-
1
-
-
0027242328
-
Cdc-2 activation: the interplay of cyclin binding and Thr161 phosphorylation
-
(1993)
Trends Cell Biol
, vol.3
, pp. 287-289
-
-
Draetta1
-
4
-
-
0027336491
-
1 cyclins
-
(1993)
Cell
, vol.73
, pp. 1059-1065
-
-
Sherr1
-
6
-
-
0027173109
-
Cyclins and cyclin-dependent kinases: take your partners
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 195-197
-
-
Pines1
-
7
-
-
0026703325
-
Creative blocks: cell-cycle checkpoints and feedback controls
-
(1992)
Nature
, vol.359
, pp. 599-604
-
-
Murray1
-
8
-
-
0027172527
-
Exercising self-restraint: discouraging illicit acts of S and M in eukaryotes
-
(1993)
Cell
, vol.74
, pp. 223-226
-
-
Li1
Deshaies2
-
9
-
-
0026768559
-
Checkpoint controls that couple mitosis to completion of DNA replication
-
(1992)
Trends Cell Biol
, vol.2
, pp. 277-281
-
-
Roberge1
-
10
-
-
0027768579
-
Braking the cycle
-
(1993)
Cell
, vol.75
, pp. 839-841
-
-
Hunter1
-
12
-
-
0028072520
-
Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle.
-
in press
-
(1994)
Cell
-
-
Peter1
Herskowitz2
-
13
-
-
0023651321
-
Dual regulation of the CDC28-p40 protein kinase complex: cell cycle, phermone, and nutrient limitation effects
-
(1987)
Cell
, vol.50
, pp. 927-935
-
-
Mendenhall1
Jones2
Reed3
-
14
-
-
0027339342
-
An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae
-
of special interest, This paper showed the first biochemical evidence for an inhibitor protein found associated with a Cdk. The p40 protein, later called Sic1, was purified and shown to inhibit the histone H1 kinase activity of immunoprecipitated or Cks1 affinity purified Cdc28-cyclin complexes.
-
(1993)
Science
, vol.259
, pp. 216-242
-
-
Mendenhall1
-
15
-
-
0028206855
-
An inhibitor of yeast cyclin-dependent kinase plays an important role ensuring the genomic integrity of daughter cells
-
of outstanding interest, The p40 protein had been identified previously as a Cdc28-associated protein capable of inhibiting Cdc28 complexes [see 14 of special interest]. Here the gene encoding p40 was isolated and called SIC1. Overproduction of SIC1 produced a phenotype similar to that of cells lacking mitotic cyclins, suggesting a role in inhibiting mitosis. Cells lacking SIC1 were viable but contained broken or damaged chromosomes, suggesting a potential problem in S phase.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 3320-3328
-
-
Nugroho1
Mendenhall2
-
19
-
-
0027078396
-
Phosphorylation of FAR1 in response to α-factor: a possible requirement for cell cycle arrest
-
(1992)
Mol Biol Cell
, vol.3
, pp. 445-450
-
-
Chang1
Herskowitz2
-
20
-
-
0027191189
-
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
-
of outstanding interest, The Fus3 protein kinase is activated in response to α-factor through a MAP kinase cascade and this activation is necessary for cell cycle arrest. This paper shows that Fus3 kinase can phosphorylate Far1 protein and regulate its association with Cdc28. Although Far1 had not been shown biochemically to be an inhibitor of Cdc28, genetically it behaved as one. This, together with the final demonstration of inhibitor activity [21 of outstanding interest], connected the entire α-factor signal transduction pathway to cell cycle arrest. This is the first complete pathway for negative growth factor arrest.
-
(1993)
Cell
, vol.73
, pp. 747-760
-
-
Peter1
Gartner2
Horecka3
Ammerer4
Herskowitz5
-
21
-
-
0028085427
-
Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
-
of outstanding interest, Finally, finally, direct evidence that Far1 is a biochemical inhibitor of cyclin dependent kinases. (see [20 of outstanding interest]).
-
(1994)
Science
, vol.265
, pp. 1228-1231
-
-
Peter1
Herskowitz2
-
23
-
-
0028044610
-
+ gene
-
of outstanding interest, This amazing paper describes the identification of a protein, rum1, which when overexpressed can cause S. pombe cells to continue to undergo successive rounds of S phase without an intervening mitosis. This is similar to the well documented endoreplication which occurs in certain tissues of multicellular eukaryotes such as mammals and Drosophila melanogaster.
