B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin α-dependent fashion

Journal of Experimental Medicine

Volumn 187, Issue 7, 1998, Pages 1009-1018

  Fu, Yang Xin ^a   Huang, Guangming ^a   Wang, Yang ^a   Chaplin, David D ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; GERMINAL CENTER; HUMORAL IMMUNITY; IMMUNIZATION; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-LYMPHOCYTES; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CHIMERA; DENDRITIC CELLS; DNA-BINDING PROTEINS; GERMINAL CENTER; HOMEODOMAIN PROTEINS; IMMUNITY; IMMUNOHISTOCHEMISTRY; LYMPHOTOXIN-ALPHA; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; TRANSPLANTATION, ISOGENEIC;

EID: 0032489920     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.7.1009     Document Type: Article

References (36)

1. Ruddle, N. 1992. Tumor necrosis factor (TNFα) and lymphotoxin (TNFβ). Curr. Opin. Immunol. 4:327-332.
2. Ware, C.F., T.L. VanArsdale, P.D. Crowe, and J.L. Browning. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175-218.
3. Browning, J.L., A. Ngam-ek, P. Lawton, J. DeMarinis, R. Tizard, E.P. Chow, C. Hession, B. O'Brine-Greco, S.F. Foley, and C.F. Ware. 1993. Lymphotoxin β, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 72:847-856.
4. Browning, J.L., I. Dougas, A. Ngam-ek, P.R. Bourdon, B.N. Ehrenfels, K. Miatkowski, M. Zafari, A.M. Yampaglia, P. Lawton, W. Meier, C.P. Benjamin, and C. Hession. 1995. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J. Immunol. 154:33-46.
5. Crowe, P.D., T.L. VanArsdale, B.N. Walter, C.F. Ware, C. Hession, B. Ehrenfels, J.L. Browning, W.S. Din, R.G. Goodwin, and C.A. Smith. 1994. A lymphotoxin-β-specific receptor. Science. 264:707-710.
6. De Togni, P., J. Goellner, N.H. Ruddle, P.R. Streeter, A. Fick, S. Mariathasan, S.C. Smith, R. Carlson, L.P. Shornick, J. Strauss-Schoenberger, et al. 1994. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 264:703-707.
7. Banks, T.A., B.T. Rouse, M.K. Kerley, P.J. Blair, V.L. Godfrey, N.A. Kuklin, D.M. Bouley, J. Thomas, S. Kanangat, and M.L. Mucenski. 1995. Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155:1685-1693.
8. Matsumoto, M., S. Mariathasan, M.H. Nahm, F. Baranyay, J.J. Peschon, and D.D. Chaplin. 1996. The role of lymphotoxin and type I TNF receptor in the formation of germinal centers. Science. 271:1289-1291.
9. Koni, P.A., R. Sacca, P. Lawton, J.L. Browning, N.H. Ruddle, and R.A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphoroxins α and β revealed in lymphotoxin β-deficient mice. Immunity. 6:491-500.
10. Neumann, B., A. Luz, K. Pfeffer, and B. Holzmann. 1996. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184: 259-264.
11. Pasparakis, M., L. Alexopoulou, V. Episkopou, and G. Kollias. 1996. Immune and inflammatory responses in TNFα-deficient mice: a critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response J. Exp. Med. 184:1397-1411.
12. Eugster, H.-P., M. Muller, U. Karrer, B.D. Car, B. Schnyder. V.M. Eng, G. Woerly, M. Le Hir, F. di Padova, M. Aguet, et al. 1996. Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice. Int. Immunol. 8:23-36.
13. Fu, Y.-X., H. Molina, M. Matsumoto, G. Huang, J. Min, and D.D. Chaplin. 1997. Lymphotoxin-α supports development of splenic follicular structure that is required tor IgG response. J. Exp. Med. 185:2111-2120.
14. Stedra, J., and J. Cerny. 1994. Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody. J. Immunol. 152:1718-1726.
15. Miller, C. J. Stedra, G. Kelsoe, and J. Cerny. 1995. Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. J. Exp. Med. 181:1319-1331.
