Regulation of telomere length review and telomerase in T and B cells: A mechanism for maintaining replicative potential

Immunity

Volumn 9, Issue 2, 1998, Pages 151-157

  Weng, Nan Ping ^a,b   Hathcock, Karen S ^b   Hodes, Richard J ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

B LYMPHOCYTE; CHROMOSOME ANALYSIS; HUMAN; IMMUNOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; T LYMPHOCYTE; TELOMERE;

EID: 0032143590     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80597-X     Document Type: Review

References (59)

1. Blackburn, E.H. (1991). Structure and function of telomeres. Nature 350, 569-573.
2. Blackburn, E.H, (1992). Telomerases. Annu. Rev. Biochem. 61, 113-129.
3. Blasco, M.A., Funk, W., Villeponteau, B., and Greider, C.W. (1995). Functional characterization and developmental regulation of mouse telomerase. Science 269, 1267-1270.
4. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., and Greider, C.W. (1997). Telomerase shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34.
5. Bodnar, A.G., Kim, N.W., Effros, R.B., and Chiu, C-P. (1996). Mechanism of telomerase induction during T cell activation. Exp. Cell Res. 228, 58-64.
6. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C-P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
7. Broccoli, D., Young, J.W., and de Lange, T. (1995). Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92, 9082-9086.
8. Buchkovich, K.J., and Greider, C.W. (1996). Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Biol. Cell 7, 1443-1454.
9. Chadeneau, C., Siegel, P., Harley, C.B., Muller, W.J., and Bacchetti, S. (1995). Telomerase activity in normal and malignant murine tissues. Oncogene 11, 893-898.
10. Chang, E., and Harley, C.B. (1995). Telomere length and replicative aging in human vascular tissues. Proc. Natl. Acad. Sci. USA 92, 11190-11194.
11. Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., and de Lange, T. (1995). A human telomeric protein. Science 270, 1663-1667.
12. Counter, C.M., Botelho, F.M., Wang, P., Harley, C.B., and Bacchetti, S. (1994). Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J. Virol. 68, 3410-3414.
13. Coviello-McLaughlin, G.M., and Prowse, K.R. (1997). Telomere length regulation during postnatal development and ageing in Mus spretus. Nucleic Acid Res. 25, 3051-3058.
14. Effros, R.B., Allsopp, R., Chiu, C.P., Hausner, M.A., Hirji, K., Wang, L., Harley, C.B., Villeponteau, B., West, M.D., and Giorgi, J.V. (1996). Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10, F17-F22.
15. Feng, J., Funk, W.D., Wang, S.S., Weinrich, S.L., Avilion, A.A., Chiu, C.P., Adama, R.R., Chang, E., Allsopp, B.C., Yu, J., et al. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
16. Greider, C.W. (1996). Telomere length regulation. Annu. Rev. Biochem. 65, 337-365.
17. Guerrini, A.M., Camponeschi, B., Ascenzioni, F., Piccolella, E., and Donini, P. (1993). Subtelomeric as well as telomeric sequences are lost from chromosomes in proliferating B lymphocytes. Hum. Mol. Genet. 2, 455-460.
18. Harley, C.B., Futcher, A.B., and Greider, C.W. (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
19. Harrington, L., Zhou, W., McPhail, T., Oulton, R., Yeung, D.S., Mar, V., Bass, M.B., and Robinson, M.O. (1997a). Human telomerase contains evolutionary conserved catalytic and structural subunits. Genes Dev. 11, 3109-3115
20. Harrington, L., McPhail, T., Mar, V., Zhou, W., Oulton, R., Bass, M.B., Arruda, I., and Robinson, M.O. (1997b). A mammalian telomerase-associated protein. Science 275, 973-977.
21. Hastie, N.D., Dempster, M., Dunlop, M.G., Thompson, A.M., Green, D.K., and Allshire, R.C (1990). Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866-868.
22. Hathcock, K.S., Weng, N.-p., Merica, R., Jenkins, M.K., and Hodes, R.J. (1998). Cutting edge: antigen-dependent regulation of telomerase activity in murine T cells. J. Immunol., in press.
23. Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636.
24. Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M.A., Shay, J.W., Ishioka, S., and Yamakido, M. (1995). Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 755, 3711-3715.
25. Ho, D.D., Neumann, A.U., Perelson, A.S., Chen, W., Leonard, J.M., and Markowitz, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-126.
26. Hu, B.T., Lee, S.C., Marin, E., Ryan, D.H., and Insel, R.A. (1997). Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro. J. Immunol. 159, 1068-1071.
27. Igarashi, H., and Sakaguchi, N. (1996). Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes. Biochem. Biophys. Res. Commun. 219, 649-655.
28. Igarashi, H., and Sakaguchi, N. (1997). Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor. Blood 89, 1299-1307.
29. Kelsoe, G. (1996). Life and death in germinal centers (redux). Immunity 4, 107-111.
