. These studies imply that ectopic formation of GC-like microenvironments may underpin affinity maturation previously reported to occur in the absence of splenic GCs [24].
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5739-5743
-
-
Fu, Y.X.1
Huang, G.2
Matsumoto, M.3
Molina, H.4
Chaplin, D.D.5
-
26
-
-
0032489920
-
B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
-
Fu YX, Huang G, Wang Y, Chaplin DD: B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med 1998, 187:1009-1018.
-
(1998)
J Exp Med
, vol.187
, pp. 1009-1018
-
-
Fu, Y.X.1
Huang, G.2
Wang, Y.3
Chaplin, D.D.4
-
27
-
-
0030917003
-
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
-
Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA: Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 1997, 6:491-500.
-
(1997)
Immunity
, vol.6
, pp. 491-500
-
-
Koni, P.A.1
Sacca, R.2
Lawton, P.3
Browning, J.L.4
Ruddle, N.H.5
Flavell, R.A.6
-
28
-
-
0032127301
-
The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
-
Futterer A, Mink K, Luz A, Kosco-Vilbois MH, Pfeffer K: The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 1998, 9:59-70.
-
(1998)
Immunity
, vol.9
, pp. 59-70
-
-
Futterer, A.1
Mink, K.2
Luz, A.3
Kosco-Vilbois, M.H.4
Pfeffer, K.5
-
29
-
-
0032127288
-
Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
-
Rennert PD, James D, Mackay F, Browning JL, Hochman PS: Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity 1998, 9:71-79.
-
(1998)
Immunity
, vol.9
, pp. 71-79
-
-
Rennert, P.D.1
James, D.2
Mackay, F.3
Browning, J.L.4
Hochman, P.S.5
-
30
-
-
0031985287
-
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
-
Caamano JH, Rizzo CA, Durham SK, Barton DS, Raventos-Suarez C, Snapper CM, Bravo R: Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med 1998, 187:185-196.
-
(1998)
J Exp Med
, vol.187
, pp. 185-196
-
-
Caamano, J.H.1
Rizzo, C.A.2
Durham, S.K.3
Barton, D.S.4
Raventos-Suarez, C.5
Snapper, C.M.6
Bravo, R.7
-
31
-
-
0031964855
-
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
-
Franzoso G, Carlson L, Poljak L, Shores EW, Epstein S, Leonardi A, Grinberg A, Tran T, Scharton-Kersten T, Anver M et al.: Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med 1998, 187:147-159.
-
(1998)
J Exp Med
, vol.187
, pp. 147-159
-
-
Franzoso, G.1
Carlson, L.2
Poljak, L.3
Shores, E.W.4
Epstein, S.5
Leonardi, A.6
Grinberg, A.7
Tran, T.8
Scharton-Kersten, T.9
Anver, M.10
-
32
-
-
17144433112
-
Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions
-
Franzoso G, Carlson L, Scharton-Kersten T, Shores EW, Epstein S, Grinberg A, Tran T, Shacter E, Leonardi A, Anver M et al.: Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity 1997, 6:479-490. Using gene ablation, these studies implicate BCL-3 in responses of helper T cells and B cells in vivo. Splenic and LN architecture was disorganized, with impaired GC formation upon T-cell-dependent immunization.
-
(1997)
Immunity
, vol.6
, pp. 479-490
-
-
Franzoso, G.1
Carlson, L.2
Scharton-Kersten, T.3
Shores, E.W.4
Epstein, S.5
Grinberg, A.6
Tran, T.7
Shacter, E.8
Leonardi, A.9
Anver, M.10
-
33
-
-
0031933037
-
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc
-
Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH: Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity 1998, 8:125-134.
-
(1998)
Immunity
, vol.8
, pp. 125-134
-
-
Ranger, A.M.1
Hodge, M.R.2
Gravallese, E.M.3
Oukka, M.4
Davidson, L.5
Alt, F.W.6
De La Brousse, F.C.7
Hoey, T.8
Grusby, M.9
Glimcher, L.H.10
-
34
-
-
17144439800
-
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
-
Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RSK et al.: The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 1997, 16:161-170. Together with reference [35••], this paper shows that lack of BCL-6 results in an inflammatory response that targets multiple organs and appears due to an over-expression of Th2-type cytokines. While B cell and T cell development appears normal, T-cell-dependent antibody responses were grossly deficient - with defective isotype-switch and GC formation.
