Hypermutation of immunoglobulin genes in memory B cells of DNA repair- deficient mice

Journal of Experimental Medicine

Volumn 187, Issue 11, 1998, Pages 1735-1742

  Jacobs, Heinz ^a,b   Fukita, Yosho ^b   Van Der Horst, Gijsbertus T J ^c   De Boer, Jan ^c   Weeda, Geert ^c   Essers, Jeroen ^c   De Wind, Niels ^d   Engelward, Bevin P ^g   Samson, Leona ^g   Verbeek, Sjef ^e   De Murcia, Josiane Ménissier ^f   De Murcia, Gilbert ^f   Te Riele, Hein ^d   Rajewsky, Klaus ^b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF COLOGNE   (Germany)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITÉ DE STRASBOURG   (France)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

DNA repair; DNA repair deficient mice; Memory B cells; Naive B cells; Somatic mutations

Indexed keywords

DNA GLYCOSYLTRANSFERASE;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; DNA REPAIR; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE MUTATION; GENETIC COMPLEMENTATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROPOSON; SOMATIC MUTATION; STEM CELL; XERODERMA PIGMENTOSUM;

ANIMALS; B-LYMPHOCYTES; DNA REPAIR; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MICE; MICE, MUTANT STRAINS; MUTATION; POLYMERASE CHAIN REACTION;

EID: 0032101017     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.11.1735     Document Type: Article

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