30. Kipling, D., and Cooke, H.J. (1990). Hypervariable ultra-long telomeres in mice. Nature 347, 400-402.
31. Lee, H-W., Blasco, M.A., Gottlieb, G.J., Horner, J.W. II, Greider, C.W., and DePinho, R.A. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574.
32. Lindsey, J., McGill, N.I., Lindsey, L.A., Green, D.K., and Cooke, H.J. (1991). In vivo loss of telomeric repeats with age in humans. Mutat. Res. 256, 45-48.
33. Mandai, M., and Kumar, R. (1997). Bcl-2 modulates telomerase activity. J. Biol. Chem. 272, 14183-14187.
34. Metcalfe, J.A., Parkhill, C., Campbell, L., Stacey, M., Biggs, P., Byrd, P.J., and Taylor, A.M. (1996). Accelerated telomere shortening in ataxia telangiectasia. Nat. Genet. 13, 350-353.
35. Meyerson, M., Counter, C.M., Eaton, E.N., Ellisen, L.W., Steiner, P., Caddle, S.D., Ziaugra, L., Beijersbergen, R.L., Davidoff, M.J., Liu, Q., et al., (1997). hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785-795.
36. Monteiro, J., Batliwalla, F., Ostrer, H., and Gregersen, P.K. (1996). Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J. Immunol. 756, 3587-3590.
37. Morrison, S.J., Prowse, K.R., Ho, P., and Weissman, I.L. (1996). Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5, 207-216.
38. Nakamura, T.M., Morin, G.B., Chapman, K.B., Weinrich, S.L., Andrews, W.H., Lingner, J., Harley, C.B., and Cech, T.R. (1997). Telomerase catalytic subunit homelogs from fission yeast and human. Science 277, 955-959.
39. Nakayama, J., Tahara, H., Tahara, E., Saito, M., Ito, K., Nakamura, H., Nakanishi, T., Tahara, E., Ide, T., and Ishikawa, F. (1998). Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat. Genet. 18, 65-68.
40. Norrback, K.F., Dahlenborg, K., Carlsson, R., and Roos, G. (1996). Telomerase activation in normal B-lymphocytes and non-Hodgkins-lymphomas. Blood 88, 222-229.
41. Ogoshi, M., Takashima, A, and Taylor, R.S. (1997). Mechanisms regulating telomerase activity in murine T cells. J. Immunol. 158, 622-628.
42. Palmer, L.D., Weng, N.P., Levine, B.L., June, C.H., Lane, H.C., and Modes, R.J. (1997). Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. J. Exp. Med. 185, 1381-1386.
43. Prowse, K.R., and Greider, C.W. (1995). Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92, 4818-4822.
44. Shay, J.W., and Wright, W.E. (1996). Telomerase activity in human cancer. Curr. Opin. Oncol. 8, 66-71.
45. Slagboom, P.E., Droog, S., and Boomsma, D.I. (1994). Genetic determination of telomere size in humans: a twin study of three age groups. Am. J. Hum. Genet. 55, 876-882.
46. Smith, S., and de Lange, T. (1997). TRF1, a mammalian telomeric protein. Trends Genet. 13, 21-26.
47. van Steensel, B., Smogorzewska, A., and de Lange, T. (1998). TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413.
48. van Steensel, B., and de Lange, T. (1997). Control of telomere length by the human telomeric protein TRF1. Nature 385, 740-743.
49. Vaziri, H., Schachter, F., Uchida, I., Wei, L., Zhu, X., Effros, R., Cohen, D., and Harley, C.B. (1993). Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52, 661-667.
50. Vaziri, H., Dragowska, W., Allsopp, R.C., Thomas, T.E., Harley, C.B., and Lansdorp, P.M. (1994). Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA 91, 9857-9860.
51. Watson J. (1972). Origin of concatemeric T7 DNA. Nat. New Biol. 239, 197-201.
52. Weinrich, S.L., Pruzan, R., Ma, L., Ouellette, M., Tesmer, V.M., Holt, S.E., Bodnar, A.G., Lichtsteiner, S., Kim, N.W., Trager, J.B., et al. (1997). Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17, 498-502.
53. Weng, N., Levine, B.L., June, C.H., and Hodes, R.J. (1995). Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 92, 11091-11094.
54. Weng, N., Levine, B.L., June, C.H., and Hodes, R.J. (1996). Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183, 2471-2479.
55. Weng, N., Levine, B.L., June, C.H., and Hodes, R.J. (1997a). Regulation of telomerase RNA template expression in human T lymphocyte development and activation. J. Immunol. 158, 3215-3220.
56. Weng, N., Palmer, L., Levine, B.L., Lane, H.C., June, C.H., and Hodes, R.J. (1997b). Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160, 43-54.
57. Weng, N.P., Granger, L., and Hodes, R.J. (1997c). Telomere lengthening and telomerase activation during human B cell differentiation. Proc. Natl. Acad. Sci. USA 94, 10827-10832.
58. Wolthers, K.C., Bea, G., Wisman, A., Otto, S.A., de Roda Husman, A.M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R.A., van der Zee, A.G., et al. (1996). T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover. Science 274, 1543-1547.
59. Yashima, K., Piatyszek, M.A., Saboorian, H.M., Virmani, A.K., Brown, D., Shay, J.W., and Gazdar, A.F. (1997). Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes. J. Clin. Pathol. 50, 110-117.