Role of cyclin-dependent kinases and their inhibitors in cellular differentiation and development

Current Topics in Microbiology and Immunology

Volumn 227, Issue , 1997, Pages 57-103

  Chellappan, S P ^a  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

CANCER SUSCEPTIBILITY; CELL DIFFERENTIATION; ENZYME INHIBITION; ENZYME REGULATION; FIBROBLAST; HEMATOPOIETIC CELL; KERATINOCYTE; MOLECULAR CLONING; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P18; CYCLIN-DEPENDENT KINASE INHIBITOR P19; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASE INHIBITOR P57; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; FORECASTING; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0031440272     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (226)

1. Andres V, Walsh K (1996) Myogenin expression, cell cycle withdrawal and phenotypic dilTerentiation are temporally separable events that precede cell fusion upon myogenesis. J Cell Biol 132:657-666
2. Aprelikova O, Xiong Y, Liu ET (1995) Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem 1270:18195-18197
3. Bates S, Peters G (1995) Cyclin Dl as a cellular proto-oncogene. Semin Cancer Biol 6:73-82
4. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61:49-59
5. Biggs JR, Kraft AS (1995) Inhibitors of cyclin-dependent kinase and cancer. J Mo1 Med 75:509-514
6. Bishop JM (1987) The molecular genetics of cancer. Science 235:305-311
7. Bishop JM (1991) Molecular themes in oncogenesis. Cell 64:235-248
8. Breitman T, Delonick D, Collins S (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Nail Acad Sci USA 77:2936-2940
9. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-557
10. Kip1, to regions involved in human cancer. Cancer Res 55:1199-1205
11. Calautti E, Missero C, Stein PL, Ezzell RM, Dotto GP (1995) Fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev 9:2279-2291
12. Caruso M, Martelli F, Giordano A, Felsani A (1993) Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus EIA oncoproteins. Oncogene 8:267-278
13. Castresana JS, Rubi MP, Vazquez J, Idoate M, Sober AJ, Seizinger BR, Barnhill RL (1993) Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma. Intl J Oncol 55:562-565
14. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A (1995) Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol 15:2682-2688
15. Chellappan SP (1994) The E2F transcription factor: role in cell cycle regulation and differentiation. Mol Cell Diff 2(3):201-220
16. Chen J, Jackson PK, Kireschner MW, Dutta A (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:386-388
17. Chen X, Bargonetti J, Prives C (1995) p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res 55:4257-4263
18. Clark W (1991) Tumor progression and the nature of cancer. Br J Cancer 64:631-644
19. Clurman BE, Bruns G (1995) Cell cycle and cancer. J Natl Cancer Inst 87:1499-1501
20. Coats S, Flanagan WM, Nourse J, Roberts JM (1996) Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877-880
21. Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA (1992) The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci 17:312-315
22. Collins SJ (1987) The HL-60 promyelocytic leukemia cell line: proliferation, dilTerentiation, and cellular oncogene expression. Blood 70:1233-1244
23. Collins SJ, Ruscetti FW, Gallagher R, Gallo R (1978) Terminal dilTerentiation of the human promyelocytic leukemia cells induced by dimethylsulfoxide and other polar compounds. Proc Natl Acad Sci USA 75:2458-2462
24. Coppola JA, Lewis BA, Cole MD (1990) Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types. Oncogene 5:1731-1733
25. De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363:595-602
26. Del Sal G, Murphy M, Ruaro EM, Lazarevic D, Levine AJ, Schneider C (1996) Cyclin Dl and p21/wafl are both involved in p53 growth suppression. Oncogene 12:177-185
27. Desai D, Wessling HC, Fisher RP, Morgan DO (1995) Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol 15:345-350
28. CIP1/WAF1 undergo normal development, but are defective in GI checkpoint control. Cell 82:675-684
29. DiGiuseppe JA, Redstone MS, Yeo CJ, Kern SE, Hruban RH (1995) p53-indepcndent expression of the cyclin-dependent kinase inhibitor p21 in pacreatic carcinoma. Am J Pathol 147:884-888
30. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221
31. Dover R, Wright NA (1991) The cell proliferation kinetics of the epidermis. In: Goldsmith LA (ed) Physiology, biochemistry, and molecular biology of the skin. Oxford University Press, New York, pp 239-265
