Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

Cell

Volumn 64, Issue 2, 1991, Pages 327-336

  Liotta, Lance A ^a   Steeg, Patricia S ^a   Stetler Stevenson, William G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE; PROTEINASE;

ANGIOGENESIS; CANCER INVASION; CARCINOGENICITY; EXTRACELLULAR MATRIX; HUMAN; METASTASIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMAL; ENDOPEPTIDASES; HUMAN; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 0026027556     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90642-C     Document Type: Review

References (113)

1. Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases
2. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during angiogenesis
3. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells
4. Signal transduction for chemotaxis and haplotaxis by matrix molecules in tumor cells
5. Loss of basement membrane components by invasive tumors but not by their benign counterparts
6. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential
7. A Drosphila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase
8. Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line
9. cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases
10. The GTPase superfamily: a conserved switch for diverse cell functions
11. Independent expression and cellular processing of the 72-kDa type IV collagenase and interstitial collagenase in human tumorigenic cell lines
12. Primary structure and cDNA cloning of human fibroblast collagenase inhibitor
13. Observations on healing tissues a combined light and electron microscopic investigation
14. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen
15. Plasminogen activators, tissue degradation and cancer
16. b3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis
17. b3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis
18. Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells
19. Augmentation of type IV collagenase laminin receptor and Ki67 proliferation antigen associated with human colon gastric and breast carcinoma progression
20. Transformation by oncogenes encoding protein kinases induces the metastatic phenotype
21. Characterization of the cellular binding site for the urokinase-type plasminogen activator
22. Identification of the procollagen IV cleavage products produced by a specific tumor collagenase
23. Biologic diversity in metastatic neoplasms—origins and implications
24. The role of ras and myc oncogenes in human solid tumours and their relevance in diagnosis and prognosis
25. Tumor angiogenesis: therapeutic implications
26. Angiogenic factors
27. Induction of angiogenesis during the transition from hyperplasia to neoplasia
28. Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not C-ha-ras plus Ad2-Ela
29. Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement
30. Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2
31. The role of proteases in cancer
32. Oncogenes and metastatic progression
33. Cytokine-induced pseudopodial protrusion is coupled to tumour cell migration
34. Human neutrophil collagenase
35. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase
36. Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor
37. Expression of the anti-metastic gene nm23 in human breast cancer association with a good prognosis
38. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors
39. Clonal heterogeneity, experimental metastatic ability, and p21 expression in H-ras-transformed NIH 3T3 Cells
40. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells
41. Integrins: a family of cell surface receptors
42. Basement membrane collagen: degradation by migrating endothelial cells
43. Growth dominance of the metastatic cancer cell: cellular and molecular aspects
44. Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways
45. Antisense RNA-induced reduction in murine TIMP level confers oncogenicity on Swiss 3T3 cells
46. Conversion of GDP to GTP by nucleoside diphosphate kinase on the GTP-binding proteins
47. Increased membrane associated nucleotide diphosphate kinase activity as a possible basis for enhanced guanine nucleotide dependent adenylate cyclase activity induced by picolinic acid treatment of simian virus 40-transformed normal rat kidney cells
48. Membrane-associated nucleoside diphosphate kinase from rat liver
49. Isolation and characterization of a cDNA clone encoding rat nucleoside diphosphate kinase
50. Association of a plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells
51. Increased expression of the 72 kDa type IV collagenase in human colonic adenocarcinoma
52. Amplification of the int-2 gene in primary human breast tumors
53. Clues to the function of nm23 and Awd proteins in development, signal transduction, and tumor metastasis provided by studies of Dictyostelium discoideum
54. Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation
55. Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor
56. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
57. Tumor invasion and the extracellular matrix
58. Tumor cell autocrine motility factor
59. The Dictyostelium discoideum plasma membrane a model system for the study of actin-membrane interactions
60. The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precurson form of cathepsin L
61. Stromelysin/transin and tumor progression
62. How to use prognostic factors in axillary node-negative breast cancer patients
63. Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade
64. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases
65. Immunohistologic distribution of type IV collagenase in normal, benign and malignant breast tissue
66. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene
67. Identification of an inhibitor of neovascularization from cartilage
68. Nucleoside diphosphate kinase from Myxococcus xanthus. I. Cloning and sequencing of the gene
69. An inhibitor of collagenase from human amniotic fluid Purification characterization and action on metalloproteinase
70. Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell
71. Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones different metastatic potentials
72. Inhibition of retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells
73. Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells
74. The microtubule-associated nucleoside diphosphate kinase
75. Tumor cell instability, diversification and progression to the metastatic phenotype: from oncogene to oncofetal expression
76. Organ specificity of tumor metastasis: role of preferential adhesion, invasion, and growth of malignant cells at specific secondary sites
77. Antibodies to plasminogen activator inhibit human tumor metastasis
78. Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression
79. Nucleoside diphosphokinases
80. Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro
81. p53 increases experimental metastatic capacity of murine carcinoma cells
82. Primary rat embryo cells transformed by one or two oncogenes show different metastatic potentials
83. Evidence for a precursor of the high-affinity metastasis associated murine laminin receptor
84. A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B
85. Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells
86. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development
87. Increase of urokinase type plasminogen activator gene expression in human lung and breast carcinomas
88. Experimental approaches, theoretical concepts, and impacts for treatment strategies
89. Inhibition by recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells
90. Cell fusion segregates progressive growth from metastasis
91. Studies of the HER-2lneu proto-oncogene in human breast and ovarian cancer
92. Cysteine proteinases and metastasis
93. Evidence for a novel gene associated with low tumor metastatic potential
94. The activation of human type IV collagenase proenzyme
95. Tissue inhibitor of metalloproteinase (TIMP-2)
96. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues
97. Cathepsin D and prognosis in breast cancer
98. Cloning and characterization of human tumor cell interstitial collagenase
99. Overexpression of normal and mutated forms of CHaRas induce orthotopic bladder invasion in a human transitional cell carcinoma
100. Effect of natural protease inhibitors and a chemoattractant on tumor cell invasion in vitro
101. protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro
102. NIH 3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice
103. ras transfection and expression does not induce progression from tumorigenicity to metastatic ability in mouse LTA cells
104. Expression of collagenase IV (basement membrane collagenase) activity in murine tumor cell hybrids that differ in metastatic potential
105. Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells
106. Zinc coordination, function and structure of zinc enzymes and other proteins
107. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family
108. Dictyostelium nucleoside diphosphate kinase highly homologous to nm23 and awd proteins involved in mammalian tumor metastasis and Drosophila development
109. Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines
110. Blocking of collagenase secretion by estamustine during in vitro tumor cell invasion
111. Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells
112. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages
113. Molecular architecture of basement membranes