V(D)J recombinase activity in a subset of germinal center B lymphocytes

Science

Volumn 278, Issue 5336, 1997, Pages 301-305

  Han, Shuhua ^a   Dillon, Stacey R ^b   Zheng, Biao ^a   Shimoda, Michiko ^a   Schlissel, Mark S ^b   Kelsoe, Garnett ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINASE;

ARTICLE; B LYMPHOCYTE; ENZYME ACTIVITY; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GERMINAL CENTER; IMMUNOGLOBULIN GENE; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; DNA NUCLEOTIDYLTRANSFERASES; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; GENES, RAG-1; GERMINAL CENTER; IMMUNIZATION; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECOMBINATION, GENETIC; VDJ RECOMBINASES;

EID: 0030764978     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5336.301     Document Type: Article

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47. We thank J. Cerny and A. Perelson for their review of this manuscript. Supported in part by USPHS grants HL48722 and AI40227 (M.S.S.) and AI24335, AG10207, and AG13789 (G. K). S.R.D. is a recipient of an Arthritis Foundation Postdoctoral Fellowship, M.S.S acknowledges the support of a Leukemia Society Scholarship and G.K. received funding from the Jeanne M. and Joseph P. Sullivan Foundation and the Santa Fe Institute.