32. Dracopoli NC, Sam B, Fountain JW, Schartl M (1992) A homolog of the Xiphophorus melanoma-inducing locus Xmrk maps to 6q27 a region frequently involved in rearrangements and deletions in human melanomas. Abstr Am J Hum Genet 54:A51
33. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lces E, Harper JW, Elledge S3, Reed SI (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced Gl arrest. Cell 76:1013-1023
34. Duro D, Bernard O, Delia Valle V, Berger R, Larsen CJ (1995) A new type of p16INK4/MTSl gene transcript expressed in B-cell malignancies. Oncogene 11:21-29
35. Duro D, Bernard O, Delia Valle V, Leblanc T, Berger R, Larsen CJ (1996) Inactivation of the P16INK4/ MTSI gene by a chromosome translocation t(9;14)(p21-22;q11) in an acute lymphoblastic leukemia of B-cell type. Cancer Res 56:848-854
36. Elbendary A, Berchuck A, Davis P, Havrilesky L, Bast RC, Iglehart JD, Marks JR (1994) Transforming growth factor βl can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Diff 5:1301-1307
37. EI-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator ofp53 tumor suppression. Cell 75:817-825
38. Elledge SJ, Harper JW (1994) Cdk inhibitors: on the threshold of checkpoints and development. Curr Opin Cell Biol 6:847-852
39. Ewen M E ( 1994) The cell cycle and the retinoblastoma protein family. Cancer Metastas Reviews 13:45-66
40. Ewen ME, Sluss UK, Sherr CJ, Matsushime H, Kato J, Livingston DM (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497
41. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kipl)-deficient mice. Cell 85:733-744
42. Filvaroff E, Stern DF, Dotto GP (1990) Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol Cell Biol 10:1164-1173
43. Firpo EJ, Koff A, Solomon MJ, Roberts JM (1994) Inactivation of cdk2 inhibitor during interleukin 2-induced proliferation of human T-lymphocytes. Mol Cell Biol 14:4889-4901
44. Fisher PB, Schachter D, Abbott RE, Callaham MF, Huberman E (1984) Membrane lipid dynamics in human promyelocytic leukemia cells sensitive and resistant to 12-O-tetradecanoyl-phorbol-13-acetate induction of differentiation. Cancer Res 44:5550-5554
45. Fisher PB, Prignoli DR, Hermo H Jr, Weinstein IB, Pestka S (1985) Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells. J Interferon Res 5:11-22
46. Fisher RP, Morgan DO (1994) A novel cyclin associates MOI5/CDK7 to form the CDK-activating kinase. Cell 78:713-724
47. Flores-Rozas H, Kelman Z, Dean FB, Pan Z, Harper WJ, Elledge SJ, O'Donnell M, Hurwitz J (1994) Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase and holoenzyme. Proc Natl Acad Sci USA 91:8655-8659
48. Fountain JW, Bale SJ, Housman DE, Dracopoli NC (1990) Genetics of melanoma. Cancer Surv 9:645-671
49. Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Fisher PB, Chellappan SP, Grant S (1997) Effects of antisense p21 (WAF1/CIP1/MDA-6) expression on the induction of differentiation and drug-medi-ated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11:504-513
50. Galktionov K, Jesus C, Beach D (1995) Raf-1 interaction with Cdc25 phosphatase ties mitogenic signaling to cell cycle activation. Genes Dev 9:1046-1058
51. Gautier J, Solomon M, Booher R, Bazan J, Kirshner M (1991) Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67:197-211
52. Giordano A, Kaiser II (1996) The retinoblastoma gene: its role in cell cycle and cancer. In Vivo, 10:223-228
53. Goldstein S (1990) Replicative senescence: the human fibroblast comes of age. Science 249:1129-1133
54. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM (1995) Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531-4535
55. Grana X, Reddy EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11:211-219
56. Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878
57. Gu W, Schneider JW, Condorelli G, Nadal-Ginard B (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309-324
58. Gu Y, Roscnblatt J, Morgan DO (1992) Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyrl5. EMBO J 11:3995-4005
59. Gu Y, Turck CW, Morgan DO (1993) Inhibition of CDK2 activity in vivo by an associated 20 K regulatory subunit. Nature 366:707-710
60. Guan K, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (1994) Growth suppression by p18, a p16INK/MTS1 and p14INK4/MTS2-related CDK6 inhibitor, correlates with wild-type RB function. Genes Dev 8:2939-2952
61. Guan X, Meltzer PS, Cao J, Trent, JM (1992) Rapid generation of region-specific genomic clones by chromosome microdissection: isolation of DNA from a region frequently deleted in malignant melanoma. Gcnomics 14:680-684
62. Guo K, Wang J, Andres V, Smith RC, Walsh K (1995) MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocytc terminal differentiation. Mol Cell Biol 15:3823-3829
63. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018-1021
64. Hall M, Bates S, Peters G (1995) Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11:1581-1588
65. Hannon GJ, Beach D (1994) p15INK4b is a potential effector of cell cycle arrest mediated by TGFβ. Nature 371:257-261
66. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993) The p2l CDK-interacting protein CIP1 is a potential inhibitor of Gl cyclin-dependent kinases. Cell 75:805-816
67. Hartwell LH, Kastan MB (1994) Cell cycle control and cancer. Science 266:1821-1828
68. Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A, Donehower LA (1994) Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nature Genet 5:225-229
69. INK4A) and MTS2 (p15INK4l1) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood 84:4038-4044
70. Hengst L, Reed SI (1996) Translational control of p27Kipl accumulation during the cell cycle. Science 271:1861-1864
71. Hennings H, Micahel D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254
72. Hermeking H, Funk JO, Reichert M, Ellwart JW, Eick D (I995) Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p2irAn.cipi/SDii Qncogene 11:1409-1415
73. Herlyn M (1990) Human melanoma: development and progression. Cancer Metastas Rev 9:101-112
74. Mirai H, Roussel MF, Kalo JY, Ashmun RA, Sherr CJ (1995) Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-2681
75. Hollenstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science, 253:49-53
76. Hollingsworth RJ, Hensey CE, Lee WH (1993) Retinoblastoma protein and the cell cycle. Curr Opin Genet Dev 3:55-62
77. Hooper ML (1994) The role of the p53 and Rb-1 genes in cancer, development and apoptosis. J Cell Sci Suppl 18:13-17
78. Horowitz JM, Udvadia AJ, (1995) Regulation of transcription by the retinoblastoma (Rb) protein. Mol Cell Diff 3(4):275-314
79. Huberman E, Callaham MF (1979) Induction of terminal differentiation in human promyeolcytic leukemia cells by tumor-promoting agents. Proc Natl Acad Sci USA 76:1293-1297
80. Hunter T, Pines J (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79:573-582
81. Jacks T, Fazeli A, Schmitt EM, Bronson RY, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 359:295-300
82. Jacks T, Remington L, Wiliams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (I994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4:1-7
83. Jiang H, Fisher PB (1993) Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells. Mol Cell Diff 1(3):285-299
84. Jiang H, Su Z-Z, Boyd J, Fisher PB (1993) Gene expression changes associated with reversible growth suppression and the induction of terminal differentiation in human melanoma cells. Mol Cell Diff 1(1):41-66
85. Jiang H, Lin J, Fisher PB (1994a) A molecular definition of terminal cell differentiation in humun melanoma cells. Mol Cell Diff 2(3):221-239
86. Jiang H, Lin J, Su Z-Z, Collart FR, Huberman E, Fisher PB (1994b) Induction of differentiation in
87. human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene 9:3389-3396
88. Jiang H, Lin JJ, Su Z-Z, Goldstein NI, Fisher PB (1995a) Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11:2477-2486
89. Jiang H, Lin J, Su Z-Z, Herlyn M, Kerbel RS, Weissman BE, Welch DR, Fisher PB, (1995b) The melanoma differentiation associated gene mda-6, which encodes the cyclin-depcndent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene 10:1855-1864
90. Jiang H, Lin J, Young S-M, Goldstein NI, Waxman S, Davilla V, Chellappan SP, Fisher PB (I995c) Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. Oncogene 11:1179-1189
91. Jiang II, Lin J, Su Z-Z, Fisher PB (1996a) The melanoma differentiation associated gene-6 (mda-6), which encodes the cyclin-dependent kinase inhibitor p21, may function as a negative regulator of human melanoma growth and progression. Mol Cell Diff 4(I):67-89
92. Jiang H, Su Z-Z, Lin JJ, Goldstein NI, Young CSH, Fisher PB (1996b) The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci USA 93:9160-9165
93. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H (1994) Cdc25A is a novel phosphatase functioning early in the cell cycle. EM BO J 13:1549-1556
94. Kacker RK, Giovanella BC, Pathak S (1990) Consistent karyotypic abnormalities in human malignant melanomas. Anticancer Res 10:859-872
95. Kamb A (1995) Cell-cycle regulators and cancer. Trends Genet 11:136-140
96. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stocken E, Day RS III, Johnson BE, Skolnick Mil (1994) A cell cycle regulator involved in genesis of many tumor types. Science 264:436-440
