메뉴 건너뛰기




Volumn 5, Issue 3, 1993, Pages 225-229

Spontaneous and carcinogen−induced tumorigenesis in p53−deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 0027521657     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1193-225     Document Type: Article
Times cited : (495)

References (34)
  • 1
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine, A. J., Momand, J. & Finlay, C. A. The p53 tumour suppressor gene. Nature 351, 453-456 (1991).
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 3
    • 0026579237 scopus 로고
    • TP53 tumor suppressor gene: A model for investigating human mutagenesis
    • Caron de Fromentel, C. & Soussi, T. TP53 tumor suppressor gene: A model for investigating human mutagenesis. Genes, Chrom. Cancer 4, 1-15 (1992).
    • (1992) Genes, Chrom. Cancer , vol.4 , pp. 1-15
    • Caron de Fromentel, C.1    Soussi, T.2
  • 4
    • 0027458942 scopus 로고
    • The p53 tumor suppressor gene as a common cellular target in human carcinogenesis
    • Chang, F., Syrjanen, S., Kurvinen, K. & Syrjanen, K. The p53 tumor suppressor gene as a common cellular target in human carcinogenesis. Am. j. Gastroenterol. 88, 174-186 (1993).
    • (1993) Am. j. Gastroenterol , vol.88 , pp. 174-186
    • Chang, F.1    Syrjanen, S.2    Kurvinen, K.3    Syrjanen, K.4
  • 5
    • 0024387728 scopus 로고
    • Mutations in the p53 gene occur in diverse human tumour types
    • Nigro, J. M. et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 342, 705-708 (1989).
    • (1989) Nature , vol.342 , pp. 705-708
    • Nigro, J.M.1
  • 7
    • 0025938198 scopus 로고
    • Infrequent p53 gene mutations in medulloblastomas
    • Saylors, R. L. et al. Infrequent p53 gene mutations in medulloblastomas. Cancer Res. 51, 4721-4723 (1991).
    • (1991) Cancer Res , vol.51 , pp. 4721-4723
    • Saylors, R.L.1
  • 8
    • 0026780478 scopus 로고
    • Rare occurrence of p53 gene mutations in multiple myeloma
    • Preudhomme, C. et al. Rare occurrence of p53 gene mutations in multiple myeloma. Br. J. Haematol. 81, 440 (1992).
    • (1992) Br. J. Haematol , vol.81 , pp. 440
    • Preudhomme, C.1
  • 9
    • 0026693045 scopus 로고
    • Mutation of p53 gene does not play a critical role in myelodysplastic syndrome and its transformation to acute leukaemia
    • Tsushita, K., Hotta, T., Ichikawa, A. & Saito, H. Mutation of p53 gene does not play a critical role in myelodysplastic syndrome and its transformation to acute leukaemia. Br. J. Haematol. 81, 456 (1992).
    • (1992) Br. J. Haematol , vol.81 , pp. 456
    • Tsushita, K.1    Hotta, T.2    Ichikawa, A.3    Saito, H.4
  • 10
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
    • Moll, U., Riou, G. & Levine, A. J. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. natn. Acad. Sci. U. S. A. 89, 7262-7266 (1992).
    • (1992) Proc. natn. Acad. Sci. U. S. A , vol.89 , pp. 7262-7266
    • Moll, U.1    Riou, G.2    Levine, A.J.3
  • 11
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin, D. et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250, 1233-1238 (1990).
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1
  • 12
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancerprone family with Li-Fraumeni syndrome
    • Srivastava, S., Zou, Z., Pirollo, K., Blattner, W. & Chang, E. Germ-line transmission of a mutated p53 gene in a cancerprone family with Li-Fraumeni syndrome. Nature 348, 747-749 (1990).
    • (1990) Nature , vol.348 , pp. 747-749
    • Srivastava, S.1    Zou, Z.2    Pirollo, K.3    Blattner, W.4    Chang, E.5
  • 13
    • 0026525839 scopus 로고
    • Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma
    • Toguchida, J. et al. Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma. New Engl. J. Med. 326, 1301-1308 (1992).
    • (1992) New Engl. J. Med , vol.326 , pp. 1301-1308
    • Toguchida, J.1
  • 14
    • 0026530299 scopus 로고
    • Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms
    • Malkin, D. et al. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. New Engl. J. Med. 326, 1309-1315 (1992).
    • (1992) New Engl. J. Med , vol.326 , pp. 1309-1315
    • Malkin, D.1
  • 15
    • 0026070065 scopus 로고
    • Friend virus-induced erythroleukemia and the multistage nature of cancer
    • Ben-David, Y. & Bernstein, A. Friend virus-induced erythroleukemia and the multistage nature of cancer. Cell 66, 831-834 (1991).
    • (1991) Cell , vol.66 , pp. 831-834
    • Ben-David, Y.1    Bernstein, A.2
  • 16
    • 0024431245 scopus 로고
    • High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
    • Lavigueur, A. et al. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Molec. cell. Biol. 9, 3982-3991 (1989).