-
(1997)
Nat Genet
, vol.16
, pp. 161-170
-
-
Ye, B.H.1
Cattoretti, G.2
Shen, Q.3
Zhang, J.4
Hawe, N.5
De Waard, R.6
Leung, C.7
Nouri-Shirazi, M.8
Orazi, A.9
Chaganti, R.S.K.10
-
35
-
-
0030901289
-
Control of inflammation, cytokine expression, and germinal center formation by BCL-6
-
Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM: Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997, 276:589-592. See annotation [34••].
-
(1997)
Science
, vol.276
, pp. 589-592
-
-
Dent, A.L.1
Shaffer, A.L.2
Yu, X.3
Allman, D.4
Staudt, L.M.5
-
36
-
-
0028961269
-
Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro
-
Decker DJ, Linton PJ, Zaharevitz S, Biery M, Gingeras TR, Klinman NR: Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. Immunity 1995, 2:195-203.
-
(1995)
Immunity
, vol.2
, pp. 195-203
-
-
Decker, D.J.1
Linton, P.J.2
Zaharevitz, S.3
Biery, M.4
Gingeras, T.R.5
Klinman, N.R.6
-
37
-
-
0029879794
-
Somatic mutation of immunoglobulin V genes in vitro
-
Kallberg E, Jainandunsing S, Gray D, Leanderson T: Somatic mutation of immunoglobulin V genes in vitro. Science 1996, 271:1285-1289.
-
(1996)
Science
, vol.271
, pp. 1285-1289
-
-
Kallberg, E.1
Jainandunsing, S.2
Gray, D.3
Leanderson, T.4
-
38
-
-
0030992768
-
Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells
-
Lin MM, Zhu M, Scharff MD: Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells. Proc Natl Acad Sci USA 1997, 94:5284-5289.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5284-5289
-
-
Lin, M.M.1
Zhu, M.2
Scharff, M.D.3
-
39
-
-
0343417077
-
Induction of somatic mutation in a human B cell line in vitro
-
Denepoux S, Razanajaona D, Blanchard D, Meffre G, Capra JD, Banchereau J, Lebecque S: Induction of somatic mutation in a human B cell line in vitro. Immunity 1997, 6:35-46. While the frequency of somatic mutation in this Burkitt's lymphoma cell line is low, this study describes a long-awaited in vitro model of a cell line capable of somatic hypermutation upon cross-linking of surface immunoglobulin and coculture with activated T cells.
-
(1997)
Immunity
, vol.6
, pp. 35-46
-
-
Denepoux, S.1
Razanajaona, D.2
Blanchard, D.3
Meffre, G.4
Capra, J.D.5
Banchereau, J.6
Lebecque, S.7
-
40
-
-
0031041632
-
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
-
Tumas-Brundage K, Manser T: The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 1997, 185:239-250.
-
(1997)
J Exp Med
, vol.185
, pp. 239-250
-
-
Tumas-Brundage, K.1
Manser, T.2
-
41
-
-
0032127810
-
Somatic hypermutation in the heavy chain locus correlates with transcription
-
Fukita Y, Jacobs H, Rajewsky K: Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity 1998, 9:105-114.
-
(1998)
Immunity
, vol.9
, pp. 105-114
-
-
Fukita, Y.1
Jacobs, H.2
Rajewsky, K.3
-
42
-
-
0032101017
-
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
-
- B cells that expressed Vλ1 light chains (compared with naïve B cells) from an extensive series of mutant mouse strains that were deficient in DNA repair.
-
(1998)
J Exp Med
, vol.187
, pp. 1735-1743
-
-
Jacobs, H.1
Fukita, Y.2
Van Der Horst, G.T.J.3
De Boer, J.4
Weeda, G.5
Essers, J.6
De Wind, N.7
Engelward, B.P.8
Samson, L.9
Verbeek, S.10
-
43
-
-
0032549125
-
Mismatch repair co-opted by hypermutation
-
Cascalho M, Wong J, Steinberg C, Wabl M: Mismatch repair co-opted by hypermutation. Science 1998, 279:1207-1210. This is a study of somatic hypermutation in a cross between 'quasimonoclonal' mice and mice lacking a mismatch-repair gene pms2. The results implicate mismatch repair in 'fixing' introduced mutations in the newly synthesized DNA rather than eliminating them (as may have been expected).