97. Kato J, Matsushime II, Hiebert SW, Hwen ME, Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylalion by the cyclin D-dependent kinase CDK4. Genes Dev .7:331-342
98. Kato JY, Matsuoka M, Polyak K, Massague J, Sherr CJ (1994a) Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kipl) of cyclin-dependent kinase 4 activation. Cell 79:487-496
99. Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994b) Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol 14:2713-2721
100. Kerbel RS (1990) Growth dominance and the metastatic cancer cell: cellular and molecular aspects. Adv Cancer Res 55:87-132
101. Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, HolTman ES, Ono M, Khanam D, Mayday AC, Frohman LA, Koff A (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85:721-732
102. Kobayashi II, Man S, MacDougall JR, Graham CH, Lu C, Kerbel RS (1994) Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype. Am J Pathol 144:776-786
103. Koff A, Ohtuski M, Polyak K, Roberts JM, Massague J (1993) Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGFβ. Science 260:536-539
104. Koh J, Enders GH, Dynlacht BD, Harlow E (1995) Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375:506-510
105. Laiho M, DeCaprio J, Ludlow J, Livingston DM, Massague J (1990) Growth suppression by TGFβ linked to suppression of retinoblastoma protein phosphorylation. Cell 62:175-185
106. Lassar AB, Skapek SX, Novitch B (1994) Regulatory mechanisms that coordinate skeletal muscle dif-ferentiation and cell cycle withdrawal. Curr Opin Cell Biol 6:788-794
107. Lee EY-HP, Chang CY, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee WH, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and hematopoiesis. Nature 359: 288-294
108. Lee MHJ, Reynisdottir I, Massague J (1995) Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9:639-649
109. Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massague J (1996) The brain-specific activator p35 allows Cdk5 to escape inhibition by p27KIP1 in neurons. Proc Natl Acad Sci USA 93:3259-3263
110. Li R, Waga S, Hannon GJ, Beach D, Stillman B (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371:534-537
111. Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995) The cdc-2-related PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res 55:3992-3996
112. Li Y, Jenkins CW, Nichols MA, Xiong Y (1994) Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9:2261-2268
113. Liotta LA, Steeg PG, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336
114. Liu M, Lee M-H, Cohen M, Bommakanti M, Freedman LP (1996) Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10:142-153
115. Loganzo F Jr, Nabeya Y, Maslak P, Albino AP ( 1994) Stabilization of p53 protein is a critical response to UV radiation in human melanocytes: implications for melanoma development. Mol Cell DifT2(1): 23-43
116. Lotem J, Sachs L (1979) Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc Natl Acad Sci USA 76:5158-5162
117. Lu C, Kerbel RS (1994) Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol 6:212-220
118. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J (1995) Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375:503-506
119. Luo Y, Hurwitz J, Massague, J (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21cipl. Nature 375:159-161
120. MacDougall JR, Kobayashi H, Kerbel RS (1993) Responsiveness of normal/dysplastic melanocytes and melanoma cells from different lesional stages of disease progression to the growth inhibitory effects of TGF-β. Mol Cell Diff 1(1):21-40
121. MacLachlan TK, Sang N, Giordano A (1995) Cyclins, cyclin-dependent kinases and Cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Express 5(2):127-156
122. Macleod FF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995) p53-dependent and independent expression of p21 during cell growth, differentiation and DNA damage. Genes Dev 9:935-944
123. MacJohnson DD, Vojta PJ, Barrett JC, Noda A, Pereira-Smith OM, Smith JR (1994) Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol Carcinog 11:59-64
124. Mal A, Poon RY, Howe PH.Toyoshima H, Hunter T, Harter ML (1996) Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells. Nature 380:262-265
125. 3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol 98:391-398
126. Massague J, Polyak K (1995) Mammalian antiproliferative signals and their targets. Curr Opin Genet Dev 5:91-96
127. Marshall CJ (1991) Tumor suppressor genes. Cell 64:313-326
128. Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ (1994) Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol 14:7265-7275
129. Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ (1995) p57KIP2, a structurally distinct member of the p21CIPl Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9(6):650-662
130. Matsushime H, Roussel M, Ashmun R, Sherr CJ (1991) Colony stimulating factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 65:701-713
131. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kalo JY (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14:2066-2076
132. McCarthy DM, San Miguel J, Freake HC, Green PM, Zola H, Catowsky D, Goldman J (1983) 1,25-dihydroxyvitamin D} inhibits the proliferation of human promyelocytic leukemia cell line (HL-60) cells and induces monocyte-macrophage differentiation in HL-60 and normal bone marrow cells. Leuk Res 7:51-55
133. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54:3391-3395
134. Miele ME, Robertson G, Lee J-H, Coleman A, McGary CT, Fisher PB, Lugo TG, Welch DR (1996) Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosome 1 or 6. Mol Carcinog 15:284-299
135. Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM, Dotto PG (1995) Involvement of the cell-cycle inhibitor Cipl/Wafl and the ElA-associated p300 protein in terminal differentiation. Proc Nail Acad Sci USA 92:5451-5455
136. WAF1/CIP1 and terminal differentiation control of normal epithelia. Mol Cell Diff 4(1):1-16
137. 3 induces differentiation of human myeloid leukemia cells. Biochem Bipophys Res Commun 102:937-943
138. Montano X, Shamsher M, Whitehead P, Dawson K, Newton J (1994) Analysis of p53 in human cutaneous melanoma cell lines. Oncogene 9:1455-1459
139. Morgan DO (1992) Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev 2:33-37
140. Morgan DO (1995) Principles of CDK. regulation. Nature 374:131-134
141. Morgan DO (1996) Under arrest at atomic resolution. Nature 382:295-296
142. Morgan DO, De Bondt HL (1994) Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol 6(2):239-246
143. 3 and phorbol-12-myristate-13-acetate. Cancer Res 43:4989-4996
144. Nakanishi M, Robetorge RS, Adami GR, Pereira-Smith OM, Smith JR (1995) Identification of the active region of the DNA synthesis inhibitory gene p2lsd'|.clpl'WAFI. EMBO J 14:555-563
145. Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K (1996) Mice lacking p27(Kipl) display increased body size, multiple organ hypcrplusiu, retinal dysplasia, and pituitary tumors. Cell 85:707-720
146. Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429
147. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994) Deletions of the cyclin dependent kinase 4 inhibitor gene in multiple human cancers. Nature 368:753-756
148. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98
149. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree J, Roberts JM (1994) Interleukin 2-mediated elimination of p27KIP1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573
150. Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH, Harris CC (1994) Mutations and altered expression p16INK4 in human cancer. Proc Natl Acad Sci USA 91:11045-11049
151. Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Slierr CJ, Downing JR (I995a) Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. Genomics 29:623-630
152. Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui C-H, Sherr CJ, Beach D, Look AT, Downing JR (1995b) Frequent deletion ofp16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood 85:2321-2330
153. Olson EN, Klein WU (1994)bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev 8:1-8
154. Pagano M, Tarn SW, Theodoras AM, Beer-Romcro P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685
155. Paggi MG, Baldi A, Bonetto F, Giordano A (1996) The retinoblastoma protein family in cell cycle and cancer. J Cell Biochem 62:418-430
156. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ (1995) p53-independent expression of p2lclnl in muscle and other terminally differentiating cells. Science 267:1024-1027
157. Parry D, Bates S, Mann DJ, Peters G (1995) Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTSl tumour suppressor gene product. EMBO J 14(3):503-511
158. Pathak S, Drwinga HL, Hsu TC (1983) Involvement of chromosome 6 in rearrangements in human malignant melanoma. Cancer Genet Cytotgenet 36:573-579
159. Picksley SM, Lane DP (1994) p53 and Rb: their cellular roles. Curr Opin Cell Biol 6:853-858
160. Pientenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask BJ, Roberts JM, Kinzler KW, Rovley JD, Vogelslein B (1995) Assignment of the human p27Kipl gene to 12p13 and its analysis in leukemias. Cancer Res 55:1206-1210
