The retinoblastoma protein and its relatives

Seminars in Cancer Biology

Volumn 6, Issue 2, 1995, Pages 83-90

  Whyte, Peter ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Cell cycle; P107; P130; Retinoblastoma protein; Tumor suppressor genes

Indexed keywords

CYCLINE; E1A ASSOCIATED P130 PROTEIN; E1A-ASSOCIATED P130 PROTEIN; NUCLEAR PROTEIN; P107 RETINOBLASTOMA GENE PRODUCT RELATED PROTEIN; P107 RETINOBLASTOMA GENE PRODUCT-RELATED PROTEIN; PHOSPHOPROTEIN; RETINOBLASTOMA PROTEIN; VIRUS PROTEIN;

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; RETINOBLASTOMA; REVIEW; TUMOR SUPPRESSOR GENE;

ADENOVIRUS E1A PROTEINS; ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; CYCLINS; GENES, RETINOBLASTOMA; HUMAN; MICE; NUCLEAR PROTEINS; PHOSPHOPROTEINS; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC;

EID: 0029281412     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1995.0011     Document Type: Article

References (69)

1. Cowell JK and Hogg A (1992) Genetics and cytogenetics of retinoblastoma. Cancer Genet Cytogenet 64:11
2. Weinberg RA (1992) The retinoblastoma gene and gene product. Cancer Surveys 12:43-57
3. Clarke AR, Maandag ER, van Roon M, vander Lugt NMT, vander Valk M, Hooper ML, Berns A, te Riele H (1992) Requirement for a functional Rb-1 gene in murine development. Nature 359:328-330
4. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effects of an Rb mutation in the mouse. Nature 359:295-300
5. Lee EY-HP, Chang C-Y, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee W-H, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haemoatopoiesis. Nature 359:288-294
6. Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RAE, Harlow E (1988) Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product. Nature 334:124-129
7. Dyson N, Harlow E (1992) Adenovirus E1A targets key regulators of cell proliferation. Cancer Surveys 12:161-195
8. Levine AJ (1993) The tumorsuppressor genes. Annu Rev Biochem 62:623-651
9. Ewen Me, Xing Y, Lawrence JB, Livingston DM (1991) Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66:1155-1164
10. Li Y, Graham C, Lacy S, Duncan AMV, Whyte P (1993) The adenovirus E1A-associated 130 kd protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev 7:2366-2377
11. Hannon GJ, Demetrick D, Beach D (1993) Isolation of the RB-related p130 through its interaction with CDK2 and cyclins. Genes and Develop 7:2378-2391
12. Hu Q, Dyson N, Harlow E (1990) The regions of the retinoblastoma protein needed for binding to the adenovirus E1A or SV40 large T antigen are common sites for mutation. EMBO J 9:1147-1155
13. Huang S, Wang N-P, Tseng BY, Lee W-H, Lee EH-HP (1990) Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen. EMBO J 9:1815-1822
14. Kaelin WG, Ewen ME, Livingston DM (1990) Definition of the mineral simian virus 40 large T antigen- and adenovirus E1A-Binding Domain in the retinoblastoma gene product. Mol Cel. Biol 10:3761-3769
15. Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E (1993) Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev 7:1111-1125
16. Qin X, Chittenden T, Livingston DM, Kaelin WG (1992) Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev 6:953-964
17. Hiebert SW (1993) Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRB-mediated growth suppression. Mol Cell Biol 13:3384-3391
18. Qian Y, Luckey C, Horton L, Esser M, Templeton DJ (1992) Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding. Mol Cell Biol 12:5363-5372
19. Kato J, Mitsushime H, Heibert SW, Ewen ME, Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7:331-342
20. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73:487-497
21. Dowdy SF, Hinds PH, Louie K, Reed SI, Arnold A, Weinberg RA (1993) Physical interaction of the retinoblastoma protein with human D cyclins. Cell 73:499-511
22. Ewen ME, Faha B, Harlow E, Livingston D (1992) Interaction of p107 with cyclin A independent of a complex formation with viral oncoproteins. Science 255:85-87
23. Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A (1992) A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70:337-350
24. Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA Livingston DM, Flemington EK (1992) Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:35-364
25. Shan B, Zhu X, Chen P-L, Durfee T, Yang Y, Sharp D, Lee W-H (1992) Molecular cloning of cellular genes encoding retino-blastoma-associated proteins: Identification of a gene with properties of the transcription factor E2F. Mol Cell Biol 12:5620-5631
26. Ivey-Hoyle M, Conray R, Huber HE, Goodhart PJ, Oliff A, Hembrook DC (1993) Coning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol Cell Biol 13:7802-7812
27. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (1993) The retinoblastoma protein binds to a family of transcription factors. Mol Cell Biol 13:7813-7825
28. Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (1993) A new component of the transcription factor DRTF1/E2F. Nature 362:83-87
29. Rustgi AK, Dyson N, Bernards R (1991) Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product. Nature 352:541-544
30. Wang C-Y, Petryniak B, Thompson CB, Kaelin WG, Leiden JM (1993) Regulation of the ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science 260:1330-1335
31. Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A (1991) Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature 352:251-254
32. Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, Jones RE. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene 8:3149-3156
