The cell cycle and the retinoblastoma protein family

Cancer and Metastasis Reviews

Volumn 13, Issue 1, 1994, Pages 45-66

  Ewen, Mark E ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

cyclin dependent kinase; p107; retinoblastoma protein; transcription factor E2F; transforming growth factor beta; tumor suppressor

Indexed keywords

RETINOBLASTOMA PROTEIN;

ANIMAL CELL; CANCER CONTROL; CANCER GENETICS; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL ONCOGENE; CELL PROLIFERATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTO ONCOGENE; RETINOBLASTOMA; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMAL; CELL CYCLE; GENE EXPRESSION REGULATION; GENES, RETINOBLASTOMA; HUMAN; NEOPLASMS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0028009849     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00690418     Document Type: Article

References (184)

1. Mutation and cancer: statistical study of retinoblastoma
2. Patient with chromosome 13 deletion: evidence that the retinoblastoma gene is a recessive cancer gene
3. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
4. A general theory of carcinogenesis
5. Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma
6. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition
7. Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D
8. Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastoma
9. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
10. Human retinoblastoma susceptibility gene: cloning, identification, and sequence
11. Structural evidence for the authenticity of the human retinoblastoma gene
12. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity
13. Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein
14. Tumor suppressor genes
15. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells
16. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene
17. Association between an oncogene and an antioncogene: the adenovirus E1A proteins binds to the retinoblastoma gene product
18. SV40 large T antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
19. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
20. Association of adenovirus early-region 1A proteins with cellular polypeptides
21. Detection of cellular proteins associated with human adenovirus type 5 region 1A polypeptides
22. Binding of the Rb1protein to E1A products is required for adenovirus transformation
23. Point mutational inactivation of the retinoblastoma antioncogene
24. Ela regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related
25. The release of growth arrest by microinjection of adenovirus E1A DNA
26. Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins
27. The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
28. In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
29. Identification of separate domains in the adenovovirus E1A gene for immortalization activity and the activation of virus early genes
30. Multiple functional domains in the adenovirus E1A gene
31. A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products
32. Two regions of the adenovirus early region 1A proteins are required for transformation
33. Cellular targets for transformation by the adenovirus E1A proteins
34. Identification of a region of simian virus 40 large T antigen required for cell transformation
35. Separation of simian virus 40 large-Tantigen-transforming and origin-binding functions from the ability to block differentiation
36. Functional domains of adenovirus type 5 Ela proteins
37. SV40 T antigen binds specifically to a cellular 53K protein in vitro
38. The p53 proto-oncogene can act as a suppressor of transformation
39. Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line
40. Loss of a highly conserved domain of p53 as a result of a gene deletion during Freind virus-induced erythroleukemia
41. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
42. An N-terminal transformation - governing sequence of SV40 large T antigen contributes to the binding of both p110RB and a second cellular protein, p120
43. Molecular cloning chromosomal mapping, and expression of the cDNA for p107, a retin-oblastoma gene product-related protein
44. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
45. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
46. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
47. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
48. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
49. The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
50. Specific enzymatic dephosphorylation of the retinoblastoma protein
51. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
52. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression
53. G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
54. Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering
55. Nuclear binding of purified retinoblastoma gene product is determined by cell cycle-regulated phosphorylation
56. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations
57. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen
58. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product
59. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells
60. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding
61. Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen
62. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation
63. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
64. Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions
65. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2
66. Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression
67. Identification of a growth suppression domain within the retinoblastoma gene product
68. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
69. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F
70. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
71. Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type cyclins
72. Physical interaction of the retinoblastoma protein with human D cyclins
73. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product
74. A cellular protein that competes with SV40 T antigen for binding the retinoblastoma gene product
75. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
76. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
77. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
78. Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F
79. Direct binding of cyclin D to the retinoblastoma gene product and pRb phosphorylation by the cyclin D-dependent kinase, cdk4
80. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
81. Amino-terminal Domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
82. Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2
83. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