-
(1994)
Nature
, vol.367
, pp. 236-242
-
-
Moreno1
Nurse2
-
25
-
-
0027496935
-
1 cyclin-dependent kinases
-
Cip1 was also shown to be capable of blocking DNA replication and acting in a manner opposite to SV40 T-antigen. In a related paper from the Vogelstein laboratory (see [28 of outstanding interest]), the same gene was isolated as a p53-regulated transcript that was a potential mediator of the tumor-suppressing function of p53. Together these papers provided the first direct link between the most frequently observed lesion in human cancers, mutations of the p53 tumor suppressor gene, and negative regulation of the cell cycle. This [[Truncated]]
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper1
Adami2
Wei3
Keyomarsi4
Elledge5
-
26
-
-
0027717617
-
p21 is a universal inhibitor of cyclin kinases
-
of outstanding interest, Isolation of the gene encoding p21 and demonstration that it is a Cdk inhibitor (see [25 of outstanding interest]).
-
(1993)
Nature
, vol.366
, pp. 701-704
-
-
Xiong1
Hannon2
Zhang3
Casso4
Kobayashi5
Beach6
-
27
-
-
0027731971
-
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
-
(1993)
Nature
, vol.366
, pp. 707-710
-
-
Gu1
Turck2
Morgan3
-
29
-
-
0028342664
-
Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
-
of outstanding interest, It had long been hypothesized that the limitation of cellular proliferation in vitro was controlled by the synthesis of an inhibitor of DNA synthesis. This remarkable paper documents the isolation of the SD11 (CIP1, WAF1, p21) gene using a cDNA expression approach looking for proteins from senescent cells capable of blocking DNA replication. The Sdi1 transcript was shown to be induced 20-fold in senescent versus young fibroblasts. This discovery suggests that the cellular senscence phenomenon is likely to be a mechanism directly involved in prevention of cancer (see [25 of outstanding interest]).
-
(1994)
Experimental Cell Research
, vol.211
, pp. 90-98
-
-
Noda1
Ning2
Venable3
Pereira-Smiths4
Smith5
-
30
-
-
0026459047
-
D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
-
35S-labelled band found in Cdk immunoprecipitates.
-
(1992)
Cell
, vol.71
, pp. 505-514
-
-
Xiong1
Zhang2
Beach3
-
31
-
-
0027301324
-
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
-
35S-labelled band found in Cdk immunoprecipitates.
-
(1992)
Genes & Development
, vol.7
, pp. 1572-1583
-
-
Xiong1
Zhang2
Beach3
-
33
-
-
0026452949
-
Defects in cell cycle checkpoints may be responsible for the genomic instability in cancer cells
-
(1992)
Cell
, vol.71
, pp. 543-546
-
-
Hartwell1
-
37
-
-
0027756186
-
p53: at the crossroads of molecular carcinogenesis and risk assessment
-
(1993)
Science
, vol.262
, pp. 1980-1981
-
-
Harris1
-
38
-
-
0028137084
-
p53: a glimpse at the puppet behind the shadow play
-
(1994)
Science
, vol.265
, pp. 334-335
-
-
Friend1
-
40
-
-
0028352434
-
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
-
of outstanding interest, This paper and [41 of outstanding interest] document the discovery that p21 can associate with and inhibit PCNA function independently of its role as an inhibitor of cyclin-dependent kinases. p21 can directly block DNA replication in purified systems dependent upon PCNA.
-
(1994)
Nature
, vol.369
, pp. 574-578
-
-
Waga1
Hannon2
Beach3
Stillman4
-
44
-
-
0028176483
-
Cloning of p27K1P1, a cyclin-dependent kinase inhibitor and potential mediator of extracellular antimitogenic signals
-
1 when overexpressed. p27 has homology to p21 in a domain shown to be sufficient for Cdk inhibition.
-
(1994)
Cell
, vol.78
, pp. 59-66
-
-
Polyak1
Lee2
Erdjument-Bromage3
Tempst4
Massague5
-
45
-
-
0028363519
-
1 cyclin-Cdk protein kinase activity, is related to p21
-
of outstanding interest, See [44 of outstanding interest]
-
(1994)
Cell
, vol.78
, pp. 67-74
-
-
Totoshima1
Hunter2
-
48
-
-
0027769876
-
A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
-
of outstanding interest, This paper describes the cloning of the gene encoding the p16 protein and demonstrates that it acts as a specific inhibitor of Cdk4-cyclin D complexes. p16 was later shown to be mutant in a number of human tumor-derived cell lines, suggesting another direct link between cancer and negative regulation of the basic cell cycle regulatory machinery (see [49 of special interest, 50 of special interest]).
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano1
Hannon2
Beach3
-
50
-
-
0028275733
-
Delection of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
-
of special interest, See [48 of outstanding interest, 49 of special interest].
-
(1994)
Nature
, vol.368
, pp. 753-756
-
-
Nobori1
Miura2
Wu3
Lois4
Takabayashi5
Carson6
-
53
-
-
0028168242
-
INK48 is a potential effector of TGFβ-induced cell cycle arrest
-
(1994)
Nature
, vol.371
, pp. 257-261
-
-
Hannon1
Beach2
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