16. Molina, H., V.M. Holers, B. Li, Y.-F. Fang, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R.W. Karr, and D.D. Chaplin. 1996. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA. 93:3357-3361.
17. Trizio, D., and G. Cudcowicz. 1974. Separation of T and B lymphocytes by nylon wool columns: evaluation of efficacy by functional assays in vivo. J. Immunol. 113:1093-1099.
18. Mariathasan, S., M. Matsumoto, F. Baranyay, M.H. Nahm, O. Kanagawa, and D.D. Chaplin. 1995. Absence of lymph nodes in lymphotoxin-α (LTα)-deficient mice is due to abnormal organ development, not defective lymphocyte migration. J. Inflamm. 45:72-78.
19. MacLennan, I.C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117-139.
20. Kelsoe, G. 1996. Life and death in germinal centers (redux). Immunity. 4:107-111.
21. Kapasi, Z.F., G.F. Burton, L.D. Shultz, J.G. Tew, and A.K. Szakal. 1993. Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells. J. Immunol. 150:2648-2658.
22. Cerny, A., R.M. Zinkernagel, and V. Groscurth. 1988. Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice. Cell Tissue Res. 254:449-454.
23. Yoshida, K., T. van den Berg, and C.D. Dijkstra. 1994. The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes. Eur. J. Immunol. 24:464-468.
24. Borriello, F., M.P. Settna, S.D. Boyd, A.N. Schweizer, E.A. Tivol, D. Jacoby, T.B. Strom, E.M. Simpson, G.J. Freeman, and A.H. Sharpe. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 6:303-313.
25. Facchetti, F., C. Appiani, L. Salvi, J. Levy, and L.D. Notarangelo. 1995. Immunohistologic analysis of ineffective CD40-CD40 ligand interaction in lymphoid tissues from patients with X-linked immunodeficiency with hyper-IgM. Abortive germinal center cell reaction and severe depletion of follicular dendritic cells. J. Immunol. 154:6624-6633.
26. Han, S., K. Hathcock, B. Zheng, T.B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155:556-567.
27. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J.P. Galizzi, C. van Kooten, Y.J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881-922.
28. Van den Eertwegh, A.J., R.J. Noelle, M. Roy, D.M. Shepherd, A. Aruffo, J.A. Ledbetter, W.J. Boersma, and E. Claassen. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J. Exp. Med. 178: 1555-1565.
29. Worm, M., and R.S. Geha. 1994. CD40 ligation induces lymphotoxin a gene expression in human B cells. Int. Immunol. 6:1883-1890.
30. Ogata, T., M. Yamakawa, Y. Imai, and T. Takahashi. 1996. Follicular dendritic cells adhere to fibronectin and laminin fibers via their respective receptors. Blood. 88:2995-3003.
31. Xu, J., T. M. Foy, J.D. Laman, E.A. Elliott, J.J. Dunn, T.J. Waldschmidt, J. Elsemore, R.J. Noelle, and R.A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity. 1:423-431.
32. Wang, B., C. Biron, J. She, K. Higgins, M.J. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst. 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc. Natl. Acad. Sci. USA. 91:9402-9406.
33. Wang, B., G.A. Hollander, A. Nichogiannopoulou, S.J. Simpson, J.S. Orange, J.C. Gutierrez-Ramos, S.J. Burakoff, C.A. Biron, and C. Terhorst. 1996. Natural killer cell development is blocked in the context of aberrant T lymphocyte ontogeny. Int. Immunol. 8:939-949.
34. Hanissian, S.H., and R.S. Geha. 1997. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity. 6:379-387.
35. Sloan, H.E.J. 1943. The thymus in myasthenial gravis, with observations on the normal anatomy and histology of the thymus. Surgery. 13:154-174.
36. Randen, I., O.J. Mellbye, O. Forre, and J.B. Natvig. 1993. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand. J. Immunol. 41:481-486.