Survival of long-lived plasma cells is independent of antigen

International Immunology

Volumn 10, Issue 11, 1998, Pages 1703-1711

  Manz, Rudolf A ^a   Löhning, Max ^a   Cassese, Giuliana ^a   Thiel, Andreas ^a   Radbruch, Andreas ^a  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

Antibody secreting cell; Cellular affinity matrix; Humoral memory; Serum antibody titer

Indexed keywords

ANTIBODY; ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CELL SURVIVAL; CYTOMETRY; IMMUNIZATION; MEMORY CELL; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES; ANTIGENS; B-LYMPHOCYTES; BONE MARROW CELLS; CELL SURVIVAL; FLOW CYTOMETRY; HLA-D ANTIGENS; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; OVALBUMIN; PLASMA CELLS; SPLEEN;

EID: 0031754923     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.11.1703     Document Type: Article

References (35)

1. Rajewsky, K., Förster, I. and Cumano. A. 1987. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 238:1088.
2. Berek, C. and Milstein, C. 1988. The dynamic nature of the antibody repertoire, Immunol Rev. 105:5.
3. Jacob, J., Kassir, R. and Kelsoe, G. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
4. Plotkin, S. A. and Mortimer, E. A. 1994. Vaccines, 2nd edn. Saunders, Philadelphia.
5. Steinhoff, U., Müller, U., Schertler, A., Hengartner, H., Arguet, M. and Zinkernagel, R. M. 1995. Antiviral protection by VSV-specific antibodies in α/β interferon receptor deficient mice. J. Virol. 69:2153.
6. Ahmed, R. and Gray, D. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
7. Slifka, M. K., Matloubian, M. and Ahmed, R. 1995. Bone marrow is a major site of long-term antibody production after acute viral infection. J. Virol. 69:1895.
8. Fahey, J. L. and Sell, S. 1965. The immunoglobulins of mice: the metabolic (catabolic) properties of five immunoglobulin classes. J. Exp. Med. 122:41.
9. Vieira, P. and Rajewsky, K. 1988. The half-lives of serum immunoglobulins in adult mice. Eur. J. Immunol. 18:313.
10. Manz, R. A., Thiel, A. and Radbruch, A. 1997. Lifetime of plasma cells in the bone marrow. Nature 388:133.
11. Slifka, M. K., Antia, R., Withmire, J. K. and Ahmed, R. 1998. Humoral immunity due to long-lived plasma cells. Immunity 8:363.
12. Nossal, G. J. V., Abbot, A. and Mitchel, J. 1968. Antigens in immunity. XIV. Electron microscopic radioautographic studies of antigen capture in the lymph node medulla. J. Exp. Med. 127:263.
13. Nossal, G. J. V., Abbot, A., Mitchel, J. and Lummus, Z. 1968. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J. Exp. Med. 127:277.
14. Gray, D and Skarvall, H. 1988. B-cell memory is short-lived in the absence of antigen. Nature 366:70.
15. Tew, J. G and Mandel, T 1978. The maintenance and regulation of serum antibody levels: evidence indicating a role for antigen retained in lymphoid follicles. J. Immunol. 120:1063.
16. Tew, J. G., Phillips, R. P. and Mandel, T. 1980. The follicular dendritic cell: long term antigen retention during immunity, Immunol. Rev. 53:29.
17. Tew, J. G., Di Losa, R. M., Burton, G. F., Kosco, M. H., Kupp, L. I., Masuda, A. and Szakal, A. 1992. Germinal centers and antibody production in the bone marrow Immunol. Rev. 126:99.
18. Reth, M., Imanishi-Kari, T. and Rajewsky, K. 1979. Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur. J. Immunol. 9:1004.
19. Coffman, R. L. 1982. Surface antigen expression and immunoglobulin rearrangement during mouse pre-B cell development, Immunol. Rev. 69:5.
20. Manz, R. A., Assenmacher, M., Pflüger, E., Miltenyi, S. and Radbruch, A. 1995. Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix. Proc. Natl Acad. Sci. USA 92:1921.
21. Benner, R., Van Oudenaren, A. and Koch, G. 1981. Induction of antibody formation in mouse bone marrow. In Pernis, B. and Lefkovits, I., eds, Immunological Methods II, p. 247 Academic Press, New York.
22. Jerne, N. K., Henry, C., Nordin, A. A., Fuji, H., Koros, A. C. M. and Lefkovits, I. 1974. Plaque forming cells: methodology and theory. Transplant. Rev. 18:130.
23. Miltenyi, S., Müller, W., Weichel, W. and Radbruch, A., 1990. High gradient magnetic cell separation with MACS. Cytometry 11:231.
24. Hayakawa, K., Ishii, R., Yamasaki, K., Kishimoto, T. and Hardy, R. R. 1987. Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells. Proc. Natl Acad. Sci. USA 84:1379.
25. Schittek, B. and Rajewsky, K. 1990. Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature 346:749.
26. Smith, K. G. C., Hewitson, T. D., Nossal, G. J. V. and Tarlinton, D. M. 1996. The phenotype and fate of the antibody-forming cells of the splenic foci. Eur. J. Immunol. 26:444.
27. Benner, R., Van Oudenaren, A. and de Ruiter, H. 1977. Antibody formation in the mouse bone marrow. IX. Peripheral lymphoid organs are involved in the initiation of bone marrow antibody formation. Cell. Immunol. 34:125.
28. Koch, G., Osmond, D. G., Julius, M. H. and Benner, R. 1981. The mechanism of thymus-dependent antibody formation in bone marrow. J. Immunol. 126:1447.
29. MacLennan, I. C. M., Liu, Y.-J. and Johnson, G. D. 1992. Maturation and dispersal of B-cell clones during T cell-dependent antibody responses, Immunol. Rev. 126:143.
30. MacLennan, I. C. M. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
31. + B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 22:3001.
32. 125I-labelled antigens in the secondary response. Immunology 9:349.
33. Paramithiotis, E. and Cooper, M. D. 1997. Memory B lymphocytes migrate to bone marrow in humans. Proc. Natl Acad. Sci. USA 7:208
34. Bachmann, M. F., Kündig, T. M., Odermatt, B., Hengartner, H. and Zinkernagel, R. M. 1994. Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. J. Immunol. 153:3386.
35. Haaijman, J. J., Schuit, H. R. E. and Hijmans, W. 1977. Immunoglobulin-containing cells in different lymphoid organs of the CBA mouse during its life-span Immunology 32:427.