-
(1998)
Science
, vol.279
, pp. 1207-1210
-
-
Cascalho, M.1
Wong, J.2
Steinberg, C.3
Wabl, M.4
-
44
-
-
0032127804
-
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
-
Rada C, Ehrenstein MR, Neuberger MS, Milstein C: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998, 9:135-141. This study describes a role for MSH2 underlying the 'hot spot' focusing of somatic mutation,which appears to precede a second phase that results in a more evenly spread array of mutations.
-
(1998)
Immunity
, vol.9
, pp. 135-141
-
-
Rada, C.1
Ehrenstein, M.R.2
Neuberger, M.S.3
Milstein, C.4
-
45
-
-
0032127811
-
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
-
Frey S, Bertocci B, Delbos F, Quint L, Weill JC, Reynaud CA: Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 1998, 9:127-134. This study suggests that the level of DNA damage that is present in the rapidly dividing GC B cells of MSH2- or PMS2-deficient mice leads to death in the majority of these cells and therefore indirectly 'lowers' the incidence of somatic mutaiton.
-
(1998)
Immunity
, vol.9
, pp. 127-134
-
-
Frey, S.1
Bertocci, B.2
Delbos, F.3
Quint, L.4
Weill, J.C.5
Reynaud, C.A.6
-
46
-
-
2642623612
-
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
-
Shen HM, Peters A, Baron B, Zhu X, Storb U: Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 1998, 280:1750-1752. Together with [47•], this study indicates that nonimmunoglobulin genes (but not all transcriptionally active genes) can somatically hypermutate in GC or post-GC B cells.
-
(1998)
Science
, vol.280
, pp. 1750-1752
-
-
Shen, H.M.1
Peters, A.2
Baron, B.3
Zhu, X.4
Storb, U.5
-
47
-
-
13144259651
-
BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
-
Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti RSK, Klein U, Kuppers R, Rajewsky K, Dalla-Favera R: BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA 1998, 95:11816-11821. See annotation to [46•].
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11816-11821
-
-
Pasqualucci, L.1
Migliazza, A.2
Fracchiolla, N.3
William, C.4
Neri, A.5
Baldini, L.6
Chaganti, R.S.K.7
Klein, U.8
Kuppers, R.9
Rajewsky, K.10
Dalla-Favera, R.11
-
48
-
-
0030764978
-
V(D)J recombinase activity in a subset of germinal center B lymphocytes
-
Han S, Dillon SR, Zheng B, Shimoda M, Schlissel MS, Kelsoe G: V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 1997, 278:301-305. Together with [49••], this study demonstrates V(D)J recombinase activity in GC B cells, extending on the original findings of RAG expression in the GC microenvironment. These studies highlight additional mechanisms for immunoglobulin receptor evolution.
-
(1997)
Science
, vol.278
, pp. 301-305
-
-
Han, S.1
Dillon, S.R.2
Zheng, B.3
Shimoda, M.4
Schlissel, M.S.5
Kelsoe, G.6
-
49
-
-
0030803748
-
V(D)J recombination in mature B cells: A mechanism for altering antibody responses
-
Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC: V(D)J recombination in mature B cells: A mechanism for altering antibody responses [see comments]. Science 1997, 278:298-301. See annotation [48••].
-
(1997)
Science
, vol.278
, pp. 298-301
-
-
Papavasiliou, F.1
Casellas, R.2
Suh, H.3
Qin, X.F.4
Besmer, E.5
Pelanda, R.6
Nemazee, D.7
Rajewsky, K.8
Nussenzweig, M.C.9
-
50
-
-
0032487518
-
Receptor editing occurs frequently during normal B cell development
-
Retter MW, Nemazee D: Receptor editing occurs frequently during normal B cell development. J Exp Med 1998, 188:1231-1238.
