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1
-
-
0026345394
-
Protein Kinase Catalytic Domain Sequence Database: Identification of Conserved Features of Primary Structure and Classification of Family Members
-
(1991)
Methods Enzymol
, vol.200
, pp. 38-62
-
-
Hanks1
Quinn2
-
9
-
-
0027408171
-
Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor
-
of special interest, This paper and [5–8] provide a complete structural analysis of recombinant mouse cAPK in various binary and ternary complexes containing PKI, MgATP, MnATP and detergent.
-
(1993)
Biochemistry
, vol.32
, pp. 2154-2161
-
-
Zheng1
Knighton2
Ten Eyck3
Karlsson4
Xuong5
Taylor6
Sowadski7
-
10
-
-
0027409462
-
2+ Adenylyl Imidodiphosphate and Inhibitor Peptide
-
of outstanding interest, High resolution analysis of purified porcine cAPK in a complex with PKI and the MgATP analogue MnAMP-PNP. Includes a very thorough and well illustrated discussion of many important issues in cAPK catalytic function.
-
(1993)
EMBO J
, vol.12
, pp. 849-859
-
-
Bossemeyer1
Engh2
Kinzel3
Ponstingl4
Huber5
-
12
-
-
0027429591
-
Crystal Structures of the Myristylated Catalytic Subunit of cAMP-Dependent Protein Kinase Reveal Open and Closed Conformations
-
of outstanding interest, This paper and [11] provide the structure of purified porcine cAPK as an apoenzyme or in the presence of substrates. These studies reveal for the first time that the enzyme can exist in an open conformation that predominates in the absence of peptide substrate. The computer graphics program that accompanies this paper provides a nice introduction to the basics of protein kinase tertiary structure.
-
(1993)
Protein Sci
, vol.2
, pp. 1559-1573
-
-
Zheng1
Knighton2
Xuong3
Taylor4
Sowadski5
Ten Eyck6
-
13
-
-
0021887802
-
Circular Dichroic Evidence for an Ordered Sequence of Ligand/Binding Site Interactions in the Catalytic Reaction of the cAMP-Dependent Protein Kinase
-
(1985)
Biochemistry
, vol.24
, pp. 2967-2973
-
-
Reed1
Kinzel2
Kemp3
Cheng4
Walsh5
-
14
-
-
0027159007
-
Solution Structure of the cAMP-Dependent Protein Kinase Catalytic Subunit and its Contraction upon Binding the Protein Kinase Inhibitor Peptide
-
of special interest, Small-angle X-ray scattering and Fourier transform infrared spectroscopy reveal that the binding of PKI to the cAPK catalytic subunit results in a decrease in the general dimensions of the protein.
-
(1993)
Biochemistry
, vol.32
, pp. 3649-3657
-
-
Olah1
Mitchell2
Sosnick3
Walsh4
Trewhella5
-
15
-
-
0023668137
-
Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studies
-
(1987)
Biochemistry
, vol.26
, pp. 4118-4125
-
-
Yoon1
Cook2
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17
-
-
0025145585
-
Protein Kinases: Regulation by Autoinhibitory Domains
-
(1990)
J Biol Chem
, vol.265
, pp. 1823-1826
-
-
Soderling1
-
18
-
-
0025165211
-
Association of Catalytic and Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase Requires a Negatively Charged Side Group at a Conserved Threonine
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1066-1075
-
-
Levin1
Zoller2
-
19
-
-
0026640184
-
Systematic Mutational Analysis of cAMP-Dependent Protein Kinase Identifies Unregulated Catalytic Subunits and Defines Regions Important for the Recognition of the Regulatory Subunit
-
(1992)
J Biol Chem
, vol.267
, pp. 4806-4814
-
-
Gibbs1
Knighton2
Sowadski3
Taylor4
Zoller5
-
21
-
-
0027407640
-
Autoactivation of Catalytic (Cα) Subunit of Cyclic AMP-Dependent Protein Kinase by Phosphorylation of Threonine 197
-
ms for both substrates by 30- to 65-fold.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 2332-2341
-
-
Steinberg1
Cauthron2
Symcox3
Shuntoh4
-
23
-
-
0026620556
-
The Role of p34 Kinases in the G1 to S-Phase Transition
-
(1992)
Annu Rev Cell Biol
, vol.8
, pp. 529-561
-
-
Reed1
-
24
-
-
0027173109
-
Cyclins and Cyclin-Dependent Kinases: Take Your Partners
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 195-197
-
-
Pines1
-
25
-
-
0027242328
-
cdc2 Activation: the Interplay of Cyclin Binding and Thr161 Phosphorylation
-
(1993)
Trends Cell Biol
, vol.3
, pp. 287-289
-
-
Draetta1
-
28
-
-
0027532449
-
Phosphorylation-Independent Activation of Human Cyclin-Dependent Kinase 2 by Cyclin A in Vitro
-
of special interest, Detailed analysis dissects the activation of CDK2 by cyclin A binding and Thr160 phosphorylation. Although Thr160 phosphorylation is required for complete activation, considerable activation is induced by cyclin binding alone.