161. Pines J (1995a) Cyclins and cyclin-dependent kinases: theme and variations. Adv Cancer Res 66:181-212
162. Pines J (1995b) Cyclins, CDKs and cancer. Semin Cancer Biol 6:63-72
163. Pines J (1995c) Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J 308:697-711
164. Polyak K, Kalo JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, KofT A (1994a) p27Kipl, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8:9-22
165. Polyak K, Lee M-H, Erdjument-Bromage H, KofT A, Roberts JM, Tempst P, Massague J (1994b) Cloning of p27KIPI, a cyclin-dependent-kinase inhibitior and a potential mediator of extracellular antimitogenic signals. Cell 78:59-76
166. Kip1: chromosomal mapping to 12p12 and absence of mutations in human tumors. Cancer Res 55:1211-1214
167. Poon RY, Hunter T (1995) Cell regulation. Innocent bystanders or chosen collaborators? Curr Biol 5:1243-1247
168. Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J (1993) The cdc2-relatcd protein p40MO15 is the catalytic subunit of a protein kinase that can activate cdc2. EMBOJ 12(8):3123-3132
169. Poon RY, Toyoshima H, Hunter T (1995) Redistribution of the CDK inhibitor p27 between durèrent cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell 6:1197-1213
170. Quelle DE, Zindy F, Ashmun RA, Sherr CJ (1995a) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83:993-1000
171. Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KM, Walker C, Beach D, Sherr CJ, Serrano M (1995b) Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene 11:635-645
172. Rao SS, Chu C, Kohtz DS (1994) Ectopic expression of cyclin Dl prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. Mol Cell Biol 14:5259-5267
173. Reddy GP (1994) Cell cycle: regulatory events in G1-S transition of mammalian cells. J Cell Biochem 54:379-386
174. Reed SI, Bailly E, Dulic V, Hengst L, Resnitzky D, Slingerland J (1994) Gl control in mammalian cells. J Cell Sci Suppl 18:69-73
175. Reynisdottir I, Polyak K, lavarone A, Massague J (1995) Kip/Crp and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9:1831-1845
176. Sdi1,CiP1,waf1/mda-6 and expression of other cyclin-dependent kinase inhibitors in senescent cell. Mol Cell Diff4(1):113-126
177. Rovera G, Sanloli D, Damsky C (1979) Human promyeolcytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester. Proc Natl Acad Sci USA 76:2779-2783
178. Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP (1996) Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-cdk2 complex. Nature 382:325-331
179. Sang N, Baldi A, Giordano A (1995) The roles of tumor suppressors pRb and p53 in cell proliferation and cancer. Mol Cell Diff 3(1):1-29
180. Schneider JW, Gu W, Zhu L, Mahdavi V, Nadal-Ginard B (1995) Reversal of terminal differentiation meidated by p107 in Rb-/-muscle cells. Science 264:1467-1471
181. Schwaller J, Koefller HP, Niklaus G, Loetscher P, Magel S, Fey MF, Tobler A (1995) Posttranscriptional stabilization underlies p53-independent induction of p21/WAF1/CIPl/SDI1 in differentiating human leukemic cells. J Clin Invest 95:973-979
182. Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell cycle control causing specific inhibition of cyclinD-cdk4. Nature 366:704-707
183. Serrano M, Gomez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D (1995) Inhibition of ras-induced proliferation and cellular transformation by pI6INK4. Science 267:249-252
184. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA (1996) Role of INK4a locus in tumor suppression and cell mortality. Cell 85:27-37
185. Sheikh MS, Li X-S, Chen J-C, Shao Z-M, Ordonez JV, Fontana JA (1994) Mechanisms of regulation of WAFl/Cipl gene expression in human breast carcinoma:
186. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73:1059-1065
187. Sherr CJ (1994a) Gl phase progression: cycling on cue. Cell 79:551-555
188. Sherr CJ (1994b) Growth-factor-regulated Gl cyclins. Stem Cells 12[Suppl] 1:47-55
189. Sherr CJ (1995) D-type cyclins. Trends Biochem. Sci 20:187-190
190. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G| cyclin-dependent kinases. Genes Dev 9:1149-1163
191. Sherr CJ, Kalo J, Quelle DE, Matsuoka M, Roussel MF (1994) D-type cyclins and their cyclin-dependent kinases: Gl phase integrators of the mitogenic response. Cold Spring Harb Symp Quant Biol 59:11-19
192. Shiekhattar R, Mermelstein F, Fisher, RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (1995) Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374:283-287
193. Shivji MKK, Grey SJ, Strausfeld UP, Wood RD, Blow JJ (1994) Cipl inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr Biol 4:1062-1068
194. Skapek SX, Rhee J, Spiccr DB, Lassar AB (1995) Inhibition of myogenic differentiation in proliferating myoblasts by cyclin Dl-dependent kinase. Science 267:1022-1027
195. Smith JR, Pereira-Smith OM (1996) Replicative senescence: implications for in vivo aging and tumor suppression. Science 273:63-67
196. Steinman RA, HofTman B, Iro A, Guillouf C, Liebermann DA, El-Houseini ME (1994) Induction of p21 (WAF1/CIPI) during differentiation. Oncogene 9:3389-3396
197. Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A (1995) Complex structure and regulation of the P16 (MTS1) locus. Cancer Res 55:2988-2994
198. Su Z-Z, Austin VA, Zimmer SG, Fisher PB (1993) Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-rastransformed cloned rat embryo fibroblast cells. Oncogene 8:1211-1219
199. Su Z-Z, Yemul S, Estabrook A, Zimmer SG, Friedman RM, Fisher PB (1995) Transcriptional switching model for the regulation of tumorigenesis and metastasis by the Ha-ras oncogene: transcriptional changes in the Ha-ras tumor suppressor gene lysyl oxidase. Intl J Oncology 7:1279-1284
200. Tarn SW, Shay JV, Pagano M (1994) Differential expression and cell cycle regulation of the cyclin dependent kinase 4 inhibitor p16INK4. Cancer Res 54:5816-5820
201. Toyoshima H, HunterT (1994) p27, a novel inhibitior of Gl-cyclin-cdk protein kinase activity is related to p21. Cell 78:67-74
202. Trent JM (1991) Cytogenetics of human malignant melanoma. Cancer Metastas Rev 10:103-113
203. Trent JM, Stanbridge EJ, McBride HL, Meese EU, Casey G, Araujo DE, Witkowski CM, Nagle RB (1990) Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6. Science 247:568-571
204. Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56:150-153
205. Volkenandt M, Schlegel U, Nanus DM, Albino AP (1991) Mutational analysis of the human p53 gene in malignant melanoma. Pigment Cell Res 4:35-40
206. Waga S, Hannon GJ, Beach D, Stillman B (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578
207. Walsch K, Guo K, Wang J, Andres V (1996) p21 Regulation and function during myogenesis. Mol Cell Di(T 4(1): 17-31
208. Wang J, Walsh K (1996) Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 273:359-361
209. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
210. Weintraub H (I993) The MyoD family and myogenesis: redundancy, networks and thresholds. Cell 75:1241-1244
211. WAF1 a suppressor of malignant melanoma metastasis? Mol Cell Diff 4(1):91-111
212. Welch DR, Bisi JE, Miller BE, Conaway D, Seftor EA, Gilmore LB, Seftor REB, Nakajima M, Hendrix MJC (1991) Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int J Cancer 47:227-237
213. Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Weissman BE, Stanbridge EJ (1994) Microcell-mediated transfer of chromosome 6 into metastatic human C8I61 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene 9:255-262
214. Whyte P (1995) The retinoblastoma protein and its relatives. Semin Cancer Biol 6:83-90
215. Williams BO, Schmitt, EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T (1994a) Extensive contribution of Rb deficient cells to adult chimeric mice with limited histopathological consequences. EMBOJ 13:4251-4259
216. Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T (1994) Cooperative tumorigenic effects of germ-line mutations in Rb ahd p53. Nature Genet 7:480-484
217. Wu H, Wade M, Krall L, Grisliam J, Xiong Y, Van Dyke T (1996) Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development, and regeneration. Genes Dev 10:245-260
218. Xiong Y, Zhang H, Beach D (1992) D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71:505-514
219. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993a) p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704
220. Xiong Y, Zhang H, Beach D (1993b) Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7:1572-1583
221. Yang Z-Y, Perkins ND, Ohno O, Nabel EG, Nabel GJ (1995) The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nature Med 1:1052-1056
222. Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A (1996) Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271:9009-9013
223. Waf is contained in its N-terminal half Chalf-WAF'). Oncogene 11:393-395
224. Zhang H, Xiong Y, Beach D (1993) Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 4:897-906
225. Zhang H, Hannon GJ, Beach D (1994) p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750-1758
226. Zhang W, Grasso L, McClain CD, Gambel AM, Cham Y, Travali S, Deisscroth AB, Mercer WE (1995) p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55:668-674