Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases

Genomics

Volumn 29, Issue 3, 1995, Pages 623-630

  Okuda, Tsukasa ^a   Hirai, Hiroshi ^a   Valentine, Virginia A ^a   Shurtleff, Sheila A ^a   Kidd, Vincent J ^a   Lahti, Jill M ^a   Sherr, Charles J ^a   Downing, James R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0028811262     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1995.9957     Document Type: Article

References (39)

1. Baldin, V., Lukas, J., Marcóte, M. J., Pagano, M., and Draetta, G. (1993). Cyclin Dl is a nuclear protein required for cell cycle progression in Gl. Genes Dev. 7: 812-821.
2. Bunnell, B. A., Heath, L. S., Adams, D. E., Lahti, J. M., and Kidd, V. J., (1990). Increased expression of a 58-k Da protein kinase leads to changes in the CHO cell cycle [published erratum appears in Proc. Nati. Acad. Sci. USA 1991 88(6):2612]. Proc. Natl. Acad. Sci. USA 87: 7467-7471.
3. Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., and Kern, S. E., (1994). Frequent somatic mutations and homozygous deletions of the pl6 (.MTS I) gene in pancreatic adenocarcinoma. Nature Genet. 8: 27-32.
4. Chan, F. K. M., Zhang, J., Chen, L., Shapiro, D. N., and Winoto, A. (1995). Identification of human/mouse pl9. a novel cdk4/cdk6 inhibitor with homology to pl6INK4. Mol. Cell. Biol. 15: 2682-2688.
5. Dalton, W. T., Ahearn, M. J., Mc Credir, K. B., Freireich, E. J., Stass, S. A., and Trujillo, J. M., (1988). HL60 cell line was derived from a patient with FAB-M2 and not FAB-M3. Blood 71: 242-247.
6. Ewen, M. D., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J. Y., and Livingston, D. M., (1993). Functional interaction of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487-497.
7. Gallagher, R., Collins, S., Trujillo, J., Mc Credie, K., Ahearn, M., Tsai, S., Metzgar, R., Aulakh, G., Ting, R., Ruscetti, F., and Gallo, R. (1979). Characterization of the continuous, differentiating myeloid cell line (HL60) from a patient with acute promyelocytic leukemia. Blood 54: 713-718.
8. Guan, K. L., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O’Keefe, C. L., Matera, G., and Xiong, Y. (1994). Growth suppression by pl8. a P16/w’/wrs/-and pl4/Wiß/v/r^-related CDK6 inhibitor, correlates with wild-type p Rb function. Genes Dev. 8: 2939-2952.
9. Hannon, G. J., and Beach, D. (1994). pl5INK4B is a potential effector of TGF-B-induced cell cycle arrest. Nature 371: 257-261.
10. Hebert, J., Cayuela, J. M., Berkeley, J., and Sigaux, F. (1994). Candidate tumor-suppressor genes MTS I (pl6/, v/r M) and MTS2 (p75, W4S) display frequent homozygous deletions in primary cells from T-but not from B-cell lineage acute lymphoblastic leukemias. Blood 84: 4038-4044.
11. Hlrai, H., Roussel, M. F., Kato, J. Y., Ashmun, R. A., and Sherr, C. J., (1995). Novel INK4 proteins. pl9 and pi8: Specific inhibitors of cyclin D-dependent kinases. Cdk4 and Cdk6. Mol. Cell. Biol. 15: 2672-2681.
12. Hunter, T. (1993). Braking the cycle. Cell 75: 839-841.
13. Hunter, T., and Pines, J. (1994). Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 79: 573-582.
14. Hussussian, C. J., Struewing, J. P., Goldstein, A. M., Higgins, P. A. T., Ally, D. S., Sheahan, M. D., Clark, W. H., Tucker, M. A., and Dracopoli, N. C., (1994). Germline pi6 mutations in familial melanoma. Nature Genet. 8: 15-26.
15. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., and Skolnick, M. H., (1994). A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440.
16. Kamps, M. P., Murre, C., Sun, X. H., and Baltimore, D. (1990). A new homeobox gene contributes the DNA binding domain of the t(l: 19) translocation protein in pre-B ALL. Cell 60: 547-555.
17. Kato, J.-Y., Matsushlme, H., Hiebert, S. W., Ewen, M. E., and Sherr, C. J., (1993). Direct binding of cyclin D to the retinoblastoma gene product (p Rb) and p Rb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7: 331-342.
18. Kato, J., Matsuoka, M., Strom, D. K., and Sherr, C. J., (1994). Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14: 2713-2720.