    • (1989) Molec. cell. Biol , vol.9 , pp. 3982-3991
    • Lavigueur, A.1
  • 17
    • 0025731379 scopus 로고
    • Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
    • Milner, J. & Medcalf, E. A. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 65, 765-774 (1991).
    • (1991) Cell , vol.65 , pp. 765-774
    • Milner, J.1    Medcalf, E.A.2
  • 18
    • 0026510193 scopus 로고
    • Oncogenic forms of p53 inhibit p53-regulated gene expression
    • Kern, S. et al. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256, 827-830 (1992).
    • (1992) Science , vol.256 , pp. 827-830
    • Kern, S.1
  • 19
    • 0026770424 scopus 로고
    • Wild-type p53 activates transcription in vitro
    • Farmer, G. et al. Wild-type p53 activates transcription in vitro. Nature 358, 83-86 (1992).
    • (1992) Nature , vol.358 , pp. 83-86
    • Farmer, G.1
  • 20
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 21
    • 0014359253 scopus 로고
    • Sr. Pulmonary and hepatic oncogenesis during treatment of male RF mice with dimethylnitrosamine
    • Clapp, N. K., Craig, A. W. & Toya, R. E. Sr. Pulmonary and hepatic oncogenesis during treatment of male RF mice with dimethylnitrosamine. J. natn Cancer Inst. 41, 1213-1221 (1968).
    • (1968) J. natn Cancer Inst , vol.41 , pp. 1213-1221
    • Clapp, N.K.1    Craig, A.W.2    Toya, R.E.3
  • 22
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone, L. et al. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70, 923-935 (1992).
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.1
  • 23
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin, Y., Tainsky, M. A., Bischoff, F. Z., Strong, L. C. & Wahl, G. M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70, 937-948 (1992).
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 24
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan, M. et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.1
  • 26
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke, A. R. et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852 (1993).
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1
  • 27
    • 0345210657 scopus 로고
    • Unique features of childhood cancer
    • 3rd edn, (eds Holland, J. F. et al.) (Lea & Febiger, Malvern, Philadelphia)
    • Triche, T. J. Unique features of childhood cancer. In Cancer Medicine, 3rd edn, (eds Holland, J. F. et al.) 2144-2152 (Lea & Febiger, Malvern, Philadelphia, 1993).
    • (1993) Cancer Medicine , pp. 2144-2152
    • Triche, T.J.1
  • 28
    • 0016282859 scopus 로고
    • Childhood deaths by cell type
    • Miller, R. W. & Dalager, B. U. S. childhood deaths by cell type. J. Pediat. 85, 664 (1974).
    • (1974) J. Pediat , vol.85 , pp. 664
    • Miller, R.W.1    Dalager, B.U.S.2
  • 29
    • 84966187117 scopus 로고
    • Results from Contributing Centers-List of Tables
    • (Oxford University Press)
    • Parkin, D. M. et al. Results from Contributing Centers-List of Tables. InInternational Incidence of Childhood Cancer, No. 87, 101-107 (Oxford University Press, 1988).
    • (1988) International Incidence of Childhood Cancer , Issue.87 , pp. 101-107
    • Parkin, D.M.1
  • 30
    • 0023584218 scopus 로고
    • Genetics of cancer predisposition
    • Hansen, M. F. & Cavenee, W. K. Genetics of cancer predisposition. Cancer Res. 47, 5518-5527 (1987).
    • (1987) Cancer Res , vol.47 , pp. 5518-5527
    • Hansen, M.F.1    Cavenee, W.K.2
  • 31
    • 0025481692 scopus 로고
    • Biotransformation of dimethylnitrosamine
    • Fournier, P. Biotransformation of dimethylnitrosamine. J. Toxicol. Clin. Exp. 10, 283-296 (1990).
    • (1990) J. Toxicol. Clin. Exp , vol.10 , pp. 283-296
    • Fournier, P.1
  • 32
    • 0024401864 scopus 로고
    • Apoptosis-The mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity
    • Pritchard, D. J. & Butler, W. H. Apoptosis-The mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity. J. Pathol. 158, 253-260 (1989).
    • (1989) J. Pathol , vol.158 , pp. 253-260
    • Pritchard, D.J.1    Butler, W.H.2
  • 33
    • 0027203921 scopus 로고
    • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    • Kemp, C., Donehower, L. A., Bradley, A. & Balmain, A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822 (1993).
    • (1993) Cell , vol.74 , pp. 813-822
    • Kemp, C.1    Donehower, L.A.2    Bradley, A.3    Balmain, A.4
  • 34
    • 0026349058 scopus 로고
    • Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice
    • Burns, P. A. et al. Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene 6, 2363-2369 (1991).
    • (1991) Oncogene , vol.6 , pp. 2363-2369
    • Burns, P.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.