-
(1998)
J Exp Med
, vol.188
, pp. 1231-1238
-
-
Retter, M.W.1
Nemazee, D.2
-
51
-
-
0032537732
-
V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
-
Hertz M, Kouskoff V, Nakamura T, Nemazee D: V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling. Nature 1998, 394:292-295. These studies indicate that receptor editing in the periphery modifies immunoglobulin receptors with weak (but not those with strong) reactivity to antigen. These data highlight different mechanisms for receptor editing in tolerance induction centrally and for the immune response in the periphery.
-
(1998)
Nature
, vol.394
, pp. 292-295
-
-
Hertz, M.1
Kouskoff, V.2
Nakamura, T.3
Nemazee, D.4
-
52
-
-
0030821164
-
Structural insights into the evolution of an antibody combining site
-
Wedemayer GJ, Patten PA, Wang LH, Schultz PG, Stevens RC: Structural insights into the evolution of an antibody combining site. Science 1997, 276:1665-1669.
-
(1997)
Science
, vol.276
, pp. 1665-1669
-
-
Wedemayer, G.J.1
Patten, P.A.2
Wang, L.H.3
Schultz, P.G.4
Stevens, R.C.5
-
53
-
-
0032100706
-
Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
-
Batista FD, Neuberger MS: Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate. Immunity 1998, 8:751-759.
-
(1998)
Immunity
, vol.8
, pp. 751-759
-
-
Batista, F.D.1
Neuberger, M.S.2
-
54
-
-
0032006177
-
Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development
-
Hande S, Notidis E, Manser T: Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development. Immunity 1998, 8:189-198.
-
(1998)
Immunity
, vol.8
, pp. 189-198
-
-
Hande, S.1
Notidis, E.2
Manser, T.3
-
55
-
-
0032006227
-
Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens
-
Santulli-Marotto S, Retter MW, Gee R, Mamula MJ, Clarke SH: Autoreactive B cell regulation: Peripheral induction of developmental arrest by lupus-associated autoantigens. Immunity 1998, 8:209-219.
-
(1998)
Immunity
, vol.8
, pp. 209-219
-
-
Santulli-Marotto, S.1
Retter, M.W.2
Gee, R.3
Mamula, M.J.4
Clarke, S.H.5
-
56
-
-
0032562609
-
Dependence of germinal center B cells on expression of CD21/CD35 for survival
-
Fischer MB, Goerg S, Shen L, Prodeus AP, Goodnow CC, Kelsoe G, Carroll MC: Dependence of germinal center B cells on expression of CD21/CD35 for survival. Science 1998, 280:582-585.
-
(1998)
Science
, vol.280
, pp. 582-585
-
-
Fischer, M.B.1
Goerg, S.2
Shen, L.3
Prodeus, A.P.4
Goodnow, C.C.5
Kelsoe, G.6
Carroll, M.C.7
-
57
-
-
0032055828
-
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
-
Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clarke EA, Goodnow GC: Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 1998, 8:497-508.
-
(1998)
Immunity
, vol.8
, pp. 497-508
-
-
Cornall, R.J.1
Cyster, J.G.2
Hibbs, M.L.3
Dunn, A.R.4
Otipoby, K.L.5
Clarke, E.A.6
Goodnow, G.C.7
-
58
-
-
0032191170
-
Aiolos regulates B cell activation and maturation to effector state
-
Wang J-H, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K: Aiolos regulates B cell activation and maturation to effector state. Immunity 1998, 9:543-553. This paper describes a novel zinc-finger DNA-binding protein (aiolos) expressed in mature B cells. Ablation of aiolos results in hyper-reactive mature B cell responsiveness in vitro and in vivo. Autoantibody production and B cell lymphomas are frequently seen in these animals.
-
(1998)
Immunity
, vol.9
, pp. 543-553
-
-
Wang, J.-H.1
Avitahl, N.2
Cariappa, A.3
Friedrich, C.4
Ikeda, T.5
Renold, A.6
Andrikopoulos, K.7
Liang, L.8
Pillai, S.9
Morgan, B.A.10
Georgopoulos, K.11
-
59
-
-
0028796357
-
Bone marrow is a major site of long-term antibody production after acute viral infection
-
Slifka MK, Matloubian M, Ahmed R: Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol 1995, 69:1895-1902.