19. Khatib, Z. A., Inaba, T., Valentine, M., and Look, A. T., (1994). Chromosome localization and c DNA cloning of the human DBP and TEF genes. Genomics 23: 344-351.
20. Lozzio, C. B., and Lossio, B. B., (1985). Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood 45: 321-326.
21. Lukas, J., Muller, M., Bartkova, J., Spitkovsky, D., Kjerulff, A. A., Jansen-Durr, P., Strauss, M., and Bartek, J. (1994). DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell’s requirement for cyclin D1 function in Gl, J. Cell Biol. 125: 625-638.
22. Lukas, J., Bartkova, J., Rohde, M., Strauss, M., and Bartek, J. (1995). Cyclin D1 is dispensable for Gl control in retinoblastoma gene-deficient cells, independent of cdk4 activity. Mol. Cell. Biol. 15: 2600-2611.
23. Matsushime, H., Roussel, M. F., Ashmun, R. A., and Sherr, C. J., (1991). Colony-stimulating factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 65: 701-713.
24. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J., and Kato, J. (1994). D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14: 2066-2076.
25. Meyerson, M., and Harlow, E. (1994). Identification of a Gl kinase activity for cdk6. a novel cyclin D partner. Mol. Cell. Biol. 14: 2077-2086.
26. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashl, K., and Car-son, D. A., (1994). Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368: 753-756.
27. Nourse, J., Mellentin, J. D., Galili, N., Wilkinson, J., Stanbridge, E., Smith, S. D., and Cleary, M. L., (1990). Chromosomal translocation t(l: 19) results in synthesis of a homeobox fusion m RNA that codes for a potential chimeric transcription factor. Cell 60: 535-545.
28. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B., Serrano, M., Beach, D. H., and Harris, C. C., (1994). Mutations and altered expression of pl6, NK in human cancer. Proc. Natl. Acad. Sci. USA 91: 11045-11049.
29. Okuda, T., Cleveland, J. L., and Downing, J. R., (1992). PCTAIRE 1 and PCTAIRE-3. two members of a novel cdc2/CDC28-related protein kinase gene family. Oncogene 7: 2249-2258.
30. Okuda, T., Shurtleff, S. A., Valentine, M. B., Raimondi, S. C., Head, D. R., Behm, F., Curcio-Brint, A. M., Liu, Q., Pul, C. H., Sherr, C. J., Beach, D., Look, A. T., and Downing, J. R., (1995). Frequent deletion of pl€?NK4a/MTSl and pi 5INKib/MTS2 in pediatric acute lymphoblastic leukemia. Blood 85: 2321-2330.
31. Otterson, G. A., Kratzke, R. A., Coxon, A., Kim, Y. W., and Kaye, F. J., (1994). Absence of pl O^^ protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9: 3375-3378.
32. Parry, D., Bates, S., Mann, D. J., and Peters, G. (1995). Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of pl6/AK*/!V*75/tumor suppressor gene product. EMBO J. 14: 503-511.
33. Privitera, E., Kamps, M. P., Hayashi, Y., Inaba, T., Shapiro, L. H., Raimondi, S. C., Behm, F., Hendershot, L., Carroll, A. J., Baltimore, D., and Look, A. T., (1992). Different molecular consequences of the 1:19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia. Blood 79: 1781-1788.
34. Pui, C. H., Crist, W. M., and Look, A. T., (1990). Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 76: 1449-1463.
35. Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J. Y., Bar-Sagi, D., Roussel, M. F., and Sherr, C. J., (1993). Overexpression of mouse D-type cyclins accelerate Gl phase in rodent fibroblasts. Genes Dev. 7: 1559-1571.
36. Serrano, M., Hannon, G. J., and Beach, D. (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
37. Sherr, C. J., (1994). Gl phase progression: Cycling on cue. Cell 79: 551-555.
38. Sherr, C. J., and Roberts, J. M., (1995). Inhibition of mammalian Gl cyclin-dependent kinases. Genes Dev. 9: 1149-1163.
39. Strong, R. C., Korsmeyer, S. J., Parkin, J. L., Arthur, D. C., and Kersey, J. H., (1985). Human acute leukemia cell line with the t(4:11) chromosome rearrangement exhibit B lineage and monocytic characteristics. Blood 65: 21-26.