-
(1993)
Mol Biol Cell
, vol.4
, pp. 79-92
-
-
Connell-Crowley1
Solomon2
Wei3
Harper4
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29
-
-
0027296041
-
The MO15 Gene Encodes the Catalytic Subunit of a Protein Kinase that Activates cdc2 and Other Cyclin-Dependent Kinases (CDKs) Through Phosphorylation of Thr161 and its Homologues
-
of special interest, Purified CDK-activating kinase from starfish oocytes contains two subunits, and peptide sequences obtained from one of these subunits indicates that its catalytic subunit is the starfish homologue of a previously identified enzyme, MO15, from Xenopus.
-
(1993)
EMBO J
, vol.12
, pp. 3111-3121
-
-
Fesquet1
Labbe2
Derancourt3
Capony4
Galas5
Girard6
Lorca7
Shuttleworth8
Doree9
Cavadore10
-
30
-
-
0027251024
-
cdc2
-
of special interest, Studies of the Xenopus MO15 kinase indicate that it is the catalytic subunit of the CDK-activating kinase, and suggest that the activation of this kinase requires phosphorylation and/or association with another subunit.
-
(1993)
EMBO J
, vol.12
, pp. 3123-3132
-
-
Poon1
Yamashita2
Adamczewski3
Hunt4
Shuttleworth5
-
31
-
-
0027185999
-
MO15
-
of special interest, The Xenopus MO15 protein co-purifies through several chromatographic steps with CDK-activating kinase from Xenopus oocytes.
-
(1993)
EMBO J
, vol.12
, pp. 3133-3142
-
-
Solomon1
Harper2
Shuttleworth3
-
33
-
-
0026713875
-
Cell Cycle Regulation of CDK2 Activity by Phosphorylation of Thr160 and Tyr15
-
(1992)
EMBO J
, vol.11
, pp. 3995-4005
-
-
Gu1
Rosenblatt2
Morgan3
-
34
-
-
0026027660
-
cdc2 Kinase at the G1/S and G2/M Transitions of the Cell Cycle: Identification of Major Phosphorylation Sites
-
(1991)
EMBO J
, vol.10
, pp. 305-316
-
-
Krek1
Nigg2
-
38
-
-
0027496935
-
The p21 Cdk-Interacting Protein Cip1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases
-
of special interest, This paper and [39⊎,40⊎] describe a 21 kDa mammalian regulatory subunit that binds and inhibits the activity of certain CDK/cyclin complexes.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper1
Adami2
Wei3
Keyomarsi4
Elledge5
-
39
-
-
0027731971
-
Inhibition of CDK2 Activity in Vivo by an Associated 20K Regulatory Subunit
-
of special interest, Description of a previously unknown mouse protein that binds tightly to CDK2/cyclin complexes in vivo and inhibits their kinase activity (see also [38⊎,40⊎]).
-
(1993)
Nature
, vol.366
, pp. 707-710
-
-
Gu1
Turck2
Morgan3
-
40
-
-
0027717617
-
p21 is a Universal Inhibitor of Cyclin Kinases
-
of special interest, Identification of a 21 kDa human protein that binds to a variety of CDK/cyclin complexes in vivo and inhibits their activity (see also [38⊎,39⊎]).
-
(1993)
Nature
, vol.366
, pp. 701-704
-
-
Xiong1
Hannon2
Zhang3
Casso4
Kobayashi5
Beach6
-
41
-
-
0027339342
-
CDC28 Protein Kinase Activity from Saccharomyces cerevisiae
-
of special interest, Characterization of a 40 kDa protein from budding yeast that binds and inhibits the activity of CDC28, the major yeast CDK.
-
(1993)
Science
, vol.259
, pp. 216-219
-
-
Mendenhall1
-
42
-
-
0027191189
-
FAR1 Links the Signal Transduction Pathway to the Cell Cycle Machinery in Yeast
-
of special interest, Thorough analysis of FAR1, a protein that appears to bind and inhibit CDK activity in budding yeast. Interestingly, the inhibitory activity of FAR1 requires phosphorylation by another protein kinase.
-
(1993)
Cell
, vol.73
, pp. 747-760
-
-
Peter1
Gartner2
Horecka3
Ammerer4
Herskowitz5
-
45
-
-
0027482006
-
Human CksHs2 Atomic Structure: a Role for its Hexameric Assembly in Cell Cycle Control
-
of outstanding interest, Human CKS2 crystallizes as a beautiful hexamer that may function to oligomerize CDK/cyclin complexes in the cell.
-
(1993)
Science
, vol.262
, pp. 387-395
-
-
Parge1
Arvai2
Murtari3
Reed4
Tainer5
-
46
-
-
0027182223
-
Crystal Structure of Cyclin-Dependent Kinase 2
-
of outstanding interest, The crystal structures of the inactive CDK2 apoenzyme and MgATP complex reveal that two mechanisms seem to suppress kinase activity: first, the protein substrate binding site is blocked, and second, the phosphates of ATP are not oriented correctly.