33. Hagemeier C, Bannister AJ, Cook A, Kouzarides T (1993) The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci USA 90:1580-1584
34. Hu Q, Lees JA, Buckhovich KJ, Harlow E (1992) The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol 12:971-980
35. Qian Y-W, Wang Y-CJ, Hollingsworth RE, Jones D, Ling N, Lee EY-H (1993) A retinoblastoma-binding protein related to a negative regulator of ras in yeast. Nature 364:648-652
36. Durfee T, Becherer K, Chen P-L, Yeh S-H, Yang Y, Kilburn AE, Lee W-H, Elledge SJ (1993) The retinoblastoma protein associates with the protein phophatase type 1 catalytic subunit. Genes Dev 7:555-569
37. Welch PJ, Wang JYJ (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-abl tyrosine kinase in the cell cycle. Cell 75:779-790
38. Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72:309-324
39. Kim S-J, Wagner S, Liu F, O’Reilly MA, Robbins PD, Green MR (1992) Retinoblastoma gene product activates expression of the human TGF-B2 gene through transcription factor ATF-2. Nature 358:331-334
40. Iavaronne A, Garg P, Lasorella A, Hsu J, Israel MA (1994) The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev 8:1270-1284
41. Nevins JR (1992) E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429
42. La Thangue NB (1994) DP and E2F proteins: Components of a heterodimeric transcription factor implicated in cell cycle control. Current Biology 6:443-450
43. Gu W, Bhatia K, Magrath IT, Dang CV, Dalla-Favera R (1994) Binding and suppression of the myc transcriptional activation domain by p107. Nature 264:251-254
44. Faha B, Ewen M, Harlow E, Livingston D (1992) Interaction between cyclin A and adenovirus E1A-associated p107 protein. Science 255:87-90
45. Lees E, Faha B, Dulic V, Reed SI, Harlow E (1992) Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner, Genes Dev 6:1874-1885
46. Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA (1993) Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404
47. Lee W-H, Shew J-Y, Hong FD, Sery TW, Donoso LA, Young L-J, Bookstein R, Lee EY-HP (1987) The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 329:642-645
48. Buchkovich KJ, Duffy LA, Harlow E (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097-1105
49. Chen P-L, Scully P, Shew J-Y, Wang JYJ, Lee W-H (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-1198
50. DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwinica WH, Huang CA, Livingston DM (1989) The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 58:1085-1095
51. Lees JA, Buchkovich KJ, Marchak DR, Anderson CW, Harlow E (1991) The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J 10:4279-4290
52. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992) Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006
53. Ludlow JW, Shon J, Pipas MD, Livingston M, DeCaprio JA (1990) The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell 60:387-396
54. Peeper DS, Parker LL, Ewen ME, Toebes M, Hall FL, Xu M, Zantema A, van der Eb AJ, Piwinica-Worms H (1993) A and B type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. EMBO J 12:1947-1954
55. Robbins PD, Horowitz JM, Mulligan RC (1990) Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature 346:668-671
56. Kim S-J, Lee H-D, Robbins PD, Busam K, Spron MB, Roberts AB (1991) Regulation of transforming growth factor B1 gene expression by the product of the retinoblastoma-susceptibility gene. Proc Natl Acad Sci USA 88:3052-3056
57. Kim S-J, Onwuta US, Lee YI, Li R, Botchan MR, Robbins PL (1992) The retinoblastoma gene product regulates Sp1-medi-ated transcription. Mol Cell Biol 12:2455-2463
58. Udvadia AJ, Rogers KT, Higgins PFR, Murata Y, Martin KH, Humphrey PA, Horowitz JM (1993) Sp-1 binds promoter elements regulated by the RB protein and Sp-1 mediated transcription is stimulated by the RB co-expression. Proc Natl Acad Sci USA 90:3265-3269
59. Goodrich DW, Wang NP, Qian Y-W, Lee E-H, Lee W-H (1991) The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67:293-302
60. Templeton DJ, Park SH, Lanier L, Weinberg RA (1991) Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association and nuclear tethering. Proc Natl Acad Sci USA 88:3033-3037
61. Fung Y-KT, T’Ang A, Murchree AL, Zhang F-H, Qiu W-R, Wang S-W, Shi H-H, Lee L, Driscoll B, Wu K-J (1993) The RB gene suppresses the growth of normal cells. Oncogene 8:2659-2672
62. Muncaster MM, Cohen BL, Phillips RA, Gallie BL (1992) Failure of RB1 to reverse the malignant phenotype of human tumor cell lines. Cancer Res 52:645-661
63. Huang H-JS, Yee J-K, Shew J-Y, Chen P-L, Bookstein R, Friedmann T, Lee E-YH-P, Lee W-H (1988). Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 242:1563-1566
64. Bookstein R, Shew J-Y, Chen P-L, Scully P, Lee W-H (1990). Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247:712-715
65. Zhou Y, Li J, Xu K, Hu S-X, Benedict W, Xu H-J (1994) Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells. Proc Natl Acad Sci USA 91:4165-4169
66. Madreperla SA, Whittum-Hudson JA, Prendergast RA, Chen P-L, Lee W-H (1991) Intraocular tumor suppression of retino-blastoma gene-reconstituted retinoblastoma cells. Cancer Res 51:6481-6384
67. Schneider JW, Gu W, Zhu L, Mahdavi V, Nadal-Ginard B (1994) Reversal of terminal differentiation mediated by p107 in Rb -/muscle cells. Nature 264:1467-1471
68. Beijersbergen BL, Kerkhoven RM, Zhu L, Carlee L, Voorhoeve PM, Bernards R (1994) E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690
69. Ginsberg D, Vairo G, Chittenden T, Xiao Z-X, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (1994) E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev 8:2665-2679