Mutational Analysis of the Human p53 Gene in Malignant Melanoma

Pigment Cell Research

Volumn 4, Issue 1, 1991, Pages 35-40

  VOLKENANDT, MATTHIAS ^a   SCHLEGEL, UWE ^a   NANUS, DAVID M ^a   ALBINO, ANTHONY P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Human melanocytes; Transformation; Tumor suppressor gene

Indexed keywords

ARTICLE; CELL LINE; EXON; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CELL LINE; DNA MUTATIONAL ANALYSIS; EXONS; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES;

EID: 0026110727     PISSN: 08935785     EISSN: 16000749     Source Type: Journal    
DOI: 10.1111/j.1600-0749.1991.tb00311.x     Document Type: Article

References (26)

1. Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity
2. Class II histocompatibility antigen expression in human melanocytes transformed by Harvey murine sarcoma virus (Ha‐MSV) and Kirsten MSV retroviruses
3. The role of oncogenes in the pathogenesis of malignant melanoma
4. Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype
5. Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression
6. Expression of the c‐src protooncogene in human skin tumors
7. Genetic and immunochemical analysis of mutant p53 in breast cancer cell lines
8. A variation in the structure of the proteincoding region of the human p53 gene
9. Single‐step method of RNA isolation by acid guanidinium thiocyanate‐phenol‐chloroform extraction
10. Sequence analysis of a human gene responsible for drug resistance: a rapid method for manual and automated direct sequencing of products generated by the polymerase chain reaction
11. Mutational analysis of human N‐ras genes in malignant melanoma: rapid methods for oligonucleotide hybridization, manual and automated direct sequencing of products generated by the polymerase chain reaction
12. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin
13. A Taqi RFLP of the human TGF alpha gene is significantly associated with cutaneous malignant melanoma
14. Increased expression of mutant forms of p53 oncogene in primary lung cancer
15. Mutations in the p53 gene occur in diverse human tumour types
16. Activation of N‐ras in a human melanoma cell line
17. Nonrandom chromosome structural aberrations and oncogene loci in human malignant melanoma
18. Chromosome and growth factor abnormalities in melanoma
19. An improvement of the single‐step method of RNA isolation by acid guanidinium thiocyanate‐phenol‐chloroform extraction
20. Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay
21. Primer‐directed enzymatic amplification of DNA with a thermostable DNA polymerase
22. Molecular cloning and the total nucleotide sequence of the human c‐Ha‐ras‐1 gene activated in a melanoma from a Japanese patient
23. Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53
24. DNA sequence analysis with a modified bacteriophage T7 DNA polymerase
25. Sequence analysis of DNA from paraffin embedded human malignant melanoma