-
(1993)
Nature
, vol.363
, pp. 595-602
-
-
De Bondt1
Rosenblatt2
Jancarik3
Jones4
Morgan5
Kim6
-
49
-
-
0027282118
-
A Three-Dimensional Model of the Cdc2 Protein Kinase: Localization of Cyclin- and Suc1-Binding Regions and Phosphorylation Sites
-
of special interest, In this paper and its two predecessors [47,48], small clusters of charged residues (or single charged residues) in human CDC2 were changed to alanine, and the resulting mutants were tested for their ability to bind cyclin A and CKS proteins. A model of the CDC2 structure, based on the cAPK crystal structure, was used to map the possible cyclin- and CKS-binding sites on the CDC2 surface.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 5122-5131
-
-
Marcote1
Knighton2
Basi3
Sowadski4
Brambilla5
Draetta6
Taylor7
-
50
-
-
0027509501
-
Phosphorylation and Activation of Human cdc25-C by cdc2-cyclin B and its Involvement in the Self-Amplification of MPF at Mitosis
-
of special interest, A complex of CDC2/cyclin B, but not of CDC2/cyclin A, phosphorylates and activates the phosphatase CDC25. As in [51⊎], the work provides an example of the influence of the cyclin subunit on substrate specificity of the CDK catalytic subunit.
-
(1993)
EMBO J
, vol.12
, pp. 53-63
-
-
Hoffman1
Clarke2
Marcote3
Karsenti4
Draetta5
-
51
-
-
0027207334
-
A- and B-Type Cyclins Differentially Modulate Substrate Specificity of Cyclin-Cdk Complexes
-
of special interest, Clear example of the ability of the cyclin subunit to influence the substrate specificity of the associated CDK subunit. CDK2/cyclin A, but not CDK2/cyclin B, is able to phosphorylate p107 at a significant rate in vitro. p107 is shown to bind the CDK2/cyclin A complex and not the complex containing cyclin B, suggesting a direct interaction between this substrate and cyclin A.
-
(1993)
EMBO J
, vol.12
, pp. 1947-1954
-
-
Peeper1
Parker2
Ewen3
Toebes4
Hall5
Xu6
Zantema7
van der Eb8
Piwnica-Worms9
-
52
-
-
0028157664
-
Atomic Structure of the MAP Kinase ERK2 at 2.3 Ȧ Resolution
-
of outstanding interest, in press, The crystal structures of ERK2 and an MgATP complex reveal the complex conformational restraints that appear to suppress kinase activity in the unphosphorylated enzyme.
-
(1994)
Nature
-
-
Zhang1
Strand2
Robbins3
Cobb4
Goldsmith5
-
56
-
-
0027532627
-
Regulation and Properties of Extracellular Signal-Regulated Protein Kinases 1 and 2 in Vitro
-
of special interest, Complete analysis of phosphorylation of ERK1 and ERK2 in vitro by autophosphorylation and by the activating kinase.
-
(1993)
J Biol Chem
, vol.268
, pp. 5097-5106
-
-
Robbins1
Zhen2
Owaki3
Vanderbilt4
Ebert5
Geppert6
Cobb7
-
57
-
-
0025120244
-
Requirement for Integration of Signals from Two Distinct Phosphorylation Pathways for Activation of MAP Kinase
-
(1990)
Nature
, vol.343
, pp. 651-653
-
-
Anderson1
Maller2
Tonks3
Sturgill4
-
58
-
-
0025832605
-
Multiple Components in an Epidermal Growth Factor-Stimulated Protein Kinase Cascade: in Vitro Activation of a Myelin Basic Protein/Microtubule-Associated Protein 2 Kinase
-
(1991)
J Biol Chem
, vol.266
, pp. 4220-4227
-
-
Ahn1
Seger2
Bratlien3
Diltz4
Tonks5
Krebs6
-
59
-
-
0022494971
-
Replacement of Insulin Receptor Tyrosine Residues 1162 and 1163 Compromises Insulin-Stimulated Kinase Activity and Uptake of 2-Deoxyglucose
-
(1986)
Cell
, vol.45
, pp. 721-732
-
-
Ellis1
Clauser2
Morgan3
Edery4
Roth5
Rutter6
-
62
-
-
0025885070
-
Isolation of the Human cdk2 Gene that Encodes the Cyclin A- and Adenovirus E1A-Associated p33 Kinase
-
(1991)
Nature
, vol.353
, pp. 174-177
-
-
Tsai1
Harlow2
Meyerson3
-
64
-
-
0020566206
-
Structure and Sequence of the Cellular Gene Homologous to the RSV src Gene and the Mechanism for Generating the Transforming Virus
-
(1983)
Cell
, vol.32
, pp. 881-890
-
-
Takeya1
Hanafusa2
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