-
(1995)
J Virol
, vol.69
, pp. 1895-1902
-
-
Slifka, M.K.1
Matloubian, M.2
Ahmed, R.3
-
60
-
-
0032033127
-
Humoral immunity due to long-lived plasma cells
-
Slifka MK, Antia R, Whitmire JK, Ahmed R: Humoral immunity due to long-lived plasma cells. Immunity 1998, 8:363-372. An analysis of persistent virus-specific antibody response after an acute viral infection, this study examines plasma-cell longevity and indicates that a substantial fraction can survive for extended periods of time in the absence of memory B cells and without entry into cell cycle.
-
(1998)
Immunity
, vol.8
, pp. 363-372
-
-
Slifka, M.K.1
Antia, R.2
Whitmire, J.K.3
Ahmed, R.4
-
61
-
-
1842405362
-
Lifetime of plasma cells in the bone marrow
-
Manz RA, Thiel A, Radbruch A: Lifetime of plasma cells in the bone marrow. Nature 1997, 388:133-134. Along with [60••], this study documents the existence of long-lived plasma cells.
-
(1997)
Nature
, vol.388
, pp. 133-134
-
-
Manz, R.A.1
Thiel, A.2
Radbruch, A.3
-
62
-
-
0031754923
-
Survival of long-lived plasma cells is independent of antigen
-
Manz RA, Lohning M, Cassese G, Thiel A, Radbruch A: Survival of long-lived plasma cells is independent of antigen. Int Immunol 1998, 11:1703-1711. Together with [61••], this study probes the longevity of antigen-specific plasma cells and indicate that they may be as long-lived as memory B cells and appear to survive in the absence of antigen.
-
(1998)
Int Immunol
, vol.11
, pp. 1703-1711
-
-
Manz, R.A.1
Lohning, M.2
Cassese, G.3
Thiel, A.4
Radbruch, A.5
-
63
-
-
0030925491
-
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
-
Smith KG, Light A, Nossal GJV, Tarlinton DM: The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J 1997, 16:2996-3006. This is an analysis of the presence and pattern of somatic hypermutation in antigen-specific B cells that home to the bone marrow. The early output of the GC reaction appears stringently selected for migration to the bone marrow.
-
(1997)
EMBO J
, vol.16
, pp. 2996-3006
-
-
Smith, K.G.1
Light, A.2
Nossal, G.J.V.3
Tarlinton, D.M.4
-
64
-
-
0032536872
-
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection
-
Takahashi Y, Dutta PR, Cerasoli DM, Kelsoe G: In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med 1998, 187:885-895. This study demonstrates the continual increase of the affinity of serum antibody even after the decline of the splenic GC reaction. The study also demonstrates most directly that the bone-marrow-homing B cells emerge from the GC reaction of the spleen.
-
(1998)
J Exp Med
, vol.187
, pp. 885-895
-
-
Takahashi, Y.1
Dutta, P.R.2
Cerasoli, D.M.3
Kelsoe, G.4
-
65
-
-
0032476617
-
Identification of functional human splenic memory B cells by expression of CD148 and CD27
-
Tangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE: Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 1988, 188:1691-1703.
-
(1988)
J Exp Med
, vol.188
, pp. 1691-1703
-
-
Tangye, S.G.1
Liu, Y.J.2
Aversa, G.3
Phillips, J.H.4
De Vries, J.E.5
-
66
-
-
0032476611
-
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
-
Klein U, Rajewsky K, Kuppers R: Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998, 188:1679-1689.
-
(1998)
J Exp Med
, vol.188
, pp. 1679-1689
-
-
Klein, U.1
Rajewsky, K.2
Kuppers, R.3
-
67
-
-
1842405428
-
Evidence for a large compartment of IgM-expressing memory B cells in humans
-
Klein U, Kuppers R, Rajewsky K: Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 1997, 89:1288-1298.
-
(1997)
Blood
, vol.89
, pp. 1288-1298
-
-
Klein, U.1
Kuppers, R.2
Rajewsky, K.3
-
68
-
-
0031066609
-
Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells
-
Oliver AM, Martin F, Kearney JF: Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol 1997, 158:1108-1115.
