p53 and Rb: their cellular roles

Current Opinion in Cell Biology

Volumn 6, Issue 6, 1994, Pages 853-858

  Picksley, Steven M ^a   Lane, David P ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LENS PROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RETINOBLASTOMA; REVIEW;

ANIMAL; CELL DIVISION; HUMAN; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMALIA;

EID: 0028172574     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0955-0674(94)90056-6     Document Type: Article

References (42)

1. Sequence-specific transcriptional activation is essential for growth suppression by p53
2. Mdm2 expression is induced by wild-type p53 activity
3. The p53-mdm-2 autoregulatory feedback loop
4. p21 is a universal inhibitor of cyclin kinases
5. WAF1, a potential mediator of p53 tumor suppression
6. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
7. Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
8. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
9. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
10. Requirement for a functional Rb-1 gene in murine development
11. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
12. Effects of an Rb mutation in the mouse
13. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
14. Cooperative tumorigenic effects of germline mutations in Rb and p53
15. p53-dependent apoptosis produced by Rb-deficiency in the eye
16. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development
17. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
18. p53-dependent apoptosis suppresses tumor growth and progression in vivo
19. Thymocyte apoptosis induced by p53-dependent and independent pathways
20. p53 is required for radiation-induced apoptosis in mouse thymocytes
21. p53 and E2F-1 cooperate to mediate apoptosis
22. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
23. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to Mdm-2 and the adenovirus 5 E1B 55-kD protein
24. Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino- and carboxy-termini of the protein
25. Immunochemical analysis of the interaction of p53 with MDM2 — fine mapping of the MDM2 binding site on p53 using synthetic peptides
26. Interaction of p53 with MDM2 is independent of E6 and does not mediate wild-type transformation suppressor function
27. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
28. A temperature-sensitive mutant of human p53
29. Allosteric activation of latent p53 tetramers.
30. Crystal structure of a p53-tumour suppressor-DNA complex: understanding tumourigenic mutations
31. High-resolution structure of the oligomerization domain of p53 by multi-dimensional NMR
32. Tight DNA binding and oligomerization are dispensible for the ability of p53 to transactivate target genes and suppress transformation
33. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding
34. Allosteric activation of latent p53 tetramers
35. p53-catalyzed annealing of complementary single-stranded nucleic acids
36. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer
37. Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP
38. Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization
39. Evidence for a protein domain superfamily shared by the cyclins, TFIIB and Rb/p107
40. Identification of a growth suppression domain within the retinoblastoma gene product
41. Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein
42. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle