Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of P27Kip1

Cell

Volumn 85, Issue 5, 1996, Pages 721-732

  Kiyokawa, Hiroaki ^a   Kineman, Rhonda D ^b   Manova Todorova, Katia O ^a   Soares, Vera C ^a   Huffman, Eric S ^c   Ono, Masao ^a   Khanam, Dilruba ^a   Hayday, Adrian C ^c   Frohman, Lawrence A ^b   Koff, Andrew ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE DISRUPTION; GROWTH REGULATION; HYPOPHYSIS INTERMEDIATE LOBE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LUTEAL CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALIA;

EID: 15844415946     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81238-6     Document Type: Article

References (44)

1. Chen, I.-T., Akamatsu, M., Smith, M.L., Lung, F.-D.L., Duba, D., Roleer, P.P., Fornace, A.J., Jr., and O'Connor, P.M. (1996). Characterization of p21 Cip1/Waf1 peptide domains required for cyclin E/ Cdk2 and PCNA interaction. Oncogene 12, 595-607.
2. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., and Wylie, A.M. (1993). Thymoycte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.
3. Kip1 for restriction point control of the fibroblast cell cycle. Science, in press.
4. Dudley, E.C., Petrie, H.T., Shah, L.M., Owen, M.J., and Hayday, A.C. (1994). T cell receptor β chain gene rearrangment and selection during thymocyte development in adult mice. Immunity 1, 83-93.
5. Ewen, M.E., Sluss, H.K., Whitehouse, L.L., and Livingston, D.M. (1993). TGFβ inhibition of CDK4 synthesis is linked to cell cycle arrest. Cell 74, 1009-1020.
6. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S.A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
7. Gu, Y., Turck, C.W., and Morgan, D.O. (1993). Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710.
8. Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., and Elledge, S.J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816.
9. Harper, J.W., Elledge, S.J., Keyomarsi, K., Dynlacht, B., Tsai, L.H., Zhang, P., Dobrowolski, S., Bai, C., Connell-Crowley, L., Swindell, E., Fox, M.P., and Wei, N. (1995). Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 6, 387-400.
10. Hinds, P.W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S.I., and Weinberg, R.A. (1992). Regulation of retinoblastoma functions by ectopic expression of human cyclins. Cell 70, 993-1006.
11. Δ20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9, 1021-1027.
12. Jacks, T., Fazeli, A., Schmitt, E.M., Bronson, R.T., Goodell, M.A., and Weinberg, R.A. (1992). Effects of an Rb mutation in the mouse. Nature 359, 295-300.
13. KIP1, an inhibitor of cyclin-dependent kinases. In Progress in Cell Cycle Research, Volume 1, L. Meijer, S. Guidet, and H.Y.L. Tung, eds. (New York: Plenum Press), pp. 141-147.
14. Kranenburg, O., Scharnhorst, V., Van der Eb, A., and Zantema, A. (1995). Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells. J. Cell Biol. 131, 227-234.
15. KIP2, a cyclin-dependent kinase inhibitor with a unique domain structure and tissue distribution. Genes Dev. 9, 639-649.
16. Liu, M., Lee, M.H., Cohen, M., Bommakanti, M., and Freedman, L.P. (1996). Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev. 10, 142-153.
17. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
18. Cip1. Nature 375, 159-161.
19. Mansour, S.L., Thomas, K.R., and Capecchi, M.R. (1988). Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 366, 348-354.
20. Mathews, L.S., Hammer, R.E., Behringer, R.R., D'Ercole, A.J., Bell, G.I., Brinster, R.L., and Palmiter, R.D. (1988). Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology 123, 2827-2833.
21. CIP1 Cd k inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 9, 650-662.
22. Morgan, D.O. (1995). Principles of CDK regulation. Nature 374, 131-134.
23. Morstyn, G., Hsu, S.M., Kinsella, T., Gratzner, H., Russo, A., and Mitchell, J.B. (1983). Bromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody. J. Clin. Invest. 72, 1877-1883.
24. Sdi1/CIP1/WAF1. EMBO J. 14, 555-563.
25. Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, l., Loh, D.Y., and Nakayama, K.-i. (1996). Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, this issue.
26. Nelson, J.F., Felicio, L.S., Randall, P.K., Sims, C., and Finch, C.B. (1982). A longitudinal study of estrous cyclicity in aging C57BL/6J mice. I. Cycle frequency, length, and vaginal cytology. Biol. Reprod. 27, 327-339.
27. Ohtsubo, M., and Roberts, J.M. (1993). Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259, 1908-1912.
28. Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Brinberg, N.C., and Evans, R.M. (1982). Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300, 611-615.
29. Pardee, A.B. (1989). G1 events and the regulation of cell proliferation. Science 246, 603-608.
30. KIP1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev. 8, 9-22.
31. Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Koff, A., Roberts, J.M., Tempst, P., and Massagué, J. (1994b). Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66.
32. Prescott, D.M. (1976). Reproduction of Eukaryotic Cells (New York: Academic Press).
33. Quelle, D.E., Ashmun, R.A., Shurtleff, S.A., Kato, J.Y., Bar-Sagi, D., Roussel, M.F., and Sherr, C.J. (1993). Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev. 7, 1559-1571.
34. Resnitzky, D., and Reed, S.I. (1995). Different roles for cyclin D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol. 15, 3463-3469.
35. Reynisdottir, I., Polyak, K., Iavarone, A., and Massagué, J. (1995). Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9, 1831-1845.
36. Sherr, C.J. (1993). Mammalian G1 cyclins. Cell 73, 1059-1065.
37. Sherr, C.J., and Roberts, J.M. (1995). Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
38. Slingerland, J.M., Hengst, L., Pan, C.H., Alexander, D., Stampfer, M.R., and Reed, S.I. (1994). A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol. 14, 3683-3694.
39. Soos, T.J., Kiyokawa, H., Yan, J.S., Rubin, M.S., Giordano, A., DeBlasio, A., Bottega, S., Wong, B., Mendelsohn, J., and Koff, A. (1996). Formation of p27-CDK complexes during the human cell cycle. Cell Growth Differ. 7, 135-146.
40. Swiatek, P.J., and Gridley, T. (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7, 2071-2084.
41. Toyoshima, H., and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67-74.
42. -) thymocytes using eight different surface markers. J. Immunol. 140, 1461-1470.
43. Xiong, Y., Hannon, G.J., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. (1993). p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704.
44. Zhang, H., Hannon, G.J., and Beach, D. (1994). p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8, 1750-1758.