84. E2F: a link between Rb tumor supressor protein and viral oncoproteins
85. Adenovirus E1A can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation
86. The E2F transcription factor is a cellular target for the RB protein
87. Adenovirus E1A prevents the retinoblastoma gene product from complexing with a cellular transcription factor
88. The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
89. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
90. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor
91. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway
92. Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 by the product of the RB1 gene
93. Cell cycle regulation of the human cdc2 gene
94. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the DHFR promoter
95. Human DNA polymerase alpha gene, sequences controlling expression in cycling and serum-stimulated cells
96. The identification of a 70 base pair cellcycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors
97. Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo
98. Oncogenic activation of cyclin A
99. Thymidine kinase transcription is regulated at G1-S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase
100. The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter
101. Retinoblastoma protein switches the E2F site from positive to negative element
102. Adenovirus E1A prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor
103. Transcription factor E2F binds DNA as a heterodimer
104. A new component of the transcription factor DRTF1/E2F 1
105. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner
106. A cyclin A protein kinase complex possesses sequence specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
107. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
108. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner
109. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response
110. The NFAT-1 DNA binding complex in activated T-cells contains Fra-1 and JunB
111. Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes
112. Negative regulation of human c-fos expression by the retinoblastoma gene product
113. Regulation of transforming growth factor β1 gene expression by the product of the retinoblastoma-susceptibility gene
114. The retinoblastoma gene product regulates Sp-1 mediated transcription
115. Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
116. Transforming growth factor β1 supression of c-myc gene transcription: role in inhibition of keratinocyte proliferation
117. TGF-β inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
118. Transforming growth factor-β inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSH-I
119. The transforming growth factor-β family
120. Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells
121. Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor b1 and by the retinoblastoma gene product
122. Early gene responses to transforming growth factor-β in cells lacking growth suppressive RB function
123. Abrogation by c-myc of G1 phase arrest induced RB protein but not by p53
124. When the products of oncogenes and anti-oncogenes meet
125. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoetic cells
126. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
127. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
128. Effects oan Rb mutation in the mouse
129. Requirement for a functional Rb-1 gene in murine development
130. For our eyes only
131. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein
132. Animal cell cycles and their control
133. Universal control mechanism regulating onset of M-phase
134. A novel cyclin encoded by a bcll-linked candidate oncogene
135. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
136. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
137. Cyclin D and oncogenesis
138. A new human protein kinase, cdk2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homologue of Xenopus Eg1
139. CDK2 encodes a 33-kDa cyclin A associated protein kinase and is expressed before CDC2 in the cell cycle
140. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
141. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation
142. A family of human cdc2-related protein kinases
143. D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
144. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
145. Cyclin A is required at two points in the human cell cycle
146. A cdc2-like protein is involved in the initiation of DNA replication in xenopus egg extracts
147. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
148. Cyclin A is required in S phase in normal epithelial cells
149. cdc2 is a component of M phase-specific histone H1 kinase: evidence for identity with MPF
150. The retinoblastoma protein physcially associates with the human cdc2 kinase
151. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase
152. In vitro phosphorylation of the tumor suppressor gene Rb protein by mitosis-specific histone H1 kinase
153. Co-purification of p34 cdc2/p58 cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine-threonine protein kinase with a tumor-suppressor protein
154. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
155. Human cyclin is A adenovirus E1A-associated protein p60 and behaves differently from cyclin
156. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
157. Association of human cyclin E with a periodic G1-S phase protein kinase
158. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
159. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
160. Cyclin-dependent regulation of G1 in mammalian fibroblasts
161. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β1
162. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
163. Cloning of a D-type cyclin from murine erythroleukemia cells
164. Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents
165. Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts
166. Distinct, essential roles of type 1 and 2A protein phosphateses in control of the fission yeast cell division cycle
167. Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit
168. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins
169. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells
170. Interaction between human cyclin A and adenovirus E1A-associated p107 protein
171. Role for cyclin A in the dependence of mitosis on completion of DNA replication
172. Adenovirus E1A is associated with a serine/threonine protein kinase
173. Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E
174. Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells
175. Changes in growth and tumorigenicity following reconstitution of retinoblastoma gene function in various human cancer cell types by microcell transfer of chromosome 13
176. G1 events and regulation of cell proliferation