-
(1997)
J Immunol
, vol.158
, pp. 1108-1115
-
-
Oliver, A.M.1
Martin, F.2
Kearney, J.F.3
-
69
-
-
0032525003
-
Kinetics of establishing the memory B cell population as revealed by CD38 expression
-
Ridderstad A, Tarlinton DM: Kinetics of establishing the memory B cell population as revealed by CD38 expression. J Immunol 1998, 160:4688-4695.
-
(1998)
J Immunol
, vol.160
, pp. 4688-4695
-
-
Ridderstad, A.1
Tarlinton, D.M.2
-
70
-
-
0032143590
-
Regulation of telomere length and telomerase in T and B cells: A mechanism for maintaining replicative potential
-
Weng NP, Hathcock KS, Hodes RJ: Regulation of telomere length and telomerase in T and B cells: A mechanism for maintaining replicative potential. Immunity 1998, 9:151-157.
-
(1998)
Immunity
, vol.9
, pp. 151-157
-
-
Weng, N.P.1
Hathcock, K.S.2
Hodes, R.J.3
-
71
-
-
0031202137
-
Telomerase is up-regulated in human germinal center B cells in vivo and can be reexpressed in memory B cells activated in vitro
-
Hu BT, Lee SC, Marin E, Ryan DH, Insel RA: Telomerase is up-regulated in human germinal center B cells in vivo and can be reexpressed in memory B cells activated in vitro. J Immunol 1997, 159:1068-1071.
-
(1997)
J Immunol
, vol.159
, pp. 1068-1071
-
-
Hu, B.T.1
Lee, S.C.2
Marin, E.3
Ryan, D.H.4
Insel, R.A.5
-
72
-
-
1842377430
-
Endosomal targeting by the cytoplasmic tail of membrane immunogobulin
-
Weiser P, Muller R, Braun U, Reth M: Endosomal targeting by the cytoplasmic tail of membrane immunogobulin. Science 1997, 276:407-409. These three studies [72•-74•] highlight the role of the cytoplasmic tail of downstream immunoglobulin isotypes. In this study, IgG2a's cytoplasmic tail is demonstrated to enhance endosomal targeting of antigen.
-
(1997)
Science
, vol.276
, pp. 407-409
-
-
Weiser, P.1
Muller, R.2
Braun, U.3
Reth, M.4
-
73
-
-
0030991751
-
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response
-
Achatz G, Nitschke L, Lamers MC: Effect of transmembrane and cytoplasmic domains of IgE on the IgE response. Science 1997, 276:409-411. Together with [72•,74•], this study highlights the role of the cytoplasmic tail of downstream immunoglobulin isotypes. In this study, truncation of IgE's cytoplasmic tail leads to decreased serum IgE, loss of 40-80% of specific IgE in the primary response and loss of IgE memory.
-
(1997)
Science
, vol.276
, pp. 409-411
-
-
Achatz, G.1
Nitschke, L.2
Lamers, M.C.3
-
74
-
-
0030994044
-
The roles of γI heavy chain membrane expression and cytoplasmic tail in IgG1 responses
-
Kaisho T, Schwenk F, Rajewsky K: The roles of γI heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science 1997, 276:412-415. Together with [72•,73•], this study highlights the role of the cytoplasmic tail of downstream immunoglobulin isotypes. In this study, IgGI's cytoplasmic tail also appears essential for propagation and expansion of memory of IgG1-secreting B cells.
-
(1997)
Science
, vol.276
, pp. 412-415
-
-
Kaisho, T.1
Schwenk, F.2
Rajewsky, K.3
-
75
-
-
0031457217
-
Immunization with immune complex alters the repertoire of antigen-reactive B cells in the germinal centers
-
Nie X, Basu S, Cerny J: Immunization with immune complex alters the repertoire of antigen-reactive B cells in the germinal centers. Eur J Immunol 1997, 27:3517-3525.
-
(1997)
Eur J Immunol
, vol.27
, pp. 3517-3525
-
-
Nie, X.1
Basu, S.2
Cerny, J.3
|